Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1991880332', 'doi': 'https://doi.org/10.1111/j.1471-4159.2009.06558.x', 'title': 'An update on clinical proteomics in Alzheimer’s research', 'display_name': 'An update on clinical proteomics in Alzheimer’s research', 'publication_year': 2009, 'publication_date': '2009-12-24', 'ids': {'openalex': 'https://openalex.org/W1991880332', 'doi': 'https://doi.org/10.1111/j.1471-4159.2009.06558.x', 'mag': '1991880332', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20050976'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.2009.06558.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.06558.x', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.06558.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024592413', 'display_name': 'Minna A. Korolainen', 'orcid': 'https://orcid.org/0000-0002-8593-5918'}, 'institutions': [{'id': 'https://openalex.org/I175532246', 'display_name': 'University of Eastern Finland', 'ror': 'https://ror.org/00cyydd11', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I175532246']}, {'id': 'https://openalex.org/I4210092991', 'display_name': 'Kuopio University Hospital', 'ror': 'https://ror.org/00fqdfs68', 'country_code': 'FI', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092991']}, {'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Minna A. Korolainen', 'raw_affiliation_strings': ['Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Kuopio, Finland', 'Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland', 'Protein Chemistry Research Group, Institute of Biotechnology, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Kuopio, Finland', 'institution_ids': ['https://openalex.org/I175532246']}, {'raw_affiliation_string': 'Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland', 'institution_ids': ['https://openalex.org/I4210092991']}, {'raw_affiliation_string': 'Protein Chemistry Research Group, Institute of Biotechnology, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071351094', 'display_name': 'Tuula A. Nyman', 'orcid': 'https://orcid.org/0000-0001-8787-5886'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Tuula A. Nyman', 'raw_affiliation_strings': ['Protein Chemistry Research Group, Institute of Biotechnology, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Protein Chemistry Research Group, Institute of Biotechnology, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016681267', 'display_name': 'Tero Aittokallio', 'orcid': 'https://orcid.org/0000-0002-0886-9769'}, 'institutions': [{'id': 'https://openalex.org/I155660961', 'display_name': 'University of Turku', 'ror': 'https://ror.org/05vghhr25', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I155660961']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Tero Aittokallio', 'raw_affiliation_strings': ['Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland'], 'affiliations': [{'raw_affiliation_string': 'Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland', 'institution_ids': ['https://openalex.org/I155660961']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076156274', 'display_name': 'Tuula Pirttilä', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092991', 'display_name': 'Kuopio University Hospital', 'ror': 'https://ror.org/00fqdfs68', 'country_code': 'FI', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092991']}, {'id': 'https://openalex.org/I175532246', 'display_name': 'University of Eastern Finland', 'ror': 'https://ror.org/00cyydd11', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I175532246']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Tuula Pirttilä', 'raw_affiliation_strings': ['Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Kuopio, Finland', 'Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland', 'institution_ids': ['https://openalex.org/I4210092991']}, {'raw_affiliation_string': 'Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Kuopio, Finland', 'institution_ids': ['https://openalex.org/I175532246']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.222, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 