Publication Information

{'id': 'https://openalex.org/W1992233046', 'doi': 'https://doi.org/10.1073/pnas.95.20.11834', 'title': 'Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation', 'display_name': 'Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation', 'publication_year': 1998, 'publication_date': '1998-09-29', 'ids': {'openalex': 'https://openalex.org/W1992233046', 'doi': 'https://doi.org/10.1073/pnas.95.20.11834', 'mag': '1992233046', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9751751', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/21726'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.95.20.11834', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.95.20.11834', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082260916', 'display_name': 'Fanping Wang', 'orcid': 'https://orcid.org/0000-0001-6927-3654'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fanping Wang', 'raw_affiliation_strings': ['Center for Immunology, Departments of Pathology and Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110'], 'affiliations': [{'raw_affiliation_string': 'Center for Immunology, Departments of Pathology and Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030253907', 'display_name': 'Ching‐Yu Huang', 'orcid': 'https://orcid.org/0000-0002-5758-281X'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ching-Yu Huang', 'raw_affiliation_strings': ['Center for Immunology, Departments of Pathology and Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110'], 'affiliations': [{'raw_affiliation_string': 'Center for Immunology, Departments of Pathology and Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004360797', 'display_name': 'Osami Kanagawa', 'orcid': 'https://orcid.org/0000-0001-6028-7742'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Osami Kanagawa', 'raw_affiliation_strings': ['Center for Immunology, Departments of Pathology and Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110'], 'affiliations': [{'raw_affiliation_string': 'Center for Immunology, Departments of Pathology and Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110', 'institution_ids': ['https://openalex.org/I204465549']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.878, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 104, 'citation_normalized_percentile': {'value': 0.86468, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '95', 'issue': '20', 'first_page': '11834', 'last_page': '11839'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gene-rearrangement', 'display_name': 'Gene rearrangement', 'score': 0.7656604}, {'id': 'https://openalex.org/keywords/double-negative', 'display_name': 'Double negative', 'score': 0.69323045}, {'id': 'https://openalex.org/keywords/thymocyte', 'display_name': 'Thymocyte', 'score': 0.6199965}, {'id': 'https://openalex.org/keywords/negative-selection', 'display_name': 'Negative selection', 'score': 0.50862825}], 'concepts': [{'id': 'https://openalex.org/C19317047', 'wikidata': 'https://www.wikidata.org/wiki/Q412037', 'display_name': 'T-cell receptor', 'level': 4, 'score': 0.92438567}, {'id': 'https://openalex.org/C2992511266', 'wikidata': 'https://www.wikidata.org/wiki/Q1093098', 'display_name': 'Gene rearrangement', 'level': 3, 'score': 0.7656604}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.698653}, {'id': 'https://openalex.org/C91394840', 'wikidata': 'https://www.wikidata.org/wiki/Q48964', 'display_name': 'Double negative', 'level': 4, 'score': 0.69323045}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.6429191}, {'id': 'https://openalex.org/C2778954852', 'wikidata': 'https://www.wikidata.org/wiki/Q7799635', 'display_name': 'Thymocyte', 'level': 4, 'score': 0.6199965}, {'id': 'https://openalex.org/C114684123', 'wikidata': 'https://www.wikidata.org/wiki/Q419458', 'display_name': 'CD3', 'level': 4, 'score': 0.5862538}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5132837}, {'id': 'https://openalex.org/C7386963', 'wikidata': 'https://www.wikidata.org/wiki/Q3954859', 'display_name': 'Negative selection', 'level': 4, 'score': 0.50862825}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.4794049}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.43795097}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.28978628}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.28908432}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.07879168}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015332', 'descriptor_name': 'Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.95.20.11834', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc21726', 'pdf_url': 'https://europepmc.org/articles/pmc21726?