Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1993355802', 'doi': 'https://doi.org/10.1074/jbc.c400046200', 'title': 'Analysis of Clathrin-mediated Endocytosis of Epidermal Growth Factor Receptor by RNA Interference', 'display_name': 'Analysis of Clathrin-mediated Endocytosis of Epidermal Growth Factor Receptor by RNA Interference', 'publication_year': 2004, 'publication_date': '2004-04-01', 'ids': {'openalex': 'https://openalex.org/W1993355802', 'doi': 'https://doi.org/10.1074/jbc.c400046200', 'mag': '1993355802', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14985334'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.c400046200', 'pdf_url': 'http://www.jbc.org/article/S0021925820883963/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820883963/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057048713', 'display_name': 'Fangtian Huang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087413', 'display_name': 'University of Colorado Health', 'ror': 'https://ror.org/0107w4315', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087413']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fangtian Huang', 'raw_affiliation_strings': ['Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80111, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80111, USA', 'institution_ids': ['https://openalex.org/I4210087413']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002641644', 'display_name': 'Anastasia Khvorova', 'orcid': 'https://orcid.org/0000-0001-6928-8071'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anastasia Khvorova', 'raw_affiliation_strings': ['Dharmacon, Inc., Lafayette, Colorado 80026'], 'affiliations': [{'raw_affiliation_string': 'Dharmacon, Inc., Lafayette, Colorado 80026', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033145743', 'display_name': 'William S. Marshall', 'orcid': 'https://orcid.org/0000-0002-5792-8710'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William Marshall', 'raw_affiliation_strings': ['Dharmacon, Inc., Lafayette, Colorado 80026'], 'affiliations': [{'raw_affiliation_string': 'Dharmacon, Inc., Lafayette, Colorado 80026', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073726679', 'display_name': 'Alexander Sorkin', 'orcid': 'https://orcid.org/0000-0002-4446-1920'}, 'institutions': [{'id': 'https://openalex.org/I4210087413', 'display_name': 'University of Colorado Health', 'ror': 'https://ror.org/0107w4315', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087413']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexander Sorkin', 'raw_affiliation_strings': ['Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80111'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80111', 'institution_ids': ['https://openalex.org/I4210087413']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 29.023, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 455, 'citation_normalized_percentile': {'value': 0.999921, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '279', 'issue': '16', 'first_page': '16657', 'last_page': '16661'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/internalization', 'display_name': 'Internalization', 'score': 0.79904175}, {'id': 'https://openalex.org/keywords/transferrin-receptor', 'display_name': 'Transferrin receptor', 'score': 0.5153177}], 'concepts': [{'id': 'https://openalex.org/C28005876', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytosis', 'level': 3, 'score': 0.88676196}, {'id': 'https://openalex.org/C63162447', 'wikidata': 'https://www.wikidata.org/wiki/Q21100804', 'display_name': 'Clathrin', 'level': 4, 'score': 0.8188906}, {'id': 'https://openalex.org/C79747257', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytic cycle', 'level': 4, 'score': 0.8093284}, {'id': 'https://openalex.org/C139770010', 'wikidata': 'https://www.wikidata.org/wiki/Q1339807', 'display_name': 'Internalization', 'level': 3, 'score': 0.79904175}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.703331}, {'id': 'https://openalex.org/C22615655', 'wikidata': 'https://www.wikidata.org/wiki/Q203221', 'display_name': 'Small interfering RNA', 'level': 4, 'score': 0.7022605}, {'id': 'https://openalex.org/C117943116', 'wikidata': 'https://www.wikidata.org/wiki/Q1135604', 'display_name': 'Receptor-mediated endocytosis', 'level': 4, 'score': 0.61388236}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5636578}, {'id': 'https://openalex.org/C2776362946', 'wikidata': 'https://www.wikidata.org/wiki/Q424374', 'display_name': 'Epidermal growth factor', 'level': 3, 'score': 0.5497308}, {'id': 'https://openalex.org/C32264632', 'wikidata': 'https://www.wikidata.org/wiki/Q1134983', 'display_name': 'Transferrin receptor', 'level': 3, 'score': 0.5153177}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.4896496}, {'id': 'https://openalex.org/C156407911', 'wikidata': 'https://www.wikidata.org/wiki/Q420160', 'display_name': 'Dynamin', 'level': 4, 'score': 0.46261624}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.4242114}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.41942012}, {'id': 'https://openalex.org/C22814914', 'wikidata': 'https://www.wikidata.org/wiki/Q410473', 'display_name': 'Transferrin', 'level': 2, 'score': 0.41888517}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.2738783}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.21270695}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14721948}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002966', 'descriptor_name': 'Clathrin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002966', 'descriptor_name': 'Clathrin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.c400046200', 'pdf_url': 'http://www.jbc.org/article/S0021925820883963/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14985334', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.c400046200', 'pdf_url': 'http://www.jbc.org/article/S0021925820883963/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1491787713', 'https://openalex.org/W1492722920', 'https://openalex.org/W1548893012', 'https://openalex.org/W1564784444', 'https://openalex.org/W1565471250', 'https://openalex.org/W1938129101', 'https://openalex.org/W1971065575', 'https://openalex.org/W1977731456', 'https://openalex.org/W1979274256', 'https://openalex.org/W1983989958', 'https://openalex.org/W2011625746', 'https://openalex.org/W2017214646', 'https://openalex.org/W2017642141', 'https://openalex.org/W2019387053', 'https://openalex.org/W2032444338', 'https://openalex.org/W2042238592', 'https://openalex.org/W2064575247', 'https://openalex.org/W2067005574', 'https://openalex.org/W2090596259', 'https://openalex.org/W2099162346', 'https://openalex.org/W2100278600', 'https://openalex.org/W2108328973', 'https://openalex.org/W2125251546', 'https://openalex.org/W2128212057', 