Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1990417198', 'doi': 'https://doi.org/10.1002/ddr.20218', 'title': 'Medicinal chemistry of the vanilloid (Capsaicin) TRPV1 receptor: current knowledge and future perspectives', 'display_name': 'Medicinal chemistry of the vanilloid (Capsaicin) TRPV1 receptor: current knowledge and future perspectives', 'publication_year': 2007, 'publication_date': '2007-12-01', 'ids': {'openalex': 'https://openalex.org/W1990417198', 'doi': 'https://doi.org/10.1002/ddr.20218', 'mag': '1990417198'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ddr.20218', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S26306840', 'display_name': 'Drug Development Research', 'issn_l': '0272-4391', 'issn': ['0272-4391', '1098-2299'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://dea.lib.unideb.hu/bitstreams/b958993f-2b62-4fa8-9d70-d165dc84f834/download', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020026077', 'display_name': 'Laxmikant A. Gharat', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131532', 'display_name': 'Glenmark Pharmaceuticals (India)', 'ror': 'https://ror.org/037fhg487', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I4210131532']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Laxmikant Gharat', 'raw_affiliation_strings': ['Department of Chemistry, Glenmark Pharmaceuticals, Navi Mumbai, 400709 India'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Glenmark Pharmaceuticals, Navi Mumbai, 400709 India', 'institution_ids': ['https://openalex.org/I4210131532']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073311910', 'display_name': 'A Szállaśi', 'orcid': 'https://orcid.org/0000-0001-7236-5373'}, 'institutions': [{'id': 'https://openalex.org/I72816309', 'display_name': 'Drexel University', 'ror': 'https://ror.org/04bdffz58', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I72816309']}, {'id': 'https://openalex.org/I1342092835', 'display_name': 'Monmouth Medical Center', 'ror': 'https://ror.org/00xmn3c34', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1342092835']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arpad Szallasi', 'raw_affiliation_strings': ['Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102', 'Department of Pathology, Monmouth Medical Center, Long Branch, NJ 07740'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102', 'institution_ids': ['https://openalex.org/I72816309']}, {'raw_affiliation_string': 'Department of Pathology, Monmouth Medical Center, Long Branch, NJ 07740', 'institution_ids': ['https://openalex.org/I1342092835']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.17, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.700555, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '68', 'issue': '8', 'first_page': '477', 'last_page': '497'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11204', 'display_name': 'Ion Channels and Receptors', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11204', 'display_name': 'Ion Channels and Receptors', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10196', 'display_name': 'Pain Mechanisms and Treatments', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13483', 'display_name': 'Herbal Medicine Research Studies', 'score': 0.9731, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/capsaicin', 'display_name': 'Capsaicin', 'score': 0.7678038}], 'concepts': [{'id': 'https://openalex.org/C160145004', 'wikidata': 'https://www.wikidata.org/wiki/Q413209', 'display_name': 'TRPV1', 'level': 4, 'score': 0.98166895}, {'id': 'https://openalex.org/C155164980', 'wikidata': 'https://www.wikidata.org/wiki/Q304043', 'display_name': 'Transient receptor potential channel', 'level': 3, 'score': 0.7717103}, {'id': 'https://openalex.org/C2780051329', 'wikidata': 'https://www.wikidata.org/wiki/Q273169', 'display_name': 