Apocalmodulin and Ca2+-Calmodulin Bind to Neighboring Locations on the Ryanodine Receptor

Name: Work Video:
Duration: 3 min 30 s
Montserrat Samsó; Terence Wagenknecht
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4451, 4468, 4653, 4676, 4686, 4699, 4775, 4880], 'presence': [18, 143, 1306, 2010, 2075], 'Ca2+,': [20, 145, 3472, 3515], 'regulates': [22, 147], 'activity': [24, 28, 149, 153, 673, 1401], 'by': [29, 154, 292, 451, 588, 600, 776, 828, 1523, 1626, 2332, 2482, 2659, 2774, 3048, 3257, 3277, 3514, 3549, 3635, 3768, 3805, 4138, 4344, 4449, 4649], 'activating': [30, 155, 3501], 'inhibiting': [32, 157, 3493], 'it,': [33, 158], 'respectively.': [34, 159], 'Using': [35, 160], 'cryo-electron': [36, 161], 'microscopy': [37, 162, 1264, 1636, 1667, 4889], 'three-dimensional': [39, 164, 1273, 1300, 1735, 1829, 1881, 2171, 2386, 2413, 2416, 2506, 2515, 2988, 3551], 'reconstruction,': [40, 165], 'we': [41, 166, 1293, 1434, 2356, 2525, 3192, 3926, 4587, 4881], 'found': [42, 70, 167, 195, 1345, 2357, 2580, 3083, 3193, 3745, 4642], 'that': [43, 92, 168, 217, 367, 432, 961, 1055, 1234, 1257, 1436, 1942, 1965, 2072, 2107, 2123, 2158, 2358, 2397, 2472, 2527, 2794, 2814, 3017, 3191, 3209, 3271, 3322, 3660, 3746, 3794, 3872, 4135, 4145, 4167, 4297, 4386, 4496, 4569, 4598, 4791, 4800], 'one': [44, 169, 278, 619, 1067, 2347, 3023, 3028, 3284, 3775, 3795, 4257, 4351], 'apoCaM': [45, 100, 170, 225, 622, 1065, 1260, 1317, 1344, 2166, 2179, 2296, 2344, 2348, 2483, 2538, 2575, 2675, 2702, 2798, 3032, 3093, 3152, 3220, 3250, 3620, 3750, 3807, 3865, 3919, 4037, 4130, 4170, 4188, 4388, 4774], 'per': [47, 172, 623, 629, 1061, 2349], 'RyR1': [48, 173, 411, 447, 488, 584, 599, 614, 624, 631, 1080, 1278, 1303, 1427, 1475, 1529, 1581, 1706, 1741, 1832, 1872, 2103, 2174, 2291, 2350, 2432, 2468, 2480, 2514, 2614, 2639, 2742, 2766, 2824, 2849, 3019, 3077, 3129, 3242, 3269, 3316, 3467, 3488, 3511, 3554, 3681, 3802, 4035, 4074, 4119, 4148, 4368, 4467, 4504, 4568, 4593, 4615, 4790], 'subunit': [49, 174, 625, 1062, 1410, 3020, 3078, 4366], 'along': [50, 175, 3263], 'sides': [52, 177, 2760], 'cytoplasmic': [55, 180, 284, 2196, 2334, 2763, 3964, 4549], 'assembly': [56, 181, 2197, 2764], 'receptor.': [59, 184], 'This': [60, 185, 404, 2545, 2810], 'location': [61, 69, 186, 194, 1357, 2573, 2578, 4591, 4681], 'is': [62, 187, 405, 449, 489, 585, 602, 836, 1240, 1243, 1349, 1966, 2087, 2155, 2297, 2471, 2631, 2811, 3194, 3275, 3323, 3469, 3623, 3645, 3662, 4171, 4342], 'distinct': [63, 188, 1350, 2625, 3157, 3862, 3884, 4771], 'from': [64, 189, 298, 421, 1351, 1504, 1517, 1749, 2106, 2266, 2510, 2534, 2643, 3046, 3650, 3774, 3952, 3962, 4118], 'but': [65, 190, 697, 1242, 1352, 2460, 3158, 4608, 4770], 'close': [66, 191, 1353, 3916], 'for': [71, 77, 107, 117, 196, 202, 232, 242, 289, 410, 572, 863, 964, 1064, 1068, 1343, 1358, 1399, 1599, 1705, 1710, 1740, 1745, 1871, 1876, 2581, 2839, 3212, 3538, 3640, 3789, 3860, 3864, 3886, 3901, 3942, 4036, 4168, 4186, 4193, 4773, 4877, 4884], 'Ca2+-CaM,': [72, 197, 2718, 3402, 4139], 'providing': [73, 198], 'a': [74, 104, 114, 199, 229, 239, 383, 388, 416, 428, 454, 543, 616, 1073, 1231, 1397, 1407, 1421, 1574, 1671, 1687, 1715, 1720, 1855, 1902, 1940, 1975, 2025, 2078, 2092, 2112, 2193, 2203, 2274, 2284, 2363, 2422, 2555, 2826, 3069, 3148, 3237, 3258, 3311, 3320, 3326, 3334, 3357, 3474, 3479, 3531, 3536, 3631, 3764, 3899, 