Title: Nosocomial transmission of community-associated meticillin-resistant Staphylococcus aureus: an emerging threat
Abstract: Nicola Zetola and colleagues 1 Zetola N Francis JS Nuermberger EL Bishai WR Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis. 2005; 5: 275-286 Summary Full Text Full Text PDF PubMed Scopus (670) Google Scholar have described the emerging threat of meticillin-resistant Staphylococcus aureus (MRSA) infection acquired in the community by patients without previous health-care contact. Compared with health-care-associated MRSA, community-associated strains are typically susceptible to most antistaphylococcal antimicrobials, have a more diverse genetic background, carry small versions (usually types IV or V) of staphylococcal cassette chromosome mec (SCCmec), often produce the Panton-Valentine leukocidin (PVL), and can be highly virulent. 1 Zetola N Francis JS Nuermberger EL Bishai WR Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis. 2005; 5: 275-286 Summary Full Text Full Text PDF PubMed Scopus (670) Google Scholar , 2 Robinson DA Kearns AM Holmes A et al. Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone. Lancet. 2005; 365: 1256-1258 Summary Full Text Full Text PDF PubMed Scopus (224) Google Scholar , 3 Vandenesch F Naimi T Enright MC et al. Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis. 2003; 9: 978-984 Crossref PubMed Scopus (1501) Google Scholar Zetola and colleagues noted in passing that community-associated MRSA might cause outbreaks of nosocomial infection when affected patients are hospitalised. 1 Zetola N Francis JS Nuermberger EL Bishai WR Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis. 2005; 5: 275-286 Summary Full Text Full Text PDF PubMed Scopus (670) Google Scholar We review the accumulating evidence that community-associated MRSA can readily produce hospital outbreaks, acquire multiple antibiotic resistance, and shuttle between hospital and community. This emerging epidemiology further adds to the threats posed by these organisms.
Publication Year: 2006
Publication Date: 2006-11-21
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 103
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