Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1993112159', 'doi': 'https://doi.org/10.1016/j.taap.2005.09.006', 'title': 'Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats', 'display_name': 'Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats', 'publication_year': 2005, 'publication_date': '2005-10-15', 'ids': {'openalex': 'https://openalex.org/W1993112159', 'doi': 'https://doi.org/10.1016/j.taap.2005.09.006', 'mag': '1993112159', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16226777'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.taap.2005.09.006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42307217', 'display_name': 'Toxicology and Applied Pharmacology', 'issn_l': '0041-008X', 'issn': ['0041-008X', '1096-0333'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101560253', 'display_name': 'Ana I. Morales', 'orcid': 'https://orcid.org/0000-0001-6836-6138'}, 'institutions': [{'id': 'https://openalex.org/I184999862', 'display_name': 'Universidad de Salamanca', 'ror': 'https://ror.org/02f40zc51', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I184999862']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ana I. Morales', 'raw_affiliation_strings': ['Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.', 'institution_ids': ['https://openalex.org/I184999862']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006173107', 'display_name': 'C. Vicente-Sánchez', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I184999862', 'display_name': 'Universidad de Salamanca', 'ror': 'https://ror.org/02f40zc51', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I184999862']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'César Vicente-Sánchez', 'raw_affiliation_strings': ['Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.', 'institution_ids': ['https://openalex.org/I184999862']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061100168', 'display_name': 'Mirjana Jerkić', 'orcid': 'https://orcid.org/0000-0002-0623-0347'}, 'institutions': [{'id': 'https://openalex.org/I184999862', 'display_name': 'Universidad de Salamanca', 'ror': 'https://ror.org/02f40zc51', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I184999862']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Mirjana Jerkic', 'raw_affiliation_strings': ['Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.', 'institution_ids': ['https://openalex.org/I184999862']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003880070', 'display_name': 'José M. Santiago', 'orcid': 'https://orcid.org/0000-0002-0615-5033'}, 'institutions': [{'id': 'https://openalex.org/I4210099034', 'display_name': 'Complejo Hospitalario de Salamanca', 'ror': 'https://ror.org/0131vfw26', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I184999862', 'https://openalex.org/I4210099034']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'José M. Santiago', 'raw_affiliation_strings': ['Departamento de Bioquímica Clínica, Hospital Universitario de Salamanca, Salamanca, Spain'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica Clínica, Hospital Universitario de Salamanca, Salamanca, Spain', 'institution_ids': ['https://openalex.org/I4210099034']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021554347', 'display_name': 'Penélope Sánchez‐González', 'orcid': 'https://orcid.org/0000-0001-8351-7854'}, 'institutions': [{'id': 'https://openalex.org/I184999862', 'display_name': 'Universidad de Salamanca', 'ror': 'https://ror.org/02f40zc51', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I184999862']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Penélope D. Sánchez-González', 'raw_affiliation_strings': ['Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.', 'institution_ids': ['https://openalex.org/I184999862']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016461332', 'display_name': 'Fernando Pérez‐Barriocanal', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I184999862', 'display_name': 'Universidad de Salamanca', 'ror': 'https://ror.org/02f40zc51', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I184999862']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Fernando Pérez-Barriocanal', 'raw_affiliation_strings': ['Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.', 'institution_ids': ['https://openalex.org/I184999862']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005374126', 'display_name': 'José M. López‐Novoa', 'orcid': 'https://orcid.org/0000-0002-6211-7269'}, 'institutions': [{'id': 'https://openalex.org/I184999862', 'display_name': 'Universidad de Salamanca', 'ror': 'https://ror.org/02f40zc51', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I184999862']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'José M. López-Novoa', 'raw_affiliation_strings': ['Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.', 'institution_ids': ['https://openalex.org/I184999862']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3920, 