Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1991453413', 'doi': 'https://doi.org/10.1074/jbc.m506846200', 'title': 'Targeting Prostaglandin E2 Receptors as an Alternative Strategy to Block Cyclooxygenase-2-dependent Extracellular Matrix-induced Matrix Metalloproteinase-9 Expression by Macrophages', 'display_name': 'Targeting Prostaglandin E2 Receptors as an Alternative Strategy to Block Cyclooxygenase-2-dependent Extracellular Matrix-induced Matrix Metalloproteinase-9 Expression by Macrophages', 'publication_year': 2005, 'publication_date': '2005-12-08', 'ids': {'openalex': 'https://openalex.org/W1991453413', 'doi': 'https://doi.org/10.1074/jbc.m506846200', 'mag': '1991453413', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16338931'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m506846200', 'pdf_url': 'http://www.jbc.org/article/S0021925820817219/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820817219/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078006225', 'display_name': 'Svetlana Pavlović', 'orcid': 'https://orcid.org/0000-0001-7790-2692'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Svetlana Pavlovic', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104256366', 'display_name': 'Baoheng Du', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Baoheng Du', 'raw_affiliation_strings': ['Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002411838', 'display_name': 'Kazuko Sakamoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kazuko Sakamoto', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110697571', 'display_name': 'Korsa Khan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K.M. Faisal Khan', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'Vascular Biology Center, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}, {'raw_affiliation_string': 'Vascular Biology Center, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078737059', 'display_name': 'Chandramohan Natarajan', 'orcid': 'https://orcid.org/0009-0008-1770-1846'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chandramohan Natarajan', 'raw_affiliation_strings': ['Department of Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082516184', 'display_name': 'Richard Breyer', 'orcid': 'https://orcid.org/0000-0001-5828-4403'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard M. Breyer', 'raw_affiliation_strings': ['Department of Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013077524', 'display_name': 'Andrew J. Dannenberg', 'orcid': 'https://orcid.org/0000-0002-1901-6497'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew J. Dannenberg', 'raw_affiliation_strings': ['Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110881081', 'display_name': 'Domenick J. Falcone', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Domenick J. Falcone', 'raw_affiliation_strings': ['Department of Cell and Developmental Biology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'Vascular Biology Center, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021'], 'affiliations': [{'raw_affiliation_string': 'Vascular Biology Center, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}, {'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}, {'raw_affiliation_string': 'Department of Cell and Developmental Biology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5110881081'], 'corresponding_institution_ids': ['https://openalex.org/I205783295'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 7.132, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 97, 'citation_normalized_percentile': {'value': 0.921089, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '281', 'issue': '6', 'first_page': '3321', 'last_page': '3328'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/prostaglandin-e2-receptor', 'display_name': 'Prostaglandin E2 receptor', 'score': 0.8277905}], 'concepts': [{'id': 'https://openalex.org/C178592051', 'wikidata': 'https://www.wikidata.org/wiki/Q28208812', 'display_name': 'Prostaglandin E2 receptor', 'level': 4, 'score': 0.8277905}, {'id': 'https://openalex.org/C22615655', 'wikidata': 'https://www.wikidata.org/wiki/Q203221', 'display_name': 'Small interfering RNA', 'level': 4, 'score': 0.66267985}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5395488}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5234741}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5206922}, {'id': 'https://openalex.org/C2779276759', 'wikidata': 'https://www.wikidata.org/wiki/Q412747', 'display_name': 'Forskolin', 'level': 3, 'score': 0.48632795}, {'id': 'https://openalex.org/C2777956040', 'wikidata': 'https://www.wikidata.org/wiki/Q416554', 'display_name': 