'https://openalex.org/W2133237847', 'https://openalex.org/W2133809169', 'https://openalex.org/W2140398258', 'https://openalex.org/W2145333947', 'https://openalex.org/W2145559584', 'https://openalex.org/W2147149482', 'https://openalex.org/W2166802510', 'https://openalex.org/W3724546'], 'related_works': ['https://openalex.org/W2154156417', 'https://openalex.org/W2124229990', 'https://openalex.org/W2113304473', 'https://openalex.org/W2107801352', 'https://openalex.org/W2094346937', 'https://openalex.org/W2045279426', 'https://openalex.org/W2015704490', 'https://openalex.org/W1958198767', 'https://openalex.org/W1696439153', 'https://openalex.org/W1515622122'], 'abstract_inverted_index': {'To': [0, 195, 1131, 2987, 3895, 4518], 'identify': [1, 196], 'proteins': [2, 17, 101, 120, 197, 212, 296, 315, 402, 494, 604, 621, 773, 1141, 2160, 2295, 2527, 2765, 3439, 3489, 4124, 4208, 4290, 4551], 'that': [3, 29, 151, 164, 198, 224, 346, 359, 495, 528, 605, 804, 1167, 1378, 1698, 2244, 2283, 2494, 2579, 2971, 3109, 3140, 3175, 3196, 3212, 3288, 3384, 3392, 3422, 3540, 3546, 3582, 3593, 3707, 3768, 3878, 3883, 3942, 3958, 4003, 4041, 4089, 4206, 4451, 4565], 'participate': [4, 199], 'in': [5, 20, 158, 200, 215, 353, 485, 946, 953, 960, 979, 1012, 1081, 1177, 1530, 1554, 1602, 1620, 1635, 1667, 1681, 1859, 2007, 2020, 2173, 2257, 2301, 2337, 2339, 2511, 2561, 2704, 2736, 2899, 3020, 3032, 3134, 3162, 3269, 3353, 3387, 3455, 3490, 3523, 3586, 3596, 3630, 3675, 3743, 3850, 3886, 3904, 3935, 3960, 3971, 3977, 4009, 4028, 4109, 4138, 4214, 4345, 4373, 4473, 4497, 4504, 4527, 4537, 4616], 'clathrin-mediated': [6, 201, 670, 678], 'endocytosis': [7, 46, 107, 116, 137, 202, 241, 302, 311, 332, 393, 671, 722, 795, 1011, 2977, 2994, 3027, 3050, 3300, 3341, 3401, 3613, 3629, 3952, 4024, 4078, 4231, 4421], 'of': [8, 39, 47, 58, 64, 77, 81, 87, 98, 112, 126, 203, 234, 242, 253, 259, 272, 276, 282, 293, 307, 321, 394, 414, 423, 470, 480, 488, 577, 649, 665, 669, 723, 731, 741, 766, 793, 800, 808, 813, 859, 862, 866, 924, 948, 962, 965, 977, 982, 1009, 1015, 1071, 1084, 1092, 1135, 1158, 1332, 1344, 1373, 1386, 1476, 1642, 1654, 1662, 1692, 1731, 1831, 1872, 1966, 2034, 2132, 2176, 2180, 2185, 2195, 2229, 2238, 2265, 2286, 2298, 2309, 2330, 2374, 2464, 2478, 2523, 2532, 2541, 2567, 2587, 2630, 2648, 2665, 2672, 2689, 2712, 2716, 2733, 2748, 2758, 2761, 2763, 2775, 2778, 2787, 2797, 2812, 2825, 2833, 2836, 2897, 2923, 2964, 2974, 2983, 2998, 3006, 3025, 3035, 3045, 3049, 3057, 3066, 3081, 3116, 3125, 3137, 3153, 3171, 3183, 3199, 3207, 3223, 3233, 3243, 3274, 3292, 3377, 3389, 3394, 3433, 3443, 3452, 3518, 3532, 3552, 3564, 3598, 3609, 3615, 3627, 3640, 3673, 3710, 3758, 3783, 3801, 3811, 3889, 3893, 3902, 3948, 3975, 4015, 4022, 4038, 4053, 4076, 4090, 4100, 4112, 4118, 4130, 4133, 4188, 4193, 4195, 4217, 4227, 4232, 4286, 4296, 4330, 4343, 4355, 4365, 4377, 4380, 4406, 4408, 4419, 4458, 4461, 4471, 4480, 4502, 4512, 4530, 4534, 4543, 4546, 4549, 4559, 4608], 'the': [9, 44, 55, 59, 75, 118, 146, 165, 184, 190, 204, 239, 250, 254, 270, 313, 341, 360, 379, 385, 477, 481, 486, 504, 603, 658, 662, 666, 724, 732, 739, 762, 788, 791, 801, 805, 811, 814, 863, 873, 878, 925, 963, 980, 1078, 1082, 1093, 1102, 1133, 1156, 1178, 1374, 1399, 1492, 1555, 1690, 1699, 1727, 1771, 1782, 1828, 1832, 1836, 1870, 1885, 1906, 1914, 2032, 2174, 2196, 2220, 2236, 2263, 2284, 2307, 2371, 2461, 2479, 2521, 2530, 2536, 2565, 2627, 2645, 2662, 2669, 2697, 2713, 2734, 2737, 2749, 2759, 2894, 2975, 2980, 2996, 3004, 3046, 3064, 3075, 3107, 3114, 3135, 3205, 3220, 3224, 3230, 3272, 3378, 3395, 3423, 3427, 3431, 3448, 3530, 3536, 3553, 3557, 3561, 3599, 3612, 3637, 3670, 3759, 3793, 3864, 3887, 3890, 3900, 3946, 3954, 3972, 4010, 4045, 4064, 4074, 4098, 4110, 4191, 4293, 4327, 4356, 4416, 4456, 4469, 4476, 4500, 4510, 4528, 4531, 4544, 4547, 4556, 4566, 4583, 4589, 4606, 4609], 'epidermal': [10, 205, 681], 'growth': [11, 206, 682], 'factor': [12, 207], 'receptor': [13, 208, 726, 939, 2680], '(EGFR),': [14, 209], '13': [15, 210, 2764], 'endocytic': [16, 211, 1140, 3345, 3380, 4550], 'were': [18, 30, 49, 121, 213, 225, 244, 316, 1199, 1212, 1269, 1324, 1367, 1403, 1432, 1464, 1600, 1618, 1648, 1688, 1708, 1720, 1734, 1766, 1784, 1824, 1838, 1849, 1930, 1981, 2010, 2084, 2161, 2187, 2253, 2360, 2485, 2500, 2507, 2546, 2658, 2720, 3347, 3775, 3985, 4183, 4199], 'depleted': [19, 122, 214, 317, 1014, 2292, 3034, 3852, 4184], 'HeLa': [21, 216, 1633, 2260, 2512, 2705], 'cells': [22, 217, 955, 1013, 1599, 1634, 1765, 2079, 2706, 2814, 3015, 3033, 3631, 3744, 3802, 3862, 3962, 3981, 4139], 'using': [23, 32, 218, 227, 1369, 1472, 1736, 1817, 1840, 1895, 2151, 2165, 2191, 2554, 2604, 2722, 2741, 2991, 3010, 3284], 'highly': [24, 219, 4368, 4491], 'efficient': [25, 166, 220, 361, 4569], 'small': [26, 40, 172, 221, 235, 367, 691, 2810], 'interfering': [27, 41, 173, 222, 236, 368, 692, 3286], 'RNAs': [28, 42, 223, 237], 'designed': [31, 171, 226, 366, 2188], 'a': [33, 155, 228, 350, 473, 489, 542, 574, 764, 1406, 1473, 1881, 1900, 1910, 2226, 2482, 2570, 2598, 2798, 2802, 2809, 3123, 3132, 3163, 3181, 3217, 3382, 3781, 3872, 3876, 4035, 4186, 4284, 4336, 4340, 4374, 4459], 'novel': [34, 229, 1147], 'selection': [35, 230], 'algorithm.': [36, 231], 'The': [37, 62, 232, 257, 411, 468, 492, 647, 721, 2328, 2514, 2710, 2772, 2791, 2921, 3053, 3344, 3607, 3754, 3777, 4019], 'effects': [38, 53, 73, 233, 248, 268, 1091, 2359, 2664, 2757, 2832, 4047, 4329, 4349], 'on': [43, 54, 74, 106, 238, 249, 269, 301, 476, 541, 790, 1074, 1096, 2081, 2169, 2668, 2767, 2817, 2840, 3003, 3063, 3298, 3339, 3349, 4404], 'ligand-induced': [45, 240], 'EGFR': [48, 141, 159, 243, 336, 354, 794, 809, 926, 966, 983, 1010, 1075, 1097, 1105, 1143, 1189, 2177, 2690, 2782, 2841, 2900, 3110, 3340, 3519, 3533, 3554, 3628, 3715, 3740, 3845, 3905, 3951, 3976, 4016, 4077, 4101, 4235, 4383, 4420, 4538], 'compared': [50, 245, 4049], 'with': [51, 246, 784, 1398, 1424, 1469, 1651, 1811, 1844, 1853, 1874, 1899, 2012, 2086, 2102, 2516, 2538, 2564, 2634, 3078, 3106, 3282, 3357, 3435, 3539, 3633, 3669, 3786, 3803, 3863, 3957, 3997, 4050, 4066, 4141, 4292, 4359, 4495, 4515, 4624], 'those': [52, 247, 1422, 2602], 'constitutive': [56, 251], 'internalization': [57, 76, 93, 252, 271, 288, 816, 871, 1076, 1110, 2049, 2670, 2776, 2842, 2890, 2901, 2969, 3172, 3255, 3276, 3534, 3716, 3741, 3773, 3858, 3937, 3973, 4131, 4194, 4378, 4397], 'transferrin': [60, 92, 115, 136, 255, 287, 310, 331], 'receptor.': [61, 256], 'knock-downs': [63, 258], 'clathrin': [65, 260, 420, 538, 1016, 1094, 1195, 1318, 2788, 2837, 2898, 2965, 2999, 3234, 3244, 3258, 3293, 3397, 3437, 3543, 4054, 4067], 'heavy': [66, 261, 425, 1196, 2789, 2838, 3000, 3235, 4068], 'chain': [67, 262, 1197, 2839, 3001, 3295, 4069], 'and': [68, 