Publication Information

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3309, 3347, 3463, 3567, 3663, 3687, 3722, 3746, 3795, 3836, 3889, 3903], 'Scholar)': [44, 659, 1054, 1090, 1952, 2700, 3077, 3747], 'and': [45, 207, 266, 302, 318, 327, 341, 394, 502, 611, 630, 666, 745, 760, 762, 837, 887, 1055, 1192, 1216, 1221, 1226, 1234, 1263, 1333, 1355, 1363, 1451, 1465, 1476, 1495, 1503, 1513, 1548, 1577, 1602, 1606, 1693, 1785, 1795, 1953, 1976, 2167, 2177, 2216, 2234, 2239, 2283, 2553, 2706, 2812, 3078, 3192, 3221, 3266, 3315, 3408, 3414, 3421, 3484, 3494, 3603, 3627, 3689, 3912, 3931, 3991, 4036, 4040, 4062], 'an': [46, 100, 612, 1007, 1477, 1980, 1984, 2002, 2529, 3601], 'important': [47, 313, 1380, 2530, 3602], 'intracellular': [48, 2668], 'signaling': [49, 2669, 3579], 'molecule': [50], '(2Kolesnick': [51], 'R.': [52, 516, 976, 1036, 1068, 1132, 1650, 1666, 1752, 2782, 3666, 3676], 'Clin.': [54, 3828], 'Invest.': [55], '110:': [57], '3-8Crossref': [58], '(389)': [61], 'Scholar,': [63, 165, 226, 365, 466, 534, 939, 1154, 1720, 1740, 1849, 1882, 1936, 2580, 2602, 2726, 2854, 2879, 2907, 2938, 2969, 3664, 3723, 3890], '3Hannun': [64], 'Y.A.': [65, 2429, 2682, 2734, 2889, 2919, 2953, 3016, 3101, 3152, 3290, 3444, 3872, 3894], 'Obeid': [66, 2683, 3291, 3445, 3873], 'L.M.': [67, 2684, 3292, 3446, 3874], '25847-25850Abstract': [73, 2690, 3880], '(770)': [81, 2698, 3888], 'Scholar).': [83, 246, 385, 429, 482, 555, 600, 741, 876, 950, 1028, 1176, 1303, 1330, 1676, 1814, 1971, 2099, 2164, 2336, 2744, 2800, 2990, 3117, 3171, 3217, 3257, 3464, 3568, 3837, 3904], 'consists': [85], 'a': [87, 94, 190, 292, 401, 572, 625, 636, 678, 717, 791, 807, 816, 839, 847, 893, 1267, 1313, 1339, 1352, 1409, 1490, 1589, 1776, 2124, 2379, 2647, 2825, 3842, 3860, 3996], 'sphingoid': [88, 141, 4037], 'long': [89, 3800], 'chain': [90, 2213, 3802], 'base': [91, 638, 2041, 4038], 'to': [92, 139, 201, 324, 329, 399, 435, 486, 558, 773, 914, 1092, 1117, 1224, 1232, 1247, 1281, 1311, 1427, 1533, 1597, 1681, 1955, 2173, 2209, 2236, 2313, 2449, 2657, 2664, 2816, 3361, 3471, 3497, 3857, 3859, 3946, 3950, 3999, 4060, 4104], 'which': [93, 1375, 1453, 1543, 1826, 2121, 3185, 3797], 'fatty': [95, 136, 194, 263, 280, 310, 404, 2384, 2456, 2536, 2625, 2651, 3518, 3539, 3609, 3850], 'acid': [96, 129, 137, 264, 281, 821, 2457, 2626, 3540, 3610, 3851], 'attached': [98, 138], 'via': [99, 2677, 3224], 'amide': [101], 'bond': [102], '(Fig.': [103, 1185, 3940, 3989, 4013, 4102], '1).': [104], 'When': [105, 1204], 'chemical': [107], 'composition': [108, 282, 2627, 3541, 3611, 3852], 'SLs': [110, 188, 562], 'was': [111, 131, 397, 412, 432, 492, 498, 568, 633, 674, 714, 890, 952, 2111, 2306, 2311, 3176, 3187, 3397], 'first': [112, 484, 2101], 'determined': [113], '1940s': [116], '(4Klenk': [117], 'E.Z.': [118, 1621], 'Physiol.': [119], '1942;': [121], '273:': [122], '76-86Crossref': [123], '(146)': [125], 'Scholar),': [127, 182, 836, 1006, 1394, 1774, 1909, 2001, 2207, 2233, 2253, 2362, 2445, 2523, 2620, 3034, 3310, 3348, 3688, 3796], 'stearic': [128], '(C18:0)': [130], 'identified': [132], 'as': [133, 677, 812, 842, 1408, 2119, 2415, 2467, 3264, 3953, 3969, 4100], 'major': [135, 1509, 2806], 'base.': [142], 'Later,': [143], 'with': [144, 661, 1257, 1273, 1506, 1792, 1911, 1983, 2007, 2265, 2338, 2374, 2454, 2701, 3575, 3750, 3942], 'development': [146, 1382, 2550], 'more': [148, 2554, 3526, 4105], 'sensitive': [149, 2555], 'techniques': [150], '(5Trams': [151], 'E.G.': [152], 'Giuffrida': [153], 'L.E.': [154], 'Karmen': [155], 'A.': [156, 524, 701, 826, 972, 988, 992, 1044, 1074, 1138, 1291, 1320, 1639, 1644, 1648, 1758, 1837, 2059, 2067, 2071, 2221, 2244, 2279, 2284, 2427, 2610, 2768, 3553, 3670, 3823], 'Nature.': [157, 931], '1962;': [158], '193:': [159], '680-681Crossref': [160], '(15)': [163], "6O'Brien": [166], 'J.S.': [167], 'Fillerup': [168], 'D.L.': [169], 'Mead': [170], 'J.F.': [171], 'Lipid': [173, 2590, 3652, 3733], 'Res.': [174, 651, 1168, 2591, 3653, 3734], '1964;': [175], '15:': [176, 374, 1709, 2512], '109-116Abstract': [177], 'it': [183, 497, 1424, 3372, 3468], 'became': [184], 'clear': [185], 'that': [186, 203, 305, 500, 1099, 1276, 1400, 1414, 1423, 1780, 2290, 2367, 2389, 2410, 2461, 2643, 3355, 3383, 3804, 4024, 4071], 'mammalian': [187, 297, 559, 2046, 2108, 2130, 2291, 2376, 2393], 'contain': [189, 209, 563, 1312, 1787, 3349], 'wide': [191], 'variety': [192, 402], 'acids,': [195], 'ranging': [196], 