3928, 3970, 4079, 4207, 4211, 4324, 4345, 4356, 4363, 4381, 4463, 4492, 4500, 4506, 4596, 4600, 4787, 4804], 'structural': [75, 200, 1232, 2465, 2724, 2989, 4222], 'basis': [76, 201, 1433], 'efficient': [78, 203], 'switching': [79, 204, 3902], 'CaM': [81, 118, 206, 243, 601, 608, 702, 770, 783, 835, 864, 893, 955, 969, 1120, 1400, 1418, 1437, 1510, 1555, 2605, 2622, 2756, 2817, 2840, 3172, 3207, 3227, 3262, 3294, 3300, 3331, 3354, 3369, 3379, 3485, 3509, 3543, 3557, 3644, 3769, 3891, 3931, 3960, 3996, 4116, 4182, 4203, 4213, 4218, 4331, 4354, 4359, 4377, 4801], 'between': [82, 207, 2467, 3185, 3216, 3448, 3619, 3667, 3903, 3933, 4215, 4466], 'these': [83, 208, 1296, 2159, 2340, 3073, 3934, 4784], 'two': [84, 209, 853, 890, 1058, 2068, 2271, 2310, 2753, 2780, 3038, 3169, 3290, 3861, 3888, 3905, 3935, 4217, 4221, 4300, 4370, 4511, 4767], 'positions': [85, 210, 3936], 'with': [86, 211, 382, 457, 516, 615, 858, 1121, 1428, 1588, 1660, 1826, 1864, 1901, 1936, 1985, 2020, 2175, 2184, 2198, 2353, 2771, 2992, 3089, 3124, 3175, 3231, 3303, 3370, 3382, 3390, 3398, 3478, 3679, 3779, 3782, 3937, 4081, 4114, 4131, 4147, 4206, 4234, 4255, 4348, 4566, 4610, 4709, 4780, 4794], 'oscillating': [88, 213, 3939], 'intracellular': [89, 214, 418, 3995], 'Ca2+': [90, 215, 285, 297, 419, 431, 452, 575, 777, 2620, 2832, 3498, 3505, 4086, 4133, 4180], 'concentration': [91, 216, 3997], 'generates': [93, 218], 'relaxation/contraction': [95, 220], 'cycles.': [96, 221, 4123], 'The': [97, 222, 374, 1340, 1580, 1857, 2170, 2668, 2752, 2779, 3297, 3351, 3637, 3955, 4437, 4764], 'locations': [98, 223, 1315, 1415, 2770, 3541], 'Ca2+-CaM': [102, 227, 829, 1359, 2582, 2651, 2673, 2700, 2800, 3026, 3034, 3095, 3154, 3222, 3252, 3622, 3752, 3921, 4039, 4196, 4390, 4682, 4776], 'at': [103, 228, 461, 698, 842, 1135, 1602, 1679, 1686, 1695, 1719, 1939, 2127, 2277, 2554, 2564, 2624, 2825, 3460, 3481, 3496, 3503, 3544, 3558, 3562, 4084, 4149, 4355], 'critical': [105, 230], 'region': [106, 231, 1422, 2080, 2286, 3313, 4296, 4550, 4788], 'RYR1-dihydropyridine': [108, 233], 'receptor': [109, 234, 256, 259, 274], 'interaction': [110, 235, 4565, 4708], 'are': [111, 236, 343, 368, 825, 1057, 2124, 2474, 2688, 2782, 2792, 3173, 3512, 3603, 4136, 4204, 4673, 4704, 4882], 'suggestive': [112, 237], 'direct': [115, 240, 773, 4806], 'role': [116, 241, 544, 4807], 'mechanism': [121, 246, 1248, 1443, 3765, 3900, 4440, 4811], 'excitation-contraction': [123, 248, 260, 1445], 'coupling.': [124, 249], 'isoform': [252, 493], 'calmodulin': [257], 'dihydropyridine': [258, 355], 'Imperatoxin': [261, 3689], 'A': [262, 2182, 2305, 2666, 2749, 3690, 4548], '1,4-piperazinediethanesulfonic': [263], 'acid': [264, 266, 951, 3233], '3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic': [265], 'In': [267, 479, 534, 767, 1290], 'muscle,': [269, 487, 4446], 'calcium': [271], 'channel/ryanodine': [273], '(RyR1)1': [275], 'functions': [276], 'as': [277, 885, 887, 1406, 1478, 1620, 1780, 1854, 1889, 2208, 2728, 2730, 3146, 3535, 3684, 3761, 3812, 3814, 3973, 4078, 4334, 4362, 4473, 4555], 'main': [281, 591, 2449], 'regulators': [282], 'concentration,': [286, 2621], 'signal': [288], 'contraction,': [291], 'allowing': [293, 3969], 'rapid': [294], 'translocation': [295, 4329], 'sarcoplasmic': [300, 372], 'reticulum': [301], 'cytoplasm': [304], '(1Ogawa': [305, 4019], 'Y.': [306, 1768, 4020], 'Crit.': [307, 