Hsp60 chaperonopathies and chaperonotherapy: targets and agents

Name: Work Video:
Duration: 3 min 30 s
Description: Introduction: Hsp60 (Cpn60) assembles into a tetradecamer that interacts with the co-chaperonin Hsp10 (Cpn10) to assist client polypeptides to fold, but it also has other roles, including participation in pathogenic mechanisms.
Francesco Cappello; Antonella Marino; Antonio Palumbo Piccionello; Claudia Campanella; Andrea Pace; Everly Conway de Macario; Alberto J.L. Macario
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[0], 'Hsp60': [1], '(Cpn60)': [2], 'assembles': [3], 'into': [4], 'a': [5], 'tetradecamer': [6], 'that': [7], 'interacts': [8], 'with': [9], 'the': [10], 'co-chaperonin': [11], 'Hsp10': [12], '(Cpn10)': [13], 'to': [14, 18], 'assist': [15], 'client': [16], 'polypeptides': [17], 'fold,': [19], 'but': [20], 'it': [21], 'also': [22], 'has': [23], 'other': [24], 'roles,': [25], 'including': [26], 'participation': [27], 'in': [28], 'pathogenic': [29], 'mechanisms.': [30]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1991579889', 'counts_by_year': [{'year': 2024, 'cited_by_count': 21}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 8}], 'updated_date': '2025-01-12T01:30:13.267173', 'created_date': '2016-06-24'}
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