'currency': 'USD', 'value_usd': 3920, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.247, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 124, 'citation_normalized_percentile': {'value': 0.999855, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '210', 'issue': '1-2', 'first_page': '128', 'last_page': '135'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10790', 'display_name': 'Metal-Induced Oxidative Stress and Health Effects', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10790', 'display_name': 'Metal-Induced Oxidative Stress and Health Effects', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10915', 'display_name': 'Copper and Zinc in Health and Disease', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10139', 'display_name': 'Environmental Impact of Heavy Metal Contamination', 'score': 0.9781, 'subfield': {'id': 'https://openalex.org/subfields/2310', 'display_name': 'Pollution'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/metallothionein', 'display_name': 'Metallothionein', 'score': 0.7465104}, {'id': 'https://openalex.org/keywords/cadmium-carcinogenesis', 'display_name': 'Cadmium Carcinogenesis', 'score': 0.507791}, {'id': 'https://openalex.org/keywords/nephrotoxicity', 'display_name': 'Nephrotoxicity', 'score': 0.4996562}, {'id': 'https://openalex.org/keywords/endothelial-nos', 'display_name': 'Endothelial NOS', 'score': 0.48149812}], 'concepts': [{'id': 'https://openalex.org/C2781263971', 'wikidata': 'https://www.wikidata.org/wiki/Q409478', 'display_name': 'Quercetin', 'level': 3, 'score': 0.8579743}, {'id': 'https://openalex.org/C20719415', 'wikidata': 'https://www.wikidata.org/wiki/Q416896', 'display_name': 'Metallothionein', 'level': 3, 'score': 0.7465104}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.7288486}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6131603}, {'id': 'https://openalex.org/C2778326061', 'wikidata': 'https://www.wikidata.org/wiki/Q1761022', 'display_name': 'Enos', 'level': 4, 'score': 0.60211754}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.59096825}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.53011084}, {'id': 'https://openalex.org/C126189478', 'wikidata': 'https://www.wikidata.org/wiki/Q1468324', 'display_name': 'Nephrotoxicity', 'level': 3, 'score': 0.4996562}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4868047}, {'id': 'https://openalex.org/C2779698670', 'wikidata': 'https://www.wikidata.org/wiki/Q408853', 'display_name': 'Endothelial NOS', 'level': 5, 'score': 0.48149812}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.45737246}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.44318125}, {'id': 'https://openalex.org/C544657597', 'wikidata': 'https://www.wikidata.org/wiki/Q1091', 'display_name': 'Cadmium', 'level': 2, 'score': 0.4071962}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3637312}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2970779}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.25099617}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23157501}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.16778147}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019187', 'descriptor_name': 'Cadmium Compounds', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D008668', 'descriptor_name': 'Metallothionein', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D020011', 'descriptor_name': 'Protective Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011794', 'descriptor_name': 'Quercetin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019187', 'descriptor_name': 'Cadmium Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002908', 'descriptor_name': 'Chronic Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004790', 'descriptor_name': 'Enzyme Induction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008668', 'descriptor_name': 'Metallothionein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020011', 'descriptor_name': 'Protective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011794', 'descriptor_name': 'Quercetin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.taap.2005.09.006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42307217', 'display_name': 'Toxicology and Applied Pharmacology', 'issn_l': '0041-008X', 'issn': ['0041-008X', '1096-0333'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16226777', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.41, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320309969', 'funder_display_name': 'Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W103037428', 'https://openalex.org/W1536581914', 'https://openalex.org/W1571941866', 'https://openalex.org/W1807257653', 'https://openalex.org/W196233321', 'https://openalex.org/W1964979213', 'https://openalex.org/W1968770520', 'https://openalex.org/W1972108132', 'https://openalex.org/W1976856100', 'https://openalex.org/W1984562766', 'https://openalex.org/W1995138033', 