91, 114, 193, 263, 286, 309, 388, 399, 409, 417, 426, 580, 582, 585, 590, 614, 622, 629, 771, 787, 934, 1017, 1111, 1138, 1172, 1210, 1235, 1265, 1322, 1346, 1349, 1365, 1405, 1491, 1597, 1614, 1659, 1781, 1835, 1855, 1909, 1917, 1927, 1968, 1976, 2031, 2036, 2104, 2149, 2158, 2178, 2183, 2189, 2233, 2241, 2262, 2275, 2288, 2355, 2471, 2498, 2505, 2509, 2518, 2544, 2584, 2677, 2718, 2740, 2769, 2781, 2801, 3070, 3103, 3122, 3210, 3248, 3566, 3617, 3717, 3720, 3764, 3836, 3882, 3979, 4017, 4070, 4115, 4149, 4158, 4181, 4197, 4234, 4382, 4392, 4455, 4493, 4568, 4602, 4611], 'dynamin': [69, 264, 626, 1249, 3058, 3082, 3120, 3154, 4056, 4071], 'produced': [70, 265, 3176, 4125], 'maximal': [71, 266, 2312, 2357], 'inhibitory': [72, 267, 3055, 3337], 'both': [78, 273, 2542, 2779, 4134, 4179], 'receptors.': [79, 274], 'Depletion': [80, 275, 4364], 'α,': [82, 277], 'β2,': [83, 278], 'or': [84, 279, 530, 1684, 1723, 1876, 1879, 1889, 2016, 2077, 2256, 2573, 2652, 3180, 3240, 4055, 4143], 'μ2': [85, 280, 584, 1558, 3638], 'subunits': [86, 281], 'AP-2': [88, 283, 508, 572, 1018, 1072, 3641, 3674, 3711, 3746, 3851, 3903, 4001, 4011, 4026, 4039, 4080, 4228, 4297], 'reduced': [89, 284, 2547, 2580, 2590, 3348, 3529, 3611, 3950], 'EGF': [90, 113, 285, 308, 685, 695, 725, 932, 1972, 2770, 2985, 3616, 3804], 'rates': [94, 289, 2671, 2715, 2777, 3346, 3531, 3614, 3742, 3774, 3859, 3888, 3974, 3984, 4132, 4192, 4379], 'by': [95, 169, 290, 364, 1019, 1327, 1339, 1352, 1562, 1768, 1773, 1815, 1861, 1893, 2224, 2269, 2296, 2487, 2548, 2582, 2593, 2696, 2785, 2927, 2960, 3061, 3156, 3177, 3351, 3426, 3487, 3542, 3568, 3619, 3682, 3718, 3749, 3792, 3860, 3910, 4025, 4079, 4185, 4201, 4509, 4572], '40-60%.': [96, 291], 'Down-regulation': [97, 292], 'several': [99, 294, 1812, 2382, 2653, 4122], 'accessory': [100, 295, 617, 4123], 'individually': [102, 297, 2766, 4400], 'had': [103, 298, 1381, 3333], 'no': [104, 299, 1069, 3038, 3290, 3969, 4006], 'effect': [105, 300, 1070, 2997, 3056, 3291, 3338, 3424, 3575], 'but': [108, 138, 303, 333, 3335, 4211], 'caused': [109, 304, 2784, 3541], 'significant': [110, 305, 2599, 4007, 4152], 'inhibition': [111, 306, 3626, 4021, 4075], 'when': [117, 312, 3982, 4398], 'homologous': [119, 314, 4369], 'simultaneously.': [123, 318], 'Surprisingly,': [124, 319], 'knockdown': [125, 320], 'clathrin-assembly': [127, 322], 'lymphoid': [128, 323], 'myeloid': [129, 324], 'leukemia': [130, 325], 'protein,': [131, 326], 'CALM,': [132, 327, 1181], 'did': [133, 328, 3252, 3364, 3570, 4333, 4394, 4482], 'not': [134, 329, 1128, 2348, 2501, 2821, 3191, 3253, 3262, 3365, 3373, 3571, 3577, 3713, 4334, 4395, 4483], 'influence': [135, 330], 'considerably': [139, 334], 'affected': [140, 335], 'internalization.': [142, 337, 1190, 2771, 3894, 4539], 'Thus,': [143, 338, 3257, 3663], 'CALM': [144, 339, 529, 589, 1268, 2320, 2334, 2346, 2517, 3362, 3396, 3428, 3445, 3567, 3583, 3594], 'is': [145, 340, 535, 573, 655, 803, 818, 1185, 2379, 2682, 2694, 3104, 3111, 3201, 3216, 3280, 3371, 3385, 3420, 3548, 3580, 3584, 3590, 3767, 3879, 4005, 4453, 4465, 4490, 4552], 'second': [147, 342], 'protein': [148, 343, 506, 2480, 2591, 2649, 2666, 3138, 3214, 3370, 4160], 'besides': [149, 344], 'Grb2': [150, 345, 978, 1526, 3526, 3547, 3565], 'appears': [152, 347, 3129], 'to': [153, 181, 348, 376, 502, 697, 718, 737, 782, 869, 920, 957, 972, 1149, 1153, 1183, 1194, 1248, 1263, 1267, 1317, 1389, 1415, 1498, 1570, 1627, 1631, 1673, 1717, 1826, 1851, 2046, 2163, 2235, 2333, 2369, 2639, 2643, 2660, 2730, 2745, 2808, 2979, 3130, 3144, 3203, 3229, 3264, 3535, 3604, 3636, 3771, 3841, 3953, 4000, 4034, 4063, 4083, 4097, 4102, 4121, 4353, 4389, 4467, 4554, 4580], 'play': [154, 349, 3265], 'specific': [156, 351, 815, 1262, 2048, 3336, 3444, 4341, 4417, 4567], 'role': [157, 352, 976, 2896, 2925, 3232, 3268, 3672, 3901, 4470], 'endocytosis.': [160, 355, 967, 1098, 3520, 3588, 4092], 'This': [161, 356, 1161, 3278, 3677, 4093, 4562], 'study': [162, 357, 738, 2164, 4563], 'demonstrates': [163, 358, 4564], 'gene': [167, 362, 2631, 2657, 3225, 4570], 'silencing': [168, 363, 2249, 2266, 2358, 2581, 2667, 4571], 'rationally': [170, 365], 'RNA': [174, 369, 688, 949, 3287], 'can': [175, 370, 2386, 4094, 4574], 'be': [176, 371, 503, 719, 942, 2387, 2958, 3131, 3142, 3485, 4032, 4084, 4095, 4103, 4351, 4507, 4575], 'used': [177, 372, 675, 970, 1146, 3780, 3909, 4576], 'as': [178, 189, 373, 384, 403, 405, 598, 625, 1467, 1574, 1740, 1786, 1864, 1983, 2053, 2108, 2381, 2391, 2552, 4048, 4577, 4588], 'an': [179, 374, 599, 974, 1370, 2192, 2555, 2574, 2961, 2992, 3266, 3374, 3573, 4578], 'approach': [180, 375, 4579], 'functionally': [182, 377, 4581], 'analyze': [183, 378, 922, 4582], 'entire': [185, 380, 4584], 'cellular': [186, 381, 4585], 'machineries,': [187, 382, 4586], 'such': [188, 383, 624, 2924, 4060, 4587], 'clathrin-coated': [191, 386, 415, 2686, 4535, 4590], 'pits': [192, 387, 416, 1108, 1127, 2693, 3816, 3848, 4536], 'vesicles.': [194, 389], 'Clathrin-coated': [390], 'vesicles': [391, 418], 'mediate': [392], 'many': [395, 857], 'receptors,': [396, 2674], 'channels,': [397], 'transporters,': [398], 'other': [400, 1139, 3126, 3436, 3488, 4287, 4360, 4477, 4516], 'transmembrane': [401], 'well': [404], 'various': [406], 'soluble': [407], 'macromolecules': [408], 'viruses.': [410], 'main': [412], 'components': [413, 4533], 'are': [419, 500, 592, 780, 1123, 1552, 2245, 2701, 3667], 'triskelions,': [421], 'consisting': [422], 'three': [424, 427, 1427, 1685, 2351, 4367, 4462], 'light': [428, 1319, 3245, 3259, 3294, 3388], 'chains': [429, 1320, 3246, 3260], '(1Brodsky': [430], 'F.M.': [431, 3312], 'Chen': [432, 2440, 3309], 'C.Y.': [433, 3310], 'Knuehl': [434], 'C.': [435, 839, 889, 4239, 4431], 'Towler': [436], 'M.C.': [437], 'Wakeham': [438], 'D.E.': [439], 'Annu.': [440], 'Rev.': [441, 456, 637, 749], 'Cell': [442, 458, 513, 751, 824, 1030, 1586, 1752, 1955, 2852, 2911, 3695, 3727, 3923, 4249, 4437], 'Dev.': [443], 'Biol.': [444, 459, 514, 752, 825, 845, 895, 993, 1031, 1051, 1283, 1305, 1541, 1587, 1753, 1796, 1940, 1995, 2065, 2120, 2413, 2853, 2873, 2912, 2942, 3409, 3505, 3696, 3728, 3826, 3924, 4250, 4438], '2001;': [445, 564, 3476], '17:': [446], '517-568Crossref': [447], 'PubMed': [448, 463, 518, 567, 642, 756, 829, 853, 903, 914, 998, 1035, 1061, 1293, 1310, 1457, 1488, 1521, 1546, 1591, 1757, 1801, 1945, 1960, 2000, 2070, 2125, 2423, 2452, 2620, 2857, 2883, 2916, 2952, 3098, 3325, 3414, 3479, 3510, 3656, 3700, 3732, 3831, 3928, 4173, 4254, 4321, 4442], 'Scopus': [449, 464, 519, 568, 643, 757, 830, 915, 999, 1036, 1062, 1294, 1311, 1458, 1522, 1547, 1592, 1758, 1802, 1946, 1961, 2001, 2071, 2126, 2215, 2424, 2453, 2621, 2858, 2884, 2917, 2953, 3099, 3326, 3415, 3480, 3511, 3657, 3701, 3733, 3832, 3929, 4174, 4255, 4322, 