Publication Information

{'id': 'https://openalex.org/W1993006993', 'doi': 'https://doi.org/10.1158/1535-7163.targ-13-b75', 'title': 'Abstract B75: A first in-human phase I study to evaluate the MEK1/2 inhibitor GDC-0623 in patients with advanced solid tumors.', 'display_name': 'Abstract B75: A first in-human phase I study to evaluate the MEK1/2 inhibitor GDC-0623 in patients with advanced solid tumors.', 'publication_year': 2013, 'publication_date': '2013-11-01', 'ids': {'openalex': 'https://openalex.org/W1993006993', 'doi': 'https://doi.org/10.1158/1535-7163.targ-13-b75', 'mag': '1993006993'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.targ-13-b75', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013744957', 'display_name': 'Anthony B. El-Khoueiry', 'orcid': 'https://orcid.org/0000-0002-9053-3841'}, 'institutions': [{'id': 'https://openalex.org/I4210117038', 'display_name': 'USC Norris Comprehensive Cancer Center', 'ror': 'https://ror.org/01nmyfr60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800154431', 'https://openalex.org/I4210117038']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anthony El-Khoueiry', 'raw_affiliation_strings': ['1USC Norris Comprehensive Cancer Center, Los Angeles, CA'], 'affiliations': [{'raw_affiliation_string': '1USC Norris Comprehensive Cancer Center, Los Angeles, CA', 'institution_ids': ['https://openalex.org/I4210117038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075063422', 'display_name': 'Carla Kurkjian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27253931', 'display_name': 'Oklahoma City University', 'ror': 'https://ror.org/02bs0cv29', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27253931']}, {'id': 'https://openalex.org/I8692664', 'display_name': 'University of Oklahoma', 'ror': 'https://ror.org/02aqsxs83', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I8692664']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carla Kurkjian', 'raw_affiliation_strings': ['2University of Oklahoma, Oklahoma City, OK'], 'affiliations': [{'raw_affiliation_string': '2University of Oklahoma, Oklahoma City, OK', 'institution_ids': ['https://openalex.org/I27253931', 'https://openalex.org/I8692664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016991744', 'display_name': 'Thomas J. Semrad', 'orcid': 'https://orcid.org/0000-0002-7810-5887'}, 'institutions': [{'id': 'https://openalex.org/I4390039352', 'display_name': 'UC Davis Comprehensive Cancer Center', 'ror': 'https://ror.org/02kcc1z29', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160856', 'https://openalex.org/I4390039352']}, {'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas Semrad', 'raw_affiliation_strings': ['3UC Davis Comprehensive Cancer Center, Davis, CA'], 'affiliations': [{'raw_affiliation_string': '3UC Davis Comprehensive Cancer Center, Davis, CA', 'institution_ids': ['https://openalex.org/I4390039352', 'https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022619396', 'display_name': 'Luna Musib', 'orcid': 'https://orcid.org/0000-0002-6476-7919'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Luna Musib', 'raw_affiliation_strings': ['4Genentech, Inc., South San Francisco, CA'], 'affiliations': [{'raw_affiliation_string': '4Genentech, Inc., South San Francisco, CA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034301580', 'display_name': 'Mary Gates', 'orcid': 'https://orcid.org/0009-0006-8576-2769'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mary Gates', 'raw_affiliation_strings': ['4Genentech, Inc., South San Francisco, CA'], 'affiliations': [{'raw_affiliation_string': '4Genentech, Inc., South San Francisco, CA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030987405', 'display_name': 'Steve Eppler', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Steve Eppler', 'raw_affiliation_strings': ['4Genentech, Inc., South San Francisco, CA'], 'affiliations': [{'raw_affiliation_string': '4Genentech, Inc., South San Francisco, CA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049416849', 'display_name': 'Ilsung Chang', 'orcid': 'https://orcid.org/0000-0002-9975-8449'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ilsung Chang', 'raw_affiliation_strings': ['4Genentech, Inc., South San Francisco, CA'], 'affiliations': [{'raw_affiliation_string': '4Genentech, Inc., South San Francisco, CA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041140599', 'display_name': 'Iris T. Chan', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Iris Chan', 'raw_affiliation_strings': ['4Genentech, Inc., South San Francisco, CA'], 'affiliations': [{'raw_affiliation_string': '4Genentech, Inc., South San Francisco, CA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000291728', 'display_name': 'Isabelle