Title: Enantioselective Strecker Reaction Promoted by Chiral N-Oxides
Abstract: The asymmetric Strecker reaction of aldimines and trimethylsilyl cyanide promoted by 1 equivalent of chiral N-oxide affords the corresponding α-amino nitriles with enantioselectivities of up to 73% most effectively for electron-deficient aldimines under mild reaction conditions. Two new resolving methods and one new synthetic methodology were developed to obtain three novel chiral N-oxides.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 82
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