Publication Information

{'id': 'https://openalex.org/W1992299744', 'doi': 'https://doi.org/10.2174/157488707779318053', 'title': 'Is Exenatide Improving the Treatment of Type 2 Diabetes? Analysis of the Individual Clinical Trials with Exenatide', 'display_name': 'Is Exenatide Improving the Treatment of Type 2 Diabetes? Analysis of the Individual Clinical Trials with Exenatide', 'publication_year': 2007, 'publication_date': '2007-01-01', 'ids': {'openalex': 'https://openalex.org/W1992299744', 'doi': 'https://doi.org/10.2174/157488707779318053', 'mag': '1992299744', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18473991'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/157488707779318053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S164609936', 'display_name': 'Reviews on Recent Clinical Trials', 'issn_l': '1574-8871', 'issn': ['1574-8871', '1876-1038'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071085963', 'display_name': 'Sheila A Doggrell', 'orcid': 'https://orcid.org/0000-0002-0942-0795'}, 'institutions': [{'id': 'https://openalex.org/I29894533', 'display_name': 'Charles Darwin University', 'ror': 'https://ror.org/048zcaj52', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I29894533']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Sheila Doggrell', 'raw_affiliation_strings': ['School of Science, Faculty of Education, Health and Science, Charles Darwin University, Darwin, Northern Territory 0909, Australia.'], 'affiliations': [{'raw_affiliation_string': 'School of Science, Faculty of Education, Health and Science, Charles Darwin University, Darwin, Northern Territory 0909, Australia.', 'institution_ids': ['https://openalex.org/I29894533']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5071085963'], 'corresponding_institution_ids': ['https://openalex.org/I29894533'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.201, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.629518, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 78}, 'biblio': {'volume': '2', 'issue': '1', 'first_page': '77', 'last_page': '84'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10401', 'display_name': 'Diabetes Treatment and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10401', 'display_name': 'Diabetes Treatment and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10560', 'display_name': 'Diabetes Management and Research', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sulfonylurea', 'display_name': 'Sulfonylurea', 'score': 0.8026283}], 'concepts': [{'id': 'https://openalex.org/C2780533449', 'wikidata': 'https://www.wikidata.org/wiki/Q417762', 'display_name': 'Exenatide', 'level': 4, 'score': 0.981398}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.89140344}, {'id': 'https://openalex.org/C2777180221', 'wikidata': 'https://www.wikidata.org/wiki/Q3025883', 'display_name': 'Type 2 diabetes', 'level': 3, 'score': 0.82095873}, {'id': 'https://openalex.org/C2778854520', 'wikidata': 'https://www.wikidata.org/wiki/Q418776', 'display_name': 'Sulfonylurea', 'level': 3, 'score': 0.8026283}, {'id': 'https://openalex.org/C2780323712', 'wikidata': 'https://www.wikidata.org/wiki/Q19484', 'display_name': 'Metformin', 'level': 3, 'score': 0.7923635}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.7073376}, {'id': 'https://openalex.org/C2778199505', 'wikidata': 'https://www.wikidata.org/wiki/Q2992990', 'display_name': 'Postprandial', 'level': 3, 'score': 0.67037314}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.65887827}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.61492527}, {'id': 'https://openalex.org/C2779920387', 'wikidata': 'https://www.wikidata.org/wiki/Q417317', 'display_name': 'Insulin glargine', 'level': 4, 'score': 0.5947126}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.5488088}, {'id': 'https://openalex.org/C2780668416', 'wikidata': 'https://www.wikidata.org/wiki/Q202758', 'display_name': 'Hypoglycemia', 'level': 3, 'score': 0.4891296}, {'id': 'https://openalex.org/C2780473172', 'wikidata': 'https://www.wikidata.org/wiki/Q5572518', 'display_name': 'Glycemic', 'level': 3, 'score': 0.484649}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3383072}], 'mesh': [{'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D014688', 'descriptor_name': 'Venoms', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003692', 'descriptor_name': 'Delayed-Action Preparations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077270', 'descriptor_name': 'Exenatide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069036', 'descriptor_name': 'Insulin Glargine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049528', 'descriptor_name': 'Insulin, Long-Acting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008687', 'descriptor_name': 'Metformin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D008687', 'descriptor_name': 'Metformin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013453', 'descriptor_name': 'Sulfonylurea Compounds', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013453', 'descriptor_name': 'Sulfonylurea Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014688', 'descriptor_name': 'Venoms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/157488707779318053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S164609936', 'display_name': 'Reviews on Recent Clinical