'length': [198], 'from': [199, 1372, 2995, 3038], 'C14': [200], 'C32,': [202], 'are': [204, 604, 756, 912, 1180, 1200, 1209, 1218, 1222, 1244, 1359, 1376, 1441, 1454, 1469, 2262, 2294, 2370, 2653, 3805, 3933, 3958, 3982, 4016, 4030, 4042], 'predominantly': [205], 'saturated': [206], 'can': [208], 'α-': [210], 'or': [211, 2024, 2501, 2636, 2676, 2751, 2760, 3369, 3379, 3525, 3596, 3975, 4046], 'ω-hydroxyl': [212], 'groups': [213], '(7van': [214], 'Meer': [215, 1014], 'G.': [216, 452, 1015, 1922], 'EMBO': [217, 525, 1045, 1992, 2353, 3895], '2005;': [219, 239, 373, 1296, 1708, 1842, 1994, 2226, 2324, 2355, 2511, 2573, 2895, 3022, 3556, 3735], '24:': [220, 1995, 2356], '3159-3165Crossref': [221], '(423)': [224], '8Merrill': [227], 'Sullards': [230, 1860, 2142, 2564], 'M.C.': [231, 1861, 2143, 2565], 'Allegood': [232, 1858, 1885, 2140, 2183, 2566, 3699, 3772], 'J.C.': [233, 520, 641, 1040, 1060, 1124, 1744, 1859, 1886, 2075, 2141, 2184, 2567, 3286, 3440, 3700, 3773], 'Kelly': [234, 2568], 'S.': [235, 536, 700, 928, 962, 980, 1626, 1634, 2270, 2277, 2318, 2419, 2569, 2608, 2911, 3144, 3272, 3278, 3321, 3325, 3335, 3426, 3432], 'Wang': [236, 1069, 1133, 1753, 1887, 2185, 2570, 3701, 3774], 'E.': [237, 721, 858, 926, 970, 1722, 1888, 2186, 2272, 2571, 2584, 3646, 3702, 3775], 'Methods.': [238, 2572], '36:': [240, 2574], '207-224Crossref': [241, 2575], '(484)': [244, 2578], 'Within': [247], 'past': [249], 'few': [250], 'years,': [251], 'there': [252, 1179, 1396, 3934], 'has': [253, 803, 1594, 1696, 2545, 2641, 2661, 2813], 'been': [254, 749, 780, 804, 1595, 1698, 2037, 2546, 2662, 2814, 3231], 'renewed': [255], 'interest': [256], 'functional': [259, 2105], 'significance': [260], 'this': [262, 267, 2363, 2543], 'variability,': [265], 'minireview': [268], 'will': [269, 290, 3502], 'focus': [270], 'on': [271, 882, 1266, 1443, 1456, 2755, 2761, 3084], 'current': [272], 'advances': [273], 'our': [275], 'understanding': [276, 3864], 'how': [278, 4041, 4047], 'regulated.': [286], 'In': [287, 1177, 1331, 3258, 3581], 'particular,': [288], 'we': [289, 4093], 'discuss': [291], 'recently': [293], 'discovered': [294], 'family': [295, 1416, 2056, 3843, 3964], 'synthase': [299, 4027, 4081], '(CerS)': [300], 'genes': [301, 576, 606, 778, 789, 957, 1184, 1199, 1308, 1350, 1406, 1440, 1471, 1529, 1679, 2110, 3493, 3591, 3632, 3696, 3845, 3919, 4077, 4099], 'emerging': [303], 'evidence': [304, 1399, 2102, 4068], 'specific': [306, 810, 2104, 2535, 2644, 3510, 3570, 3625], 'ceramides': [307, 2214, 2453, 2533, 2629, 2645, 3480, 3515, 3571, 3626, 3803, 3854], 'containing': [308, 2534, 2646, 3516], 'distinct': [309, 1212, 1255], 'acids': [311, 2537, 2652, 3519], 'play': [312], 'roles': [314, 2106, 3508], 'cell': [316, 2539, 2763, 3081, 3131, 3269, 3363, 3387, 3411, 3423, 3522], 'growth': [317, 3395, 3424], 'apoptosis.': [319], 'CerS': [320, 389, 430, 491, 718, 1107, 1119, 1820, 2017, 2315, 2340, 2484, 3642, 3973, 4012], 'acylates': [321], 'sphinganine': [322, 332], '(dihydrosphingosine)': [323], 'form': [325, 330, 1239], 'dihydroceramide': [326], 'sphingosine': [328, 342], 'ceramide;': [331], 'produced': [334], 'through': [335, 344, 920], 'de': [337, 989, 1637, 1642, 2678, 2920, 2949, 3039, 3097, 3153, 3226, 3820], 'novo': [338, 2679, 3040, 3227], 'biosynthetic': [339, 2495], 'mainly': [343, 564], 'SL': [345, 2494], 'degradation': [346, 2673], '9Futerman': [366], 'Riezman': [368, 541, 1703, 1806, 1856, 1990, 2138, 2351, 2506], 'H.': [369, 542, 1158, 1160, 1641, 1704, 1807, 1857, 1991, 2139, 2280, 2285, 2352, 2421, 2507, 2883, 2915, 2948, 3010, 3096, 3148, 3331, 3337], 'Trends': [370, 861, 1705, 1725, 2508], 'Cell': [371, 1019, 1706, 2509, 2613], '312-318Abstract': [375, 1710, 2513], '(270)': [383, 1718, 2521], 'Early': [386, 3636], 'studies': [387], 'detected': [388], 'activity': [390, 431, 1120, 2018, 2044, 2316, 2341, 3587, 3629, 4002, 4082], 'microsomal': [392], 'fractions,': [393], 'enzyme': [396], 'shown': [398, 499, 1596, 2172, 2312, 2663], 'utilize': [400, 2175], 'acyl-CoAs': [405], 'although': [406, 1775, 2254], 'some': [407, 1110, 2411, 3944], 'specificity': [408], 'toward': [409], 'certain': [410, 2658], 'CoAs': [411], 'recognized': [413], '(10Morell': [414], 'P.': [415, 1624, 1636, 2423, 3241], 'Radin': [416], 'N.S.': [417], '1970;': [421], '245:': [422], '342-350Abstract': [423], 'later': [433], 'localized': [434], 'cytoplasmic': [437], 'leaflet': [438], 'reticulum': [442], '(ER)': [443], '(11Mandon': [444, 