Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1989861182', 'doi': 'https://doi.org/10.1006/jmcc.1996.0091', 'title': 'Polymyxin B, a Protein Kinase C Inhibitor, Abolishes Preconditioning-induced Protection against Contractile Dysfunction in the Isolated Blood Perfused Rat Heart', 'display_name': 'Polymyxin B, a Protein Kinase C Inhibitor, Abolishes Preconditioning-induced Protection against Contractile Dysfunction in the Isolated Blood Perfused Rat Heart', 'publication_year': 1996, 'publication_date': '1996-05-01', 'ids': {'openalex': 'https://openalex.org/W1989861182', 'doi': 'https://doi.org/10.1006/jmcc.1996.0091', 'mag': '1989861182', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8762036'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1006/jmcc.1996.0091', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111163638', 'display_name': 'Journal of Molecular and Cellular Cardiology', 'issn_l': '0022-2828', 'issn': ['0022-2828', '1095-8584'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1006/jmcc.1996.0091', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109190572', 'display_name': 'Alison Cave', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1298207432', 'display_name': "Guy's Hospital", 'ror': 'https://ror.org/04r33pf22', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1298207432', 'https://openalex.org/I200166805', 'https://openalex.org/I4210111135']}, {'id': 'https://openalex.org/I111088046', 'display_name': 'Boston University', 'ror': 'https://ror.org/05qwgg493', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111088046']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Alison C. Cave', 'raw_affiliation_strings': ['Cardiac Muscle Research Laboratory, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA', "Division of Radiological Sciences, 18th Floor of the Guy's Tower, Guy's Hospital, London, SE1 9RT, UK."], 'affiliations': [{'raw_affiliation_string': "Division of Radiological Sciences, 18th Floor of the Guy's Tower, Guy's Hospital, London, SE1 9RT, UK.", 'institution_ids': ['https://openalex.org/I1298207432']}, {'raw_affiliation_string': 'Cardiac Muscle Research Laboratory, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA', 'institution_ids': ['https://openalex.org/I111088046']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090004654', 'display_name': 'Carl S. Apstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111088046', 'display_name': 'Boston University', 'ror': 'https://ror.org/05qwgg493', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111088046']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carl S. Apstein', 'raw_affiliation_strings': ['Cardiac Muscle Research Laboratory, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA'], 'affiliations': [{'raw_affiliation_string': 'Cardiac Muscle Research Laboratory, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA', 'institution_ids': ['https://openalex.org/I111088046']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3550, 'currency': 'USD', 'value_usd': 3550, 'provenance': 'doaj'}, 'apc_paid': {'value': 3550, 'currency': 'USD', 'value_usd': 3550, 'provenance': 'doaj'}, 'fwci': 3.393, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.604796, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '28', 'issue': '5', 'first_page': '977', 'last_page': '987'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9873, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10645', 'display_name': 'Cardiac Arrest and Resuscitation', 'score': 0.9821, 'subfield': {'id': 'https://openalex.org/subfields/2711', 'display_name': 'Emergency Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/polymyxin-b', 'display_name': 'Polymyxin B', 'score': 0.62815773}, {'id': 'https://openalex.org/keywords/creatine-kinase', 'display_name': 'Creatine kinase', 'score': 0.6000055}], 'concepts': [{'id': 'https://openalex.org/C146957229', 'wikidata': 'https://www.wikidata.org/wiki/Q1266915', 'display_name': 'Perfusion', 'level': 2, 'score': 0.67806864}, {'id': 'https://openalex.org/C2780026444', 'wikidata': 'https://www.wikidata.org/wiki/Q1088175', 'display_name': 'Polymyxin B', 'level': 3, 'score': 0.62815773}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.6141949}, {'id': 'https://openalex.org/C36880943', 'wikidata': 'https://www.wikidata.org/wiki/Q409458', 'display_name': 'Creatine kinase', 'level': 2, 'score': 0.6000055}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.5249229}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.44964185}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36908212}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36300185}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.35027248}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.34651107}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28308973}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015428', 'descriptor_name': 'Myocardial Reperfusion Injury', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D011113', 'descriptor_name': 'Polymyxins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015428', 'descriptor_name': 'Myocardial Reperfusion Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010101', 