4443], '(540)': [450], 'Google': [451, 466, 521, 570, 645, 759, 832, 854, 904, 917, 1001, 1038, 1064, 1296, 1313, 1460, 1489, 1524, 1549, 1594, 1760, 1804, 1948, 1963, 2003, 2073, 2128, 2217, 2426, 2455, 2623, 2860, 2886, 2919, 2955, 3101, 3328, 3417, 3482, 3513, 3659, 3703, 3735, 3834, 3931, 4176, 4257, 4281, 4324, 4445], 'Scholar,': [452, 833, 905, 1039, 1297, 1949, 2427, 2861, 4258], '2Kirchhausen': [453], 'T.': [454, 1275, 1279, 1511, 2404, 2615], 'Nat.': [455, 636, 748, 1452, 2210], 'Mol.': [457, 750, 992, 1304, 1540, 1795, 1939, 1994, 2064, 2119, 3408, 3504, 3825], '2000;': [460, 639, 1485, 4439], '1:': [461, 640], '187-198Crossref': [462], '(422)': [465], 'Scholar).': [467, 522, 571, 646, 760, 855, 918, 1002, 1065, 1314, 1461, 1525, 1595, 1761, 1805, 1964, 2004, 2074, 2129, 2218, 2456, 2624, 2887, 2920, 3329, 3418, 4177, 4282, 4325, 4446], 'assembly': [469, 540, 3450], 'triskelions': [471], 'into': [472, 1710, 1776, 1905, 1913, 1919, 2259, 3814, 3846, 4415], 'cage-like': [474], 'lattice': [475, 539, 596, 3449], 'cytosolic': [478], 'side': [479], 'plasma': [482], 'membrane': [483, 610], 'results': [484, 2596, 3766], 'formation': [487, 499, 654], 'coated': [490, 497, 652, 1085, 1107, 1119, 1126, 2156, 2293, 2692, 2803, 3605, 3815, 3847, 4288], 'pit.': [491, 4591], 'major': [493], 'drive': [496], 'pit': [498, 2157, 2294, 4289], 'thought': [501], 'adaptor': [505], 'complex': [507, 3603], '(3Robinson': [509], 'M.S.': [510, 1028, 1584, 1750, 2850, 2909, 3693, 3921], 'Curr.': [511], 'Opin.': [512], '1994;': [515], '6:': [516], '538-544Crossref': [517], '(306)': [520], 'However,': [523, 661, 777, 4283], 'it': [524, 3579], 'was': [525, 1221, 1231, 1237, 1251, 1409, 1495, 1528, 1560, 1572, 1695, 1809, 1857, 1891, 2039, 2136, 2222, 2267, 2311, 2321, 2335, 2367, 2535, 2577, 2783, 3008, 3017, 3042, 3430, 3642, 3747, 3933, 3968, 4042, 4136, 4413], 'recently': [526], 'suggested': [527], 'its': [531], 'neuronal': [532], 'homolog': [533], 'AP180': [534, 591], 'sufficient': [536, 3840, 4058], 'for': [537, 602, 1109, 1142, 1188, 1418, 2095, 2106, 2138, 2528, 2655, 2675, 3119, 3219, 3550, 3899, 4013, 4044, 4059, 4223, 4339, 4605, 4614], 'lipid': [543], 'monolayer': [544], '(4Ford': [545, 3457], 'M.G.': [546, 3458], 'Pearse': [547, 3459], 'B.M.': [548, 3460], 'Higgins': [549, 3461], 'M.K.': [550, 3462], 'Vallis': [551, 3463, 4300], 'Y.': [552, 3464, 4301], 'Owen': [553, 3465], 'D.J.': [554, 3466, 4299], 'Gibson': [555, 3467], 'A.': [556, 744, 909, 989, 991, 1022, 1273, 1303, 1505, 1537, 1539, 1578, 1744, 1794, 1938, 1953, 1991, 1993, 2061, 2063, 2116, 2118, 2201, 2209, 2406, 2844, 2903, 3308, 3321, 3407, 3468, 3501, 3503, 3645, 3687, 3822, 3824, 3915, 4237, 4245, 4427, 4433], 'Hopkins': [557, 3469], 'C.R.': [558, 3470], 'Evans': [559, 3471, 4308], 'P.R.': [560, 3472, 4309], 'McMahon': [561, 3473, 4310], 'H.T.': [562, 3474, 4311], 'Science.': [563, 3475], '291:': [565, 3477], '1051-1055Crossref': [566, 3478], '(606)': [569, 3481], 'heterotetramer': [575], 'composed': [576], '100-kDa': [578], 'α': [579, 4224, 4361], 'β2-adaptins': [581], '50-kDa': [583], '17-kDa': [586], 'σ2': [587], 'subunits.': [588], 'monomeric': [593], 'proteins.': [594, 1160, 4561], 'Clathrin': [595], 'serves': [597], 'organizing': [600], 'scaffold': [601], 'carry': [606], 'out': [607], 'cargo': [608], 'sorting,': [609], 'invagination,': [611], 'vesicle': [612, 653], 'scission,': [613], 'uncoating.': [615], 'These': [616, 1099, 2595, 3193], 'molecules': [618, 3209], 'include': [619], 'adaptor/scaffold': [620], 'enzymes,': [623], 'GTPase,': [627], 'kinases,': [628], 'phosphatases': [630], '(5Slepnev': [631], 'V.I.': [632], 'De': [633, 2442], 'Camilli': [634, 2443], 'P.': [635, 1354, 1355, 2444, 4268, 4596, 4597], 'Neurosci.': [638], '161-172Crossref': [641], '(426)': [644], 'sequence': [648, 2240, 4153], 'events': [650], 'during': [651, 2041], 'understood': [656], 'at': [657, 1334, 1676, 2028, 2098, 2272, 2313, 2707, 2727, 3788, 3796, 3805, 3868], 'morphological': [659], 'level.': [660], 'molecular': [663], 'mechanisms': [664, 740, 792, 964, 3600], 'individual': [667, 3237, 4532], 'steps': [668, 3892], '(CME)': [672], '1The': [673], 'abbreviations': [674], 'are:': [676], 'CME,': [677, 1179], 'endocytosis;': [679], 'EGF,': [680], 'factor;': [683], 'EGFR,': [684], 'receptor;': [686, 703], 'RNAi,': [687], 'interference;': [689], 'siRNA,': [690], 'RNA;': [693], 'EGF-Rh,': [694], 'conjugated': [696], 'rhodamine;': [698], 'Tnf,': [699], 'transferrin;': [700], 'TnfR,': [701], 'Tnf': [702], 'DMEM,': [704], "Dulbecco's": [705, 1603], 'modified': [706, 1474, 1604], "Eagle's": [707, 1605], 'medium;': [708], 'GFP,': [709], 'green': [710], 'fluorescent': [711, 715], 'protein;': [712], 'YFP,': [713], 'yellow': [714], 'protein.': [716], 'remain': [717, 796], 'elucidated.': [720], '(EGFR)': [727], 'has': [728, 4523], 'been': [729, 769, 775], 'one': [730, 3597], 'most': [733, 2305, 3551, 3755], 'popular': [734], 'experimental': [735, 929, 2140], 'systems': [736], 'CME': [742, 923, 981, 2175, 2750, 3270, 3558, 4014, 4485, 4505], '(6Sorkin': [743], 'Von': [745], 'Zastrow': [746], 'M.': [747, 1445, 1564, 2433, 2435, 3086, 3649, 3651, 4600], '2002;': [753, 1513, 2449, 2617, 3322, 4170], '3:': [754], '600-614Crossref': [755], '(706)': [758], 'Over': [761], 'years': [763], 'number': [765, 865, 1083, 3124, 4285], 'models': [767, 779], 'have': [768, 774, 1174, 4151, 4209], 'proposed': [770, 1112], 'numerous': [772], 'implicated.': [776], 'these': [778, 1121, 1159, 2341, 3762, 3944, 3983, 4207, 4348, 4560], 'difficult': [781, 2368], 'reconcile': [783], 'each': [785, 1393, 1693, 2139, 2656, 2762], 'other,': [786], 'views': [789], 'controversial.': [797], 'One': [798, 2651], 'source': [799], 'discrepancies': [802, 3760], 'important': [806, 958, 4210], 'feature': [807], 'endocytosis,': [810, 1144, 2805, 3368, 3906, 4346], 'saturability': [812], 'pathway,': [817], 'often': [819], 'overlooked': [820], '(7Wiley': [821], 'H.S.': [822, 843, 893], 'J.': [823, 844, 894, 1029, 1043, 1050, 1282, 1439, 1443, 1503, 1585, 1751, 1954, 2412, 2611, 2851, 2865, 2872, 2910, 2934, 2941, 3694, 3726, 3922, 4248, 4436, 4612], '1988;': [826], '107:': [827], '801-810Crossref': [828], '(169)': [831], '8Lund': [834], 'K.A.': [835, 885], 'Opresko': [836, 886], 'L.K.': [837, 887], 'Strarbuck': [838, 888], 'Walsh': [840, 890], 'B.J.': [841, 891], 'Wiley': [842, 892], 'Chem.': [846, 896, 1052, 1284, 2414, 2874, 2943], '1990;': [847, 897], '265:': [848, 898], '15713-15723Abstract': [849, 899], 'Full': [850, 900, 1056, 1058, 1288, 1290, 1516, 1518, 2418, 2420, 2878, 2880, 2947, 2949, 4316, 4318], 'Text': [851, 901, 1057, 1059, 1289, 1291, 1517, 1519, 2419, 2421, 2879, 2881, 2948, 2950, 4317, 4319], 'PDF': [852, 902, 1060, 1292, 1520, 2422, 2882, 2951, 4320], 'In': [856, 1842, 