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21726', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9751751', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.95.20.11834', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1562198317', 'https://openalex.org/W1832245834', 'https://openalex.org/W1972331668', 'https://openalex.org/W1989875191', 'https://openalex.org/W2000199728', 'https://openalex.org/W2000894919', 'https://openalex.org/W2023200899', 'https://openalex.org/W2023647117', 'https://openalex.org/W2024538588', 'https://openalex.org/W2027527107', 'https://openalex.org/W2035223596', 'https://openalex.org/W2045008512', 'https://openalex.org/W2054878761', 'https://openalex.org/W2056708779', 'https://openalex.org/W2064072571', 'https://openalex.org/W2082919075', 'https://openalex.org/W2085464647', 'https://openalex.org/W2085597255', 'https://openalex.org/W2093578282', 'https://openalex.org/W2103788710', 'https://openalex.org/W2113334969', 'https://openalex.org/W2155350253', 'https://openalex.org/W2321420859', 'https://openalex.org/W258316223', 'https://openalex.org/W4242240529'], 'related_works': ['https://openalex.org/W72712021', 'https://openalex.org/W4313383228', 'https://openalex.org/W2166899299', 'https://openalex.org/W2100497713', 'https://openalex.org/W2072807977', 'https://openalex.org/W2067087802', 'https://openalex.org/W2027284694', 'https://openalex.org/W1992233046', 'https://openalex.org/W1971801318', 'https://openalex.org/W1668774261'], 'abstract_inverted_index': {'A': [0], 'rearranged': [1], 'T': [2, 15, 101, 129, 188], 'cell': [3, 16, 102, 189], 'receptor': [4], '(TCR)': [5], 'Vα': [6], 'and': [7, 39, 53, 89], 'Jα': [8, 23], 'gene': [9, 30, 178], 'from': [10, 95, 112], 'a': [11, 34, 47, 66, 144], 'cytochrome': [12, 98], 'c-': [13, 99], 'specific': [14, 100], 'hybridoma': [17, 103], 'was': [18], 'introduced': [19, 26, 76, 85, 117, 133], 'into': [20], 'the': [21, 51, 75, 81, 84, 90, 96, 113, 116, 123, 132, 140, 174, 184, 187], 'genomic': [22], 'region.': [24], 'The': [25], 'TCR': [27, 58, 69, 77, 86, 92, 118, 134, 156, 175], 'α': [28, 59, 70, 87, 119, 157, 176], 'chain': [29, 71, 88, 94, 120, 158, 177], 'is': [31, 63], 'expressed': [32], 'in': [33, 183], 'majority': [35], 'of': [36, 50, 68, 80, 115, 147, 173, 186], 'CD3': [37], 'positive': [38, 106], 'CD4': [40], 'CD8': [41], 'double-negative': [42], 'immature': [43], 'thymocytes.': [44], 'However,': [45, 143], 'only': [46], 'few': [48], 'percent': [49], 'double-positive': [52, 110, 141], 'single-positive': [54], 'thymocytes': [55, 111, 148], 'express': [56], 'this': [57], 'chain.': [60], 'This': [61], 'decrease': [62], 'caused': [64], 'by': [65, 152, 160], 'rearrangement': [67, 162], 'locus,': [72], 'which': [73], 'deletes': [74], 'gene.': [78, 121], 'Analysis': [79], 'mice': [82, 124], 'carrying': [83], 'transgenic': [91], 'β': [93], 'original': [97], 'revealed': [104], 'that': [105, 170], 'selection': [107, 151], 'efficiently': [108], 'rescues': [109], 'loss': [114], 'In': [122], 'with': [125], 'negatively': [126], 'selecting': [127], 'conditions,': [128], 'cells': [130], 'expressing': [131], 'αβ': [135], 'chains': [136], 'were': [137], 'deleted': [138], 'at': [139], 'stage.': [142], 'large': [145], 'number': [146], 'escape': [149], 'negative': [150], 'using': [153], 'an': [154, 180], 'endogenous': [155], 'created': [159], 'secondary': [161, 171], 'maintaining': [163], 'normal': [164], 'thymocyte': [165], 'development.': [166], 'These': [167], 'results': [168], 'suggest': [169], 'rearrangements': [172], 'play': [179], 'important': [181], 'role': [182], 'formation': [185], 'repertoire.': [190]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1992233046', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-10T00:28:29.794985', 'created_date': '2016-06-24'}