'Capsaicin', 'level': 3, 'score': 0.7678038}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5590886}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5421792}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.47003147}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4341225}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.41875842}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.36145127}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34723356}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.17947617}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12795973}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ddr.20218', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S26306840', 'display_name': 'Drug Development Research', 'issn_l': '0272-4391', 'issn': ['0272-4391', '1098-2299'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2437/181513', 'pdf_url': 'https://dea.lib.unideb.hu/bitstreams/b958993f-2b62-4fa8-9d70-d165dc84f834/download', 'source': {'id': 'https://openalex.org/S4306402089', 'display_name': 'University of Debrecen Electronic Archive (University of Debrecen)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I132735039', 'host_organization_name': 'University of Debrecen', 'host_organization_lineage': ['https://openalex.org/I132735039'], 'host_organization_lineage_names': ['University of Debrecen'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2437/181513', 'pdf_url': 'https://dea.lib.unideb.hu/bitstreams/b958993f-2b62-4fa8-9d70-d165dc84f834/download', 'source': {'id': 'https://openalex.org/S4306402089', 'display_name': 'University of Debrecen Electronic Archive (University of Debrecen)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I132735039', 'host_organization_name': 'University of Debrecen', 'host_organization_lineage': ['https://openalex.org/I132735039'], 'host_organization_lineage_names': ['University of Debrecen'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.68, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 181, 'referenced_works': ['https://openalex.org/W112162998', 'https://openalex.org/W135618988', 'https://openalex.org/W1488245315', 'https://openalex.org/W1488329806', 'https://openalex.org/W1492591187', 'https://openalex.org/W1511198581', 'https://openalex.org/W1526664679', 'https://openalex.org/W1527988408', 'https://openalex.org/W1549329305', 'https://openalex.org/W1562645017', 'https://openalex.org/W1581034902', 'https://openalex.org/W1589228373', 'https://openalex.org/W1595128246', 'https://openalex.org/W1883044208', 'https://openalex.org/W1942930266', 'https://openalex.org/W1945754804', 'https://openalex.org/W1963531856', 'https://openalex.org/W1964430829', 'https://openalex.org/W1965509871', 'https://openalex.org/W1965925550', 'https://openalex.org/W1966923258', 'https://openalex.org/W1969521925', 'https://openalex.org/W1971456679', 'https://openalex.org/W1971754431', 'https://openalex.org/W1971826341', 'https://openalex.org/W1973913639', 'https://openalex.org/W1974620224', 'https://openalex.org/W1979902669', 'https://openalex.org/W1979924020', 'https://openalex.org/W1981333657', 'https://openalex.org/W1982284880', 'https://openalex.org/W1984096754', 'https://openalex.org/W1984546928', 'https://openalex.org/W1986018857', 'https://openalex.org/W1986072332', 'https://openalex.org/W1986235007', 'https://openalex.org/W1986693123', 'https://openalex.org/W1987418164', 'https://openalex.org/W1987745165', 'https://openalex.org/W1989749187', 'https://openalex.org/W1992107007', 'https://openalex.org/W1992358268', 'https://openalex.org/W1992964418', 'https://openalex.org/W1995705528', 'https://openalex.org/W1999665243', 'https://openalex.org/W2003706636', 'https://openalex.org/W2004213712', 'https://openalex.org/W2006132476', 'https://openalex.org/W2006210468', 'https://openalex.org/W2008045899', 