1914], 'E.C.': [445, 1915], 'Ehses': [446, 1916], 'I.': [447, 512, 1032, 1058, 1122, 1742, 1917], 'Rother': [448, 1918], 'Van': [450, 1920], 'Echten': [451, 1921], 'Sandhoff': [453, 1923], 'K.': [454, 468, 824, 978, 1318, 1646, 1660, 1851, 1924, 1938, 2133, 3276, 3430, 3672], '1992;': [458, 932, 943, 1928, 1964], '267:': [459, 1929], '11144-11148Abstract': [460, 1930], '12Hirschberg': [467, 1937], 'Rodger': [469, 1939], 'Futerman': [471, 825, 1319, 1865, 1892, 1941, 2147, 2190, 2319, 3706, 3779], 'Biochem.': [473, 862, 1294, 1726, 1808, 1840, 1943, 2224, 2247, 2735], '1993;': [475, 1387, 1945], '290:': [476, 1946], '751-757Crossref': [477, 1947], '(164)': [480, 1950], 'The': [483, 669, 877, 901, 1236, 1250, 1367, 1412, 1436, 1677, 1687, 1815, 1972, 2012, 2043, 2100, 2459, 3838], 'clue': [485], 'molecular': [488], 'identity': [489], 'obtained': [493, 2112, 2307], 'yeast,': [495], 'when': [496, 2308, 4008], 'Lag1p': [501], 'Lac1p': [503], 'were': [504, 763, 1115, 2170, 3404], 'required': [505, 2015], 'for': [506, 574, 895, 956, 1106, 1825, 2016, 2103, 2397, 2532, 2542, 4034], 'synthesis': [508, 2261, 2399, 2451, 2680, 3041], 'C26-ceramide': [510], '(13Guillas': [511, 1031], 'Kirchman': [513, 642, 1033], 'P.A.': [514, 643, 1034, 2862, 3060], 'Chuard': [515, 1035, 1067, 1131, 1751], 'Pfefferli': [517, 1037], 'M.': [518, 645, 1038, 1630, 1632, 1656, 2063, 2582, 2772, 2778, 2780, 2856, 2946, 2971, 3054, 3094, 3198, 3323, 3644, 3668], 'Jiang': [519, 1039, 1059, 1123, 1743, 3285, 3439], 'Jazwinski': [521, 587, 648, 1041, 1071, 1135, 1755, 2076, 3287, 3441], 'S.M.': [522, 588, 649, 1042, 1072, 1136, 1756, 2077, 2612, 3288, 3442], 'Conzelmann': [523, 1043, 1073, 1137, 1757], '2001;': [527, 548, 1047, 2433, 2957, 3105, 3250], '20:': [528, 1048], '2655-2665Crossref': [529, 1049], '(228)': [532, 1052], '14Schorling': [535], 'Vallee': [537], 'B.': [538, 966, 1989, 2350, 2942, 3090, 3294, 3448], 'Barz': [539], 'W.P.': [540, 723], 'Oesterhelt': [543], 'D.': [544, 924, 1066, 1130, 1750, 2774], 'Mol.': [545, 1018, 2614], 'Cell.': [547, 3677], '12:': [549, 1670], '3417-3427Crossref': [550], '(230)': [553], '3In': [556], 'contrast': [557], 'cells,': [560, 3262], 'yeast': [561, 1095, 1283, 1362, 1782, 1973, 2348], 'C26-fatty': [565], 'acid.': [566], 'Lag1': [567, 744, 898, 1784, 1975], 'originally': [569], 'isolated': [570, 676], 'screen': [573, 639], 'longevity-related': [575], "(15D'Mello": [577], 'N.P.': [578], 'Childress': [579], 'A.M.': [580], 'Franklin': [581], 'D.S.': [582], 'Kale': [583], 'S.P.': [584], 'Pinswasdi': [585], 'C.': [586, 1062, 1064, 1126, 1128, 1746, 1748, 1853, 1884, 2069, 2135, 2182, 2275, 2944, 3092, 3698, 3771], '1994;': [592], '269:': [593], '15451-15459Abstract': [594], 'A': [601, 1304, 3172, 3389], 'paralog,': [602], '4Paralogs': [603, 1468], 'parallel': [605, 1470, 2753], 'same': [609, 618, 1458, 1474, 1483, 1518], 'species,': [610, 1475], 'ortholog': [613, 629, 1478, 1494], '(see': [614, 1479], 'below)': [615, 1480], 'gene': [619, 671, 680, 1484], 'different': [621, 1444, 1486, 3517, 3634, 4053], 'species;': [622, 1487], 'homolog': [623, 1488], 'term': [626, 1491], 'encompassing': [627, 1492], 'both': [628, 1493, 1500, 3582], 'paralog.': [631, 1496], 'Lac1,': [632, 1786, 1977], 'found': [634, 750, 781, 853, 891, 953, 1360, 2038], 'data': [637, 1828, 2040], '(16Jiang': [640], 'Zagulski': [644], 'Hunt': [646], 'Genome': [650], '1998;': [652, 2592, 3654], '8:': [653], '1259-1272Crossref': [654], '(29)': [657], 'along': [660], 'homologs': [662, 896, 2032], 'human,': [664], 'mouse,': [665, 761], 'Caenorhabditis': [667], 'elegans.': [668], 'Asc1': [670], 'tomato': [673], 'subsequently': [675, 2171], 'toxin-resistant': [679], '(17Brandwagt': [681], 'B.F.': [682], 'Mesbah': [683], 'L.A.': [684, 2728], 'Takken': [685], 'F.L.': [686], 'Laurent': [687], 'P.L.': [688], 'Kneppers': [689], 'T.J.': [690], 'Hille': [691], 'Nijkamp': [693], 'H.J.': [694], 'Proc.': [695], 'Natl.': [696], 'Acad.': [697, 2717], 'Sci.': [698, 863, 1727, 2718], 'U.': [699], '2000;': [702, 2719], '97:': [703], '4961-4966Crossref': [704], '(182)': [707], 'Scholar);': [709], 'among': [710], 'toxins': [712], 'tested': [713, 1114], 'fumonisin': [715], 'B1,': [716], 'inhibitor': [719], '(18Wang': [720], 'Norred': [722], 'Bacon': [724], 'C.W.': [725], 'Riley': [726], 'R.T.': [727], 'Merrill': [728, 1862, 1889, 2144, 2187, 3703, 3776], '1991;': [733], '266:': [734], '14486-14490Abstract': [735], 