Trials', 'issn_l': '1574-8871', 'issn': ['1574-8871', '1876-1038'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18473991', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.82}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1909310469', 'https://openalex.org/W1969759659', 'https://openalex.org/W1969932276', 'https://openalex.org/W1972204120', 'https://openalex.org/W1976367840', 'https://openalex.org/W1980130009', 'https://openalex.org/W1984740259', 'https://openalex.org/W1984755045', 'https://openalex.org/W1986085856', 'https://openalex.org/W1992412433', 'https://openalex.org/W1992966015', 'https://openalex.org/W2003444892', 'https://openalex.org/W2005334239', 'https://openalex.org/W2017201029', 'https://openalex.org/W2025162869', 'https://openalex.org/W2028272916', 'https://openalex.org/W2042845313', 'https://openalex.org/W2054564814', 'https://openalex.org/W2055987651', 'https://openalex.org/W2057926043', 'https://openalex.org/W2060949491', 'https://openalex.org/W2061862376', 'https://openalex.org/W2062109893', 'https://openalex.org/W2065867087', 'https://openalex.org/W2067636490', 'https://openalex.org/W2068183831', 'https://openalex.org/W2069150029', 'https://openalex.org/W2073996229', 'https://openalex.org/W2080045468', 'https://openalex.org/W2081392051', 'https://openalex.org/W2087063469', 'https://openalex.org/W2087707716', 'https://openalex.org/W2092561092', 'https://openalex.org/W2093738306', 'https://openalex.org/W2101613382', 'https://openalex.org/W2101718966', 'https://openalex.org/W2103266155', 'https://openalex.org/W2109069837', 'https://openalex.org/W2121894019', 'https://openalex.org/W2122979966', 'https://openalex.org/W2127409471', 'https://openalex.org/W2134376988', 'https://openalex.org/W2136254957', 'https://openalex.org/W2143014102', 'https://openalex.org/W2146400000', 'https://openalex.org/W2154407827', 'https://openalex.org/W2162934281', 'https://openalex.org/W4234825176'], 'related_works': ['https://openalex.org/W4388732827', 'https://openalex.org/W4293579534', 'https://openalex.org/W3117830969', 'https://openalex.org/W3111487352', 'https://openalex.org/W2965764969', 'https://openalex.org/W2792502347', 'https://openalex.org/W2431567440', 'https://openalex.org/W2320948677', 'https://openalex.org/W1986085856', 'https://openalex.org/W1831980957'], 'abstract_inverted_index': {'The': [0], 'obesity': [1], 'epidemic': [2, 14], 'in': [3, 56, 108, 147, 164, 206], 'the': [4, 36, 62, 69, 127, 154, 216, 229], 'developed': [5], 'and': [6, 35, 91, 141, 143, 153, 174, 177, 191, 225], 'developing': [7], 'world': [8], 'is': [9, 48, 54, 73, 99, 103, 116], 'being': [10], 'followed': [11], 'by': [12], 'an': [13, 49, 124], 'of': [15, 68, 71, 139], 'type': [16, 20, 81, 112, 150, 209, 234], '2': [17, 21, 82, 113, 151, 210, 235], 'diabetes.': [18, 114, 236], 'In': [19, 78, 219], 'diabetes,': [22, 83, 152], 'subjects': [23, 79, 110, 148, 165, 207], 'cannot': [24], 'manage': [25], 'glucose': [26, 65, 94, 140, 145], 'properly': [27], 'because': [28], 'they': [29], 'do': [30], 'not': [31, 104, 212], 'produce': [32], 'enough': [33], 'insulin,': [34, 142], 'peripheral': [37], 'tissues': [38], 'have': [39], 'become': [40], 'resistant': [41], 'to': [42, 58, 60, 74, 179, 194, 228, 232], 'insulin.': [43], 'Glucagon-like': [44], 'peptide': [45, 51, 120], '1': [46], '(GLP-1)': [47], 'intestinal': [50], 'hormone': [52], 'that': [53, 121], 'secreted': [55], 'response': [57], 'food': [59], 'regulate': [61], 'postprandial': [63, 137], 'blood': [64, 93], 'concentration.': [66], 'One': [67], 'actions': [70], 'GLP-1': [72, 87, 98, 128], 'stimulate': [75], 'insulin': [76, 89, 204], 'secretion.': [77], 'with': [80, 111, 149, 183, 208, 215], 'intravenous': [84], 'or': [85, 172], 'subcutaneous': [86, 131], 'stimulated': [88], 'production': [90], 'decreased': [92, 136], 'levels.': [95], 'However,': [96], 'as': [97, 123, 201, 203], 'rapidly': [100], 'metabolised,': [101], 'it': [102], 'suitable': [105], 'for': [106], 'use': [107], 'most': [109], 'Exendin-4': [115], 'a': [117, 169, 175, 223], '39-amino': [118], 'acid': [119], 'acts': [122], 'agonist': [125], 'at': [126], 'receptor.': [129], 'After': [130], 'administration,': [132], 'synthetic': [133], 'exendin-4': [134], '(exenatide)': [135], 'concentrations': [138], 'fasting': [144], 'levels': [146], 'effects': [155], 'lasted': [156], 'several': [157], 'hours.': [158], 'Subsequently,': [159], 'exenatide': [160, 221], 'was': [161], 'been': [162], 'trialled': [163], 'taking': [166], 'metformin': [167, 173], 'only,': [168, 171], 'sulfonylurea': [170], 'sulfonylurea,': [176], 'shown': [178], 'improve': [180], 'glycemic': [181], 'control': [182], 'few': [184], 'adverse': [185], 'events,': [186], 'initially': [187], 'over': [188], '30': [189], 'weeks,': [190], 'then': [192], 'extended': [193], '82': [195], 'weeks.': [196], 'Exenatide': [197], 'may': [198], 'also': [199], 'be': [200], 'effective': [202], 'glargine': [205], 'diabetes': [211], 'adequately': [213], 'controlled': [214], 'oral': [217], 'agents.': [218], 'conclusion,': [220], 'represents': [222], 'new': [224], 'beneficial': [226], 'addition': [227], 'medicines': [230], 'used': [231], 'treat': [233]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1992299744', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-14T03:38:36.957675', 'created_date': '2016-06-24'}