'https://openalex.org/W2009294684', 'https://openalex.org/W2009326432', 'https://openalex.org/W2009902430', 'https://openalex.org/W2015697709', 'https://openalex.org/W2016547570', 'https://openalex.org/W2018814467', 'https://openalex.org/W2020226714', 'https://openalex.org/W2020588358', 'https://openalex.org/W2021815265', 'https://openalex.org/W2022785733', 'https://openalex.org/W2022973904', 'https://openalex.org/W2025077832', 'https://openalex.org/W2026842778', 'https://openalex.org/W2028522240', 'https://openalex.org/W2028729618', 'https://openalex.org/W2030424226', 'https://openalex.org/W2031705330', 'https://openalex.org/W2032087136', 'https://openalex.org/W2035619095', 'https://openalex.org/W2036038321', 'https://openalex.org/W2036330488', 'https://openalex.org/W2036815564', 'https://openalex.org/W2039155621', 'https://openalex.org/W2039393505', 'https://openalex.org/W2039522435', 'https://openalex.org/W2041363373', 'https://openalex.org/W2042178403', 'https://openalex.org/W2043328385', 'https://openalex.org/W2044632947', 'https://openalex.org/W2045959196', 'https://openalex.org/W2046677990', 'https://openalex.org/W2048466249', 'https://openalex.org/W2050781058', 'https://openalex.org/W2052810218', 'https://openalex.org/W2053181080', 'https://openalex.org/W2053332960', 'https://openalex.org/W2055100907', 'https://openalex.org/W2055335617', 'https://openalex.org/W2057709157', 'https://openalex.org/W2059396066', 'https://openalex.org/W2059398421', 'https://openalex.org/W2059674658', 'https://openalex.org/W2064136641', 'https://openalex.org/W2064260030', 'https://openalex.org/W2064441047', 'https://openalex.org/W2066451287', 'https://openalex.org/W2066559312', 'https://openalex.org/W2067906797', 'https://openalex.org/W2068168026', 'https://openalex.org/W2069804249', 'https://openalex.org/W2070948590', 'https://openalex.org/W2071297569', 'https://openalex.org/W2071480300', 'https://openalex.org/W2072091854', 'https://openalex.org/W2072524544', 'https://openalex.org/W2072591002', 'https://openalex.org/W2073606727', 'https://openalex.org/W2073864577', 'https://openalex.org/W2075072901', 'https://openalex.org/W2076350174', 'https://openalex.org/W2078730596', 'https://openalex.org/W2078980646', 'https://openalex.org/W2079261707', 'https://openalex.org/W2080252996', 'https://openalex.org/W2083954992', 'https://openalex.org/W2085802434', 'https://openalex.org/W2087978036', 'https://openalex.org/W2088764206', 'https://openalex.org/W2089362566', 'https://openalex.org/W2092635728', 'https://openalex.org/W2098712238', 'https://openalex.org/W2100352770', 'https://openalex.org/W2100585655', 'https://openalex.org/W2100713606', 'https://openalex.org/W2103569887', 'https://openalex.org/W2105163313', 'https://openalex.org/W2106201634', 'https://openalex.org/W2106207830', 'https://openalex.org/W2107705149', 'https://openalex.org/W2107756388', 'https://openalex.org/W2109293109', 'https://openalex.org/W2110383467', 'https://openalex.org/W2114058936', 'https://openalex.org/W2116327412', 'https://openalex.org/W2117301151', 'https://openalex.org/W2118590048', 'https://openalex.org/W2118626190', 'https://openalex.org/W2119832782', 'https://openalex.org/W2121860740', 'https://openalex.org/W2121896543', 'https://openalex.org/W2124141753', 'https://openalex.org/W2125441842', 'https://openalex.org/W2127140021', 'https://openalex.org/W2130306694', 'https://openalex.org/W2130600650', 'https://openalex.org/W2134742719', 'https://openalex.org/W2135567029', 'https://openalex.org/W2137445147', 'https://openalex.org/W2137852743', 'https://openalex.org/W2142413196', 'https://openalex.org/W2144182791', 'https://openalex.org/W2144868091', 'https://openalex.org/W2146883061', 'https://openalex.org/W2149044422', 'https://openalex.org/W2153936909', 'https://openalex.org/W2154990688', 'https://openalex.org/W2157486885', 