'Homologs': [742], 'Lac1': [746], 'have': [747, 779, 790, 1338, 1351, 2035, 2482, 3229, 3978], 'now': [748], 'most': [752, 2487], 'species.': [753, 3512], 'Six': [754], 'paralogs': [755], 'known': [757, 2118, 2392, 2402, 2526, 3618, 4109], 'human': [759, 1111, 1207, 1438, 1531], 'named': [764], 'Lass': [765, 788, 1307, 1365, 1405, 1678, 2047, 2109, 3492, 3590, 3631, 3695, 3918, 4005, 4076, 4098], '(longevity': [766], 'assurance)': [767], 'genes;': [768], 'all': [770, 1335, 2401, 4065], 'species': [771, 2465, 2808, 2820, 3382], 'studied': [772], 'date,': [774, 1534], 'at': [775, 1461, 1537, 2263, 3466, 3765], 'least': [776, 1538, 1823], 'two': [777, 883, 1254, 1508, 1539, 2502], 'every': [783], 'organism.': [784], 'All': [785, 1197, 1527], 'distinguishing': [792], 'motif': [793, 802], 'C-terminal': [796], 'portion': [797], 'protein.': [800], 'This': [801, 1270, 4089], 'defined': [805, 3482], 'narrow': [808], 'but': [809, 910, 1243, 1336, 1395, 1460, 1563, 2404, 2527, 3124], 'manner': [811, 841], 'Lag': [814], 'domain,': [815, 846, 1341, 1354], 'region': [817, 848], '∼50': [819], 'amino': [820], 'residues': [822, 851], '(19Venkataraman': [823, 1317], 'FEBS': [827, 1321], 'Lett.': [828, 1322], '528:': [830, 1324], '3-4Crossref': [831, 1325], '(57)': [834, 1328], 'broader': [840, 878], 'Tram-Lag-CLN8': [844], '(TLC)': [845], '∼200': [850], 'also': [852, 2447, 3119, 3230, 3358, 3398], 'other': [855, 1194, 1228, 1603, 2054, 2266, 2412, 2464, 2490, 3963, 4063], 'proteins': [856, 906, 1113, 1208, 1230, 1238, 1284, 1800, 1821, 1960, 2048, 2293, 2369, 2395, 3939, 3974, 4023], '(20Winter': [857], 'Ponting': [859, 1723], 'C.P.': [860, 1724], '27:': [865, 1729], '381-383Abstract': [866, 1730], '(144)': [874, 1738], 'definition': [879], 'based': [881], 'additional': [884, 1985], 'proteins,': [885, 1374, 1783, 2413], 'TRAM1': [886, 889, 1030], 'CLN8;': [888], 'search': [894], 'humans.': [900], 'exact': [902, 1688], 'function': [903, 3813, 3911], 'TRAM': [905, 1237], 'not': [908, 1104, 1697, 2036, 2525, 3125], 'known,': [909], 'they': [911, 3967, 3977, 3993, 4049], 'thought': [913], 'be': [915, 1428, 1598, 1608, 2020, 2051, 2408, 2665, 2748, 2817, 3359, 3535, 3600, 3951], 'involved': [916, 1429, 1609, 3385, 3806, 3846], 'polypeptide': [918], 'transition': [919], 'ER': [922, 1833, 2004], '(21Gorlich': [923], 'Hartmann': [925], 'Prehn': [927], 'Rapoport': [929], 'T.A.': [930, 941, 1962, 3284, 3438], '357:': [933], '47-52Crossref': [934], '(241)': [937], '22Rapoport': [940], 'Science.': [942, 1963], '258:': [944, 1965], '931-936Crossref': [945, 1966], '(279)': [948, 1969], 'CLN8': [951, 1056, 1225], 'by': [954, 1516, 1613, 2053, 2548, 2671, 3537, 3594], 'screening': [955], 'causing': [958], 'neuronal': [959], 'ceroid-lipofuscinosis': [960], '(23Ranta': [961], 'Zhang': [963, 2775], 'Y.': [964, 1156, 1289, 1293, 1835, 1839, 2219, 2223, 2242, 2246, 2586, 2588, 2716, 2730, 2881, 3008, 3327, 3648, 3650], 'Ross': [965], 'Lonka': [967], 'L.': [968, 2079, 2951, 3099, 3817], 'Takkunen': [969], 'Messer': [971], 'Sharp': [973], 'Wheeler': [975], 'Kusumi': [977], 'Mole': [979], 'Liu': [981], 'W.': [982, 3282, 3436], 'Soares': [983], 'M.B.': [984], 'Bonaldo': [985], 'M.F.': [986], 'Hirvasniemi': [987], 'la': [990, 3821], 'Chapelle': [991], 'Gilliam': [993], 'T.C.': [994], 'Lehesjoki': [995], 'A.E.': [996], 'Nat.': [997, 1016, 1667], 'Genet.': [998], '1999;': [999, 2788, 2842], '23:': [1000], '233-236Crossref': [1001], '(258)': [1004], 'inherited': [1008], 'metabolic': [1009], 'disorder': [1010], '(24Futerman': [1011], 'van': [1013, 1622, 1627], 'Rev.': [1017], '2004;': [1021, 2475, 3298, 3452, 3897], '5:': [1022, 3898], '554-565Crossref': [1023], '(655)': [1026], 'Both': [1029, 2745], '(25Guillas': [1057, 1121], 'Vionnet': [1061, 1125, 1745], 'Roubaty': [1063, 1127, 1747], 'Uldry': [1065, 1129, 1749], '2003;': [1078, 1142, 1762, 1897, 2195, 2616, 2872, 2926, 3070, 3159, 3341, 3711, 3784, 3830], '278:': [1079, 1143, 1763, 1898, 2196, 2927, 3160, 3712, 3785], '37083-37091Abstract': [1080, 1144, 1764], '(88)': [1088, 1152, 1772], 'failed': [1091], 'complement': [1093, 1118], 'Lag1/Lac1': [1096], 'knock-out,': [1097], 'suggesting': [1098, 3354], 'TLC': [1101, 1182, 1552, 2055, 3929, 3937], 'domain': [1102, 1316, 1369, 1403, 1421, 1547, 3930], 'sufficient': [1105], 'activity,': [1108], 'whereas': [1109, 2486, 3035, 3134], 'LASS': [1112, 1439, 1525, 1584, 2292, 2368, 2394, 4022, 4054], 'able': [1116, 