4021], 'Rev.': [308, 321, 333, 442, 873, 4022, 4398, 4522], 'Biochem.': [309, 744, 981, 3437, 4023], 'Mol.': [310, 1926, 4024], 'Biol.': [311, 646, 802, 1033, 1044, 1097, 1110, 1213, 1285, 1373, 1494, 1651, 1775, 1795, 1849, 1927, 2034, 2055, 2218, 2239, 2259, 2596, 2895, 2906, 3111, 3138, 3428, 3439, 3578, 3596, 3705, 3723, 3835, 3852, 4025, 4542, 4580, 4634, 4667, 4717, 4727, 4743, 4758], '1994;': [312, 693, 716, 929, 1046, 1391, 1822, 1850, 2056, 2240, 2908, 2925, 2966, 3989, 4026, 4056, 4582, 4837], '29:': [313, 4027], '229-274Google': [314, 4028], 'Scholar,': [315, 327, 651, 680, 719, 733, 751, 807, 919, 932, 988, 1015, 1038, 1102, 1154, 1165, 1194, 1217, 1378, 2038, 2222, 2243, 2877, 2900, 2911, 2956, 2969, 3432, 3583, 3710, 4059, 4402, 4415, 4526, 4536, 4721, 4732, 4824, 4840], '2Franzini-Armstrong': [316], 'C.': [317, 498, 684, 1106, 1181, 2371, 3134, 3848, 3980, 4275, 4624, 4740, 4828], 'Protasi': [318], 'F.': [319, 743, 980, 1017, 2879, 2915, 2923], 'Physiol.': [320, 441, 872, 4397, 4521, 4866, 4868], '1997;': [322, 648, 1375, 1496, 2598, 3580, 3707], '77:': [323], '699-729Scopus': [324], '(590)': [325], 'Google': [326], '3Shoshan-Barmatz': [328], 'V.': [329, 1836, 2042, 2226], 'Ashley': [330, 503], 'R.H.': [331, 504], 'Int.': [332], 'Cytol.': [334], '1998;': [335, 506, 1286, 1653, 1928, 2035, 2219, 3440, 4544, 4718, 4729, 4760], '183:': [336], '185-270Google': [337], 'Scholar).': [338, 403, 446, 478, 533, 567, 766, 822, 877, 946, 1049, 1115, 1289, 1394, 1474, 1499, 1656, 1799, 1931, 2153, 2263, 2601, 2983, 3116, 3349, 3443, 3600, 3727, 3992, 4164, 4318, 4436, 4484, 4547, 4585, 4639, 4763, 4872], 'Some': [339], 'RyR1s': [342, 1972, 1983], 'thought': [344], 'contact': [346, 2606], 'directly': [347, 611], 'be': [350, 1439, 2804, 2820, 3085, 3255, 3521, 3626, 3908, 3967], 'under': [351, 1682], 'control': [353, 1582, 1707, 1742, 1873, 2104, 2290], 'receptors': [356, 4512], '(DHPRs),': [357], 'voltage': [358, 4470], 'sensors': [359], 'situated': [360, 2632, 3646], 'on': [361, 780, 1431, 1670, 1714, 1999, 2096, 2618, 2627, 2739, 2758, 3161, 3801, 3913, 4592, 4777], 'cell': [363], 'membrane': [364, 378, 519], 'infoldings': [365], '(T-tubules)': [366], 'juxtaposed': [369], 'reticulum.': [373], 'DHPR': [375, 520, 4475, 4490, 4553, 4607, 4710], 'senses': [376], 'depolarization': [379], 'wave': [380], 'associated': [381], 'neuronal': [384], 'impulse': [385], 'undergoes': [387, 4491], 'conformational': [389, 2477, 2488, 2552, 3446, 3533, 3606, 3632, 4494, 4501], 'change': [390, 3358, 3534, 3633, 4495, 4502], 'intramembrane': [392], 'charge': [393], 'movement': [394, 4209, 4349], '(4Rios': [395, 4476], 'E.': [396, 1189, 4283, 4477, 4518], 'Brum': [397, 4478], 'G.': [398, 473, 655, 661, 675, 725, 727, 737, 817, 906, 912, 938, 940, 974, 1029, 1108, 1145, 2140, 2891, 2943, 2949, 2975, 2977, 3001, 3007, 3053, 3059, 3136, 3736, 3738, 3850, 4065, 4067, 4096, 4098, 4309, 4479, 4520, 4528, 4578, 4819, 4846, 4848], 'Nature.': [399, 529, 1011, 1226, 2873, 3345, 4457, 4480], '1987;': [400, 4481], '325:': [401, 4482], '717-720Google': [402, 4483], 'apparently': [406], 'necessary': [407, 1244], 'sufficient': [409, 1623], 'activation,': [412], 'which': [413, 1726, 2558, 2719, 3015, 3151, 3771, 4115, 4672], 'results': [414, 2436, 2994, 3675, 3875], 'global': [417], 'increase': [420, 4191], 'above': [422, 470], 'pCa': [423, 426, 462, 467, 