Publication Information

{'id': 'https://openalex.org/W1993435783', 'doi': 'https://doi.org/10.1001/jama.2012.304', 'title': 'Dexmedetomidine vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation', 'display_name': 'Dexmedetomidine vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation', 'publication_year': 2012, 'publication_date': '2012-03-21', 'ids': {'openalex': 'https://openalex.org/W1993435783', 'doi': 'https://doi.org/10.1001/jama.2012.304', 'mag': '1993435783', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22436955'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1001/jama.2012.304', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S172573765', 'display_name': 'JAMA', 'issn_l': '0098-7484', 'issn': ['0098-7484', '1538-3598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064425085', 'display_name': 'Stephan M. 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J. Garratt', 'orcid': 'https://orcid.org/0000-0002-2137-1017'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Chris Garratt', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107928419', 'display_name': 'Stuart J. Pocock', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Stuart J Pocock', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008189593', 'display_name': 'J. Raymond Bratty', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Raymond Bratty', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103397184', 'display_name': 'Jukka Takala', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jukka Takala', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105900541', 'display_name': 'Dexmedetomidine for Long-Term Sedation Investigators', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210134544', 'display_name': 'Centre Hospitalier Universitaire de Liège', 'ror': 'https://ror.org/044s61914', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210134544']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Dexmedetomidine for Long-Term Sedation Investigators', 'raw_affiliation_strings': ['Centre Hospitalier Universitaire de Liège - CHU >  > Frais communs médecine - Pool assistants >'], 'affiliations': [{'raw_affiliation_string': 'Centre Hospitalier Universitaire de Liège - CHU >  > Frais communs médecine - Pool assistants >', 'institution_ids': ['https://openalex.org/I4210134544']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 49.097, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 833, 'citation_normalized_percentile': {'value': 0.999496, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '307', 'issue': '11', 'first_page': '1151', 'last_page': '1151'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10867', 'display_name': 'Intensive Care Unit Cognitive Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2706', 'display_name': 'Critical Care and Intensive Care Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10867', 'display_name': 'Intensive Care Unit Cognitive Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2706', 'display_name': 'Critical Care and Intensive Care Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10436', 'display_name': 'Anesthesia and Sedative Agents', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2703', 'display_name': 'Anesthesiology and Pain Medicine'}, 'field': 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'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D020927', 'descriptor_name': 'Dexmedetomidine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D006993', 'descriptor_name': 'Hypnotics and Sedatives', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008874', 'descriptor_name': 'Midazolam', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D015742', 'descriptor_name': 'Propofol', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D012121', 'descriptor_name': 'Respiration, Artificial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016292', 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'https://openalex.org/W2082311304', 'https://openalex.org/W2092925442', 'https://openalex.org/W2109005423', 'https://openalex.org/W2114262384', 'https://openalex.org/W2117839048', 'https://openalex.org/W2123098876', 'https://openalex.org/W2129562049', 'https://openalex.org/W2135672238', 'https://openalex.org/W2138141660', 'https://openalex.org/W2151086162', 'https://openalex.org/W2160359556', 'https://openalex.org/W2322707526'], 'related_works': ['https://openalex.org/W4376620542', 'https://openalex.org/W3168452958', 'https://openalex.org/W3045564087', 'https://openalex.org/W3031161757', 'https://openalex.org/W2946554642', 'https://openalex.org/W2364894582', 'https://openalex.org/W2328587505', 'https://openalex.org/W2133883601', 'https://openalex.org/W2036097790', 'https://openalex.org/W1843147913'], 'abstract_inverted_index': {'<h3>Context</h3>Long-term': [0], 'sedation': [1, 123, 153, 179, 221, 250], 'with': [2, 57, 80, 96, 147, 171, 190, 269, 286, 308, 394, 404, 413], 'midazolam': [3, 39, 79, 276, 344, 378, 395, 405], 'or': [4, 40, 150], 'propofol': [5, 41, 95, 293, 380], 'in': [6, 45, 82, 87, 98, 101, 108, 224, 246, 381], 'intensive': [7], 'care': [8], 'units': [9], '(ICUs)': [10], 'has': [11], 'serious': [12], 'adverse': [13, 409], 'effects.': [14], 'Dexmedetomidine,': [15], 'an': [16], 'α<sub>2</sub>-agonist': [17], 'available': [18], 'for': [19, 124], 'ICU': [20, 113, 216, 334, 367], 'sedation,': [21], 'may': [22], 'reduce': [23], 'the': [24, 34, 91], 'duration': [25, 49, 193, 263, 389], 'of': [26, 36, 50, 84, 175, 194, 215, 264, 333, 390], 'mechanical': [27, 51, 116, 195, 265, 371, 391], 'ventilation': [28, 117, 266, 392], 'and': [29, 53, 61, 105, 155, 186, 213, 256, 322, 335, 338, 357, 379, 396, 406], 'enhance': [30], 'patient': [31], 'comfort.