88, 'citation_normalized_percentile': {'value': 0.694559, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '112', 'issue': '6', 'first_page': '1386', 'last_page': '1414'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10519', 'display_name': 'Advanced Proteomics Techniques and Applications', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C46111723', 'wikidata': 'https://www.wikidata.org/wiki/Q471857', 'display_name': 'Proteomics', 'level': 3, 'score': 0.7052671}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.51365155}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.50562334}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.43138394}, {'id': 'https://openalex.org/C2522767166', 'wikidata': 'https://www.wikidata.org/wiki/Q2374463', 'display_name': 'Data science', 'level': 1, 'score': 0.33465147}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.32881224}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3279579}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3190375}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.19186077}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.18926898}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08358252}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D035843', 'descriptor_name': 'Biomedical Research', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009483', 'descriptor_name': 'Neuropsychological Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.2009.06558.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.06558.x', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20050976', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.2009.06558.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.06558.x', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.52, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 212, 'referenced_works': ['https://openalex.org/W111028273', 'https://openalex.org/W116844149', 'https://openalex.org/W134184183', 'https://openalex.org/W1432624184', 'https://openalex.org/W146961858', 'https://openalex.org/W1540104393', 'https://openalex.org/W1554358454', 'https://openalex.org/W1567351918', 'https://openalex.org/W1575834956', 'https://openalex.org/W15770206', 'https://openalex.org/W1577837690', 'https://openalex.org/W1602112568', 'https://openalex.org/W1607863238', 'https://openalex.org/W1611407165', 'https://openalex.org/W1648996057', 'https://openalex.org/W177319969', 'https://openalex.org/W1841942689', 'https://openalex.org/W1893971962', 'https://openalex.org/W1916371153', 'https://openalex.org/W1934766033', 'https://openalex.org/W1960958837', 'https://openalex.org/W1963762598', 'https://openalex.org/W1966806720', 'https://openalex.org/W1969563784', 'https://openalex.org/W1970016175', 'https://openalex.org/W1970088462', 'https://openalex.org/W1970130998', 'https://openalex.org/W1970673364', 'https://openalex.org/W1973945485', 'https://openalex.org/W1974005435', 'https://openalex.org/W1976449735', 'https://openalex.org/W1978287335', 'https://openalex.org/W1978316664', 'https://openalex.org/W1980842500', 'https://openalex.org/W1981196417', 'https://openalex.org/W1981322456', 'https://openalex.org/W1981484621', 'https://openalex.org/W1981870052', 'https://openalex.org/W1982223943', 'https://openalex.org/W1984841197', 'https://openalex.org/W1988634498', 'https://openalex.org/W1990752558', 'https://openalex.org/W1991278991', 'https://openalex.org/W1993198499', 'https://openalex.org/W1993429790', 'https://openalex.org/W1993993136', 'https://openalex.org/W1995859195', 'https://openalex.org/W1996980605', 'https://openalex.org/W1997990361', 'https://openalex.org/W1998920224', 'https://openalex.org/W1999055613', 'https://openalex.org/W1999639760', 'https://openalex.org/W2000075190', 'https://openalex.org/W2001179326', 'https://openalex.org/W2001628753', 'https://openalex.org/W2002156115', 'https://openalex.org/W2002974363', 'https://openalex.org/W2005168372', 'https://openalex.org/W2006698270', 'https://openalex.org/W2007377859', 