Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1993363796', 'doi': 'https://doi.org/10.1046/j.1365-2443.2003.00615.x', 'title': 'A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway', 'display_name': 'A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway', 'publication_year': 2003, 'publication_date': '2003-01-01', 'ids': {'openalex': 'https://openalex.org/W1993363796', 'doi': 'https://doi.org/10.1046/j.1365-2443.2003.00615.x', 'mag': '1993363796', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12558800'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1046/j.1365-2443.2003.00615.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48908450', 'display_name': 'Genes to Cells', 'issn_l': '1356-9597', 'issn': ['1356-9597', '1365-2443'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023294408', 'display_name': 'Naoki Kimura', 'orcid': 'https://orcid.org/0000-0002-6419-0443'}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}, {'id': 'https://openalex.org/I137459256', 'display_name': 'Hyogo Medical University', 'ror': 'https://ror.org/001yc7927', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I137459256']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naoki Kimura', 'raw_affiliation_strings': ['Biosignal Research Center, Kobe University, Kobe 657-8501, Japan', 'Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan', 'These authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'Biosignal Research Center, Kobe University, Kobe 657-8501, Japan', 'institution_ids': ['https://openalex.org/I65837984']}, {'raw_affiliation_string': 'Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan', 'institution_ids': ['https://openalex.org/I137459256']}, {'raw_affiliation_string': 'These authors contributed equally to this work.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029163724', 'display_name': 'Chiharu Tokunaga', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Chiharu Tokunaga', 'raw_affiliation_strings': ['Biosignal Research Center, Kobe University, Kobe 657-8501, Japan', 'These authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'These authors contributed equally to this work.', 'institution_ids': []}, {'raw_affiliation_string': 'Biosignal Research Center, Kobe University, Kobe 657-8501, Japan', 'institution_ids': ['https://openalex.org/I65837984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061920772', 'display_name': 'Sushila Dalal', 'orcid': 'https://orcid.org/0000-0003-1207-0500'}, 'institutions': [{'id': 'https://openalex.org/I107672454', 'display_name': 'Dartmouth College', 'ror': 'https://ror.org/049s0rh22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I107672454']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sushila Dalal', 'raw_affiliation_strings': ['Department of Medicine and Biochemistry, Division of Endocrinology, Diabetes and Metabolism, Dartmouth Medical School, Hanover, New Hampshire 03755, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine and Biochemistry, Division of Endocrinology, Diabetes and Metabolism, Dartmouth Medical School, Hanover, New Hampshire 03755, USA', 'institution_ids': ['https://openalex.org/I107672454']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070253707', 'display_name': 'Christine Richardson', 'orcid': 'https://orcid.org/0000-0003-2622-2261'}, 'institutions': [{'id': 'https://openalex.org/I107672454', 'display_name': 'Dartmouth College', 'ror': 'https://ror.org/049s0rh22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I107672454']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine Richardson', 'raw_affiliation_strings': ['Department of Medicine and Biochemistry, Division of Endocrinology, Diabetes and Metabolism, Dartmouth Medical School, Hanover, New Hampshire 03755, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine and Biochemistry, Division of Endocrinology, Diabetes and Metabolism, Dartmouth Medical School, Hanover, New Hampshire 03755, USA', 'institution_ids': ['https://openalex.org/I107672454']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076090873', 'display_name': 'Koichi Yoshino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ken‐ichi Yoshino', 'raw_affiliation_strings': ['Biosignal Research Center, Kobe University, Kobe 657-8501, Japan'], 'affiliations': [{'raw_affiliation_string': 'Biosignal Research Center, Kobe University, Kobe 657-8501, Japan', 'institution_ids': ['https://openalex.org/I65837984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011213919', 'display_name': 'Kenta Hara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenta Hara', 'raw_affiliation_strings': ['Biosignal Research Center, Kobe University, Kobe 657-8501, Japan'], 'affiliations': [{'raw_affiliation_string': 'Biosignal Research Center, Kobe University, Kobe 657-8501, Japan', 'institution_ids': ['https://openalex.org/I65837984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061636268', 'display_name': 'Bruce E. Kemp', 'orcid': 'https://orcid.org/0000-0001-6735-5082'}, 'institutions': [{'id': 'https://openalex.org/I77826658', 'display_name': 'St Vincents Institute of Medical Research', 'ror': 'https://ror.org/02k3cxs74', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I77826658']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Bruce E. Kemp', 'raw_affiliation_strings': ["St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia"], 'affiliations': [{'raw_affiliation_string': "St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia", 