605, 699, 3482, 3559, 3563], '7': [424, 471], '6–4,': [427], 'level': [429, 2131, 2566], 'triggers': [433], 'contraction': [434], 'fiber': [438], '(5Endo': [439], 'M.': [440, 636, 1004, 1006, 1023, 1139, 1169, 1175, 1196, 1204, 1210, 1280, 1363, 1463, 1484, 1762, 1770, 1784, 1834, 2029, 2040, 2213, 2224, 2256, 2369, 2586, 2866, 2868, 2885, 2921, 3411, 3419, 3425, 3434, 3568, 3585, 3695, 3712, 4263, 4269, 4303, 4421, 4656, 4712], '1977;': [443], '57:': [444], '71-108Google': [445], 'itself': [448, 3468, 4620], 'regulated': [450, 587, 1238, 4137], 'biphasic': [455], 'fashion': [456, 3389], 'an': [458, 490, 705, 1325, 1827, 2343, 2359, 2678, 3387], 'activation': [459, 3476], 'peak': [460], '∼5.5': [463], 'inhibition': [465], 'below': [466], '3': [468, 2083, 2608, 2661, 3669, 4652, 4698], 'or': [469, 848, 854, 3027, 3033, 3094, 3278, 3285], '(6Meissner': [472, 674, 4818], 'Biochemistry.': [474, 664, 676, 715, 762, 915, 928, 1190, 2924, 2952, 2965, 3010, 3062, 4055, 4284, 4820], '1986;': [475, 677, 4821], '25:': [476, 678, 4822], '244-251Google': [477, 679, 4823], 'addition': [480], 'its': [482, 2097, 2320, 3383], 'vital': [483], 'function': [484], 'abundant': [491], 'RyR': [492], 'cerebellar': [495], 'neurons': [496], '(7Martin': [497], 'Chapman': [499], 'K.E.': [500], 'Seckl': [501], 'J.R.': [502], 'Neuroscience.': [505], '85:': [507], '205-216Google': [508], 'Scholar)': [509, 668, 1779, 1825, 1853, 2059, 3744, 3840, 4013, 4104], 'where': [510, 1316], 'it': [511, 3502, 3772, 3869], 'also': [512, 784, 826, 1586, 3407, 4105], 'appears': [513, 2095, 2652], 'communicate': [515], 'plasma': [518], '(8Chavis': [521], 'P.': [522, 739, 976, 1177, 1641, 1764, 1910, 2138, 2913, 4271, 4538, 4723], 'Fagni': [523], 'L.': [524, 659, 723, 813, 910, 936, 2947, 2973, 3005, 3057, 3734, 4063, 4094, 4425, 4576, 4844], 'Lansman': [525], 'J.B.': [526], 'Bockaert': [527], 'J.': [528, 640, 645, 729, 801, 811, 942, 1019, 1032, 1043, 1091, 1096, 1109, 1183, 1283, 1367, 1372, 1382, 1390, 1465, 1469, 1488, 1493, 1650, 1760, 1766, 1773, 1793, 1820, 1840, 1847, 1924, 1925, 2032, 2046, 2053, 2216, 2230, 2237, 2590, 2595, 2881, 2894, 2905, 2979, 3105, 3110, 3137, 3572, 3577, 3594, 3699, 3704, 3721, 3740, 3829, 3834, 3851, 4069, 4100, 4277, 4541, 4579, 4633, 4665, 4715, 4726, 4741, 4748, 4757, 4850, 4865, 4875], '1996;': [530, 1776, 2373, 4245], '382:': [531], '719-722Google': [532], 'brain,': [536], 'RyRs': [537], 'have': [538, 958, 1132, 1268, 1294, 2735, 2841, 2931, 3199, 3676, 4380], 'been': [539, 570, 899, 959, 1133, 1269, 1456, 2736, 2842, 3200, 3408, 3677, 3975, 4560], 'hypothesized': [540], 'play': [542, 4803], 'synaptic': [546], 'plasticity': [547], 'apoptosis': [549], '(9Mattson': [550], 'M.P.': [551], 'LaFerla': [552], 'F.M.': [553], 'Chan': [554], 'S.L.': [555, 663, 761, 800, 914, 1095, 2253, 2951, 3009, 3061, 3109, 3833], 'Leissring': [556], 'M.A.': [557, 1219, 3338], 'Shepel': [558], 'P.N.': [559], 'Geiger': [560], 'J.D.': [561], 'Trends': [562], 'Neurosci.': [563], '2000;': [564, 763, 819, 1470, 4869], '23:': [565], '222-229Google': [566], 'As': [568, 2264], 'has': [569, 852, 898, 1455, 3406, 3974, 4559], 'reported': [571, 3922, 3976], 'some': [573, 3604], 'other': [574, 1513, 3120, 3287, 3680, 3781, 4384], 'channels': [576, 4134], '(10Levitan': [577], 'I.B.': [578], 'Neuron.': [579, 4160, 4411], '1999;': [580, 665, 804, 874, 916, 1191, 1214, 