'https://openalex.org/W2007659050', 'https://openalex.org/W2008337653', 'https://openalex.org/W2010089695', 'https://openalex.org/W2010227723', 'https://openalex.org/W2010359252', 'https://openalex.org/W2012144638', 'https://openalex.org/W2013454338', 'https://openalex.org/W2013869842', 'https://openalex.org/W2014829395', 'https://openalex.org/W2014886338', 'https://openalex.org/W2016429383', 'https://openalex.org/W2017064090', 'https://openalex.org/W2017260345', 'https://openalex.org/W2017966763', 'https://openalex.org/W2018590113', 'https://openalex.org/W2021731232', 'https://openalex.org/W2025199580', 'https://openalex.org/W2025935592', 'https://openalex.org/W2026892832', 'https://openalex.org/W2027240228', 'https://openalex.org/W2027708488', 'https://openalex.org/W2029115752', 'https://openalex.org/W2029695041', 'https://openalex.org/W2029874231', 'https://openalex.org/W2031155126', 'https://openalex.org/W2032456599', 'https://openalex.org/W2033172620', 'https://openalex.org/W2035484178', 'https://openalex.org/W2036346181', 'https://openalex.org/W2036755018', 'https://openalex.org/W2037708171', 'https://openalex.org/W2040404554', 'https://openalex.org/W2041032262', 'https://openalex.org/W2042085383', 'https://openalex.org/W2047219385', 'https://openalex.org/W2047406096', 'https://openalex.org/W2048532208', 'https://openalex.org/W2050098268', 'https://openalex.org/W2051212454', 'https://openalex.org/W2051561353', 'https://openalex.org/W2051629738', 'https://openalex.org/W2051952557', 'https://openalex.org/W2052209709', 'https://openalex.org/W2052742260', 'https://openalex.org/W2053880389', 'https://openalex.org/W2054635779', 'https://openalex.org/W2057613965', 'https://openalex.org/W2058427936', 'https://openalex.org/W2058622897', 'https://openalex.org/W2058760936', 'https://openalex.org/W2059179399', 'https://openalex.org/W2059356822', 'https://openalex.org/W2059948137', 'https://openalex.org/W2060458492', 'https://openalex.org/W2061866146', 'https://openalex.org/W2064926380', 'https://openalex.org/W2066783517', 'https://openalex.org/W2067195259', 'https://openalex.org/W2068003070', 'https://openalex.org/W2068670679', 'https://openalex.org/W2068986375', 'https://openalex.org/W2071331290', 'https://openalex.org/W2072325753', 'https://openalex.org/W2073171863', 'https://openalex.org/W2073644281', 'https://openalex.org/W2074357438', 'https://openalex.org/W2074987858', 'https://openalex.org/W2075539642', 'https://openalex.org/W207593394', 'https://openalex.org/W2076398846', 'https://openalex.org/W2076534507', 'https://openalex.org/W2076541036', 'https://openalex.org/W2076740879', 'https://openalex.org/W2077164692', 'https://openalex.org/W2079370736', 'https://openalex.org/W2079540265', 'https://openalex.org/W2081831345', 'https://openalex.org/W2086055500', 'https://openalex.org/W2088403248', 'https://openalex.org/W2090496922', 'https://openalex.org/W2091071531', 'https://openalex.org/W2092800022', 'https://openalex.org/W2094094604', 'https://openalex.org/W2095153662', 'https://openalex.org/W2096410114', 'https://openalex.org/W2097030000', 'https://openalex.org/W2098245087', 'https://openalex.org/W2104488717', 'https://openalex.org/W2106814023', 'https://openalex.org/W2106931873', 'https://openalex.org/W2108475007', 'https://openalex.org/W2109734413', 'https://openalex.org/W2110054485', 'https://openalex.org/W2110601338', 'https://openalex.org/W2111208057', 'https://openalex.org/W2112896415', 'https://openalex.org/W2113153354', 'https://openalex.org/W2114133572', 'https://openalex.org/W2114228709', 'https://openalex.org/W2115273281', 'https://openalex.org/W2116876598', 'https://openalex.org/W2117098825', 'https://openalex.org/W2117625001', 'https://openalex.org/W2119109232', 'https://openalex.org/W2120016245', 'https://openalex.org/W2122826545', 'https://openalex.org/W2124263476', 'https://openalex.org/W2124681501', 'https://openalex.org/W2125263404', 'https://openalex.org/W2128510822', 'https://openalex.org/W2129150800', 'https://openalex.org/W2129224791', 'https://openalex.org/W2129661754', 