Rooney', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Isabelle Rooney', 'raw_affiliation_strings': ['4Genentech, Inc., South San Francisco, CA'], 'affiliations': [{'raw_affiliation_string': '4Genentech, Inc., South San Francisco, CA', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028472820', 'display_name': 'Johanna C. Bendell', 'orcid': 'https://orcid.org/0000-0001-9426-5891'}, 'institutions': [{'id': 'https://openalex.org/I4210100810', 'display_name': 'Sarah Cannon', 'ror': 'https://ror.org/014t21j89', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210100810']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Johanna Bendell', 'raw_affiliation_strings': ['5Sarah Cannon Research Institute, Nashville, TN;'], 'affiliations': [{'raw_affiliation_string': '5Sarah Cannon Research Institute, Nashville, TN;', 'institution_ids': ['https://openalex.org/I4210100810']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.516, 'has_fulltext': False, 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.709182, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '12', 'issue': '11_Supplement', 'first_page': 'B75', 'last_page': 'B75'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9539, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9299, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/regimen', 'display_name': 'Regimen', 'score': 0.46970627}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.774786}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.69351184}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.60674787}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.60271144}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.524403}, {'id': 'https://openalex.org/C72563966', 'wikidata': 'https://www.wikidata.org/wiki/Q1303415', 'display_name': 'Cohort', 'level': 2, 'score': 0.4838692}, {'id': 'https://openalex.org/C2781413609', 'wikidata': 'https://www.wikidata.org/wiki/Q7308373', 'display_name': 'Regimen', 'level': 2, 'score': 0.46970627}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.45338452}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.45014834}, {'id': 'https://openalex.org/C22979827', 'wikidata': 'https://www.wikidata.org/wiki/Q5137311', 'display_name': 'Cmax', 'level': 3, 'score': 0.42828828}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.targ-13-b75', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3151787567', 'https://openalex.org/W3122926187', 'https://openalex.org/W3018168093', 'https://openalex.org/W2945264506', 'https://openalex.org/W2942467058', 'https://openalex.org/W2766550598', 'https://openalex.org/W2379280247', 'https://openalex.org/W2370929226', 'https://openalex.org/W2064759457', 'https://openalex.org/W2051764329'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Deregulation': [2], 'of': [3, 21, 64, 102, 133, 173, 218, 310, 329, 421, 480], 'the': [4, 58, 85, 100, 138, 168, 179, 231, 253, 296, 340, 371, 413, 467, 481], 'RAS/RAF/MEK/ERK': [5], 'signaling': [6], 'pathway': [7], 'has': [8, 24], 'been': [9], 'implicated': [10], 'in': [11, 28, 50, 84, 144, 178, 204, 345, 359, 471], 'diverse': [12], 'human': [13], 'tumors.': [14, 476], 'GDC-0623': [15, 70, 112, 118, 291, 300, 318, 335, 346, 383, 470], 'is': [16, 384], 'an': [17], 'orally': [18], 'bioavailable': [19], 'inhibitor': [20, 469], 'MEK1/2': [22, 468], 'which': [23, 269], 'shown': [25], 'antitumor': [26], 'activity': [27], 'preclinical': [29], 'models': [30], '(Hatzivassiliou': [31], 'et': [32], 'al.': [33], '2013).': [34], 'Methods:': [35], 'An': [36], 'open-label': [37], 'Phase': [38], 'I': [39, 463], 'dose-escalation': [40], 'study': [41, 464], 'using': [42], 'a': [43, 72, 78, 205, 216, 307, 360], '3': [44, 46], '+': [45], 'design': [47], 'was': [48, 196, 270, 301, 337, 357], 'initiated': [49], 'patients': [51, 202, 375, 472], 'with': [52, 273, 306, 362, 403, 473], 'advanced': [53, 474], 'solid': [54, 475], 'tumors': [55], 'to': [56, 98, 255, 314, 465], 'evaluate': [57, 466], 'safety': [59], 'and': [60, 106, 129, 167, 184, 187, 239, 278, 288, 304, 342, 348, 386, 389, 399, 408, 487], 'pharmacokinetic': [61], '(PK)': [62], 'characteristics': [63], 'GDC-0623.': [65], 'Patients': [66], 'were': [67, 96, 121, 153, 227, 243, 258], 'administered': [68], 'oral': [69, 326], 'as': [71], 'QD': [73, 139, 238, 372, 407], 'or': [74, 265, 331], 'BID': [75, 225, 242, 409], 'regimen': [76], 'on': [77, 111, 235, 334], '21-day': [79], 'on/7-day': [80], 'off': [81], 'dosing': [82, 208, 410], 'schedule': [83], 'fasted': [86], 'state': [87], '(minimum': [88], '2': [89], 'hour': [90], 'fast).': [91], 'In': [92], 'addition,': [93], 'two': [94], 'cohorts': [95, 147, 226], 'enrolled': [97, 143, 203, 229], 'examine': [99], 'effect': [101], 'food': [103, 330], '(4': [104], 