1796, 2953, 3011, 3063, 3429, 3597, 3724, 4285, 4399, 4433, 4636, 4668], '22:': [581], '645-648Google': [582], 'Scholar),': [583, 696, 1230, 2376, 2928, 3014, 3066, 3143, 3857, 4248, 4288, 4461, 4671], 'further': [586, 2812], 'CaM,': [589, 1252, 4082], 'mediator': [592], 'Ca2+signaling': [594], 'eukaryotes.': [596], 'Modulation': [597], 'complex.': [603], 'At': [604], '4,': [606], 'Ca2+-saturated': [607], '(Ca2+-CaM)': [609], 'stoichiometry': [617, 1337], 'mole': [620], '(i.e.': [626, 2346], 'four': [627, 2116, 2313, 2529, 2535, 2613, 2816], 'CaMs': [628, 2791], 'tetrameric': [630, 1971, 2743], 'complex)': [632], '(11Wagenknecht': [633, 1360, 1481, 2583, 3565, 3692], 'T.': [634, 994, 1008, 1187, 1206, 1208, 1282, 1361, 1380, 1467, 1482, 1649, 1792, 1846, 2031, 2052, 2215, 2236, 2584, 2856, 2870, 3421, 3423, 3436, 3566, 3593, 3693, 3720, 4281, 4423, 4664, 4714, 4736], 'Radermacher': [635, 1362, 1483, 1761, 2585, 3567, 3694], 'Grassucci': [637, 1364, 1383, 1485, 1642, 1817, 1837, 1915, 2043, 2227, 2587, 3569, 3696], 'R.': [638, 688, 735, 972, 1365, 1384, 1486, 1643, 1786, 1838, 1918, 2044, 2228, 2588, 2919, 3570, 3587, 3697, 3714, 3984, 4419, 4626, 4658, 4832], 'Berkowitz': [639, 1366, 1381, 1464, 1487, 2589, 3571, 3698, 4876], 'Xin': [641, 1105, 1368, 1489, 1644, 2591, 3133, 3573, 3700, 3847], 'H.B.': [642, 1369, 1490, 1645, 2592, 3574, 3701], 'Fleischer': [643, 1370, 1387, 1491, 1646, 1843, 2049, 2233, 2593, 3575, 3702], 'S.': [644, 741, 978, 992, 1010, 1371, 1388, 1492, 1647, 1844, 2050, 2234, 2594, 2854, 2872, 2917, 3576, 3703, 4431], 'Chem.': [647, 803, 1034, 1045, 1098, 1111, 1374, 1495, 1652, 2597, 2896, 2907, 3112, 3139, 3579, 3706, 3836, 3853, 4009, 4543, 4581, 4635, 4728, 4759], '272:': [649, 1376, 1497, 2599, 3581, 3708], '32463-32471Google': [650, 1377, 1498, 2600, 3582, 3709], '12Moore': [652], 'C.P.': [653, 904, 1085, 2941, 2999, 3051, 3099, 3823], 'Rodney': [654, 905, 2942, 3000, 3052, 3817], 'Zhang': [656, 797, 907, 1088, 2944, 3002, 3054, 3102, 3826], 'J.Z.': [657, 798, 908, 1089, 2945, 3003, 3055, 3103, 3827], 'Santacruz-Toloza': [658, 909, 2946, 3004, 3056], 'Strasburg': [660, 713, 756, 911, 926, 2948, 2963, 3006, 3058, 4053, 4860], 'Hamilton': [662, 760, 799, 913, 1094, 2252, 2950, 3008, 3060, 3108, 3832], '38:': [666, 917, 1192, 2954, 3012, 3064, 4286], '8532-8537Google': [667, 918, 2955, 3013, 3065], 'partially': [670, 2705], 'inhibits': [671], '13Fuentes': [681, 4825], 'O.': [682, 3978, 4826], 'Valdivia': [683, 689, 1789, 3590, 3717, 3979, 3985, 4631, 4661, 4827, 4833], 'Vaughan': [685, 3981, 4829], 'D.': [686, 3982, 4830], 'Coronado': [687, 3983, 4831], 'H.H.': [690, 1790, 3591, 3718, 3986, 4632, 4662, 4834], 'Cell': [691, 1794, 1848, 2054, 2238, 3438, 3595, 3722, 3987, 4666, 4742, 4835, 4867], 'Calcium.': [692, 3988, 4836], '15:': [694, 3990, 4534, 4838], '305-316Google': [695, 3991, 4839], '7,': [700], 'Ca2+-depleted': [701], '(apoCaM)': [703], 'becomes': [704, 2293], 'activator': [706], '(14Yang': [707, 4047], 'H.C.': [708, 921, 2958, 4048], 'Reedy': [709, 922, 2959, 4049], 'M.M.': [710, 923, 2960, 4050], 'Burke': [711, 924, 2961, 4051], 'C.L.': [712, 925, 2962, 4052], 'G.M.': [714, 757, 927, 1141, 2964, 4054, 4305, 4861], '33:': [717, 930, 2926, 2967, 4057], '518-525Google': [718, 931, 2968, 4058], '15Tripathy': [720, 933, 2970, 4060, 4841], 'A.': [721, 934, 1149, 1173, 1772, 1908, 2367, 2971, 3732, 