3360], '26Yu': [1155], 'Lu': [1157, 2731], 'Pan': [1159], 'Ma': [1161], 'J.H.': [1162], 'Ding': [1163], 'Z.J.': [1164], 'Li': [1165], 'Y.Y.': [1166], 'Microbiol.': [1167], '2006;': [1169, 1669, 1810, 2087, 2249, 2737, 2983, 3210], '161:': [1170, 2476], '203-211Crossref': [1171], '(4)': [1174], 'humans': [1178, 1332], '16': [1181, 1198, 1206], 'domain-containing': [1183, 3938], '2):': [1186], 'six': [1187, 1193, 1437, 1528, 2391, 4097], 'LASSes,': [1188], 'three': [1189], 'TRAMs,': [1190], 'CLN8,': [1191], 'novel': [1195, 1229, 3604], 'genes.': [1196, 1366, 1526], 'conserved': [1201, 4045], 'mouse.': [1203], 'aligned,': [1210], 'four': [1211, 1348], 'branches': [1213], 'appear.': [1214], 'FAM57A': [1215], '-B': [1217], 'one': [1219, 1345, 1541, 1581, 2008, 2500, 2803], 'subgroup': [1220, 1242], 'closer': [1223, 1280], 'than': [1231, 1285, 2300, 4084], 'LASSes': [1233, 1251, 1264], 'TRAMs.': [1235], 'their': [1240, 1694, 3500, 4079, 4085, 4108], 'own': [1241, 1261], 'relatively': [1245, 2380, 2631], 'close': [1246], 'LASSes.': [1249], 'subdivide': [1252], 'into': [1253], 'groups,': [1256], 'LASS1': [1258, 1277, 1450, 2116, 3417], 'its': [1260], 'category': [1262], '2–6': [1265], 'separate': [1268], 'branch.': [1269], 'consistent': [1272, 1910, 3749], 'fact': [1275, 1413], 'much': [1279], 'others': [1287], '(27Mizutani': [1288, 1834, 2218], 'Kihara': [1290, 1836, 2220, 2243], 'Igarashi': [1292, 1838, 2222, 2245], '390:': [1297, 1843, 2227], '263-271Crossref': [1298, 1844, 2228], '(321)': [1301, 1847, 2231], 'subset': [1305, 2382], 'predicted': [1310, 2009], 'Homeobox': [1314], '(Hox)': [1315], 'mice,': [1334], 'Lass1': [1337], 'Hox': [1340, 1353, 1357, 1368, 1402, 1420, 1512], 'Drosophila': [1343], 'only': [1344, 2499, 3943], 'TLC-containing': [1349], 'no': [1356, 1398], 'domains': [1358, 1510, 1791], 'plant': [1364], 'derived': [1371, 2994, 3037], 'homeobox': [1373, 1546], 'sequence-specific': [1377], 'transcription': [1378, 1410], 'factors': [1379], '(28Gehring': [1383], 'W.J.': [1384], 'Gene': [1385], '(Amst.).': [1386], '135:': [1388], '215-221Crossref': [1389], '(97)': [1392], 'acts': [1407], 'factor.': [1411], 'many': [1415, 3936], 'members': [1417, 2057], 'lack': [1418], 'suggest': [1422], 'unlikely': [1426], 'catalytic': [1432], 'mechanism': [1433], 'CerS.': [1435, 3756], 'located': [1442, 1455], 'chromosomes': [1445], '(with': [1446], 'exception': [1448], '-4,': [1452], 'chromosome': [1459], 'distant': [1462], 'locations).': [1463], 'Human': [1464], 'mouse': [1466], 'orthologs': [1467], 'show': [1497], 'strong': [1498], 'similarity': [1499], 'sequence': [1502], 'genomic': [1504, 1575], 'structure,': [1505], '(i.e.': [1511], 'TLC)': [1514], 'encoded': [1515], 'relative': [1519], 'exon': [1520], 'each': [1522, 2375, 2710], '(except,': [1532], 'LASS3)': [1535], 'encode': [1536, 1682], 'isoforms,': [1540], 'lacks': [1544], 'part': [1549], 'domain;': [1553], 'relevance': [1555], 'these': [1557, 4043, 4061], 'short': [1558], 'isoforms': [1559, 1579, 2503], 'currently': [1561], 'unknown': [1562], 'may': [1564, 1607, 2019, 2446, 2747], 'imply': [1565], 'similar': [1566, 1954, 3173], 'mechanisms': [1567], 'transcriptional': [1569, 3595], 'regulation.': [1570], 'Fig.': [1571], '3': [1572], 'shows': [1573], 'organization': [1576], 'protein': [1578, 2006, 2377], 'genes,': [1585, 1974, 2485], 'namely': [1586], 'LASS2.': [1587], 'Recently,': [1588], 'splice': [1590, 3987], 'variant': [1591], 'LASS5': [1593, 2168, 2310], 'expressed': [1599, 3764], 'lymphoma': [1601], 'tumor': [1604, 1611, 2999, 3261], 'cells': [1605, 2131, 3052, 3086, 3123, 3183, 3237, 3319], 'recognition': [1612], 'immune': [1615], 'system': [1616], '(29van': [1617], 'Hall': [1618], 'T.': [1619, 2061, 2864, 3062, 3239, 3329, 3333], 'Wolpert': [1620], 'Veelen': [1623], 'Laban': [1625], 'der': [1628], 'Veer': [1629], 'Roseboom': [1631], 'Bres': [1633], 'Grufman': [1635], 'Ru': [1638], 'Meiring': [1640], 'Jong': [1643], 'Franken': [1645], 'Teixeira': [1647], 'Valentijn': [1649], 'Drijfhout': [1651], 'J.W.': [1652, 2917, 3150], 'Koning': [1653], 'F.': [1654, 1658], 'Camps': [1655], 'Ossendorp': [1657], 'Karre': [1659], 'Ljunggren': [1661], 'H.G.': [1662], 'Melief': [1663], 'C.J.': [1664], 'Offringa': [1665], 'Med.': [1668], '417-424Crossref': [1671], '(132)': [1674], 'appear': [1680], 'multi-transmembrane': [1683], '(TM)': [1684], 'spanning': [1685], 'proteins.': [1686], 'number': [1689], 'TM': [1691, 1790, 2010], 