'https://openalex.org/W2159599069', 'https://openalex.org/W2165489866', 'https://openalex.org/W2167663419', 'https://openalex.org/W2167957790', 'https://openalex.org/W2168322600', 'https://openalex.org/W2168686026', 'https://openalex.org/W2171691483', 'https://openalex.org/W2171717653', 'https://openalex.org/W2209659227', 'https://openalex.org/W2312536895', 'https://openalex.org/W2326624180', 'https://openalex.org/W2405896538', 'https://openalex.org/W2417198548', 'https://openalex.org/W2417748670', 'https://openalex.org/W2441889376', 'https://openalex.org/W2462300262', 'https://openalex.org/W2485122332', 'https://openalex.org/W2491485361', 'https://openalex.org/W2765629363', 'https://openalex.org/W365202500', 'https://openalex.org/W37724093', 'https://openalex.org/W4230680940', 'https://openalex.org/W814794131', 'https://openalex.org/W95323280'], 'related_works': ['https://openalex.org/W8184359', 'https://openalex.org/W4226479235', 'https://openalex.org/W4221117701', 'https://openalex.org/W2964958677', 'https://openalex.org/W2356671327', 'https://openalex.org/W2334470388', 'https://openalex.org/W2281887241', 'https://openalex.org/W2048812251', 'https://openalex.org/W2013659300', 'https://openalex.org/W1542157645'], 'abstract_inverted_index': {'Abstract': [0], 'In': [1, 126, 154], 'peripheral': [2], 'sensory': [3], 'neurons,': [4], 'the': [5, 63, 96, 103, 130, 143, 156, 160, 164], 'vanilloid': [6, 12], 'receptor': [7, 10, 78], 'TRPV1': [8, 35, 54, 77, 100, 115, 134, 168], '(transient': [9], 'potential': [11, 148], 'subfamily,': [13], 'member': [14], '1)': [15], 'functions': [16], 'as': [17, 139], 'a': [18, 112], 'molecular': [19], 'integrator': [20], 'of': [21, 34, 76, 99, 114, 133, 151, 163], 'painful': [22], 'stimuli,': [23], 'including': [24], 'those': [25], 'mediated': [26], 'by': [27, 40], 'capsaicin,': [28], 'acid,': [29], 'and': [30, 65, 83, 88, 147], 'heat.': [31], 'Antagonist': [32], 'blockade': [33], 'activation': [36], 'is': [37, 55, 86, 89, 136, 170], 'under': [38], 'investigation': [39], 'several': [41], 'pharmaceutical': [42], 'companies': [43], 'in': [44, 62, 66], 'an': [45], 'effort': [46], 'to': [47, 80, 92, 121, 142], 'identify': [48], 'novel': [49], 'agents': [50], 'for': [51], 'pain': [52], 'management.': [53], 'also': [56], 'expressed,': [57], 'albeit': [58], 'at': [59], 'lower': [60], 'levels,': [61], 'brain': [64], 'non‐neuronal': [67], 'tissues,': [68], 'where': [69], 'its': [70], 'function(s)': [71], 'remains': [72], 'elusive.': [73], 'The': [74], 'contribution': [75], 'activity': [79], 'physiological': [81], 'reflexes': [82], 'disease': [84], 'states': [85], 'complex': [87], 'only': [90], 'beginning': [91], 'be': [93, 106], 'understood.': [94], 'Consequently,': [95], 'resultant': [97], 'effects': [98, 150], 'antagonists': [101, 116, 135, 169], 'on': [102, 159], 'body': [104], 'may': [105], 'unforeseen.': [107], 'Indeed,': [108], 'clinical': [109, 165], 'trials': [110, 166], 'with': [111, 167], 'number': [113], 'were': [117], 'recently': [118], 'terminated': [119], 'due': [120], 'their': [122], 'marked': [123], 'hyperthermic': [124], 'activity.': [125], 'this': [127], 'review': [128], 'article,': [129], 'medicinal': [131], 'chemistry': [132], 'discussed': [137], 'inasmuch': [138], 'it': [140], 'relates': [141], 'efficacy,': [144], 'safety,': [145], 'tolerability': [146], 'side': [149], 'these': [152], 'compounds.': [153], 'addition,': [155], 'available': [157], 'information': [158], 'current': [161], 'status': [162], 'summarized.': [171], 'Drug': [172], 'Dev': [173], 'Res': [174], '68:477–497,': [175], '2007.': [176], '©': [177], '2008': [178], 'Wiley‐Liss,': [179], 'Inc.': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1990417198', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-08T07:55:25.425484', 'created_date': '2016-06-24'}