4061, 4092, 4267, 4313, 4432, 4842], 'Xu': [722, 812, 935, 2972, 3733, 4062, 4093, 4575, 4843], 'Mann': [724, 937, 2974, 3735, 4064, 4095, 4845], 'Meissner': [726, 816, 939, 1028, 1107, 2890, 2976, 3135, 3737, 3849, 4066, 4097, 4577, 4847], 'Biophys.': [728, 745, 941, 982, 1389, 1468, 2978, 3739, 4068, 4099, 4849], '1995;': [730, 748, 943, 985, 2260, 2980, 3741, 4070, 4101, 4533, 4851], '69:': [731, 944, 2981, 3742, 4071, 4102, 4852], '106-119Google': [732, 945, 2982, 3743, 4072, 4103, 4853], '16Buratti': [734], 'Prestipino': [736, 973], 'Menegazzi': [738, 975], 'Treves': [740, 977, 2916], 'Zorzato': [742, 979, 2922], 'Res.': [746, 983], 'Commun.': [747, 984], '213:': [749, 986], '1082-1090Google': [750, 987], '17Rodney': [752], 'G.G.': [753, 1083, 3097, 3821], 'Williams': [754, 1086, 3100, 3824], 'B.Y.': [755, 1087, 3101, 3825], 'Beckingham': [758], 'K.': [759, 998, 1021, 2860, 2883], '39:': [764], '7807-7812Google': [765], 'cases': [769], 'reduces': [771], 'effect': [774, 3491], 'produced': [775], 'alone': [778], 'acting': [779], 'RyR1.': [782, 1412, 2169, 2486, 2544, 2629, 3954, 4178, 4199], 'mediates': [785, 4570], "RyR1's": [786, 948, 4650], 'redox': [787], 'sensitivity': [788], 'nitric': [790], 'oxide': [791], 'oxygen': [793], 'species': [794], '(18Porter': [795], 'M.C.': [796], '274:': [805, 4637], '36831-36834Google': [806], '19Eu': [808], 'J.P.': [809, 1225, 3344], 'Sun': [810], 'Stamler': [814], 'J.S.': [815], 'Cell.': [818], '102:': [820], '499-509Google': [821], 'Other': [823], 'proteins': [824, 1131, 1256, 4385], 'modulated': [827], 'apoCaM.': [831, 1310, 3030], 'Among': [832], 'these,': [833], 'either': [834, 3092], 'bound': [837, 2167, 2539, 2695, 2790, 2821, 3276, 3486, 4172, 4259], 'same': [840, 3037], 'sequence': [841, 1081, 2846, 3243, 3266, 3306, 3317], 'high': [844, 1976, 3090, 3461, 3545, 4032, 4291], 'low': [846, 1683, 2378, 3463, 3547], '[Ca2+],': [847], 'effector': [850], 'protein': [851, 1239, 3336, 3687], 'more': [855, 2642, 4805], 'binding': [856, 865, 896, 956, 970, 1059, 1341, 2484, 2796, 2837, 3088, 3208, 3332, 3686, 3753, 4219, 4228, 4590, 4680], 'sites': [857, 884, 897, 1060, 1128, 2626, 2713, 2781, 2838, 2939, 3160, 3190, 3253, 3459, 3799, 3863, 3885, 3906, 4772, 4785], 'different': [859, 3540, 4235], 'requirements': [860], '[Ca2+]': [862, 3464, 3548, 3940], '(20Jurado': [866, 4391], 'L.A.': [867, 4392], 'Chockalingam': [868, 4393], 'P.S.': [869, 4394], 'Jarrett': [870, 4395], 'H.W.': [871, 4396], '79:': [875, 4400], '661-682Google': [876, 4401], 'For': [878, 3247], 'RyR1,': [879, 1321, 4694, 4778], 'number': [881, 2936], 'CaM-binding': [883, 1127, 2938, 3458, 3613, 3798], 'well': [886, 1969, 2729, 3813], 'whether': [888], 'forms': [891, 2603, 2754, 3170, 3225, 3642, 3889], 'share': [894], 'common': [895], 'subject': [900], 'study': [902, 1348, 1454], '(12Moore': [903, 2940, 2998, 3050], '14Yang': [920, 2957], 'Within': [947], '∼5000': [949], 'amino': [950, 3232, 3364, 3392], 'residues,': [952], 'several': [953, 1130, 3204], 'putative': [954], 'motifs': [957], 'proposed': [960, 4448], 'could': [962, 1438, 2819, 3210, 3254, 3307, 3355, 3452, 4075, 4321, 4360, 4379], 'account': [963, 3211, 3788], 'Ca2+-dependent': [966], '-independent': [968], '(16Buratti': [971], '21Takeshima': [989], 'H.': [990, 996, 1002, 1171, 1179, 1185, 1198, 1202, 2852, 2858, 2864, 3413, 3417, 4265, 4273, 4279], 'Nishimura': [991, 