'institution_ids': ['https://openalex.org/I77826658']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010614852', 'display_name': 'Lee A. Witters', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107672454', 'display_name': 'Dartmouth College', 'ror': 'https://ror.org/049s0rh22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I107672454']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lee A. Witters', 'raw_affiliation_strings': ['Department of Medicine and Biochemistry, Division of Endocrinology, Diabetes and Metabolism, Dartmouth Medical School, Hanover, New Hampshire 03755, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine and Biochemistry, Division of Endocrinology, Diabetes and Metabolism, Dartmouth Medical School, Hanover, New Hampshire 03755, USA', 'institution_ids': ['https://openalex.org/I107672454']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010414704', 'display_name': 'Osamu Mimura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I137459256', 'display_name': 'Hyogo Medical University', 'ror': 'https://ror.org/001yc7927', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I137459256']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Osamu Mimura', 'raw_affiliation_strings': ['Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan', 'institution_ids': ['https://openalex.org/I137459256']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078677779', 'display_name': 'Kazuyoshi Yonezawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Kazuyoshi Yonezawa', 'raw_affiliation_strings': ['Biosignal Research Center, Kobe University, Kobe 657-8501, Japan'], 'affiliations': [{'raw_affiliation_string': 'Biosignal Research Center, Kobe University, Kobe 657-8501, Japan', 'institution_ids': ['https://openalex.org/I65837984']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5078677779'], 'corresponding_institution_ids': ['https://openalex.org/I65837984'], 'apc_list': {'value': 3800, 'currency': 'USD', 'value_usd': 3800, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 9.235, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 366, 'citation_normalized_percentile': {'value': 0.999977, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '8', 'issue': '1', 'first_page': '65', 'last_page': '79'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Role of AMP-Activated Protein Kinase in Cellular Metabolism', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rptor', 'display_name': 'RPTOR', 'score': 0.6051306}, {'id': 'https://openalex.org/keywords/amp-activated-protein-kinase', 'display_name': 'AMP-Activated Protein Kinase', 'score': 0.56415}, {'id': 'https://openalex.org/keywords/tor-signaling', 'display_name': 'TOR signaling', 'score': 0.424816}], 'concepts': [{'id': 'https://openalex.org/C104202773', 'wikidata': 'https://www.wikidata.org/wiki/Q18031289', 'display_name': 'P70-S6 Kinase 1', 'level': 4, 'score': 0.9677786}, {'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.88991034}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.7655072}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6437432}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.62193495}, {'id': 'https://openalex.org/C43060935', 'wikidata': 'https://www.wikidata.org/wiki/Q18043110', 'display_name': 'RPTOR', 'level': 4, 'score': 0.6051306}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.5374143}, {'id': 'https://openalex.org/C98490376', 'wikidata': 'https://www.wikidata.org/wiki/Q14876060', 'display_name': 'mTORC1', 'level': 4, 'score': 0.50552964}, {'id': 'https://openalex.org/C88045685', 'wikidata': 'https://www.wikidata.org/wiki/Q174576', 'display_name': 'Activator (genetics)', 'level': 3, 'score': 0.4991429}, {'id': 'https://openalex.org/C2776780712', 'wikidata': 'https://www.wikidata.org/wiki/Q295240', 'display_name': 'AMP-activated protein kinase', 'level': 5, 'score': 0.4395514}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.43415835}, {'id': 'https://openalex.org/C2909523446', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'TOR signaling', 'level': 3, 'score': 0.424816}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.41359836}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.36880788}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.184021}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08245659}], 'mesh': [{'descriptor_ui': 'D000620', 'descriptor_name': 'Aminoimidazole Carboxamide', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000620', 'descriptor_name': 'Aminoimidazole Carboxamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000620', 'descriptor_name': 'Aminoimidazole Carboxamide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012265', 'descriptor_name': 'Ribonucleotides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012265', 'descriptor_name': 'Ribonucleotides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D038762', 'descriptor_name': 'Ribosomal Protein S6 Kinases, 70-kDa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D038762', 'descriptor_name': 'Ribosomal Protein S6 Kinases, 70-kDa', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D038762', 'descriptor_name': 'Ribosomal Protein S6 Kinases, 70-kDa', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1046/j.1365-2443.2003.00615.