<h3>Objective</h3>To': [32], 'determine': [33], 'efficacy': [35], 'dexmedetomidine': [37, 81, 97, 166, 270, 287, 309, 373], 'vs': [38, 133, 142, 231, 240, 275, 292, 313, 323, 343, 351, 361], '(preferred': [42], 'usual': [43], 'care)': [44], 'maintaining': [46, 382], 'sedation;': [47], 'reducing': [48], 'ventilation;': [52], 'improving': [54], "patients'": [55, 201, 398], 'interaction': [56, 302], 'nursing': [58], 'care.<h3>Design,': [59], 'Setting,': [60], 'Patients</h3>Two': [62], 'phase': [63], '3': [64], 'multicenter,': [65], 'randomized,': [66], 'double-blind': [67], 'trials': [68], 'carried': [69], 'out': [70], 'from': [71], '2007': [72], 'to': [73, 121, 169, 173, 188, 192, 203, 377, 384, 400], '2010.': [74], 'The': [75], 'MIDEX': [76], 'trial': [77, 93], 'compared': [78, 94, 393, 403], 'ICUs': [83], '44': [85], 'centers': [86, 100, 107], '9': [88], 'European': [89, 103], 'countries;': [90], 'PRODEX': [92], '31': [99], '6': [102], 'countries': [104], '2': [106], 'Russia.': [109], 'Included': [110], 'were': [111, 200, 340, 411], 'adult': [112], 'patients': [114, 345, 368], 'receiving': [115, 369], 'who': [118], 'needed': [119], 'light': [120, 383], 'moderate': [122, 385], 'more': [125, 347], 'than': [126], '24': [127], 'hours': [128, 272, 278, 289, 295], '(midazolam,': [129, 227], 'n': [130, 135, 139, 144, 228, 233, 237, 242], '=': [131, 136, 140, 145, 229, 234, 238, 243, 282, 299, 355], '251,': [132], 'dexmedetomidine,': [134, 143, 148, 232, 241], '249;': [137], 'propofol,': [138, 236, 324], '247,': [141], '251).<h3>Interventions</h3>Sedation': [146], 'midazolam,': [149, 314], 'propofol;': [151], 'daily': [152], 'stops;': [154], 'spontaneous': [156], 'breathing': [157], 'trials.<h3>Main': [158], 'Outcome': [159], 'Measures</h3>For': [160], 'each': [161], 'trial,': [162], 'we': [163], 'tested': [164], 'whether': [165], 'was': [167, 222, 251, 306, 374], 'noninferior': [168], 'control': [170, 189], 'respect': [172, 191], 'proportion': [174], 'time': [176, 247], 'at': [177, 219, 248], 'target': [178, 220, 249], 'level': [180], '(measured': [181, 206, 303], 'by': [182], 'Richmond': [183], 'Agitation-Sedation': [184], 'Scale)': [185], 'superior': [187], 'ventilation.': [196], 'Secondary': [197], 'end': [198], 'points': [199], 'ability': [202, 399], 'communicate': [204, 401], 'pain': [205, 402], 'using': [207, 304], 'a': [208], 'visual': [209], 'analogue': [210], 'scale': [211], '[VAS])': [212], 'length': [214], 'stay.': [217], 'Time': [218], 'analyzed': [223], 'per-protocol': [225], 'population': [226], '233,': [230], '227;': [235], '214,': [239], '223).<h3>Results</h3>Dexmedetomidine/midazolam': [244], 'ratio': [245], '1.07': [252], '(95%': [253, 259], 'CI,': [254, 260, 317, 327], '0.97-1.18)': [255], 'dexmedetomidine/propofol,': [257], '1.00': [258], '0.92-1.08).': [261], 'Median': [262], 'appeared': [267], 'shorter': [268], '(123': [271], '[IQR,': [273, 279, 290, 296], '67-337])': [274], '(164': [277], '92-380];': [280], 'P': [281, 298, 319, 329, 354, 364], '.03)': [283], 'but': [284], 'not': [285, 375], '(97': [288], '45-257])': [291], '(118': [294], '48-327];': [297], '.24).': [300], "Patients'": [301], 'VAS)': [305], 'improved': [307, 397], '(estimated': [310], 'score': [311], 'difference': [312], '19.7': [315], '[95%': [316, 326], '15.2-24.2];': [318], '&lt;': [320, 330, 365], '.001;': [321], '11.2': [325], '6.4-15.9];': [328], '.001).': [331], 'Length': [332], 'hospital': [336], 'stay': [337], 'mortality': [339], 'similar.': [341], 'Dexmedetomidine': [342, 387], 'had': [346], 'hypotension': [348], '(51/247': [349], '[20.6%]': [350], '29/250': [352], '[11.6%];': [353], '.007)': [356], 'bradycardia': [358], '(35/247': [359], '[14.2%]': [360], '13/250': [362], '[5.2%];': [363], '.001).<h3>Conclusions</h3>Among': [366], 'prolonged': [370], 'ventilation,': [372], 'inferior': [376], 'sedation.': [386], 'reduced': [388], 'propofol.': [407], 'More': [408], 'effects': [410], 'associated': [412], 'dexmedetomidine.<h3>Trial': [414], 'Registration</h3>clinicaltrials.gov': [415], 'Identifiers:': [416], 'NCT00481312,': [417], 'NCT00479661': [418]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993435783', 'counts_by_year': [{'year': 2024, 'cited_by_count': 47}, {'year': 2023, 'cited_by_count': 51}, {'year': 2022, 'cited_by_count': 61}, {'year': 2021, 'cited_by_count': 86}, {'year': 2020, 'cited_by_count': 72}, {'year': 2019, 'cited_by_count': 66}, {'year': 2018, 'cited_by_count': 62}, {'year': 2017, 'cited_by_count': 63}, {'year': 2016, 'cited_by_count': 72}, {'year': 2015, 'cited_by_count': 57}, {'year': 2014, 'cited_by_count': 77}, {'year': 2013, 'cited_by_count': 78}, {'year': 2012, 'cited_by_count': 33}], 'updated_date': '2024-12-23T20:38:09.988858', 'created_date': '2016-06-24'}