Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1992408231', 'doi': 'https://doi.org/10.1083/jcb.200611152', 'title': 'Linker molecules between laminins and dystroglycan ameliorate laminin-α2–deficient muscular dystrophy at all disease stages', 'display_name': 'Linker molecules between laminins and dystroglycan ameliorate laminin-α2–deficient muscular dystrophy at all disease stages', 'publication_year': 2007, 'publication_date': '2007-03-26', 'ids': {'openalex': 'https://openalex.org/W1992408231', 'doi': 'https://doi.org/10.1083/jcb.200611152', 'mag': '1992408231', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17389231', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2064083'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200611152', 'pdf_url': 'http://jcb.rupress.org/content/176/7/979.full.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://jcb.rupress.org/content/176/7/979.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020736318', 'display_name': 'Sarina Meinen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Sarina Meinen', 'raw_affiliation_strings': ['Biozentrum, University of Basel, CH 4056 Basel, Switzerland;'], 'affiliations': [{'raw_affiliation_string': 'Biozentrum, University of Basel, CH 4056 Basel, Switzerland;', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014452514', 'display_name': 'Patrizia Barzaghi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Patrizia Barzaghi', 'raw_affiliation_strings': ['1Biozentrum, University of Basel, CH-4056 Basel, Switzerland,'], 'affiliations': [{'raw_affiliation_string': '1Biozentrum, University of Basel, CH-4056 Basel, Switzerland,', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101997641', 'display_name': 'Shuo Lin', 'orcid': 'https://orcid.org/0000-0003-2317-0339'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Shuo Lin', 'raw_affiliation_strings': ['1Biozentrum, University of Basel, CH-4056 Basel, Switzerland,'], 'affiliations': [{'raw_affiliation_string': '1Biozentrum, University of Basel, CH-4056 Basel, Switzerland,', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062908694', 'display_name': 'Hanns Lochmüller', 'orcid': 'https://orcid.org/0000-0003-2324-8001'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hanns Lochmüller', 'raw_affiliation_strings': ['2Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, 80336 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': '2Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, 80336 Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055873476', 'display_name': 'Markus A. Rüegg', 'orcid': 'https://orcid.org/0000-0002-4974-9384'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Markus A. Ruegg', 'raw_affiliation_strings': ['1Biozentrum, University of Basel, CH-4056 Basel, Switzerland,'], 'affiliations': [{'raw_affiliation_string': '1Biozentrum, University of Basel, CH-4056 Basel, Switzerland,', 'institution_ids': ['https://openalex.org/I1850255']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.49, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 68, 'citation_normalized_percentile': {'value': 0.929208, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '176', 'issue': '7', 'first_page': '979', 'last_page': '993'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10441', 'display_name': 'Molecular Mechanisms of Muscle Regeneration and Atrophy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10441', 'display_name': 'Molecular Mechanisms of Muscle Regeneration and Atrophy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.985, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13127', 'display_name': 'Proximity-Dependent Protein Labeling in Living Cells', 'score': 0.9826, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/agrin', 'display_name': 'Agrin', 'score': 0.97094953}, {'id': 'https://openalex.org/keywords/dystroglycan', 'display_name': 'Dystroglycan', 'score': 0.94908977}, {'id': 'https://openalex.org/keywords/congenital-muscular-dystrophy', 'display_name': 'Congenital muscular dystrophy', 'score': 0.72981757}, {'id': 'https://openalex.org/keywords/dystrophin', 'display_name': 'Dystrophin', 'score': 0.526205}, {'id': 'https://openalex.org/keywords/perlecan', 'display_name': 'Perlecan', 'score': 0.42929292}], 'concepts': [{'id': 'https://openalex.org/C2779024559', 'wikidata': 'https://www.wikidata.org/wiki/Q4694120', 'display_name': 'Agrin', 'level': 4, 'score': 0.97094953}, {'id': 