Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1991718508', 'doi': 'https://doi.org/10.1016/s0955-0674(00)00096-x', 'title': 'Acetylation and chromosomal functions', 'display_name': 'Acetylation and chromosomal functions', 'publication_year': 2000, 'publication_date': '2000-06-01', 'ids': {'openalex': 'https://openalex.org/W1991718508', 'doi': 'https://doi.org/10.1016/s0955-0674(00)00096-x', 'mag': '1991718508', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10801466'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0955-0674(00)00096-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103771297', 'display_name': 'Current Opinion in Cell Biology', 'issn_l': '0955-0674', 'issn': ['0955-0674', '1879-0410'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060634049', 'display_name': 'Wang L. Cheung', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W L Cheung', 'raw_affiliation_strings': ['Department of Microbiology, Box 800733, University of Virginia, Health Science Center, Charlottesville, VA 22908-0733, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Box 800733, University of Virginia, Health Science Center, Charlottesville, VA 22908-0733, USA.', 'institution_ids': ['https://openalex.org/I51556381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056204856', 'display_name': 'Scott Briggs', 'orcid': 'https://orcid.org/0000-0003-2852-3594'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S D Briggs', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052967210', 'display_name': 'C. David Allis', 'orcid': 'https://orcid.org/0000-0001-7589-713X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C D Allis', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4530, 'currency': 'USD', 'value_usd': 4530, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.711, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 294, 'citation_normalized_percentile': {'value': 0.99954, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '12', 'issue': '3', 'first_page': '326', 'last_page': '333'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Regulation of Chromatin Structure and Function', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Molecular Basis of Rett Syndrome and Related Disorders', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sap30', 'display_name': 'SAP30', 'score': 0.71963555}, {'id': 'https://openalex.org/keywords/histone-code', 'display_name': 'Histone code', 'score': 0.5398322}, {'id': 'https://openalex.org/keywords/histone-modifications', 'display_name': 'Histone Modifications', 'score': 0.478342}, {'id': 'https://openalex.org/keywords/hdac4', 'display_name': 'HDAC4', 'score': 0.44477484}, {'id': 'https://openalex.org/keywords/histone-methylation', 'display_name': 'Histone methylation', 'score': 0.4186837}, {'id': 'https://openalex.org/keywords/hdac11', 'display_name': 'HDAC11', 'score': 0.41014266}], 'concepts': [{'id': 'https://openalex.org/C2910921701', 'wikidata': 'https://www.wikidata.org/wiki/Q1036906', 'display_name': 'Histone Acetyltransferases', 'level': 4, 'score': 0.829936}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7264161}, {'id': 'https://openalex.org/C45946802', 'wikidata': 'https://www.wikidata.org/wiki/Q18033449', 'display_name': 'SAP30', 'level': 5, 'score': 0.71963555}, {'id': 'https://openalex.org/C150425827', 'wikidata': 'https://www.wikidata.org/wiki/Q2560317', 'display_name': 'Histone methyltransferase', 'level': 4, 'score': 0.67601824}, {'id': 'https://openalex.org/C56428682', 'wikidata': 'https://www.wikidata.org/wiki/Q24785535', 'display_name': 'Histone H2A', 'level': 4, 'score': 0.64071727}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.5851326}, {'id': 'https://openalex.org/C119157956', 'wikidata': 'https://www.wikidata.org/wiki/Q796604', 'display_name': 'Acetylation', 'level': 3, 'score': 0.5453916}, {'id': 'https://openalex.org/C10058791', 'wikidata': 'https://www.wikidata.org/wiki/Q910897', 'display_name': 'Histone code', 'level': 5, 'score': 0.5398322}, {'id': 'https://openalex.org/C58793620', 'wikidata': 'https://www.wikidata.org/wiki/Q21173206', 'display_name': 'HDAC4', 'level': 5, 'score': 0.44477484}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.44119236}, {'id': 'https://openalex.org/C101152365', 'wikidata': 'https://www.wikidata.org/wiki/Q838135', 'display_name': 'Histone H1', 'level': 4, 'score': 0.42397988}, {'id': 'https://openalex.org/C22709980', 'wikidata': 'https://www.wikidata.org/wiki/Q4117777', 'display_name': 'Histone methylation', 'level': 5, 'score': 0.4186837}, {'id': 'https://openalex.org/C4951695', 'wikidata': 'https://www.wikidata.org/wiki/Q18046437', 'display_name': 'HDAC11', 'level': 5, 'score': 0.41014266}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.17403051}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16607836}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.10306901}, {'id': 'https://openalex.org/C84772758', 'wikidata': 'https://www.wikidata.org/wiki/Q271794', 'display_name': 'Nucleosome', 'level': 4, 'score': 0.06769532}], 'mesh': [{'descriptor_ui': 'D002875', 'descriptor_name': 'Chromosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002875', 'descriptor_name': 'Chromosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000107', 'descriptor_name': 'Acetylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002503', 