2853], 'Matsumoto': [993, 2855], 'Ishida': [995, 2857], 'Kangawa': [997, 2859], 'Minamino': [999, 2861], 'N.': [1000, 1104, 1920, 2862, 3132, 3846, 4417, 4750], 'Matsuo': [1001, 2863], 'Ueda': [1003, 2865], 'Hanaoka': [1005, 2867], 'Hirose': [1007, 2869], 'Numa': [1009, 2871], '1989;': [1012, 2874], '339:': [1013, 2875], '439-445Google': [1014, 2876], '22Zorzato': [1016, 2878], 'Fujii': [1018, 2880], 'Otsu': [1020, 2882], 'Phillips': [1022, 2884], 'Green': [1024, 2886], 'N.M.': [1025, 2887], 'Lai': [1026, 2888], 'F.A.': [1027, 1160, 2889], 'MacLennan': [1030, 1041, 2892, 2903, 4539, 4724], 'D.H.': [1031, 1042, 2893, 2904, 4540, 4725], '1990;': [1035, 2897], '265:': [1036, 2898], '2244-2256Google': [1037, 2899], '23Chen': [1039, 2901], 'S.R.': [1040, 2902, 4242], '269:': [1047, 2909, 4583], '22698-22704Google': [1048, 2910], 'Two': [1050], 'recent': [1051], 'independent': [1052, 1326], 'reports': [1053, 2930], 'suggest': [1054], 'there': [1056, 3602, 3661], '(one': [1063], 'Ca2+-CaM),': [1069], 'contained': [1071, 3235, 3654], 'short': [1074, 1122, 3238], 'segment': [1075, 3239], '(∼30': [1076], 'residues)': [1077], '(24Rodney': [1082, 3096, 3820], 'Moore': [1084, 3098, 3822], 'Krol': [1090, 3104, 3828], 'Pedersen': [1092, 3106, 3830], 'S.E.': [1093, 3107, 3831], '2001;': [1099, 1112, 1227, 3113, 3140, 3346, 3837, 3854, 4161, 4412], '276:': [1100, 1113, 3114, 3141, 3838, 3855], '2069-2074Google': [1101, 3115, 3839], '25Yamaguchi': [1103], '22579-22585Google': [1114, 3142, 3856], 'Although': [1116, 2834, 3378, 3601], 'interactions': [1118, 1425, 3230, 3518, 4378], 'peptides': [1123, 3385], 'corresponding': [1124, 1981], 'characterized': [1134, 3328], 'atomic': [1136, 2360], 'detail': [1137], '(26Ikura': [1138, 4302], 'Clore': [1140, 4304], 'Gronenborn': [1142, 4306], 'A.M.': [1143, 4307], 'Zhu': [1144, 1765, 4308], 'Klee': [1146, 4310], 'C.B.': [1147, 4004, 4311], 'Bax': [1148, 4312], 'Science.': [1150, 1161, 4314], '1992;': [1151, 1162, 4315], '256:': [1152, 4316], '632-638Google': [1153, 4317], '27Meador': [1155], 'W.E.': [1156], 'Means': [1157], 'A.R.': [1158], 'Quiocho': [1159], '257:': [1163], '1251-1255Google': [1164], '28Elshorst': [1166], 'B.': [1167, 4261], 'Hennig': [1168, 4262], 'Forsterling': [1170, 4264], 'Diener': [1172, 4266], 'Maurer': [1174, 4268], 'Schulte': [1176, 4270], 'Schwalbe': [1178, 4272], 'Griesinger': [1180, 4274], 'Krebs': [1182, 4276], 'Schmid': [1184, 4278], 'Vorherr': [1186, 4280], 'Carafoli': [1188, 4282], '12320-12332Google': [1193, 4287], '29Osawa': [1195], 'Tokumitsu': [1197, 3412], 'Swindells': [1199, 3414], 'M.B.': [1200, 2251, 3415], 'Kurihara': [1201, 3416], 'Orita': [1203, 3418], 'Shibanuma': [1205, 3420], 'Furuya': [1207, 3422], 'Ikura': [1209, 3424], 'Nat.': [1211, 2257, 3426], 'Struct.': [1212, 1284, 1774, 2033, 2217, 2258, 3427, 4716], '6:': [1215, 3430], '819-824Google': [1216, 3431], '30Schumacher': [1218], 'Rivard': [1220, 3339], 'A.F.': [1221, 3340], 'Bachinger': [1222, 3341], 'H.P.': [1223, 3342], 'Adelman': [1224, 3343], '410:': [1228, 3347], '1120-1124Google': [1229, 3348], 'model': [1233, 1398, 2361, 3149, 3929], 'includes': [1235], 'complete': [1237], 'lacking': [1241], 'understand': [1246], 'action': [1250], 'particularly': [1253, 4695], 'those': [1255, 3815], 'bind': [1258, 2757, 3155, 3309, 4387, 4644], 'Ca2+-CaM.': [1262, 3809, 3867], 'Cryo-electron': [1263, 