'pts)': [105, 110], 'acidic': [107, 332], 'beverage': [108, 333], '(3': [109], 'PK.': [113, 391], 'Serial': [114], 'plasma': [115], 'samples': [116], 'for': [117, 406], 'PK': [119, 294, 336, 347], 'analysis': [120], 'collected': [122], 'over': [123, 295], '24': [124], 'hours': [125], 'following': [126, 324], 'first': [127, 460], 'dose': [128, 195, 297], 'after': [130], '15': [131], 'days': [132], 'continuous': [134], 'dosing.': [135, 327], 'Results:': [136], 'On': [137], 'regimen,': [140], '45': [141, 210, 240], 'pts': [142], 'eight': [145], 'successive': [146], '(7-160': [148], 'mg).': [149, 191], 'Dose-limiting': [150], 'toxicities': [151], '(DLTs)': [152], 'Grade': [154], '4': [155], '(G4)': [156], 'creatine': [157], 'phosphokinase': [158], '(CPK)': [159], 'elevation': [160], '(90': [161], 'mg),': [162, 183], 'transient': [163], 'G3': [164, 174, 185, 188], 'visual': [165, 260, 400], 'disturbance': [166, 261, 401], 'serious': [169], 'adverse': [170, 248], 'event': [171], '(SAE)': [172], 'dehydration': [175], 'both': [176], 'occurring': [177], 'same': [180, 414], 'patient': [181, 214, 361], '(120': [182], 'thrombocytopenia': [186], 'hyponatremia': [189], '(160': [190], 'The': [192, 245], 'maximum': [193], 'tolerated': [194], '120': [197], 'mg': [198, 211, 237, 241], '(QD': [199], 'cohort).': [200], 'Eight': [201], 'single': [206], 'cohort': [207], 'at': [209, 322, 370, 412], 'BID.': [212], 'One': [213, 353], 'had': [215, 319, 376], 'DLT': [217], 'G2': [219], 'retinal': [220], 'pigment': [221], 'epithelial': [222], 'detachment.': [223], 'Further': [224], 'not': [228], 'since': [230], 'AE': [232], 'profiles': [233], 'between': [234], '90': [236], 'comparable.': [244], 'most': [246], 'frequent': [247], 'events': [249], '(AE)': [250], 'attributed': [251], 'by': [252], 'investigator': [254], 'be': [256, 428], 'GDC-0623-related': [257], 'rash,': [259, 396], '-': [262, 268], 'including': [263, 395], 'impaired': [264], 'blurred': [266], 'vision': [267], 'often': [271], 'associated': [272], 'sub-retinal': [274], 'fluid,': [275], 'diarrhea,': [276], 'nausea': [277], 'vomiting,': [279], 'fatigue,': [280], 'elevated': [281], 'CPK,': [282], 'peripheral': [283], 'edema,': [284], 'decreased': [285], 'appetite,': [286], 'headache': [287], 'dizziness.': [289], 'Preliminarily,': [290], 'showed': [292, 387], 'dose-proportional': [293, 388], 'range': [298], 'administered.': [299], 'rapidly': [302], 'absorbed': [303], 'distributed,': [305], 'terminal': [308], 'half-life': [309], '4-6': [311], 'hours.': [312], 'Due': [313], 'its': [315], 'short': [316], 'half-life,': [317], 'no': [320], 'accumulation': [321], 'steady-state': [323], 'daily': [325, 416], 'Effect': [328], 'inconclusive': [338], 'given': [339], 'inter-patient': [341], 'intra-patient': [343], 'variability': [344], 'very': [349], 'small': [350], 'sample': [351], 'size.': [352], 'confirmed': [354], 'partial': [355], 'response': [356], 'observed': [358], 'KRAS': [363], 'wild': [364], 'type': [365], 'squamous': [366], 'cell': [367], 'vaginal': [368], 'carcinoma': [369], 'MTD.': [373], 'Six': [374], 'stable': [377], 'disease': [378], '≥': [379], '5': [380], 'months.': [381], 'Conclusion:': [382], 'well-tolerated': [385], 'time-independent': [390], 'Classic': [392], 'MEK-related': [393], 'AEs,': [394], 'gastrointestinal': [397], 'symptoms': [398], 'occurred': [402], 'similar': [404], 'frequency': [405], 'regimens': [411], 'total': [415], 'dose,': [417], 'suggesting': [418], 'comparable': [419], 'intensity': [420], 'MEK': [422], 'target': [423], 'effect.': [424], 'Updated': [425], 'data': [426], 'will': [427], 'presented.': [429], 'Citation': [430, 437], 'Information:': [431], 'Mol': [432, 498], 'Cancer': [433, 488, 499], 'Ther': [434, 500], '2013;12(11': [435, 501], 'Suppl):B75.': [436], 'Format:': [438], 'Anthony': [439], 'El-Khoueiry,': [440], 'Carla': [441], 'Kurkjian,': [442], 'Thomas': [443], 'Semrad,': [444], 'Luna': [445], 'Musib,': [446], 'Mary': [447], 'Gates,': [448], 'Steve': [449], 'Eppler,': [450], 'Ilsung': [451], 'Chang,': [452], 'Iris': [453], 'Chan,': [454], 'Isabelle': [455], 'Rooney,': [456], 'Johanna': [457], 'Bendell.': [458], 'A': [459], 'in-human': [461], 'phase': [462], '[abstract].': [477], 'In:': [478], 'Proceedings': [479], 'AACR-NCI-EORTC': [482], 'International': [483], 'Conference:': [484], 'Molecular': [485], 'Targets': [486], 'Therapeutics;': [489], '2013': [490], 'Oct': [491], '19-23;': [492], 'Boston,': [493], 'MA.': [494], 'Philadelphia': [495], '(PA):': [496], 'AACR;': [497], 'Suppl):Abstract': [502], 'nr': [503], 'B75.': [504]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993006993', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-24T15:47:34.512006', 'created_date': '2016-06-24'}