Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1990176006', 'doi': 'https://doi.org/10.1084/jem.179.5.1737', 'title': 'A novel biologic activity of thrombin: stimulation of monocyte chemotactic protein production.', 'display_name': 'A novel biologic activity of thrombin: stimulation of monocyte chemotactic protein production.', 'publication_year': 1994, 'publication_date': '1994-05-01', 'ids': {'openalex': 'https://openalex.org/W1990176006', 'doi': 'https://doi.org/10.1084/jem.179.5.1737', 'mag': '1990176006', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8163952', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2191479'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.179.5.1737', 'pdf_url': 'https://rupress.org/jem/article-pdf/179/5/1737/1105114/1737.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rupress.org/jem/article-pdf/179/5/1737/1105114/1737.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024426681', 'display_name': 'Giuseppe Grandaliano', 'orcid': 'https://orcid.org/0000-0003-1213-2177'}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G Grandaliano', 'raw_affiliation_strings': ['Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7882.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7882.', 'institution_ids': ['https://openalex.org/I165951966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034515720', 'display_name': 'Anthony J. Valente', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A J Valente', 'raw_affiliation_strings': ['Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7882.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7882.', 'institution_ids': ['https://openalex.org/I165951966']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073806384', 'display_name': 'H. E. Abboud', 'orcid': 'https://orcid.org/0000-0002-3741-6806'}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H E Abboud', 'raw_affiliation_strings': ['Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7882.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7882.', 'institution_ids': ['https://openalex.org/I165951966']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.126, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 102, 'citation_normalized_percentile': {'value': 0.87465, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '179', 'issue': '5', 'first_page': '1737', 'last_page': '1741'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10881', 'display_name': 'Blood Coagulation and Thrombosis Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10881', 'display_name': 'Blood Coagulation and Thrombosis Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Coagulation, Bradykinin, Polyphosphates, and Angioedema', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thrombomodulin', 'display_name': 'Thrombomodulin', 'score': 0.8207213}, {'id': 'https://openalex.org/keywords/monocyte', 'display_name': 'Monocyte', 'score': 0.6869395}, {'id': 'https://openalex.org/keywords/thrombin-receptor', 'display_name': 'Thrombin receptor', 'score': 0.59934866}, {'id': 'https://openalex.org/keywords/mesangial-cell', 'display_name': 'Mesangial cell', 'score': 0.43537444}], 'concepts': [{'id': 'https://openalex.org/C2777292125', 'wikidata': 'https://www.wikidata.org/wiki/Q409166', 'display_name': 'Thrombin', 'level': 3, 'score': 0.90669227}, {'id': 'https://openalex.org/C201267052', 'wikidata': 'https://www.wikidata.org/wiki/Q414446', 'display_name': 'Thrombomodulin', 'level': 4, 'score': 0.8207213}, {'id': 'https://openalex.org/C2781184567', 'wikidata': 'https://www.wikidata.org/wiki/Q107244', 'display_name': 'Monocyte', 'level': 2, 'score': 0.6869395}, {'id': 'https://openalex.org/C2778886182', 'wikidata': 'https://www.wikidata.org/wiki/Q24769535', 'display_name': 'Thrombin receptor', 'level': 4, 'score': 0.59934866}, {'id': 'https://openalex.org/C186738567', 'wikidata': 'https://www.wikidata.org/wiki/Q412841', 'display_name': 'Tissue factor', 'level': 3, 'score': 0.5757187}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45457312}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4509933}, {'id': 'https://openalex.org/C2779131090', 'wikidata': 'https://www.wikidata.org/wiki/Q3331086', 'display_name': 'Mesangial cell', 'level': 3, 'score': 0.43537444}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36785844}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32076916}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.25375625}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.25306648}, {'id': 'https://openalex.org/C2778382381', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Coagulation', 'level': 2, 'score': 0.23716003}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.2155329}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15329573}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.1531344}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.11141461}], 'mesh': [{'descriptor_ui': 'D002630', 'descriptor_name': 'Chemotactic Factors', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013917', 'descriptor_name': 'Thrombin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018932', 'descriptor_name': 'Chemokine CCL2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002630', 'descriptor_name': 'Chemotactic Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002630', 'descriptor_name': 'Chemotactic Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005920', 'descriptor_name': 'Glomerular Mesangium', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005920', 'descriptor_name': 'Glomerular Mesangium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005920', 'descriptor_name': 'Glomerular Mesangium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013917', 'descriptor_name': 'Thrombin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.179.5.1737', 'pdf_url': 'https://rupress.org/jem/article-pdf/179/5/1737/1105114/1737.