2304, 2350, 3013, 3030, 3227, 3623, 3854, 3965, 3993], 'types': [858], 'cells,': [860, 2261], 'occupancy': [861], 'large': [864, 1162], 'EGFRs': [867], 'leads': [868], 'their': [870, 2170, 2968], 'through': [872, 1125, 2145, 2685, 2691, 3113, 3556, 4105], 'slow': [874], 'clathrin-independent': [875, 2799, 2976, 4106], 'pathway': [876, 881, 2751, 3115], 'because': [877, 2377, 4347], 'rapid': [879], 'clathrin-dependent': [880], 'becomes': [882], 'saturated': [883], '(8Lund': [884], '9Jiang': [906], 'X.': [907, 985, 1533, 1987, 2057, 2112, 3497, 3818], 'Sorkin': [908, 990, 1302, 1538, 1793, 1937, 1952, 1992, 2062, 2117, 2405, 3406, 3502, 3823], 'Traffic.': [910, 3652], '2003;': [911, 995, 1032, 1053, 1454, 1543, 1588, 1754, 1957, 1997, 2067, 2122, 2212, 2854, 2875, 2913, 2944, 3507, 3653, 3697, 3729, 3828, 3925], '4:': [912, 3654], '529-543Crossref': [913], '(107)': [916], 'Therefore,': [919, 4326], 'comparatively': [921], 'under': [927, 2142, 3271, 3943], 'different': [928, 3769], 'conditions,': [930], 'low': [931, 2742], 'concentrations': [933, 2982], 'cell': [935, 1847, 3784], 'lines': [936], 'expressing': [937], 'moderate': [938, 2708], 'levels': [940, 2299, 2540, 2592], 'must': [941, 3141], 'used.': [943, 2986, 3776], 'Recent': [944], 'progress': [945], 'application': [947], 'interference': [950, 3434, 4354], '(RNAi)': [951], 'methods': [952, 3770], 'mammalian': [954], 'led': [956, 2234], 'advances': [959], 'elucidation': [961], 'We': [968, 4592], 'first': [969], 'RNAi': [971, 1020, 1164, 3665, 4448, 4521], 'demonstrate': [973], 'essential': [975, 2895, 3202, 3231, 3267, 3375], '(10Jiang': [984, 1986, 2056, 2111, 3496, 3817], 'Huang': [986, 1534, 1988, 2058, 2113, 3305, 3498, 3819], 'F.': [987, 1299, 1329, 1535, 1790, 1934, 1989, 2059, 2114, 3304, 3403, 3499, 3820, 4266, 4594], 'Marusyk': [988, 1536, 1990, 2060, 2115, 3500, 3821], 'Cell.': [994, 1306, 1512, 1542, 1797, 1941, 1996, 2066, 2121, 3410, 3506, 3827, 4312], '14:': [996, 1544, 1998, 2068, 2123, 3508, 3829], '858-870Crossref': [997, 1545, 1999, 2069, 2124, 3509, 3830], '(255)': [1000, 1548, 2002, 2072, 2127, 3512, 3833], 'More': [1003, 2625], 'recently,': [1004], 'two': [1005, 1683, 2673, 2828, 3358, 4189], 'groups': [1006, 2829], 'performed': [1007, 1721, 1735, 1810, 1839, 2721], 'analysis': [1008, 1165, 1808, 2228, 4522], '(11Motley': [1021, 1577, 1743, 2843, 2902, 3686, 3914], 'Bright': [1023, 1579, 1745, 2845, 2904, 3688, 3916], 'N.A.': [1024, 1580, 1746, 2846, 2905, 3689, 3917], 'Seaman': [1025, 1581, 1747, 2847, 2906, 3690, 3918], 'M.N.': [1026, 1582, 1748, 2848, 2907, 3691, 3919], 'Robinson': [1027, 1583, 1749, 2849, 2908, 3692, 3920], '162:': [1033, 1589, 1755, 2855, 2914, 3698, 3730, 3926], '909-918Crossref': [1034, 1590, 1756, 2856, 2915, 3699, 3927], '(557)': [1037, 1593, 1759, 2859, 2918, 3702, 3930], '12Hinrichsen': [1040, 2862], 'L.': [1041, 1045, 1341, 2396, 2863, 2867, 2932, 2936, 4603], 'Harborth': [1042, 2610, 2864, 2933], 'Andrees': [1044, 2866, 2935], 'Weber': [1046, 2612, 2868, 2937], 'K.': [1047, 2613, 2869, 2938], 'Ungewickell': [1048, 2870, 2939], 'E.J.': [1049, 2871, 2940], '278:': [1054, 2876, 2945], '45160-45170Abstract': [1055, 2877, 2946], '(219)': [1063, 2885, 2954], 'Both': [1066, 2699], 'studies': [1067, 1100, 3283, 3495, 3763, 3779], 'reported': [1068, 2830, 2926, 3706, 3738], 'depletion': [1073, 2463, 2760, 2963, 3060, 3152, 3297, 3363, 3563, 3608, 3947, 4040, 4057, 4081, 4548], 'despite': [1077], 'dramatic': [1079], 'reduction': [1080, 2774, 3170, 4129, 4376], 'pits,': [1086, 1120], 'while': [1087], 'they': [1088, 1116], 'observed': [1089, 2300, 2361, 3643, 3959, 4137], 'contrasting': [1090], 'knock-down': [1095, 2310, 2632, 2786, 2835, 3527, 3709, 4479], 'raised': [1101], 'question': [1103], 'whether': [1104], 'utilize': [1106, 1118, 2640], 'that,': [1113], 'even': [1114], 'if': [1115], 'do': [1117, 3261], 'receptors': [1122, 2700, 4135], 'internalized': [1124, 2035, 3112, 4104], 'containing': [1129, 1608, 4220], 'AP-2.': [1130], 'assess': [1132], 'importance': [1134], 'clathrin,': [1136, 1168, 3036, 4113], 'AP-2,': [1137, 1170, 4114], 'we': [1145, 3856], 'algorithm': [1148, 1377, 2199, 2221], 'generate': [1150, 1869], 'functional': [1151, 2248, 2646, 2663, 3147, 3166, 4046], 'siRNAs': [1152, 2186, 2287, 2331, 2342, 2636, 2654, 3569, 3998, 4027, 4119, 4145, 4387], 'efficiently': [1154, 3018], 'suppress': [1155], 'expression': [1157], 'scale': [1163], 'revealed': [1166, 3289], 'dynamin,': [1169, 4116], 'Eps15/15R,': [1171], 'Rab5': [1173, 4370, 4409, 4463, 4489, 4503, 4513], 'general': [1175, 3671], 'roles': [1176, 4213], 'whereas': [1180, 4386], 'similarly': [1182], 'Grb2,': [1184], 'required': [1186], 'specifically': [1187, 3528], 'Antibodies—The': [1191], 'monoclonal': [1192], 'antibodies': [1193, 1247, 1260, 1316, 1813, 2493], '(TD.1)': [1198], 'obtained': [1200, 1892, 2603, 3077], 'from': [1201, 1213, 1222, 1232, 1238, 1252, 1770], 'American': [1202], 'Type': [1203], 'Culture': [1204], 'Collection': [1205], '(Manassas,': [1206], 'VA);': [1207], 'EEA.1,': [1208], 'Rab5a,': [1209, 2468, 2474, 2539, 4390], 'PP1': [1211], 'BD': [1214], 'Transduction': [1215], 'Laboratories': [1216, 1240], '(Los': [1217], 'Angeles,': [1218], 'CA);': [1219, 1229], 'Tsg101': [1220], 'Santa': [1223], 'Cruz': [1224], 'Biotechnology,': [1225], 'Inc.': [1226, 1241, 1255], '(Santa': [1227], 'Cruz,': [1228], 'α-actinin': [1230], 'Chemicon,': [1233], 'Inc.;': [1234], 'GFP': [1236, 1867], 'Zymed': [1239], '(South': [1242], 'San': [1243, 1335], 'Francisco,': [1244], 'CA).': [1245, 1925], 'Polyclonal': [1246, 1315], 'II': [1250, 3059, 3121, 3155, 4072], 'Affinity': [1253], 'Bioreagents,': [1254], '(Golden,': [1256], 'CO);': [1257], 'rabbit': [1258], 'polyclonal': [1259], 'Ab32': [1261], 'β-adaptins': [1264], 'Ab20': [1266], 'described': [1270, 1529, 1575, 1741, 1787, 1865, 1931, 1984, 2054, 2109], 'previously': [1271, 1576, 1742, 1788, 1932, 1985, 2055, 2110], '(13Sorkin': [1272], 'McKinsey': [1274], 'Shih': [1276], 'W.': [1277, 2207], 'Kirchhausen': [1278], 'Carpenter': [1280], 'G.': [1281, 1449, 2402, 2439, 4264], '1995;': [1285, 3095], '270:': [1286], '619-625Abstract': [1287], '(100)': [1295, 3100], '14Tebar': [1298], 'Bohlander': [1300, 1791, 1935, 3404], 'S.': [1301, 1792, 1936, 2205, 2400, 2429, 2431, 3088, 3320, 3405, 4164, 4243, 4262], '1999;': [1307, 1798, 1942, 3411, 4313], '10:': [1308, 1799, 1943, 3412], '2687-2702Crossref': [1309, 1800, 1944, 3413], '(243)': [1312, 1803, 1947, 3416], 'A': [1321, 2130, 3247, 3296], 'B': [1323, 3249], 'kindly': [1325], 'provided': [1326, 1561, 4524], 'Dr.': [1328, 1340, 1353, 1563], 'Brodsky': [1330, 3311], '(University': [1331, 1343, 1566], 'California': [1333], 'Francisco),': [1336], 'epsin': [1337], '1': [1338, 1640, 2281, 2458, 3158], 'Traub': [1342, 4604], 