'domains,': [1692], 'topology,': [1695], 'resolved': [1699], 'experimentally': [1700, 3498], '(9Futerman': [1701, 2504], '20Winter': [1721], '25Guillas': [1741], 'recent': [1777], 'study': [1778], 'suggested': [1779, 2815, 3399], 'eight': [1788], 'putative': [1789], 'N': [1794], 'C': [1796], 'termini': [1797], 'facing': [1801], 'cytoplasm': [1803], '(30Kageyama-Yahara': [1804], 'N.': [1805, 2715, 2776], '(in': [1811, 2250], 'press)PubMed': [1812, 2251], 'subcellular': [1816], 'location': [1817, 1957], '(at': [1822], 'those': [1824], 'experimental': [1827], 'available)': [1830], '31Venkataraman': [1850], 'Riebeling': [1852, 2134], 'Bodennec': [1854, 2136], '35642-35649Abstract': [1872, 2154], '(240)': [1880, 2162], '32Riebeling': [1883], '43452-43459Abstract': [1899, 2197, 3713, 3786], '(252)': [1907, 2205, 3721, 3794], 'earlier': [1912], 'observations': [1913], 'Tram': [1959], '(22Rapoport': [1961], 'act': [1978, 3968, 3994], 'obligate': [1981], 'complex': [1982, 2346], 'protein,': [1986], 'Lip1': [1987, 2013, 2034], '(33Vallee': [1988, 2349], '730-741Crossref': [1996, 2357], '(122)': [1999, 2360], 'integral': [2003], 'membrane': [2005, 2023, 3531], 'domain.': [2011], 'regions': [2014, 4019, 4032, 4044], 'lumen': [2027], 'ER.': [2030], 'Mammalian': [2031], 'searches.': [2042], 'might': [2049, 3357, 3514, 3992], 'conceivably': [2050], 'regulated': [2052], '(34Schulz': [2058], 'Mousallem': [2060], 'Venkataramani': [2062], 'Persaud-Sawin': [2064], 'D.A.': [2065, 2891, 3018], 'Zucker': [2066], 'Luberto': [2068, 2943, 3091], 'Bielawska': [2070, 2426], 'Bielawski': [2072, 2884, 3011, 3279, 3433], 'Holthuis': [2074], 'Kozhaya': [2078], 'Dbaibo': [2080], 'G.S.': [2081], 'Boustany': [2082], 'R.M.': [2083], '281:': [2088], '2784-2794Abstract': [2089], '(67)': [2097], 'upon': [2113, 3521], 'overexpression': [2114, 3415], '(formerly': [2117], 'UOG1),': [2120], 'resulted': [2122], 'selective': [2125], 'increase': [2126], 'C18-ceramide': [2128, 2260, 3393, 3403, 3419], '(31Venkataraman': [2132], 'LASS4': [2165], '(TRH1)': [2166], '(TRH4)': [2169], 'selectively': [2174], 'C18/20': [2176], 'C16': [2178], 'acyl-CoAs,': [2179], 'respectively': [2180], '(32Riebeling': [2181, 3697, 3770], 'LASS6': [2208], 'produce': [2210, 2237], 'shorter': [2211], 'acyl': [2212, 3801], '(C14': [2215], 'C16)': [2217], 'LASS3': [2235], 'C18-': [2238], 'C24-ceramides': [2240], '(35Mizutani': [2241], 'surprisingly': [2256], 'high': [2257, 3350, 3766], 'levels': [2258, 3223, 3351, 3401, 3420, 3623, 3752, 3767], 'variance': [2264], 'analyses.': [2267], '5I.': [2268], 'Pankova-Kholmyansky,': [2269], 'Epstein,': [2271], 'Wang,': [2273], 'Allegood,': [2276], 'Kelly,': [2278], 'Merrill,': [2281], 'Futerman,': [2286], 'unpublished': [2287], 'observations.': [2288], 'Verification': [2289], 'bona': [2295], 'fide': [2296], 'synthases,': [2298, 2305, 2373], 'rather': [2299, 4083], 'regulators': [2301, 3970], 'endogenous': [2303], 'purified': [2309, 2344], 'possess': [2314], '(36Lahiri': [2317], '280:': [2325, 2896, 3023], '33735-33738Abstract': [2326], '(105)': [2334], 'Together': [2337], 'Lag1-Lac1-Lip1': [2345], 'supports': [2364], 'concept': [2366], 'genuine': [2371, 3954], 'utilizing': [2378], 'restricted': [2381, 2455, 2648, 3691], 'acyl-CoAs.': [2385], 'It': [2386, 3365], 'assumed': [2388], 'account': [2396], 'ceramides,': [2403], 'possibility': [2406, 3496], 'cannot': [2407], 'excluded': [2409], 'such': [2414, 2466, 3263], 'ceramidases': [2416], '(37El': [2417], 'Bawab': [2418], 'Birbes': [2420], 'Roddy': [2422], 'Szulc': [2424], 'Z.M.': [2425], 'Hannun': [2428, 2733, 2888, 2918, 2952, 3015, 3100, 3151, 3289, 3443, 3893], '276:': [2434, 2958, 3106], '16758-16766Abstract': [2435], '(64)': [2443], 'contribute': [2448], 'composition.': [2458], 'reason': [2460], 'mammals': [2462], '(and': [2463], 'plants': [2468], '(38Lynch': [2469], 'D.V.': [2470], 'Dunn': [2471], 'T.M.': [2472], 'New': [2473], 'Phytol.': [2474], '677-702Crossref': [2477], '(199)': [2479], 'Scholar))': [2481], 'multiple': [2483, 3751], 'enzymes': [2491], 'exist': [2497], 'implies': [2528, 4070], 'role': [2531, 3391, 3477, 3926, 4086], 'physiology.': [2540], 'Support': [2541], 'notion': [2544], 'provided': [2547], 'new': [2552, 3861], 'analytical': [2556], 'techniques,': [2557], 'particularly': [2558], 'mass': [2559], 'spectrometry': [2560], '(8Merrill': [2561], '39Yano': [2581], 'Kishida': [2583, 3645], 'Muneyuki': [2585, 3647], 'Masuzawa': [2587, 