'https://openalex.org/C2778384963', 'wikidata': 'https://www.wikidata.org/wiki/Q5319588', 'display_name': 'Dystroglycan', 'level': 4, 'score': 0.94908977}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.81555665}, {'id': 'https://openalex.org/C2779814568', 'wikidata': 'https://www.wikidata.org/wiki/Q58345', 'display_name': 'Laminin', 'level': 3, 'score': 0.8120898}, {'id': 'https://openalex.org/C2779768179', 'wikidata': 'https://www.wikidata.org/wiki/Q1321884', 'display_name': 'Congenital muscular dystrophy', 'level': 3, 'score': 0.72981757}, {'id': 'https://openalex.org/C2779030066', 'wikidata': 'https://www.wikidata.org/wiki/Q1137767', 'display_name': 'Muscular dystrophy', 'level': 2, 'score': 0.72944164}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.54348207}, {'id': 'https://openalex.org/C22731427', 'wikidata': 'https://www.wikidata.org/wiki/Q2071346', 'display_name': 'Perlecan', 'level': 4, 'score': 0.42929292}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36272448}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.34361228}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32917225}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.211795}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20348978}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20058537}, {'id': 'https://openalex.org/C80161118', 'wikidata': 'https://www.wikidata.org/wiki/Q408520', 'display_name': 'Acetylcholine receptor', 'level': 3, 'score': 0.16154411}, {'id': 'https://openalex.org/C2779335624', 'wikidata': 'https://www.wikidata.org/wiki/Q407976', 'display_name': 'Proteoglycan', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D049030', 'descriptor_name': 'Dystroglycans', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007797', 'descriptor_name': 'Laminin', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009137', 'descriptor_name': 'Muscular Dystrophy, Animal', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009137', 'descriptor_name': 'Muscular Dystrophy, Animal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018171', 'descriptor_name': 'Agrin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018171', 'descriptor_name': 'Agrin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018171', 'descriptor_name': 'Agrin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049030', 'descriptor_name': 'Dystroglycans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019812', 'descriptor_name': 'Heparan Sulfate Proteoglycans', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019812', 'descriptor_name': 'Heparan Sulfate Proteoglycans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007797', 'descriptor_name': 'Laminin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007797', 'descriptor_name': 'Laminin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009137', 'descriptor_name': 'Muscular Dystrophy, Animal', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009137', 'descriptor_name': 'Muscular Dystrophy, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200611152', 'pdf_url': 'http://jcb.rupress.org/content/176/7/979.full.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2064083', 'pdf_url': 'https://europepmc.org/articles/pmc2064083?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064083', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17389231', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200611152', 'pdf_url': 'http://jcb.rupress.org/content/176/7/979.full.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1542620420', 'https://openalex.org/W1600404162', 'https://openalex.org/W1826524642', 'https://openalex.org/W1966663918', 'https://openalex.org/W1981850472', 'https://openalex.org/W1984341575', 'https://openalex.org/W1985527057', 'https://openalex.org/W1994125861', 'https://openalex.org/W1994806065', 'https://openalex.org/W1998142660', 'https://openalex.org/W1999578623', 'https://openalex.org/W2000059256', 'https://openalex.org/W2007755400', 'https://openalex.org/W2014779210', 'https://openalex.org/W2019911049', 'https://openalex.org/W2020685420', 'https://openalex.org/W2029208162', 'https://openalex.org/W2030488929', 'https://openalex.org/W2033734515', 'https://openalex.org/W2034462747', 'https://openalex.org/W2035975703', 'https://openalex.org/W2042799534', 'https://openalex.org/W2042996461', 'https://openalex.org/W2045464700', 'https://openalex.org/W2045495957', 'https://openalex.org/W2047428077', 'https://openalex.org/W2051131650', 