'Prostaglandin E2', 'level': 2, 'score': 0.48450133}, {'id': 'https://openalex.org/C109523444', 'wikidata': 'https://www.wikidata.org/wiki/Q424216', 'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.46457705}, {'id': 'https://openalex.org/C2779178603', 'wikidata': 'https://www.wikidata.org/wiki/Q356257', 'display_name': 'Adenylyl cyclase', 'level': 3, 'score': 0.46084332}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.44872022}, {'id': 'https://openalex.org/C2780664492', 'wikidata': 'https://www.wikidata.org/wiki/Q209717', 'display_name': 'Prostaglandin', 'level': 2, 'score': 0.43484563}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.41531426}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3458534}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.29372686}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2624743}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20748055}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.108749926}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D020780', 'descriptor_name': 'Matrix Metalloproteinase 9', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D018078', 'descriptor_name': 'Receptors, Prostaglandin E', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003994', 'descriptor_name': 'Bucladesine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003994', 'descriptor_name': 'Bucladesine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068579', 'descriptor_name': 'Celecoxib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005576', 'descriptor_name': 'Colforsin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005576', 'descriptor_name': 'Colforsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020868', 'descriptor_name': 'Gene Silencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020780', 'descriptor_name': 'Matrix Metalloproteinase 9', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020780', 'descriptor_name': 'Matrix Metalloproteinase 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009841', 'descriptor_name': 'Oligonucleotides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009841', 'descriptor_name': 'Oligonucleotides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010537', 'descriptor_name': 'Peritoneum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010537', 'descriptor_name': 'Peritoneum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010654', 'descriptor_name': 'Phenylbutyrates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010654', 'descriptor_name': 'Phenylbutyrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018078', 'descriptor_name': 'Receptors, Prostaglandin E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m506846200', 'pdf_url': 'http://www.jbc.org/article/S0021925820817219/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16338931', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m506846200', 'pdf_url': 'http://www.jbc.org/article/S0021925820817219/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.54, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 70, 'referenced_works': ['https://openalex.org/W1715047706', 'https://openalex.org/W1745661527', 'https://openalex.org/W1955246945', 'https://openalex.org/W1964797510', 'https://openalex.org/W1967678975', 'https://openalex.org/W1968896068', 'https://openalex.org/W1969158410', 'https://openalex.org/W1972809962', 'https://openalex.org/W1975248941', 'https://openalex.org/W1975716287', 'https://openalex.org/W1975955687', 'https://openalex.org/W1976372129', 'https://openalex.org/W1976915409', 'https://openalex.org/W1979861588', 'https://openalex.org/W1982865160', 'https://openalex.org/W1985621460', 'https://openalex.org/W1990099367', 'https://openalex.org/W2000260906', 'https://openalex.org/W2001364102', 'https://openalex.org/W2001751920', 'https://openalex.org/W2009682874', 'https://openalex.org/W2017437032', 'https://openalex.org/W2018716226', 'https://openalex.org/W2020563114', 'https://openalex.org/W2024233889', 'https://openalex.org/W2024847459', 'https://openalex.org/W2029941300', 'https://openalex.org/W2030571587', 'https://openalex.org/W2037405899', 'https://openalex.org/W2038084627', 'https://openalex.org/W2045648679', 'https://openalex.org/W2053230224', 'https://openalex.org/W2053425043', 'https://openalex.org/W2054512672', 'https://openalex.org/W2056726045', 'https://openalex.org/W2058034672', 'https://openalex.org/W2060351304', 'https://openalex.org/W2061177902', 'https://openalex.org/W2061857216', 'https://openalex.org/W2062605111', 'https://openalex.org/W2062861788', 'https://openalex.org/W2063136699', 'https://openalex.org/W2071041511', 'https://openalex.org/W2076787271', 