3649], '39:': [2593, 3655], '2091-2098Abstract': [2594, 3656], '40Esch': [2603], 'S.W.': [2604], 'Williams': [2605], 'T.D.': [2606], 'Biswas': [2607], 'Chakrabarty': [2609], 'Levine': [2611], '49:': [2617], '779-787PubMed': [2618], 'enabling': [2621], 'analysis': [2622, 2640], 'using': [2630], 'small': [2632], 'amounts': [2633], 'tissue': [2635, 3692], 'cells.': [2637, 3635], 'Mass': [2638], 'spectrometric': [2639], 'revealed': [2642], 'set': [2649], 'generated': [2654, 2666], 'response': [2656], 'stimuli.': [2659], 'pathways': [2670, 2746], 'either': [2672], 'sphingomyelin': [2675], '(3Hannun': [2681, 3871], 'kinetics': [2703], 'appearance': [2705], 'biochemical': [2707], 'functionality': [2708], 'differing': [2711], '(41Perry': [2712], 'D.K.': [2713], 'Ann.': [2714], '905:': [2720], '91-96Crossref': [2721], '(39)': [2724, 3745], '42Cowart': [2727], 'Okamoto': [2729], 'X.': [2732], '393:': [2738], '733-740Crossref': [2739], '(38)': [2742], 'activated': [2749], 'separately': [2750], 'depending': [2754], 'kind': [2757], 'stress': [2759], 'type': [2764], '(43Liao': [2765], 'W.C.': [2766], 'Haimovitz-Friedman': [2767, 3669], 'Persaud': [2769], 'R.S.': [2770], 'McLoughlin': [2771], 'Ehleiter': [2773], 'Gatei': [2777], 'Lavin': [2779], 'Kolesnick': [2781, 3675], 'Fuks': [2783, 3673], 'Z.': [2784, 3674, 3725], '274:': [2789, 2843], '17908-17917Abstract': [2790], '(102)': [2798], 'C16-ceramide': [2801, 3036, 3135, 3186, 3356], 'non-neuronal': [2810], 'tissues': [2811], 'predominant': [2819], 'elevated': [2821, 3043, 3137, 3188], 'during': [2822, 2998, 3079], 'apoptosis': [2823, 3003, 3047], 'under': [2824], 'broad': [2826], 'spectrum': [2827], 'stimuli': [2829], '(44Thomas': [2830], 'R.L.': [2832], 'Matsko': [2833], 'C.M.': [2834], 'Lotze': [2835, 2867, 2976, 3065, 3203, 3244], 'M.T.': [2836, 2868, 2977, 3066, 3204, 3245], 'Amoscato': [2837, 2869, 2978, 3067, 3205, 3246], 'A.A.': [2838, 2870, 2979, 3068, 3206, 3247], '30580-30588Abstract': [2844], '(137)': [2852], '45Eto': [2855], 'Bennouna': [2857, 2972, 3055, 3199], 'Hunter': [2859, 2974, 3057, 3201, 3242], 'O.C.': [2860, 2975, 3058, 3202, 3243], 'Hershberger': [2861, 3059], 'Kanto': [2863, 3061], 'Johnson': [2865, 3063], 'C.S.': [2866, 3064], 'Prostate.': [2871, 3069], '57:': [2873, 3071], '66-79Crossref': [2874, 3072], '(45)': [2877, 3075], '46Osawa': [2880], 'Uchinami': [2882, 3009], 'Schwabe': [2886, 3013], 'R.F.': [2887, 3014], 'Brenner': [2890, 3017], '27879-27887Abstract': [2897, 3024], '(188)': [2905, 3032], '47Kroesen': [2908], 'B.J.': [2909, 2913, 2940, 3088, 3142, 3146], 'Jacobs': [2910, 3143], 'Pettus': [2912, 2941, 3089, 3145], 'Sietsma': [2914, 2947, 3095, 3147], 'Kok': [2916, 3149], 'Leij': [2921, 2950, 3098, 3154], 'L.F.': [2922, 3155], '14723-14731Abstract': [2928, 3161], '(93)': [2936, 3169], '48Kroesen': [2939], 'Busman': [2945, 3093], '13606-13614Abstract': [2959, 3107], '(147)': [2967, 3115], '49Eto': [2970], 'Int.': [2980, 3207, 3338], 'Urol.': [2982, 3209], '13:': [2984, 3211], '148-156Crossref': [2985, 3212], '(36)': [2988, 3215], 'For': [2991, 3757, 3921], 'instance,': [2992, 3758, 3922], 'C16-ceramide,': [2993, 3353], 'sphingomyelin,': [2996], 'increases': [2997, 3120], 'necrosis': [3000], 'factor': [3001], 'α-induced': [3002], 'primary': [3005], 'hepatocytes': [3006], '(46Osawa': [3007], 'androgen': [3045], 'ablation-induced': [3046], 'LNCaP': [3049], 'prostate': [3050, 3181], 'cancer': [3051, 3182], '(45Eto': [3053], 'B': [3080, 3130], 'receptor': [3082, 3132], 'engagement': [3083], 'Ramos': [3085, 3122], '(48Kroesen': [3087], 'C24-ceramide': [3118, 3193, 3222, 3378], 'until': [3126], '24': [3127, 3190], 'h': [3128, 3140, 3191, 3196], 'after': [3129, 3138, 3189, 3194], 'engagement,': [3133], '6': [3139], '(47Kroesen': [3141], 'temporal': [3174], 'pattern': [3175], 'observed': [3177, 3232], 'androgen-insensitive': [3179], 'DU145': [3180], '48': [3195], '(49Eto': [3197], 'Changes': [3218], 'C16-': [3220], 'bone': [3234], 'marrow-derived': [3235], 'dendritic': [3236], '(50Kanto': [3238], 'Kalinski': [3240], 'Immunol.': [3249], '167:': [3251], '3773-3784Crossref': [3252], '(86)': [3255], 'apparent': [3259], 'contrast,': [3260], 'head': [3265, 3407], 'neck': [3267, 3409], 'squamous': [3268, 3410], 'carcinoma': [3270, 3318, 3412], '(51Koybasi': [3271, 3425], 'Senkal': [3273, 3427], 'C.E.': [3274, 3428], 'Sundararaj': [3275, 3429], 'Spassieva': [3277, 3431], 'Osta': [3281, 3435], 'Day': [3283, 3437], 'Ogretmen': [3293, 