'Pittsburgh),': [1345], 'Eps15': [1347, 4142, 4148, 4180, 4218, 4331, 4344, 4357], 'Ab577': [1348], 'Eps15R': [1350, 1856, 2375, 2378, 4144, 4150, 4182], 'Ab860': [1351], 'Di': [1356, 2409, 2445, 4165, 4273, 4598], 'Fiore': [1357, 2410, 2446, 4166, 4274], '(European': [1358], 'Cancer': [1359, 4276], 'Institute,': [1360], 'Milan,': [1361], 'Italy).': [1362], 'siRNA': [1363, 1380, 1396, 1527, 1559, 1569, 1616, 1622, 1657, 1686, 1701, 1733, 2166, 2230, 2251, 2289, 2317, 2490, 2572, 2575, 2834, 3002, 3062, 3200, 3332, 3359, 3494, 3634, 3708, 3908, 4573], 'Design': [1364], 'Synthesis—siRNAs': [1366], 'selected': [1368, 1433, 2659], 'advanced': [1371], 'version': [1372, 2194], 'rational': [1375, 2197], 'design': [1376, 2198, 2606], 'ensures': [1379], 'less': [1382, 4086], 'than': [1383, 1426, 2476, 2550, 3174, 3441, 4088], '16': [1384], 'bp': [1385], 'consecutive': [1387], 'homology': [1388], 'untargeted': [1390], 'molecules.': [1391], 'For': [1392, 1679, 2473, 3149], 'gene,': [1394], 'four': [1395, 2465, 2489], 'duplexes': [1397, 1463, 1617, 1687, 2252, 2589, 3184], 'highest': [1400], 'scores': [1401], '(SMARTscores)': [1402], 'selected,': [1404], 'BLAST': [1407], 'search': [1408], 'conducted': [1410], '(Human': [1411], 'EST': [1412], 'data': [1413, 2820, 2891, 3076, 3194, 3666, 3996], 'base)': [1414], 'eliminate': [1416], 'potential': [1417], 'off-target': [1419], 'effects.': [1420, 3148, 4061, 4127], 'Only': [1421], 'sequences': [1423], 'more': [1425, 3880], 'mismatches': [1428], 'against': [1429, 2558], 'unrelated': [1430], 'genes': [1431, 3127], '(15Jackson': [1434], 'A.L.': [1435], 'Bartz': [1436], 'S.R.': [1437], 'Schelter': [1438], 'Kobayashi': [1440], 'S.V.': [1441], 'Burchard': [1442], 'Mao': [1444], 'Li': [1446], 'B.': [1447, 4241], 'Cavet': [1448], 'Linsley': [1450], 'P.S.': [1451], 'Biotechnol.': [1453, 2211], '21:': [1455], '635-637Crossref': [1456], '(1927)': [1459], 'All': [1462], 'synthesized': [1465, 1573, 2190], 'in-house': [1466], '21-mers': [1468], 'UU': [1470], 'overhands': [1471], 'method': [1475, 2167], '2′-acid': [1477], 'labile': [1478], 'orthoester': [1479], 'chemistry': [1480], '(16Scaringe': [1481], 'S.A.': [1482], 'Methods': [1483, 3093], 'Enzymol.': [1484, 3094], '317:': [1486], '3-18Crossref': [1487], 'Scholar),': [1490], 'anti-sense': [1493], 'strand': [1494], 'chemically': [1496], 'phosphorylated': [1497], 'ensure': [1499], 'maximized': [1500], 'activity': [1501], '(17Martinez': [1502], 'Patkaniowska': [1504], 'Urlaub': [1506], 'H.': [1507, 2441, 3084, 3090, 4429], 'Luhrmann': [1508], 'R.': [1509, 4260], 'Tuschl': [1510, 2614], '110:': [1514], '563-574Abstract': [1515], '(1198)': [1523], 'Ref.': [1531], '10Jiang': [1532], 'Scholar.': [1550], 'Sequences': [1551], 'presented': [1553], '"Supplemental': [1556], 'Materials."': [1557], 'Marsh': [1565, 3650], 'College,': [1567], 'London).': [1568], 'α-adaptin': [1571, 1732, 3907, 3949], 'Cells': [1596, 1707, 2005], 'Transfections—HeLa': [1598], 'grown': [1601, 2006, 2080], 'medium': [1606, 1671, 1713, 2022], '(DMEM)': [1607], '10%': [1609], 'fetal': [1610], 'bovine': [1611, 1644, 2025], 'serum,': [1612], 'antibiotics,': [1613], 'glutamine.': [1615], 'resuspended': [1619], '1×': [1621], 'Universal': [1623], 'buffer': [1624], '(Dharmacon,': [1625], 'Inc.)': [1626, 1975, 2094], '20': [1628, 1655], 'μm': [1629, 1656], 'prior': [1630, 1716], 'transfection.': [1632, 1729, 2279, 2318, 2327, 2365], '12-well': [1636, 2008], 'plates': [1637], '(50-60%': [1638], 'confluent;': [1639], 'ml': [1641], 'DMEM/fetal': [1643], 'serum': [1645, 2026], 'per': [1646], 'well)': [1647], 'transfected': [1649, 2254, 3632, 4140, 4399], 'twice': [1650], '4': [1652, 1724, 2276, 2362, 3789, 3806, 3873, 3988], 'μl': [1653, 1661, 1669], 'duplex': [1658, 1694, 3157, 3178], '3': [1660, 1722, 2314], 'LipofectAMINE': [1663], '2000': [1664], 'reagent': [1665, 1738], '(Invitrogen)': [1666, 1739], '100': [1668], 'Opti-MEM': [1670], 'according': [1672], "manufacture's": [1674], 'recommendations': [1675], '24-h': [1677], 'intervals.': [1678], 'transfections,': [1680], 'which': [1682, 1719, 2340, 2385], 'included,': [1689], 'amount': [1691], 'decreased': [1696, 4200], 'so': [1697], 'final': [1700], 'concentration': [1702, 2744], 'remained': [1703], 'constant': [1704, 2051], 'between': [1705, 3761], 'experiments.': [1706], 'placed': [1709], 'normal': [1711, 3739], 'culture': [1712], '12': [1714, 2133], 'h': [1715], 'experiments,': [1718, 2338], 'days': [1725, 2277, 2315, 2325, 2363], 'after': [1726, 2278, 2316, 2326, 3022, 3987], 'initial': [1728, 3891], 'Transfections': [1730], 'Oligofectamin': [1737], 'Western': [1762, 1806, 1862, 2270], 'Blot': [1763], 'Analysis—The': [1764], 'lysed': [1767], 'scraping': [1769], 'dish': [1772], 'rubber': [1774], 'policemen': [1775], 'Triton': [1777], 'X-100/glycerol': [1778], 'solubilization': [1779], 'buffer,': [1780], 'lysates': [1783, 1848], 'electrophoresed': [1785], '(14Tebar': [1789, 1933, 3402], 'blot': [1807, 1863], 'followed': [1814, 3791], 'detection': [1816], 'enhanced': [1818], 'chemiluminescence': [1819, 1833], 'system.': [1820], 'Several': [1821], 'x-ray': [1822], 'films': [1823], 'analyzed': [1825, 3009], 'determine': [1827, 2370], 'linear': [1829, 2042], 'range': [1830], 'signals,': [1834], 'quantifications': [1837], 'densitometry.': [1841], 'experiments': [1843, 2515, 2726, 3356, 4030, 4065, 4449], 'Eps15R-targeted': [1845], 'siRNAs,': [1846, 4073, 4190], 'subjected': [1850], 'immunoprecipitation': [1852], 'Ab860,': [1854], 'detected': [1858], 'immunoprecipitates': [1860], 'above.': [1866], 'Fusions—To': [1868], 'fusion': [1871, 2526], 'YFP': [1873], 'Rab5b': [1875, 1888, 2497, 2504], 'Rab5c': [1877, 1890, 2499, 2506, 4393], '(YFP-Rab5b': [1878], 'YFP-Rab5c),': [1880], 'DNA': [1882], 'fragment': [1883], 'encoding': [1884], 'full-length': [1886], 'human': [1887, 1978], 'PCR': [1894], 'Pfu': [1896], 'polymerase': [1897], '(Stratagene)': [1898], 'SacI': [1901], 'restriction': [1902], 'site': [1903, 1912], 'introduced': [1904], '5′': [1907], 'end': [1908, 1916], 'KpnI': [1911], '3′': [1915], 'cloned': [1918], 'pEYFP-C1': [1920], 'vector': [1921], '(Clontech,': [1922], 'Palo': [1923], 'Alto,': [1924], 'GFP-CALM': [1926], 'YFP-Rab5a': [1928], 'constructs': [1929], '18Galperin': [1950], 'E.': [1951], 'Sci.': [1956, 3318], '116:': [1958], '4799-4810Crossref': [1959], '(71)': [1962], 'Internalization': [1965, 2688], '125I-EGF': [1967, 2013, 2719, 2889, 3067, 3787, 4198], '125I-Transferrin': [1969], '(Tfn)—Mouse': [1970], 'receptor-grade': [1971], '(Collaborative': [1973], 'Research': [1974], 'iron-saturated': [1977], 'Tfn': [1979, 2676, 2679, 2768, 3299, 3367, 3618], '(Sigma)': [1980], 'iodinated': [1982], 'dishes': [2009], 'incubated': [2011, 2085], '(1': [2014, 2018], 'ng/ml)': [2015], '125I-Tfn': [2017, 