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48908450', 'display_name': 'Genes to Cells', 'issn_l': '1356-9597', 'issn': ['1356-9597', '1365-2443'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12558800', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.68, 'id': 'https://metadata.un.org/sdg/7', 'display_name': 'Affordable and clean energy'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1573949141', 'https://openalex.org/W1593448845', 'https://openalex.org/W1913661755', 'https://openalex.org/W1949632792', 'https://openalex.org/W1965367429', 'https://openalex.org/W1974022382', 'https://openalex.org/W1976261899', 'https://openalex.org/W1979612739', 'https://openalex.org/W1979770710', 'https://openalex.org/W1979819215', 'https://openalex.org/W1982558191', 'https://openalex.org/W1985046929', 'https://openalex.org/W1987105275', 'https://openalex.org/W1995754833', 'https://openalex.org/W1998762942', 'https://openalex.org/W2006559495', 'https://openalex.org/W2008239768', 'https://openalex.org/W2008294451', 'https://openalex.org/W2015174638', 'https://openalex.org/W2023012828', 'https://openalex.org/W2040605398', 'https://openalex.org/W2044301435', 'https://openalex.org/W2048006212', 'https://openalex.org/W2048059265', 'https://openalex.org/W2049961020', 'https://openalex.org/W2052550515', 'https://openalex.org/W2055248589', 'https://openalex.org/W2062801148', 'https://openalex.org/W2063013559', 'https://openalex.org/W2069207100', 'https://openalex.org/W2071993841', 'https://openalex.org/W2072314593', 'https://openalex.org/W2073727690', 'https://openalex.org/W2083849298', 'https://openalex.org/W2097774036', 'https://openalex.org/W2098476468', 'https://openalex.org/W2099389441', 'https://openalex.org/W2108478376', 'https://openalex.org/W2118260141', 'https://openalex.org/W2119194577', 'https://openalex.org/W2124536446', 'https://openalex.org/W2126493366', 'https://openalex.org/W2129191282', 'https://openalex.org/W2133201298', 'https://openalex.org/W2135090837', 'https://openalex.org/W2147594695', 'https://openalex.org/W2152600551', 'https://openalex.org/W2156763143', 'https://openalex.org/W2336771619', 'https://openalex.org/W3026241876', 'https://openalex.org/W4376543375', 'https://openalex.org/W56813229'], 'related_works': ['https://openalex.org/W4238149263', 'https://openalex.org/W4237762692', 'https://openalex.org/W3018246728', 'https://openalex.org/W2312282875', 'https://openalex.org/W2144059623', 'https://openalex.org/W21318631', 'https://openalex.org/W2093850584', 'https://openalex.org/W2087812126', 'https://openalex.org/W2025687108', 'https://openalex.org/W1971357899'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'The': [2, 39, 119], 'mammalian': [3], 'target': [4], 'of': [5, 41, 74, 82, 99, 121, 134], 'rapamycin': [6], '(mTOR)': [7], 'regulates': [8, 67], 'multiple': [9], 'cellular': [10, 198], 'functions': [11], 'including': [12], 'translation': [13], 'in': [14, 27, 36, 84, 106], 'response': [15, 28], 'to': [16, 29, 34, 127, 172, 188, 197], 'nutrients,': [17], 'especially': [18], 'amino': [19], 'acids.': [20], 'AMP‐activated': [21], 'protein': [22], 'kinase': [23, 88], '(AMPK)': [24], 'modulates': [25, 71, 115, 182], 'metabolism': [26], 'energy': [30, 199], 'demand': [31], 'by': [32, 103, 154], 'responding': [33], 'changes': [35], 'AMP.': [37], 'Results:': [38], 'treatment': [40, 78, 129], 'SV40‐immortalized': [42], 'human': [43], 'corneal': [44], 'epithelial': [45], 'cells': [46], '(HCE‐T': [47], 'cells)': [48, 113], 'with': [49], '5‐aminoimidazole‐4‐carboxamide': [50], 'ribonucleoside': [51], '(AICAR),': [52], 'widely': [53], 'used': [54], 'as': [55, 177], 'an': [56, 190], 'AMPK': [57, 68, 101, 162, 186], 'activator,': [58], 'inhibits': [59, 80], 'p70': [60, 75, 86, 116, 124, 135, 183, 194], 'S6k': [61, 117, 125, 136, 184, 195], 'activities.': [62], 'Altered': [63], 'glucose': [64], 'availability,': [65], 'which': [66, 91], 'activity,': [69], 'also': [70, 79, 114], 'the': [72, 85, 95, 122, 132, 161, 173], 'activity': [73], 'S6k.': [76], 'AICAR': [77, 128], 'phosphorylation': [81], 'Thr‐412': [83], 'S6': [87], '(p70': [89], 'S6k),': [90], 'is': [92, 137], 'indispensable': [93], 'for': [94], 'activity.': [96, 118], 'Furthermore,': [97], 'over‐expression': [98], 'mutant': [100], 'subunits': [102], 'stable': [104], 'expression': [105], 'rabbit': [107], 'pulmonary': [108], 'fibroblast': [109], 'cell': [110], 'lines': [111], '(PS120': [112], 'insensitivity': [120], 'rapamycin‐resistant': [123], 'variant': [126], 'suggests': [130], 'that': [131, 160, 181], 'inhibition': [133], 'mediated': [138], 'through': [139], 'a': [140, 144, 178], 'common': [141], 'effector,': [142], 'supporting': [143], 'model': [145], 'whereby': [146], 'mTOR': [147, 164, 174], 'and': [148, 163], 'its': [149], 'downstream': [150], 'effector': [151], 'are': [152, 167], 'controlled': [153], 'AMPK.': [155], 'Conclusion:': [156], 'These': [157], 'results': [158], 'indicate': [159], 'signalling': [165], 'pathways': [166], 'possibly': [168], 'linked.': [169], 'In': [170], 'addition': [171], 'signal': [175], 'acting': [176], 'priming': [179], 'switch': [180, 192], 'activation,': [185], 'appears': [187], 'provide': [189], 'overriding': [191], 'linking': [193], 'regulation': [196], 'metabolism.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993363796', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 21}, {'year': 2015, 'cited_by_count': 24}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 30}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-09-24T09:20:45.533512', 'created_date': '2016-06-24'}