'https://openalex.org/W2052569682', 'https://openalex.org/W2056615616', 'https://openalex.org/W2066334706', 'https://openalex.org/W2074616175', 'https://openalex.org/W2081532398', 'https://openalex.org/W2083503468', 'https://openalex.org/W2083700023', 'https://openalex.org/W2084276666', 'https://openalex.org/W2084544719', 'https://openalex.org/W2089034628', 'https://openalex.org/W2089747862', 'https://openalex.org/W2090429649', 'https://openalex.org/W2090667030', 'https://openalex.org/W2093818337', 'https://openalex.org/W2094299695', 'https://openalex.org/W2094379449', 'https://openalex.org/W2096687538', 'https://openalex.org/W2106005187', 'https://openalex.org/W2107283445', 'https://openalex.org/W2109507582', 'https://openalex.org/W2113515804', 'https://openalex.org/W2115099338', 'https://openalex.org/W2135604282', 'https://openalex.org/W2137339420', 'https://openalex.org/W2139521871', 'https://openalex.org/W2152029916', 'https://openalex.org/W2154066388', 'https://openalex.org/W2155142318', 'https://openalex.org/W2159084493', 'https://openalex.org/W2171784390', 'https://openalex.org/W2328923752', 'https://openalex.org/W2417546005', 'https://openalex.org/W2426820625', 'https://openalex.org/W388360588', 'https://openalex.org/W4252035435'], 'related_works': ['https://openalex.org/W930372924', 'https://openalex.org/W4380730510', 'https://openalex.org/W4248153235', 'https://openalex.org/W3007075554', 'https://openalex.org/W2256212941', 'https://openalex.org/W2149811187', 'https://openalex.org/W2064982295', 'https://openalex.org/W1997489050', 'https://openalex.org/W1992408231', 'https://openalex.org/W1757941228'], 'abstract_inverted_index': {'Mutations': [0], 'in': [1, 28, 130], 'laminin-α2': [2, 18], 'cause': [3], 'a': [4, 37, 115, 166, 172], 'severe': [5], 'congenital': [6], 'muscular': [7, 191], 'dystrophy,': [8], 'called': [9], 'MDC1A.': [10], 'The': [11], 'two': [12], 'main': [13], 'receptors': [14], 'that': [15, 33, 92, 149], 'interact': [16], 'with': [17], 'are': [19, 146], 'dystroglycan': [20, 46, 155], 'and': [21, 70, 82, 101, 178], 'α7β1': [22, 50], 'integrin.': [23], 'We': [24], 'have': [25], 'previously': [26], 'shown': [27], 'mouse': [29], 'models': [30], 'for': [31, 183, 189], 'MDC1A': [32, 170], 'muscle-specific': [34], 'overexpression': [35], 'of': [36, 40, 95, 122, 136, 175, 186], 'miniaturized': [38], 'form': [39], 'agrin': [41, 138], '(mini-agrin),': [42], 'which': [43], 'binds': [44], 'to': [45, 49, 107, 154, 168], 'but': [47], 'not': [48, 106], 'integrin,': [51], 'substantially': [52], 'ameliorates': [53], 'the': [54, 108, 119, 125, 132, 142, 151, 176, 184], 'disease': [55], '(Moll,': [56], 'J.,': [57], 'P.': [58, 78], 'Barzaghi,': [59, 79], 'S.': [60, 80], 'Lin,': [61, 81], 'G.': [62], 'Bezakova,': [63], 'H.': [64], 'Lochmuller,': [65], 'E.': [66], 'Engvall,': [67], 'U.': [68], 'Muller,': [69], 'M.A.': [71, 83], 'Ruegg.': [72, 84], '2001.': [73], 'Nature.': [74], '413:302–307;': [75], 'Bentzinger,': [76], 'C.F.,': [77], '2005.': [85], 'Matrix': [86], 'Biol.': [87], '24:326–332.).': [88], 'Now': [89], 'we': [90], 'show': [91], 'late-onset': [93], 'expression': [94, 135], 'mini-agrin': [96, 129], 'still': [97], 'prolongs': [98], 'life': [99], 'span': [100], 'improves': [102], 'overall': [103], 'health,': [104], 'although': [105], 'same': [109, 126], 'extent': [110], 'as': [111, 128], 'early': [112], 'expression.': [113], 'Furthermore,': [114], 'chimeric': [116], 'protein': [117], 'containing': [118], 'dystroglycan-binding': [120], 'domain': [121], 'perlecan': [123], 'has': [124], 'activities': [127], 'ameliorating': [131], 'disease.': [133, 143], 'Finally,': [134], 'full-length': [137], 'also': [139], 'slows': [140], 'down': [141], 'These': [144], 'experiments': [145], 'conceptual': [147], 'proof': [148], 'linking': [150], 'basement': [152], 'membrane': [153], 'by': [156, 161], 'specifically': [157], 'designed': [158], 'molecules': [159], 'or': [160], 'endogenous': [162], 'ligands,': [163], 'could': [164], 'be': [165], 'means': [167], 'counteract': [169], 'at': [171], 'progressed': [173], 'stage': [174], 'disease,': [177], 'thus': [179], 'opens': [180], 'new': [181], 'possibilities': [182], 'development': [185], 'treatment': [187], 'options': [188], 'this': [190], 'dystrophy.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1992408231', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-13T15:54:37.865284', 'created_date': '2016-06-24'}