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2191479', 'pdf_url': 'https://europepmc.org/articles/pmc2191479?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191479', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8163952', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.179.5.1737', 'pdf_url': 'https://rupress.org/jem/article-pdf/179/5/1737/1105114/1737.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.66}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1515935875', 'https://openalex.org/W1523923158', 'https://openalex.org/W1673986181', 'https://openalex.org/W1978136857', 'https://openalex.org/W1978834984', 'https://openalex.org/W1991720779', 'https://openalex.org/W1992715029', 'https://openalex.org/W2017347652', 'https://openalex.org/W2021873664', 'https://openalex.org/W2030089656', 'https://openalex.org/W2035451076', 'https://openalex.org/W2038780185', 'https://openalex.org/W2043254359', 'https://openalex.org/W2061570941', 'https://openalex.org/W2062874643', 'https://openalex.org/W2075331103', 'https://openalex.org/W2078663145', 'https://openalex.org/W2081753893', 'https://openalex.org/W2140606960', 'https://openalex.org/W2141375481', 'https://openalex.org/W2166170833', 'https://openalex.org/W2410738122', 'https://openalex.org/W2414139056', 'https://openalex.org/W2416484761', 'https://openalex.org/W2421963159', 'https://openalex.org/W2442530891', 'https://openalex.org/W90654970'], 'related_works': ['https://openalex.org/W2949620925', 'https://openalex.org/W2911265422', 'https://openalex.org/W26504402', 'https://openalex.org/W2593625', 'https://openalex.org/W2418186460', 'https://openalex.org/W2062568423', 'https://openalex.org/W2032884750', 'https://openalex.org/W1965232375', 'https://openalex.org/W1926932365', 'https://openalex.org/W1842710166'], 'abstract_inverted_index': {'Thrombin': [0, 24, 50], 'is': [1, 6, 25, 59, 83], 'a': [2, 15, 29, 35, 55, 101, 130, 152, 193, 226], 'serine': [3], 'protease': [4], 'that': [5, 58, 128, 165, 208, 215], 'released': [7], 'at': [8], 'sites': [9], 'of': [10, 17, 34, 37, 74, 90, 104, 113, 135, 184, 230, 247], 'vascular': [11, 44, 62, 126], 'injury': [12], 'and': [13, 47, 67, 96, 118, 145, 154, 161, 188, 232, 249], 'exerts': [14], 'variety': [16, 103], 'biologic': [18, 228], 'effects': [19, 53], 'on': [20, 115], 'different': [21], 'cell': [22], 'types.': [23], 'postulated': [26], 'to': [27, 85, 93], 'play': [28, 129], 'role': [30, 132], 'in': [31, 61, 64, 76, 100, 121, 133, 148, 151, 244], 'the': [32, 72, 77, 94, 111, 136, 181, 185, 245], 'pathogenesis': [33], 'number': [36], 'diseases': [38], 'including': [39, 106], 'atherosclerosis,': [40], 'since': [41], 'it': [42], 'activates': [43], 'smooth': [45], 'muscle': [46], 'endothelial': [48], 'cells.': [49, 108], 'mediates': [51], 'these': [52], 'through': [54], 'specific': [56], 'receptor': [57, 171, 196, 221], 'upregulated': [60], 'cells': [63, 105, 150, 210], 'atherosclerosis.': [65, 252], 'Atherosclerosis': [66], 'glomerulosclerosis': [68], 'are': [69], 'characterized': [70, 187], 'by': [71, 237, 250], 'presence': [73], 'monocyte-macrophages': [75], 'lesions.': [78], 'Monocyte': [79], 'chemotactic': [80], 'protein': [81], '(MCP-1)': [82], 'believed': [84], 'be': [86, 98], 'an': [87, 212, 234], 'important': [88], 'mediator': [89], 'monocyte': [91], 'recruitment': [92], 'tissue': [95], 'can': [97], 'induced': [99], 'broad': [102], 'mesangial': [107, 124, 149, 209], 'We': [109], 'studied': [110], 'effect': [112, 168], 'thrombin': [114, 141, 160, 163, 167, 190, 195, 220, 231], 'MCP-1': [116, 143, 202], 'production': [117, 144], 'gene': [119, 146], 'expression': [120, 147], 'well-characterized': [122], 'human': [123, 194, 219], 'cells,': [125], 'pericytes': [127], 'central': [131], 'fibrosis': [134], 'glomerular': [137], 'microvascular': [138], 'bed.': [139], 'alpha': [140], 'stimulates': [142, 201], 'dose-': [153], 'time-dependent': [155], 'manner.': [156], 'Experiments': [157], 'with': [158, 180, 217], 'diisopropylfluorophosphate': [159], 'gamma': [162], 'demonstrate': [164], 'this': [166, 239], 'requires': [169], 'both': [170], 'binding': [172], 'as': [173, 175], 'well': [174], 'catalytic': [176], 'activity,': [177], 'features': [178], 'consistent': [179], 'known': [182], 'properties': [183], 'recently': [186], 'cloned': [189], 'receptor.': [191], 'Moreover,': [192], 'activating': [197], 'peptide': [198], '(TRAP1-7)': [199], 'also': [200], 'production.': [203], 'Northern': [204], 'blot': [205], 'analysis': [206], 'demonstrated': [207], 'express': [211], 'mRNA': [213], 'transcript': [214], 'hybridizes': [216], 'labeled': [218], 'cDNA.': [222], 'These': [223], 'data': [224], 'describe': [225], 'novel': [227], 'activity': [229], 'suggest': [233], 'additional': [235], 'mechanism': [236], 'which': [238], 'coagulation': [240], 'factor': [241], 'may': [242], 'participate': [243], 'progression': [246], 'glomerulosclerosis,': [248], 'analogy,': [251]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1990176006', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T09:57:22.965350', 'created_date': '2016-06-24'}