'https://openalex.org/W1996259140', 'https://openalex.org/W1998057165', 'https://openalex.org/W1999680131', 'https://openalex.org/W2018398416', 'https://openalex.org/W2020550910', 'https://openalex.org/W2022920521', 'https://openalex.org/W2024365580', 'https://openalex.org/W2024869617', 'https://openalex.org/W2027062593', 'https://openalex.org/W2035894986', 'https://openalex.org/W2037461804', 'https://openalex.org/W2053889482', 'https://openalex.org/W2056894755', 'https://openalex.org/W2060192197', 'https://openalex.org/W2065943558', 'https://openalex.org/W2068049375', 'https://openalex.org/W2068524933', 'https://openalex.org/W2072104803', 'https://openalex.org/W2073309533', 'https://openalex.org/W2079307577', 'https://openalex.org/W2081041555', 'https://openalex.org/W2084390160', 'https://openalex.org/W2084939005', 'https://openalex.org/W2092115612', 'https://openalex.org/W2093376330', 'https://openalex.org/W2096390421', 'https://openalex.org/W2103004355', 'https://openalex.org/W2108194226', 'https://openalex.org/W2108373851', 'https://openalex.org/W2112086273', 'https://openalex.org/W2114886702', 'https://openalex.org/W2117649235', 'https://openalex.org/W2126877004', 'https://openalex.org/W2130921124', 'https://openalex.org/W2133405707', 'https://openalex.org/W2145515127', 'https://openalex.org/W2158686638', 'https://openalex.org/W2164425862', 'https://openalex.org/W2167692013', 'https://openalex.org/W2442315290', 'https://openalex.org/W2774797806', 'https://openalex.org/W4252628927', 'https://openalex.org/W4323282404'], 'related_works': ['https://openalex.org/W602906518', 'https://openalex.org/W3030505798', 'https://openalex.org/W2284947444', 'https://openalex.org/W2249728733', 'https://openalex.org/W2139541900', 'https://openalex.org/W2079264286', 'https://openalex.org/W2074042972', 'https://openalex.org/W2066360730', 'https://openalex.org/W2019650760', 'https://openalex.org/W2008305232'], 'abstract_inverted_index': {'Inflammation': [0], 'can': [1, 239], 'play': [2], 'a': [3, 11, 18], 'key': [4], 'role': [5], 'in': [6, 41, 131, 142, 167, 174, 180, 197, 208], 'Cd-induced': [7, 31, 125, 227, 246], 'dysfunctions.': [8], 'Quercetin': [9], 'is': [10], 'potent': [12], 'oxygen': [13], 'free': [14], 'radical': [15], 'scavenger': [16], 'and': [17, 34, 75, 94, 109, 113, 138, 159, 171, 190, 210, 231, 233], 'metal': [19], 'chelator.': [20], 'Our': [21, 121, 220], 'aim': [22], 'was': [23, 39, 67, 116, 128, 164, 193], 'to': [24], 'study': [25, 38], 'the': [26, 155, 184, 201, 217, 241], 'effect': [27], 'of': [28, 78, 81, 106, 229, 245], 'quercetin': [29, 57, 172, 224, 244], 'on': [30], 'kidney': [32, 143], 'damage': [33], 'metallothionein': [35, 107], 'expression.': [36, 236], 'The': [37], 'performed': [40], 'Wistar': [42], 'rats': [43, 132, 168], 'that': [44, 124, 133, 186, 223], 'were': [45, 99, 144, 213], 'administered': [46], 'during': [47, 147], '9': [48], 'weeks': [49], 'with': [50, 149, 216], 'either': [51], 'cadmium': [52, 62], '(1.2': [53], 'mg': [54], 'Cd/kg/day,': [55], 's.c.),': [56], '(50': [58], 'mg/kg/day,': [59], 'i.p.)': [60], 'or': [61, 179], '+': [63, 204], 'quercetin.': [64, 136, 160], 'Renal': [65, 104, 161], 'toxicity': [66, 127], 'evaluated': [68], 'by': [69, 101, 118, 243], 'measuring': [70], 'blood': [71], 'urea': [72], 'nitrogen': [73], 'concentration': [74], 'urinary': [76], 'excretion': [77], 'enzymes': [79], 'marker': [80], 'tubular': [82], 'damage.': [83], 'Endothelial': [84], 'nitric': [85, 90], 'oxide': [86, 91], 'synthase': [87, 92], '(eNOS),': [88], 'inducible': [89], '(iNOS)': [93], 'cyclooxygenase-2': [95], '(COX-2)': [96], 'renal': [97, 126], 'expression': [98, 105, 163, 192, 212], 'assessed': [100, 117], 'Western': [102], 'blot.': [103, 120], '1': [108], '2': [110], '(MT-1,': [111], 'MT-2)': [112], 'eNOS': [114, 162], 'mRNA': [115, 140], 'Northern': [119], 'data': [122], 'demonstrated': [123], 'markedly': [129, 194], 'reduced': [130], 'also': [134], 'received': [135, 157, 187], 'MT-1': [137], 'MT-2': [139], 'levels': [141], 'substantially': [145], 'increased': [146], 'treatment': [148, 225], 'Cd,': [150, 188], 'being': [151], 'even': [152], 'higher': [153, 166, 195], 'when': [154], 'animals': [156, 175], 'Cd': [158, 170, 177, 203], 'significantly': [165], 'receiving': [169, 176], 'than': [173, 196], 'alone': [178], 'control': [181, 198, 218], 'rats.': [182, 199], 'In': [183, 200], 'group': [185, 202], 'COX-2': [189, 209], 'iNOS': [191, 211, 230], 'quercetin,': [205], 'no': [206], 'changes': [207], 'observed': [214], 'compared': [215], 'group.': [219], 'results': [221], 'demonstrate': [222], 'prevents': [226], 'overexpression': [228], 'COX-2,': [232], 'increases': [234], 'MT': [235], 'These': [237], 'effects': [238], 'explain': [240], 'protection': [242], 'nephrotoxicity.': [247]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993112159', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2024-09-24T13:17:03.290670', 'created_date': '2016-06-24'}