Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1993433202', 'doi': 'https://doi.org/10.1001/archopht.1992.01080140044023', 'title': 'Sustained-Release Ganciclovir Therapy for Treatment of Cytomegalovirus Retinitis', 'display_name': 'Sustained-Release Ganciclovir Therapy for Treatment of Cytomegalovirus Retinitis', 'publication_year': 1992, 'publication_date': '1992-02-01', 'ids': {'openalex': 'https://openalex.org/W1993433202', 'doi': 'https://doi.org/10.1001/archopht.1992.01080140044023', 'mag': '1993433202', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1310587'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1001/archopht.1992.01080140044023', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80523760', 'display_name': 'Archives of Ophthalmology', 'issn_l': '0003-9950', 'issn': ['0003-9950', '1538-3601'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064054437', 'display_name': 'George E. Sanborn', 'orcid': 'https://orcid.org/0000-0002-0444-6988'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'George E. Sanborn', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Texas, Southwestern Medical Center, Dallas 75235-9057.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Texas, Southwestern Medical Center, Dallas 75235-9057.', 'institution_ids': ['https://openalex.org/I867280407']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5064054437'], 'corresponding_institution_ids': ['https://openalex.org/I867280407'], 'apc_list': None, 'apc_paid': None, 'fwci': 16.746, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 228, 'citation_normalized_percentile': {'value': 0.989088, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '110', 'issue': '2', 'first_page': '188', 'last_page': '188'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11194', 'display_name': 'Ocular Diseases and Behçet’s Syndrome', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10170', 'display_name': 'Retinal Diseases and Treatments', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cytomegalovirus-retinitis', 'display_name': 'Cytomegalovirus retinitis', 'score': 0.90301263}, {'id': 'https://openalex.org/keywords/cytomegalovirus', 'display_name': 'Cytomegalovirus', 'score': 0.6252209}, {'id': 'https://openalex.org/keywords/foscarnet', 'display_name': 'Foscarnet', 'score': 0.55551106}, {'id': 'https://openalex.org/keywords/vitreous-hemorrhage', 'display_name': 'Vitreous hemorrhage', 'score': 0.48717946}], 'concepts': [{'id': 'https://openalex.org/C2777965375', 'wikidata': 'https://www.wikidata.org/wiki/Q417640', 'display_name': 'Ganciclovir', 'level': 4, 'score': 0.98559654}, {'id': 'https://openalex.org/C2777016524', 'wikidata': 'https://www.wikidata.org/wiki/Q630552', 'display_name': 'Retinitis', 'level': 4, 'score': 0.9461552}, {'id': 'https://openalex.org/C2777324356', 'wikidata': 'https://www.wikidata.org/wiki/Q4271835', 'display_name': 'Cytomegalovirus retinitis', 'level': 5, 'score': 0.90301263}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.80272746}, {'id': 'https://openalex.org/C2777732132', 'wikidata': 'https://www.wikidata.org/wiki/Q6946', 'display_name': 'Cytomegalovirus', 'level': 5, 'score': 0.6252209}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.57133573}, {'id': 'https://openalex.org/C2776724271', 'wikidata': 'https://www.wikidata.org/wiki/Q420387', 'display_name': 'Foscarnet', 'level': 5, 'score': 0.55551106}, {'id': 'https://openalex.org/C2778257484', 'wikidata': 'https://www.wikidata.org/wiki/Q555066', 'display_name': 'Visual acuity', 'level': 2, 'score': 0.50623554}, {'id': 'https://openalex.org/C2777104736', 'wikidata': 'https://www.wikidata.org/wiki/Q1529650', 'display_name': 'Vitreous hemorrhage', 'level': 4, 'score': 0.48717946}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.48574072}, {'id': 'https://openalex.org/C2779820661', 'wikidata': 'https://www.wikidata.org/wiki/Q6929', 'display_name': 'Human cytomegalovirus', 'level': 3, 'score': 0.34281796}, {'id': 'https://openalex.org/C2776409557', 'wikidata': 'https://www.wikidata.org/wiki/Q149348', 'display_name': 'Herpesviridae', 'level': 4, 'score': 0.24958691}, {'id': 'https://openalex.org/C2781242345', 'wikidata': 'https://www.wikidata.org/wiki/Q924295', 'display_name': 'Vitrectomy', 'level': 3, 'score': 0.16914782}, {'id': 'https://openalex.org/C3013748606', 'wikidata': 'https://www.wikidata.org/wiki/Q15787', 'display_name': 'Human immunodeficiency virus (HIV)', 'level': 2, 'score': 0.15773788}, {'id': 'https://openalex.org/C2780727368', 'wikidata': 'https://www.wikidata.org/wiki/Q1928978', 'display_name': 'Viral disease', 'level': 3, 'score': 0.15321353}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.13096166}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.08777705}], 'mesh': [{'descriptor_ui': 'D003586', 'descriptor_name': 'Cytomegalovirus Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D004343', 'descriptor_name': 'Drug Implants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015828', 'descriptor_name': 'Eye Infections, Viral', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D015774', 'descriptor_name': 