Title: Anaplastic carcinoma of the thyroid with osteoclast-like giant cells
Abstract: An unusual malignant thyroid neoplasm with a morphologic resemblance to giant cell tumor of the bone is reported in a patient who presented with a rapidly growing thyroid mass and a history of pre-existing goiter. The light and electron microscopic studies disclosed areas of differentiated follicular carcinoma with gradual transition to undifferentiated carcinoma. Pleomorphic spindle-shaped cells and giant cells were accompanied by numerous osteoclast-like multinucleated giant cells. Desmosomes and interdigitating cell surfaces were apparent in the differentiated as well as undifferentiated areas on electron microscopy. These findings support an epithelial rather than a mesenchymal origin for this neoplasm. Cancer 52:2122-2128, 1983.
Publication Year: 1983
Publication Date: 1983-12-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 44
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