'descriptor_name': 'Oxygen Consumption', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011113', 'descriptor_name': 'Polymyxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1006/jmcc.1996.0091', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111163638', 'display_name': 'Journal of Molecular and Cellular Cardiology', 'issn_l': '0022-2828', 'issn': ['0022-2828', '1095-8584'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8762036', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1006/jmcc.1996.0091', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111163638', 'display_name': 'Journal of Molecular and Cellular Cardiology', 'issn_l': '0022-2828', 'issn': ['0022-2828', '1095-8584'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 1, 'referenced_works': ['https://openalex.org/W2146217294'], 'related_works': ['https://openalex.org/W2410295749', 'https://openalex.org/W2377778079', 'https://openalex.org/W2353218647', 'https://openalex.org/W2133219962', 'https://openalex.org/W2024170705', 'https://openalex.org/W2013175365', 'https://openalex.org/W2003179917', 'https://openalex.org/W2001668713', 'https://openalex.org/W1967839773', 'https://openalex.org/W1582753616'], 'abstract_inverted_index': {'The': [0], 'aims': [1], 'of': [2, 11, 26, 30, 81, 90, 93, 98, 106, 109, 120, 125, 151, 167, 178, 193, 202, 208, 215, 239, 242, 270, 285, 289, 292, 306, 325, 332], 'this': [3, 46, 154], 'study': [4], 'were': [5, 61, 114, 140, 162], '(1)': [6, 76], 'to': [7, 34, 49, 117, 211, 245, 264, 302, 315, 319, 322], 'determine': [8, 35, 143], 'the': [9, 24, 149, 156, 165, 186, 206, 224, 237, 240, 254, 275, 283, 307, 323], 'characteristics': [10], 'preconditioning': [12, 44, 152, 308], 'against': [13, 231, 260, 327], 'contractile': [14, 194, 212, 232, 246, 261, 328], 'dysfunction': [15, 235, 262], 'in': [16, 23, 43, 45, 148, 153, 164, 185, 223, 253, 282], 'a': [17, 27, 77, 86, 172, 200, 268, 286], 'blood': [18, 55], 'perfused': [19, 56, 62], 'isolated': [20, 53], 'heart': [21], 'model': [22], 'presence': [25, 166, 284], 'physiologic': [28, 287], 'combination': [29, 288], 'substrates,': [31], 'and': [32, 67, 73, 95, 102, 122, 136, 158, 183, 189, 205, 233, 236, 274, 279, 310], '(2)': [33, 85], 'if': [36, 144], 'protein': [37], 'kinase': [38, 138], 'C': [39], '(PKC)': [40], 'is': [41, 146, 280, 311], 'involved': [42, 147], 'model.In': [47], 'order': [48], 'investigate': [50], 'these': [51], 'aims,': [52], 'isovolumic,': [54], 'rat': [57], 'hearts': [58, 113], '(balloon-in-LV,': [59], 'n=6/group)': [60], 'normoxically': [63], 'for': [64], '30': [65, 79, 118, 123], 'min': [66, 80, 89, 92, 97, 105, 108, 119, 124], 'then': [68, 115], 'divided': [69], 'into': [70], 'three': [71], 'groups': [72], 'subjected': [74, 116], 'to:': [75], 'further': [78, 87], 'perfusion': [82], '(control': [83], 'group)': [84, 101], '20': [88], 'perfusion+5': [91], 'ischaemia': [94, 121], '5': [96], 'reperfusion': [99], '(1×preconditioned': [100], '(3)': [103], '3×(5': [104], 'ischaemia+5': [107], 'reperfusion)': [110], '(3×preconditioned': [111], 'group).All': [112], 'reperfusion.Contractile': [126], 'function,': [127], 'myocardial': [128], 'oxygen': [129], 'consumption': [130], '(MVO': [131], '2': [132, 210, 244], '),': [133], 'lactate': [134, 218, 299], 'release': [135, 139, 219, 248], 'creatine': [137], 'all': [141], 'assessed.To': [142], 'PKC': [145, 175], 'mechanism': [150, 324], 'model,': [155], 'control': [157], '3×preconditioned': [159, 190, 225], 'group': [160], 'experiments': [161], 'repeated': [163], 'polymyxin': [168, 255, 333], 'B': [169, 227, 334], '(50': [170], '\uf76d),': [171], 'relatively': [173], 'specific': [174], 'inhibitor.Final': [176], 'recovery': [177], 'LVDP': [179], 'was': [180, 196, 220, 249], '31±12,': [181], '67±6': [182], '60±5%': [184], 'control,': [187], '1×': [188], 'groups,': [191], 'respectively.Protection': [192], 'function': [195, 204, 213, 273], 'accompanied': [197, 266], 'by': [198, 267, 298], 'both': [199, 271], 'preservation': [201, 269], 'diastolic': [203, 234, 272], 'ratio': [207, 241], 'MVO': [209, 243], '(ratio': [214], 'metabolic:mechanical': [216], 'efficiency).However,': [217], 'decreased': [221], 'only': [222], 'group.Polymyxin': [226], 'abolished': [228, 335], 'preconditioning-induced': [229, 258], 'protection': [230, 238, 259, 326], 'function.Lactate': [247], 'still': [250], 'however': [251], 'reduced': [252], 'B-preconditioned': [256], 'group.Thus,': [257], 'appears': [263, 301, 318], 'be': [265, 303, 320], 'metabolic:': [276], 'mechanical': [277], 'efficiency': [278], 'effective': [281], 'substrates.However,': [290], 'limitation': [291], 'glycolysis': [293], 'during': [294], 'ischaemia,': [295], 'as': [296], 'assessed': [297], 'release,': [300], 'an': [304], 'epiphenomenon': [305], 'protocol': [309], 'not': [312], 'consistently': [313], 'related': [314], 'protection.PKC': [316], 'activation': [317], 'pivotal': [321], 'dysfunction,': [329], 'since': [330], 'administration': [331], 'any': [336], 'protection.': [337]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1989861182', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-18T04:19:36.332277', 'created_date': '2016-06-24'}