Abstract: Acta Neurologica ScandinavicaVolume 88, Issue 2 p. 97-99 Pentoxifylline inhibits experimental allergic encephalomyelitis S. Nataf, Corresponding Author S. Nataf Clinique Neurologique, CHRU Nantes, FranceS. Nataf, Clinique neurologique, Hǒpital Laënnec, C. H. R. U. Nantes 44035 Nantes cedex, FranceSearch for more papers by this authorJ. P. Louboutin, J. P. Louboutin URA CNRS 1340, Hopital Laënnec, CHRU Nantes, FranceSearch for more papers by this authorD. Chabannes, D. Chabannes Laboratoire d'lmmunologie, CHRU Nantes, FranceSearch for more papers by this authorJ. R. Fève, J. R. Fève Clinique Neurologique, CHRU Nantes, FranceSearch for more papers by this authorJ. Y. Muller, J. Y. Muller Laboratoire d'lmmunologie, CHRU Nantes, FranceSearch for more papers by this author S. Nataf, Corresponding Author S. Nataf Clinique Neurologique, CHRU Nantes, FranceS. Nataf, Clinique neurologique, Hǒpital Laënnec, C. H. R. U. Nantes 44035 Nantes cedex, FranceSearch for more papers by this authorJ. P. Louboutin, J. P. Louboutin URA CNRS 1340, Hopital Laënnec, CHRU Nantes, FranceSearch for more papers by this authorD. Chabannes, D. Chabannes Laboratoire d'lmmunologie, CHRU Nantes, FranceSearch for more papers by this authorJ. R. Fève, J. R. Fève Clinique Neurologique, CHRU Nantes, FranceSearch for more papers by this authorJ. Y. Muller, J. Y. Muller Laboratoire d'lmmunologie, CHRU Nantes, FranceSearch for more papers by this author First published: August 1993 https://doi.org/10.1111/j.1600-0404.1993.tb04198.xCitations: 38AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Pentoxifylline, a widely used methylxanthine, has been proven to inhibit the production and action of the cytokine TNF α. Since it has been suggested that TNF α is the major cytokine involved in the pathogenesis of multiple sclerosis, we tested pentoxifylline for its capacity to prevent experimental allergic encephalomyelitis (EAE). 26 Lewis rats with acute EAE were treated with either pentoxifylline or saline. The pentoxifylline treated rats showed a significantly lower incidence of clinical signs as well as significantly lower histological inflammation. The exact mechanism of this preventive effect remains to be clarified but it might be mainly related to inhibition of TNF α release from central nervous system macrophages. Citing Literature Volume88, Issue2August 1993Pages 97-99 RelatedInformation