'https://openalex.org/W2130144581', 'https://openalex.org/W2133945740', 'https://openalex.org/W2134755663', 'https://openalex.org/W2135266183', 'https://openalex.org/W2135374635', 'https://openalex.org/W2136740555', 'https://openalex.org/W2137610621', 'https://openalex.org/W2140946052', 'https://openalex.org/W2142032598', 'https://openalex.org/W2142186280', 'https://openalex.org/W2142998017', 'https://openalex.org/W2143671488', 'https://openalex.org/W2151599925', 'https://openalex.org/W2152058429', 'https://openalex.org/W2152242321', 'https://openalex.org/W2152897383', 'https://openalex.org/W2154232996', 'https://openalex.org/W2154311275', 'https://openalex.org/W2155483859', 'https://openalex.org/W2156220037', 'https://openalex.org/W2159675211', 'https://openalex.org/W2160110467', 'https://openalex.org/W2160361654', 'https://openalex.org/W2164082141', 'https://openalex.org/W2166998713', 'https://openalex.org/W2167886264', 'https://openalex.org/W2169393803', 'https://openalex.org/W2169501888', 'https://openalex.org/W2195134092', 'https://openalex.org/W2271693863', 'https://openalex.org/W2318768467', 'https://openalex.org/W2326276166', 'https://openalex.org/W2403797109', 'https://openalex.org/W2431153927', 'https://openalex.org/W3105158995', 'https://openalex.org/W3141305851', 'https://openalex.org/W4231800698', 'https://openalex.org/W4290198551', 'https://openalex.org/W80208836'], 'related_works': ['https://openalex.org/W415785311', 'https://openalex.org/W3145527116', 'https://openalex.org/W3143512440', 'https://openalex.org/W3005464483', 'https://openalex.org/W2389042962', 'https://openalex.org/W2373271064', 'https://openalex.org/W2360290178', 'https://openalex.org/W2350543355', 'https://openalex.org/W2088324202', 'https://openalex.org/W1488408180'], 'abstract_inverted_index': {'J.': [0], 'Neurochem.': [1], '(2010)': [2], '112': [3], ',': [4], '1386–1414.': [5], 'Abstract': [6], 'Alzheimer’s': [7], 'disease': [8, 73], '(AD)': [9], 'is': [10, 48, 114], 'a': [11, 98], 'pathologically': [12], 'complex': [13], 'and': [14, 47, 53, 109, 125, 152, 154], 'aetiologically': [15], 'multifactorial': [16], 'dementing': [17], 'disorder': [18], 'affecting': [19], 'millions': [20], 'of': [21, 37, 42, 59, 71, 80, 95, 100, 106, 127, 130, 140], 'people': [22], 'worldwide.': [23], 'The': [24, 40], 'pathological': [25, 81], 'brain': [26, 82], 'changes': [27], 'are': [28, 64], 'assumed': [29], 'to': [30, 34, 66, 76, 120, 157], 'occur': [31], 'decades': [32], 'prior': [33], 'the': [35, 57, 68, 72, 78, 93, 104, 122, 128, 137], 'onset': [36, 58], 'clinical': [38, 52], 'symptoms.': [39, 60], 'diagnosis': [41], 'early': [43], 'AD': [44, 87, 149], 'remains': [45], 'problematic': [46], 'mainly': [49], 'based': [50], 'on': [51, 145], 'neuropsychological': [54], 'findings': [55], 'after': [56], 'Currently': [61], 'available': [62], 'drugs': [63], 'able': [65], 'delay': [67], 'symptom': [69], 'progression': [70, 79, 129], 'but': [74], 'not': [75], 'attenuate': [77], 'changes.': [83], 'Many': [84], 'studies': [85], 'exploring': [86], 'proteomes': [88], 'have': [89], 'been': [90], 'conducted': [91], 'as': [92, 97], 'middle': [94], '1990s': [96], 'consequence': [99], 'recent': [101], 'advances': [102], 'in': [103, 148], 'development': [105], 'both': [107], 'gel‐based': [108], 'gel‐free': [110], 'proteomics': [111, 117], 'approaches.': [112], 'It': [113], 'hoped': [115], 'that': [116], 'can': [118], 'contribute': [119], 'improving': [121], 'understanding,': [123], 'diagnosis,': [124], 'follow‐up': [126], 'AD.': [131], 'In': [132], 'this': [133], 'review,': [134], 'we': [135], 'summarise': [136], 'present': [138], 'status': [139], 'proteome': [141], 'alterations,': [142], 'with': [143], 'emphasis': [144], 'quantitative': [146], 'approaches,': [147], 'brain,': [150], 'CSF': [151], 'blood,': [153], 'their': [155], 'relevance': [156], 'dementia': [158], 'research.': [159]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1991880332', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2025-01-06T10:07:16.452422', 'created_date': '2016-06-24'}