'https://openalex.org/W2083169533', 'https://openalex.org/W2083519527', 'https://openalex.org/W2084120431', 'https://openalex.org/W2084615605', 'https://openalex.org/W2085775078', 'https://openalex.org/W2094941678', 'https://openalex.org/W2099955838', 'https://openalex.org/W2103567384', 'https://openalex.org/W2106319388', 'https://openalex.org/W2113892902', 'https://openalex.org/W2117169037', 'https://openalex.org/W2125376440', 'https://openalex.org/W2129746956', 'https://openalex.org/W2131116297', 'https://openalex.org/W2138877935', 'https://openalex.org/W2142651227', 'https://openalex.org/W2146476085', 'https://openalex.org/W2149876480', 'https://openalex.org/W2153458404', 'https://openalex.org/W2153853877', 'https://openalex.org/W2164475521', 'https://openalex.org/W2164807534', 'https://openalex.org/W2172253009', 'https://openalex.org/W40731526', 'https://openalex.org/W4247652559', 'https://openalex.org/W4252146505'], 'related_works': ['https://openalex.org/W2735154671', 'https://openalex.org/W2418200535', 'https://openalex.org/W2405405598', 'https://openalex.org/W2150623384', 'https://openalex.org/W2055820236', 'https://openalex.org/W2028910572', 'https://openalex.org/W2019451990', 'https://openalex.org/W1984957160', 'https://openalex.org/W1980806930', 'https://openalex.org/W1977982331'], 'abstract_inverted_index': {'COX-2-dependent': [0, 226], 'prostaglandin': [1], '(PG)': [2], 'E2': [3], 'synthesis': [4], 'regulates': [5], 'macrophage': [6, 72, 129, 172], 'MMP': [7], 'expression,': [8, 148, 174], 'which': [9, 175, 217], 'is': [10, 121, 230], 'thought': [11], 'to': [12, 58, 115], 'destabilize': [13], 'atherosclerotic': [14], 'plaques.': [15], 'However,': [16, 138], 'the': [17, 25, 33, 41, 99, 167, 179, 196, 241], 'administration': [18], 'of': [19, 27, 35, 43, 53, 74, 109, 118, 236, 240, 244], 'selective': [20, 234], 'COX-2': [21, 54, 87, 157, 186], 'inhibitors': [22], 'paradoxically': [23], 'increases': [24], 'frequency': [26], 'adverse': [28], 'cardiovascular': [29], 'events': [30], 'potentially': [31], 'through': [32, 82], 'loss': [34], 'anti-inflammatory': [36], 'prostanoids': [37], 'and/or': [38], 'disturbance': [39], 'in': [40, 86, 134, 202, 214, 216], 'balance': [42], 'pro-': [44], 'and': [45, 60, 89, 111, 125, 149, 158], 'anti-thrombotic': [46], 'prostanoids.': [47], 'To': [48], 'avoid': [49], 'these': [50], 'collateral': [51], 'effects': [52], 'inhibition,': [55], 'a': [56, 83, 135, 238], 'strategy': [57], 'identify': [59], 'block': [61], 'specific': [62], 'prostanoid-receptor': [63], 'interactions': [64], 'may': [65], 'be': [66], 'required.': [67], 'We': [68], 'previously': [69], 'reported': [70], 'that': [71, 95], 'engagement': [73], 'vascular': [75], 'extracellular': [76], 'matrix': [77, 130], '(ECM)': [78], 'triggers': [79], 'proteinase': [80, 205, 228], 'expression': [81, 88, 108, 133, 160, 211, 229], 'MAPKerk1/2-dependent': [84], 'increase': [85], 'PGE2': [90, 100, 242], 'synthesis.': [91], 'Here': [92], 'we': [93], 'demonstrate': [94], 'elicited': [96], 'macrophages': [97, 150, 215], 'express': [98], 'receptors': [101, 113], 'EP1-4.': [102], 'When': [103, 183], 'plated': [104, 162], 'on': [105, 146, 163], 'ECM,': [106], 'their': [107], 'EP2': [110, 140, 152], 'EP4,': [112, 237], 'linked': [114], 'PGE2-induced': [116], 'activation': [117], 'adenylyl': [119], 'cyclase,': [120], 'strongly': [122], 'stimulated.': [123], 'Forskolin': [124], 'dibutryl': [126], 'cyclic-AMP': [127], 'stimulate': [128], 'metalloproteinase': [131], '(MMP)-9': [132], 'dose-dependent': [136], 'manner.': [137], 'an': [139], 'agonist': [141, 169], '(butaprost)': [142], 'has': [143], 'no': [144], 'effect': [145], 'MMP-9': [147, 159, 173, 210], 'from': [151], 'null': [153], 'mice': [154], 'exhibited': [155], 'enhanced': [156], 'when': [161], 'ECM.': [164], 'In': [165, 207], 'contrast,': [166], 'EP4': [168, 180, 197, 218], '(PGE1-OH)': [170], 'stimulated': [171], 'was': [176, 199, 212, 219], 'inhibited': [177], 'by': [178, 188, 194, 221, 233], 'antagonist': [181, 198], 'ONO-AE3-208.': [182], 'compared': [184], 'with': [185], 'silencing': [187], 'small': [189, 222], 'interfering': [190, 223], 'RNA': [191], 'or': [192], 'inhibition': [193, 235], 'celecoxib,': [195], 'as': [200], 'effective': [201], 'inhibiting': [203], 'ECM-induced': [204, 209, 227], 'expression.': [206], 'addition,': [208], 'blocked': [213, 232], 'silenced': [220], 'RNA.': [224], 'Thus,': [225], 'effectively': [231], 'member': [239], 'family': [243], 'receptors.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1991453413', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-13T13:46:19.133402', 'created_date': '2016-06-24'}