'descriptor_name': 'Centromere', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002503', 'descriptor_name': 'Centromere', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002875', 'descriptor_name': 'Chromosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004303', 'descriptor_name': 'Dosage Compensation, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020868', 'descriptor_name': 'Gene Silencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018741', 'descriptor_name': 'Replication Origin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0955-0674(00)00096-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103771297', 'display_name': 'Current Opinion in Cell Biology', 'issn_l': '0955-0674', 'issn': ['0955-0674', '1879-0410'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10801466', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 72, 'referenced_works': ['https://openalex.org/W1511815964', 'https://openalex.org/W1533604650', 'https://openalex.org/W1558348929', 'https://openalex.org/W1609966422', 'https://openalex.org/W1625510017', 'https://openalex.org/W1626483287', 'https://openalex.org/W1820378590', 'https://openalex.org/W1875189464', 'https://openalex.org/W1877035800', 'https://openalex.org/W1966185129', 'https://openalex.org/W1971870945', 'https://openalex.org/W1974306997', 'https://openalex.org/W1974936759', 'https://openalex.org/W1976886665', 'https://openalex.org/W1978416076', 'https://openalex.org/W1982295124', 'https://openalex.org/W1982453928', 'https://openalex.org/W1985030042', 'https://openalex.org/W1985187876', 'https://openalex.org/W1987861824', 'https://openalex.org/W1989610704', 'https://openalex.org/W1990861922', 'https://openalex.org/W1992825055', 'https://openalex.org/W1999952815', 'https://openalex.org/W2002698073', 'https://openalex.org/W2002780348', 'https://openalex.org/W2003959153', 'https://openalex.org/W2005272111', 'https://openalex.org/W2008340135', 'https://openalex.org/W2010466297', 'https://openalex.org/W2013973315', 'https://openalex.org/W2017846948', 'https://openalex.org/W2018774210', 'https://openalex.org/W2020865862', 'https://openalex.org/W2024298217', 'https://openalex.org/W2030571655', 'https://openalex.org/W2036701875', 'https://openalex.org/W2038661934', 'https://openalex.org/W2039186983', 'https://openalex.org/W2040506727', 'https://openalex.org/W2044599516', 'https://openalex.org/W2050189770', 'https://openalex.org/W2056258547', 'https://openalex.org/W2059333381', 'https://openalex.org/W2061183445', 'https://openalex.org/W2063560319', 'https://openalex.org/W2071729239', 'https://openalex.org/W2073905722', 'https://openalex.org/W2074362522', 'https://openalex.org/W2078220845', 'https://openalex.org/W2081195534', 'https://openalex.org/W2092722802', 'https://openalex.org/W2098141162', 'https://openalex.org/W2106900373', 'https://openalex.org/W2111447146', 'https://openalex.org/W2121392264', 'https://openalex.org/W2122380132', 'https://openalex.org/W2130001787', 'https://openalex.org/W2140450002', 'https://openalex.org/W2144792857', 'https://openalex.org/W2151282569', 'https://openalex.org/W2153900602', 'https://openalex.org/W2161506097', 'https://openalex.org/W2163046373', 'https://openalex.org/W2164935229', 'https://openalex.org/W2166021986', 'https://openalex.org/W2170085122', 'https://openalex.org/W2182220639', 'https://openalex.org/W2225935458', 'https://openalex.org/W2318764920', 'https://openalex.org/W4241272033', 'https://openalex.org/W51482956'], 'related_works': ['https://openalex.org/W317408601', 'https://openalex.org/W3147324123', 'https://openalex.org/W3145130072', 'https://openalex.org/W3121753390', 'https://openalex.org/W2441859434', 'https://openalex.org/W2392762785', 'https://openalex.org/W2073198057', 'https://openalex.org/W2038568403', 'https://openalex.org/W2021369251', 'https://openalex.org/W1965804460'], 'abstract_inverted_index': {'Since': [0], 'the': [1, 30, 42, 48, 63, 78], 'initial': [2], 'discovery': [3], 'of': [4, 32, 44, 50, 65, 80, 82, 90], 'histone': [5, 12, 15, 33, 45], 'acetyltransferases,': [6], 'numerous': [7], 'reports': [8], 'have': [9, 27, 59], 'established': [10], 'that': [11, 62], 'acetyltransferases': [13], 'and': [14, 21, 41, 54, 84], 'deacetylases': [16], 'regulate': [17], 'transcription': [18], 'by': [19, 72], 'acetylating': [20], 'deacetylating': [22], 'histones,': [23], 'respectively.': [24], 'Recent': [25, 57], 'studies': [26], 'focused': [28], 'on': [29, 35], 'effects': [31], 'acetylation': [34, 81], 'gene': [36], 'expression': [37], 'regulation': [38], 'during': [39], 'development': [40], 'roles': [43], 'hypoacetylation': [46], 'in': [47, 87], 'maintenance': [49], 'centromeric': [51], 'structure,': [52], 'X-inactivation': [53], 'genomic': [55], 'imprinting.': [56], 'findings': [58], 'also': [60, 69], 'shown': [61], 'functions': [64], 'non-histone': [66, 85], 'proteins': [67, 86], 'can': [68], 'be': [70], 'regulated': [71], 'acetylation.': [73], 'Together,': [74], 'these': [75], 'data': [76], 'highlight': [77], 'importance': [79], 'histones': [83], 'a': [88], 'variety': [89], 'chromosomal': [91], 'functions.': [92]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1991718508', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-09-01T02:35:15.958734', 'created_date': '2016-06-24'}