2717, 4196], 'μg/ml)': [2019], 'binding': [2021, 3398, 3438, 4221], '(DMEM,': [2023], '0.1%': [2024], 'albumin)': [2027], '37': [2029, 2099, 2728, 3797, 3869], '°C,': [2030, 2100], 'ratio': [2033], 'surface': [2037], 'radioactivity': [2038], 'determined': [2040, 2553], '5-min': [2043], 'time': [2044, 2724], 'course': [2045, 2725], 'calculate': [2047], 'rate': [2050, 3188], 'ke': [2052], 'Fluorescence': [2075], 'Microscopy—Mock-': [2076], 'siRNA-transfected': [2078, 3980], 'glass': [2082], 'coverslips': [2083], '2': [2087, 2324, 3179], 'ng/ml': [2088], 'EGF-rhodamine': [2089], 'conjugate': [2090], '(EGF-Rh)': [2091], '(Molecular': [2092], 'Probes,': [2093], '5': [2096, 3023], 'min': [2097, 3024], 'fixed': [2101], 'paraformaldehyde,': [2103], 'processed': [2105], 'imaging': [2107], 'Z-stack': [2131], 'two-dimensional': [2134], 'images': [2135], 'acquired': [2137], 'variant': [2141], 'identical': [2143, 4155], 'settings': [2144], 'Cy3': [2146], 'filter': [2147], 'channel': [2148], 'deconvoluted': [2150], 'SlideBook': [2152], '4.0': [2153], 'software.': [2154], 'Thirteen': [2155], 'endosomal': [2159, 2466], 'chosen': [2162], 'based': [2168, 2816], 'possible': [2171], 'involvement': [2172], 'availability': [2179], 'antibodies.': [2181], 'Individual': [2182], 'pools': [2184, 2290, 4511], 'improved': [2193], '(19Reynolds': [2200], 'Leake': [2202], 'D.': [2203, 3302], 'Scaringe': [2204], 'Marshall': [2206], 'Khvorova': [2208], '22:': [2213], '326-330Crossref': [2214], '(1648)': [2216], 'Briefly,': [2219], 'developed': [2223], 'performing': [2225], 'statistical': [2227], '(and': [2231, 2481], 'microRNA)': [2232], 'identification': [2237], 'critical': [2239], 'thermodynamic': [2242], 'attributes': [2243], 'common': [2246], 'among': [2247], 'reagents.': [2250], '(individually': [2255], 'pools)': [2258], 'level': [2264], 'quantitated': [2268], 'blotting': [2271], '2,': [2273], '3,': [2274], 'Fig.': [2280, 2457, 2754, 3524, 3939], 'shows': [2282, 2756, 3941], 'majority': [2285], 'effectively': [2291, 4229], '90-95%': [2297], 'mock-transfected': [2302, 3014, 3978], 'cells.': [2303, 2513, 3853], 'cases,': [2306, 2563], 'extent': [2308, 2373, 3136, 3537, 3955], 'Interestingly,': [2319, 3118], 'completely': [2322, 2343], 'eliminated': [2323, 2486], 'effectiveness': [2329], 'targeted': [2332, 3208, 3635, 3999, 4120, 4388], 'confirmed': [2336], 'down-regulated': [2344], 'GFP-tagged': [2345], '(data': [2347, 3190, 3576], 'shown).': [2349, 2822, 3192], 'instances': [2352], '(β2-adaptin,': [2353], 'Eps15,': [2354], 'Eps15R)': [2356], 'following': [2364], 'It': [2366, 3419, 3589], 'precise': [2372, 4557], 'depletion,': [2376, 3544], 'expressed': [2380, 2510, 2525, 2703], 'splice': [2383], 'variants': [2384], 'ubiquitylated,': [2388], 'thus': [2389], 'running': [2390], 'multiple': [2392, 2635], 'immuno-reactive': [2393], 'bands': [2394], '(20Coda': [2395], 'Salcini': [2397], 'A.E.': [2398], 'Confalonieri': [2399], 'Pelicci': [2401, 2407, 4269], 'Sorkina': [2403], 'P.G.': [2408, 4270], 'P.P.': [2411, 2447, 4167, 4275], '1998;': [2415, 4251], '273:': [2416], '3003-3012Abstract': [2417], '(69)': [2425], '21Polo': [2428], 'Sigismund': [2430], 'Faretta': [2432], 'Guidi': [2434], 'Capua': [2436], 'M.R.': [2437, 4272], 'Bossi': [2438], 'Nature.': [2448], '416:': [2450], '451-455Crossref': [2451], '(555)': [2454], 'also': [2459], 'illustrates': [2460], 'effective': [2462, 3047, 3809], 'proteins,': [2467], 'Rab5b,': [2469, 4391], 'Rab5c,': [2470], 'EEA.1.': [2472], 'greater': [2475, 2549], '99%': [2477], 'YFP-tagged': [2483, 2503], 'version)': [2484], 'all': [2488, 2562, 2588, 4366], 'duplexes.': [2491, 3360], 'Because': [2492, 3361], 'recognize': [2495], 'endogenous': [2496], 'available,': [2502], 'generated': [2508, 3425], 'Rab5a': [2519, 4411, 4452], 'validated': [2520], 'use': [2522], 'heterologously': [2524], 'testing': [2529], 'efficiency': [2531, 2629], 'siRNAs.': [2533], 'As': [2534, 3521, 4108], 'case': [2537, 4111], 'YFP-Rab5b': [2543], 'YFP-Rab5c': [2545], '99%,': [2551], 'antibody': [2556], 'directed': [2557], 'YFP.': [2559], 'Thus': [2560], 'exception': [2566], 'Eps15R,': [2568], 'either': [2569], 'single': [2571], 'pool': [2576, 2811, 3182], 'available': [2578], '>90%,': [2583], 'about': [2585], '50%': [2586, 4375], '>95%.': [2594], 'represent': [2597], 'improvement': [2600], 'over': [2601], 'conventional': [2605], 'methodologies': [2607], '(22Elbashir': [2608], 'S.M.': [2609], 'Methods.': [2616], '26:': [2618], '199-213Crossref': [2619], '(1031)': [2622], 'importantly,': [2626], 'high': [2628, 2981, 3197], 'achieved': [2633], 'enabled': [2637], 'us': [2638], 'biochemical': [2641], 'assays': [2642], 'examine': [2644], 'consequences': [2647, 4545], 'down-regulation.': [2650], 'test': [2661], 'EGF.': [2678], '(TfnR)': [2681], 'constitutively': [2683], 'endocytosed': [2684], 'pits.': [2687, 3606], 'induced': [2695], 'ligand.': [2698], 'endogenously': [2702], 'levels.': [2709], 'measurements': [2711, 2973], 'uptake': [2714, 2738, 2793, 3005, 3065, 3555], 'short': [2723], '°C': [2729, 3790, 3807, 3870, 3874, 3989], 'avoid': [2731, 2746], 'contribution': [2732], 'recycling': [2735], 'kinetics': [2739], 'ligand': [2743, 3866], 'saturation': [2747], '(for': [2752], 'EGF).': [2753], '2A': [2755], 'largest': [2773], 'TfnR': [2780, 4023, 4091, 4233, 4381], 'chain.': [2790], 'residual': [2792], '(20-25%)': [2794], 'mainly': [2795], 'consists': [2796], 'component': [2800, 3376], 'vesicle-mediated': [2804], 'presumably,': [2806], 'due': [2807, 2978, 4033, 4352], 'untransfected': [2813], '(<5%': [2815], 'immunofluorescence': [2818], 'analysis;': [2819], 'During': [2823], 'preparation': [2824], 'this': [2826, 2989, 3369, 4051, 4520], 'manuscript,': [2827], 'contradictory': [2831], 'Our': [2888, 3492, 4447], 'strongly': [2892], 'support': [2893], 'lack': [2922], 'Hinrichsen': [2928], 'et': [2929, 3684, 3912], 'al.': [2930, 3685, 3913], '(12Hinrichsen': [2931], 'Scholar)': [2956, 3102, 3483, 3514, 3660, 3704, 3736, 3835, 3932], 'could': [2957, 3837, 4350], 'explained': [2959], 'inefficient': [2962], '(80%)': [2966], 'and/or': [2967], 'assay': [2970], 'favors': [2972], 'labeled': [2984, 3865], 'substantiate': [2988], 'view': [2990, 3108, 3678], 'independent': [2993, 3355], 'assay,': [2995], 'EGF-Rh': [3007, 3016, 3071], 'fluorescence': [3011, 3041], 'microscopy.': [3012], 'accumulated': [3019], 'endosomes': [3021], 'continuous': [3026], '(Fig.': [3028, 3051, 3068, 3072, 3238, 3250, 3342, 3621, 3661, 3963, 3991, 4146, 4203, 4384, 4401, 4486], '2B).': [3029, 3052], 'contrast,': [3031, 3855, 3966], 'almost': [3037], 'punctate': [3039], 'rhodamine': [3040], 'observed,': [3043], 'indicative': [3044], 'block': [3048], 'strong': [3054], '2A)': [3069, 3239], '2B)': [3073], 'supports': [3074], 'dominant-negative': [3079, 