3447], '279:': [3299, 3453], '44311-44319Abstract': [3300, 3454], '(191)': [3308, 3462], 'Sarcoma': [3311], '180,': [3312], 'B16': [3313], 'melanoma,': [3314], 'Lewis': [3316], 'lung': [3317], '(52Koyanagi': [3320], 'Kuga': [3322], 'Soeda': [3324], 'Hosoda': [3326], 'Yokomatsu': [3328], 'Takechi': [3330], 'Akiyama': [3332], 'Shibuya': [3334], 'Shimeno': [3336], 'Cancer.': [3340], '105:': [3342], '1-6Crossref': [3343], '(28)': [3346], 'promote': [3362], 'growth.': [3364], 'therefore': [3367], 'notclearifC16-ceramideispro-apoptotic,': [3368], 'alternatively,': [3370], 'whether': [3371], 'delayed': [3375], 'elevation': [3376], 'another': [3380], 'death.': [3388], 'possible': [3390], 'arrest': [3396], 'because': [3400], 'decreased': [3405], 'samples,': [3413], 'increased': [3418], 'inhibited': [3422], 'Thus,': [3465], 'present,': [3467], 'difficult': [3470], 'draw': [3472], 'definitive': [3473], 'conclusions': [3474], 'concerning': [3475, 3909], 'particular': [3479], 'physiological': [3483], 'pathophysiological': [3485], 'events.': [3486], 'However,': [3487, 3614], 'availability': [3489], 'manipulate': [3499], 'expression,': [3501], 'permit': [3503], 'dissection': [3504], 'precise': [3507], 'How': [3513], 'impact': [3520], 'physiology?': [3523], 'One': [3524], 'biophysical': [3527], 'properties': [3528], 'lipid': [3532], 'bilayer': [3533], 'could': [3534, 3572], 'influenced': [3536], '(53Sot': [3544], 'Aranda': [3546], 'F.J.': [3547], 'Collado': [3548], 'M.I.': [3549], 'Goni': [3550], 'F.M.': [3551], 'Alonso': [3552], 'Biophys.': [3554], '88:': [3557], '3368-3380Abstract': [3558], '(100)': [3566], 'Alternatively,': [3569], 'directly': [3573], 'interact': [3574], 'downstream': [3576], 'components': [3577], 'pathways.': [3580], 'scenarios,': [3583], 'regulation': [3584, 3754, 3915], '(for': [3592], 'instance': [3593], 'post-translational': [3597, 3639], 'mechanisms)': [3598], 'would': [3599], 'mode': [3605, 3913], 'controlling': [3607], 'ceramides.': [3613], 'very': [3615, 3799], 'little': [3616], 'about': [3619], 'relationship': [3621], 'between': [3622, 4051], 'work': [3637], 'implied': [3638], 'modification': [3640], '(39Yano': [3643], '54Bose': [3665], 'Verheij': [3667], 'Scotto': [3671], '1995;': [3678], '82:': [3679], '405-414Abstract': [3680], '(794)': [3686], 'distribution': [3693], '55Xu': [3724], 'Zhou': [3726], 'McCoy': [3728], 'D.M.': [3729], 'Mallampalli': [3730], 'R.K.': [3731], '46:': [3736], '1229-1238Abstract': [3737], 'mRNA': [3760], 'Lass3': [3762], 'skin': [3769, 3815], 'contains': [3798], 'maintaining': [3808], 'water': [3810], 'permeability': [3811], 'barrier': [3812], '(56Coderch': [3816], 'Lopez': [3818], 'O.': [3819], 'Maza': [3822], 'Parra': [3824], 'J.L.': [3825], 'Am.': [3826], 'Dermatol.': [3829], '4:': [3831], '107-129Crossref': [3832], '(286)': [3835], 'unexpected': [3839], 'discovery': [3840], 'regulating': [3848], 'likely': [3856], 'lead': [3858], 'level': [3862], 'complexity': [3867], 'biology': [3870], '57Futerman': [3891], 'Rep.': [3896], '777-782Crossref': [3899], '(549)': [3902], 'Many': [3905], 'open': [3906], 'questions': [3907], 'remain': [3908], 'themselves.': [3920], 'what': [3923], 'why': [3932], 'so': [3935], '2)': [3941], 'appearing': [3945], 'meet': [3947], 'criteria': [3949], 'characterized': [3952], 'synthases?': [3956], 'What': [3957, 3981, 4015, 4029], 'functions': [3960, 3984], 'members?': [3965], 'Do': [3966], 'do': [3976, 4009, 4048], 'unrelated': [3979], 'functions?': [3980], 'variants': [3988], '3)': [3990], 'dominant-negative': [3997], 'fashion': [3998], 'modify': [4000], 'full-length': [4004], 'genes?': [4006], 'Finally,': [4007], 'Lasses': [4010], 'become': [4011], '4)?': [4014], 'critical': [4018], 'confer': [4025], 'activity?': [4028], 'responsible': [4033], 'acyl-CoA': [4035], 'selectivity': [4039], 'differ': [4050], 'proteins?': [4055], 'Irrespective': [4056], 'answers': [4059], 'questions,': [4064], 'available': [4067], 'strongly': [4069], 'attribute': [4074], 'longevity.': [4088], 'being': [4090], 'case,': [4092], 'propose': [4094], 'renaming': [4095], 'CerS1–6': [4101], '4),': [4103], 'accurately': [4106], 'reflect': [4107], 'function.': [4110]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1990115856', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 19}, {'year': 2014, 'cited_by_count': 26}, {'year': 2013, 'cited_by_count': 39}, {'year': 2012, 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