Title: Hepatocellular carcinoma presenting as bone metastasis
Abstract: CancerVolume 64, Issue 8 p. 1753-1757 ArticleFree Access Hepatocellular carcinoma presenting as bone metastasis Chuang-Chi Liaw MD, Chuang-Chi Liaw MD Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung Medical College, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorKim-Thean Ng MD, Kim-Thean Ng MD Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung Medical College, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorTong-Jong Chen MD, Tong-Jong Chen MD Department of Pathology, Chang Gung Memorial Hospital and Chang Gung Medical College, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorYun-Fan Liaw MD, Corresponding Author Yun-Fan Liaw MD Liver Unit, Chang Gung Memorial Hospital and Chang Gung Medical College, Taipei, Taiwan, Republic of ChinaLiver Unit, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei, Taiwan 10591, Republic of China===Search for more papers by this author Chuang-Chi Liaw MD, Chuang-Chi Liaw MD Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung Medical College, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorKim-Thean Ng MD, Kim-Thean Ng MD Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung Medical College, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorTong-Jong Chen MD, Tong-Jong Chen MD Department of Pathology, Chang Gung Memorial Hospital and Chang Gung Medical College, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorYun-Fan Liaw MD, Corresponding Author Yun-Fan Liaw MD Liver Unit, Chang Gung Memorial Hospital and Chang Gung Medical College, Taipei, Taiwan, Republic of ChinaLiver Unit, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei, Taiwan 10591, Republic of China===Search for more papers by this author First published: 15 October 1989 https://doi.org/10.1002/1097-0142(19891015)64:8<1753::AID-CNCR2820640833>3.0.CO;2-NCitations: 53AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract In a consecutive series of 395 patients with pathologically verified hepatocellular carcinoma, 20 patients (5%) had bone metastasis at initial presentation. Of these, 16 were men and four women ranging from 26 to 64 years of age (median, 50 years). The age, sex, hepatitis B surface antigen seroposivity, alpha-fetoprotein level, and frequency of associated cirrhosis were not statistically different from those in patients without initial bone metastasis. Initial presentation was usually the result of spinal lesion with neurologic compression, and chest wall or scalp mass. Metastasis most commonly involved spine and ribs, and occurred as osteolytic lesions or extrapleural mass. Computed tomography proved best for demonstrating an expansile soft tissue mass with bony destruction. Angiography showed hypervascular appearance over the destructive bone area. Treatment results were poor. 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