4328], 'mutants': [3080, 4332, 4358, 4407], '(23Damke': [3083], 'Gossen': [3085], 'Freundlieb': [3087], 'Bujard': [3089], 'Schmid': [3091, 3721, 3724, 4242], 'S.L.': [3092, 3725], '257:': [3096], '209-220Crossref': [3097], 'consistent': [3105, 3281, 3668], 'CME.': [3117, 3676, 4215, 4474], 'there': [3128, 3967, 4004], 'threshold': [3133, 4037, 4052], 'down-regulation': [3139, 3242], 'reached': [3143], 'cause': [3145], 'observable': [3146], 'instance,': [3150], 'incomplete': [3151, 4020], '(∼85%': [3159], 'depletion)': [3160], 'resulted': [3161, 4372], 'significantly': [3164], 'lesser': [3165], 'consequence': [3167], '(only': [3168], '30%': [3169], 'rates)': [3173], '(∼94%': [3185], 'depletion;': [3186], '>70%': [3187], 'reduction)': [3189], 'emphasize': [3195], 'potency': [3198], 'reveal': [3204, 4468], 'function': [3206, 3451, 4342, 4501, 4529, 4558], 'indicates': [3211], 'complete': [3213], 'elimination': [3215, 4457], 'requirement': [3218, 4012], 'correct': [3221], 'accession': [3222], 'function.': [3226], 'contrast': [3228], 'chain,': [3236], 'simultaneous': [3241, 3562], '3)': [3251], 'affect': [3254, 3366, 3714, 4396, 4484], 'rates.': [3256], 'appear': [3263], 'conditions': [3273, 3945], 'our': [3275, 3664, 3765, 3936, 3995, 4029], 'assays.': [3277, 3938], 'observation': [3279], 'endoribonuclease': [3285], '(24Yang': [3301], 'Buchholz': [3303], 'Z.': [3306], 'Goga': [3307], 'Bishop': [3313], 'J.M.': [3314], 'Proc.': [3315], 'Natl.': [3316], 'Acad.': [3317], 'U.': [3319], '99:': [3323], '9942-9947Crossref': [3324], '(269)': [3327], 'Unexpectedly,': [3330], 'CALM-targeted': [3331], 'partial': [3334, 3625], '2A).': [3343, 3622, 3964, 4147, 4402, 4487], 'average': [3350], '45%': [3352], 'six': [3354], 'apparently': [3372], 'clathrin-associated': [3379], 'apparatus,': [3381], 'finding': [3383], 'surprising': [3386], 'previous': [3390, 3493], 'observations': [3391], 'overexpression': [3393, 4405], 'domain': [3399, 4156, 4226, 4295], 'blocked': [3400], 'likely': [3421], 'mutant': [3429], 'result': [3432], 'rather': [3440], 'disruption': [3442], 'functions.': [3446], 'Likewise,': [3447], 'CALM/AP180': [3453], 'demonstrated': [3454, 3515], 'vitro': [3456], 'may': [3484, 4031, 4506], 'accomplished': [3486], 'vivo.': [3491], 'Grb2-mediated': [3516], 'mechanism': [3517], 'shown': [3522], '2C,': [3525], 'comparable': [3538, 3956], 'suggesting': [3545, 4205], 'responsible': [3549], 'pathway.': [3559], 'Since': [3560], 'produce': [3572], 'additive': [3574], 'shown),': [3578], 'unlikely': [3581], 'involved': [3585], 'Grb2-independent': [3587], 'possible,': [3591], 'however,': [3592, 3680], 'participates': [3595], 'linking': [3601], 'EGFR-Grb2': [3602], 'β2-adaptin': [3610], '50-60%': [3620], 'addition,': [3624], 'subunit': [3639], '(25Fraile-Ramos': [3644], 'Kohout': [3646], 'T.A.': [3647], 'Waldhoer': [3648], '243-253Crossref': [3655], '(93)': [3658], '3B).': [3662], 'was,': [3679], 'challenged': [3681], 'Motley': [3683, 3911], 'who': [3705, 3737], 'does': [3712], 'Conner': [3719], '(26Conner': [3722], 'S.D.': [3723], '773-779Crossref': [3731], '(150)': [3734], 'where': [3745], 'sequestered': [3748], 'overexpressed': [3750], 'adaptor-associated': [3751], 'kinase': [3752], '1.': [3753], 'conceivable': [3756], 'explanation': [3757], 'measure': [3772], 'latter': [3778], 'technique': [3782], 'preincubation': [3785], 'chase': [3794], 'incubation': [3795, 3800, 3990], '°C.': [3798], 'Long': [3799], 'allows': [3808], 'recruitment': [3810], 'ligand-receptor': [3812], 'complexes': [3813], 'be,': [3838], 'therefore,': [3839], 'fully': [3842], 'recruit': [3843], 'activated': [3844], 'remaining': [3849], 'measured': [3857, 3986], 'incubating': [3861], 'directly': [3867], 'without': [3871], 'preincubation,': [3875], 'condition': [3877], 'physiological': [3881], 'exposes': [3884], 'differences': [3885], 'provide': [3896, 4335], 'additional': [3897], 'evidence': [3898, 4338], 'tested': [3934], '2D': [3940], 'β2-depleted': [3961], 'difference': [3970, 4008], '2D).': [3992], 'summary,': [3994], 'indicate': [4002], 'TfnR.': [4018], 'lower': [4036], 'necessary': [4043, 4466, 4553], 'Similarly': [4062], 'tended': [4082], 'slightly': [4085], 'pronounced': [4087], 'attributed': [4096], 'ability': [4099], 'pathways.': [4107], 'none': [4117], 'EGFR-specific': [4126], '15-30%': [4128], 'homology,': [4154], 'architecture,': [4157], 'similar': [4159], 'interaction': [4161], 'motifs': [4162], '(27Confalonieri': [4163], 'FEBS': [4168], 'Lett.': [4169], '513:': [4171], '24-29Crossref': [4172], '(83)': [4175], 'When': [4178], 'combination': [4187, 4460], '40%': [4202], '3),': [4204, 4385], 'redundant': [4212], 'Overexpression': [4216], 'fragments': [4219], 'sites': [4222], 'appendage': [4225, 4362], 'inhibited': [4230], '(28Benmerah': [4236], 'Lamaze': [4238], 'Begue': [4240], 'Dautry-Varsat': [4244], 'Cerf-Bensussan': [4246], 'N.': [4247], '140:': [4252], '1055-1062Crossref': [4253], '(300)': [4256], '29Carbone': [4259], 'Fre': [4261], 'Iannolo': [4263], 'Belleudi': [4265], 'Mancini': [4267], 'Torrisi': [4271], 'Res.': [4277], '1997;': [4278], '57:': [4279], '5498-5504PubMed': [4280], 'interact': [4291], 'same': [4294], '(30Owen': [4298], 'Noble': [4302], 'M.E.': [4303], 'Hunter': [4304], 'J.B.': [4305], 'Dafforn': [4306], 'T.R.': [4307], '97:': [4314], '805-815Abstract': [4315], '(241)': [4323], 'direct': [4337], 'interactions.': [4363], 'isoforms': [4371, 4464], 'Based': [4403], 'mutants,': [4410], 'isoform': [4412], 'implicated': [4414], 'regulation': [4418], '(31Barbieri': [4422], 'M.A.': [4423], 'Roberts': [4424], 'R.L.': [4425], 'Gumusboga': [4426], 'Highfield': [4428], 'Alvarez-Dominguez': [4430], 'Wells': [4432], 'Stahl': [4434], 'P.D.': [4435], '151:': [4440], '539-550Crossref': [4441], '(198)': [4444], 'showed': [4450], 'redundant,': [4454], 'Rab5s': [4472], 'On': [4475], 'hand,': [4478], 'EEA.1': [4481, 4496], 'Although': [4488], 'co-localized': [4492], 'associated': [4494], 'early': [4498], 'endosomes,': [4499], 'mediated': [4508], 'complexed': [4514], 'effectors.': [4517], 'summarize,': [4519], 'new': [4525], 'insights': [4526], 'Further': [4540], 'detailed': [4541], 'investigation': [4542], 'elucidate': [4555], 'thank': [4593], 'Brodsky,': [4595], 'Fiore,': [4599], 'Marsh,': [4601], 'gift': [4607], 'reagents': [4610], 'Karpilow': [4613], 'assistance': [4615], 'manuscript': [4617], 'preparation.': [4618], 'Download': [4619], '.pdf': [4620], '(.03': [4621], 'MB)': [4622], 'Help': [4623], 'pdf': [4625], 'files': [4626]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993355802', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 27}, {'year': 2013, 'cited_by_count': 32}, {'year': 2012, 'cited_by_count': 42}], 'updated_date': '2025-01-18T22:21:29.444775', 'created_date': '2016-06-24'}