'Ganciclovir', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D012173', 'descriptor_name': 'Retinitis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000163', 'descriptor_name': 'Acquired Immunodeficiency Syndrome', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D000163', 'descriptor_name': 'Acquired Immunodeficiency Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003586', 'descriptor_name': 'Cytomegalovirus Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003692', 'descriptor_name': 'Delayed-Action Preparations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004341', 'descriptor_name': 'Drug Evaluation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015828', 'descriptor_name': 'Eye Infections, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005500', 'descriptor_name': 'Follow-Up Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015774', 'descriptor_name': 'Ganciclovir', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D015774', 'descriptor_name': 'Ganciclovir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012173', 'descriptor_name': 'Retinitis', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D012173', 'descriptor_name': 'Retinitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014822', 'descriptor_name': 'Vitreous Body', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1001/archopht.1992.01080140044023', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80523760', 'display_name': 'Archives of Ophthalmology', 'issn_l': '0003-9950', 'issn': ['0003-9950', '1538-3601'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1310587', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.87, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1966562440', 'https://openalex.org/W1969151374', 'https://openalex.org/W1969909913', 'https://openalex.org/W1970094487', 'https://openalex.org/W1974881857', 'https://openalex.org/W1981156436', 'https://openalex.org/W1982079405', 'https://openalex.org/W1982831269', 'https://openalex.org/W1985821978', 'https://openalex.org/W1992039589', 'https://openalex.org/W1995111831', 'https://openalex.org/W2002553384', 'https://openalex.org/W2005165933', 'https://openalex.org/W2008536957', 'https://openalex.org/W2013953798', 'https://openalex.org/W2027551222', 'https://openalex.org/W2030460966', 'https://openalex.org/W2047621907', 'https://openalex.org/W2054381386', 'https://openalex.org/W2069695433', 'https://openalex.org/W2072907988', 'https://openalex.org/W2075740239', 'https://openalex.org/W2077605130', 'https://openalex.org/W2090222270', 'https://openalex.org/W2095729328', 'https://openalex.org/W2133068342', 'https://openalex.org/W2437290684', 'https://openalex.org/W2616647315'], 'related_works': ['https://openalex.org/W2411361522', 'https://openalex.org/W2408604974', 'https://openalex.org/W2397864640', 'https://openalex.org/W2145821687', 'https://openalex.org/W2142455206', 'https://openalex.org/W2081755907', 'https://openalex.org/W2008736461', 'https://openalex.org/W1980982647', 'https://openalex.org/W1979471217', 'https://openalex.org/W13840798'], 'abstract_inverted_index': {'•': [0], 'A': [1], 'surgically': [2], 'implantable': [3], 'device': [4, 15], 'for': [5, 127], 'sustained': [6], 'intravitreal': [7, 124], 'release': [8], 'of': [9, 41, 55, 63, 96, 130], 'ganciclovir': [10, 17, 57, 125], 'has': [11], 'been': [12], 'developed.': [13], 'The': [14], 'delivers': [16], 'intraocularly': [18], 'over': [19], 'approximately': [20], '4': [21], 'to': [22], '5': [23], 'months.': [24], 'Eight': [25], 'patients': [26, 134], 'with': [27, 48, 119, 135], 'acquired': [28], 'immunodeficiency': [29], 'syndrome': [30], '(AIDS)': [31], 'and': [32, 81, 93], 'associated': [33], 'cytomegalovirus': [34], '(CMV)': [35], 'retinitis': [36, 51, 107, 132], 'were': [37], 'recruited': [38], 'as': [39, 105], 'part': [40], 'a': [42], 'phase': [43], '1': [44], 'study.': [45], 'Thirteen': [46], 'eyes': [47, 60, 104], 'active': [49], 'CMV': [50, 65, 131], 'underwent': [52], 'surgical': [53], 'implantation': [54], 'the': [56, 64, 97, 106, 128], 'device.': [58, 98], 'All': [59], 'showed': [61, 68], 'resolution': [62], 'retinitis;': [66], 'none': [67], 'progression.': [69], 'Visual': [70], 'acuity': [71], 'remained': [72], 'unchanged': [73], 'in': [74, 78, 83, 102, 133], 'three': [75, 103], 'eyes,': [76, 80], 'improved': [77], 'six': [79], 'decreased': [82], 'four': [84], 'eyes.': [85], 'Surgical': [86], 'complications': [87], 'included': [88], 'mild': [89], 'vitreous': [90], 'hemorrhage,': [91], 'astigmatism,': [92], 'suprachoroidal': [94], 'placement': [95], 'Retinal': [99], 'detachment': [100], 'occurred': [101], 'resolved.': [108], 'This': [109], 'new': [110], 'intraocular': [111], 'drug': [112], 'delivery': [113], 'system': [114], 'offers': [115], 'many': [116], 'advantages': [117], 'compared': [118], 'intravenous': [120], 'therapy': [121], 'or': [122], 'repeated': [123], 'injections': [126], 'management': [129], 'AIDS.': [136]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993433202', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-14T20:37:09.898423', 'created_date': '2016-06-24'}