Title: The development of carbachol-induced EEG ‘θ’ examined in hippocampal formation slices
Abstract: The development of carbochol-induced EEG theta (θ) activity was studied in the CA1 and dentate regions of hippocampal formation slices obtained from neonatal rats (4, 6, 8, 10, 12 and 14 days of age). When perfused with carbachol (50 μM), 4-and 6-day-old hippocampal slices exhibited only short-lasting irregular activity. The initial appearance of carbachol-induced rhythmic waves were observed in slices obtained from 8-day-old rats. From the time that θ appeared at 8 days of age, a steady increase in amplitude and frequency was noted. This observed in vitro developmental pattern of hippocampal θ-rhythm closely resembles the development of θ activity in in vivo preparations.
Publication Year: 1988
Publication Date: 1988-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 31
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