1666], 'image': [1266, 1624], 'processing': [1267], 'used': [1270, 1295, 1332], 'generate': [1272], 'reconstructions': [1274, 1301, 1809, 1882, 1933, 2172, 2272, 2414, 2516, 3552], 'native': [1276], 'isolated': [1277, 1477], '(31Samsó': [1279, 2028, 2212, 4711], 'Wagenknecht': [1281, 1466, 1648, 1791, 1845, 2030, 2051, 2214, 2235, 3592, 3719, 4663, 4713], '121:': [1287, 2036, 2220, 4719], '172-180Google': [1288, 2037, 2221, 4720], 'this': [1291, 1347, 1403, 1432, 1453, 2354, 3490, 3524, 3790, 3924, 4107, 4487], 'study,': [1292, 3925], 'techniques': [1297], 'obtain': [1299], 'Difference': [1311], 'mapping': [1312], 'shows': [1313], 'incidentally,': [1323], 'provides': [1324], 'means': [1327], 'biochemical': [1330, 2996], 'assays': [1331, 2997], 'previously': [1333, 1458, 1480, 1782, 2211, 4816], 'assess': [1335], 'binding.': [1339], 'site': [1342, 3776, 4176, 4189, 4197], 'known': [1356, 4554], '32Wagenknecht': [1379], 'Timerman': [1385, 1841, 2047, 2231], 'A.P.': [1386, 1842, 2048, 2232], '67:': [1392], '2286-2295Google': [1393], 'We': [1395, 2336, 2570, 3202, 3526, 4165, 4873], 'propose': [1396, 1435, 3203, 3927, 4166], 'whereby': [1402, 3930, 4326], 'molecule': [1404, 2345, 3024, 3961, 4214], 'acts': [1405], 'mobile': [1408, 4364], 'Ca2+-sensing': [1409, 4365], 'Furthermore,': [1413], 'RyR1-bound': [1417], 'occur': [1419], 'implicated': [1423, 4562], 'DHPR,': [1429, 4795], 'involved': [1440, 4705], '(E-C)': [1446], 'coupling': [1447, 3666, 4443, 4508, 4572, 4814], 'muscle.': [1450], 'Part': [1451], 'published': [1457], 'abstract': [1460], 'form': [1461, 2398, 2677, 4252], '(33Samsó': [1462], '78': [1471], '(A):': [1472], '149Google': [1473], 'was': [1476, 1502, 1585, 1668, 1727, 1862, 2209, 3082, 3803, 4641], 'described': [1479, 1781, 2210, 3409], 'Phosphatidylcholine': [1500], '(PC)': [1501], 'purchased': [1503, 1516], 'Avanti': [1505], 'Polar': [1506], 'Lipids,': [1507], 'Inc.;': [1508], 'brain': [1509, 4018], 'all': [1512, 1595], 'chemicals': [1514], 'were': [1515, 1521, 1597, 1612, 1658, 1693, 1712, 1747, 1803, 1810, 1883, 1934, 2419, 3144, 3757], 'Sigma.': [1518], 'RyR1·apoCaM': [1519, 2110, 2470, 2512, 3449], 'complexes': [1520, 4254], 'prepared': [1522, 2007], 'mixing': [1524], '1': [1525, 1552, 1589], 'volume': [1526, 1553, 1590], 'CaM-free': [1528], '(in': [1530], '10': [1531, 2199], 'mm': [1532, 1548, 1567], 'Na-PIPES,': [1533], 'pH': [1534, 1561], '7.4,': [1535, 1562], '0.45m': [1536], 'NaCl,': [1537], '25': [1538], 'μm': [1539, 1570, 3999, 4016], 'EGTA,': [1540, 1568], '20': [1541, 1569], 'μmleupeptin,': [1542], '1%': [1543], 'CHAPS,': [1544], '0.5%': [1545], 'PC,': [1546], '0.5': [1547, 1906], 'fresh': [1549], 'dithiothreitol)': [1550], 'buffer': [1557, 1592, 1628], 'C': [1558, 1629], '(20': [1559], 'mmTris-HCl,': [1560], '0.15': [1563], 'm': [1564], 'KCl,': [1565], '2': [1566], 'leupeptin)': [1571], 'achieve': [1573], 'CaM:RyR1': [1575], 'molar': [1576], 'ratio': [1577], '18.': [1579], '(no': [1583], 'apoCaM)': [1584], 'diluted': [1587, 1613], 'C,': [1593], 'mixtures': [1596], 'incubated': [1598], '20–40': [1600], 'min': [1601], 'room': [1603], 'temperature': [1604], 'prior': [1605, 1733], 'cryo-plunging.': [1607], 'PC': [1608], 'CHAPS': [1610], 'concentrations': [1611, 3499], '0.09': [1615], '0.2%,': [1617], 'respectively,': [1618, 1900, 2191], 'so': [1619, 3760], 'allow': [1622], 'contrast,': [1625], 'adding': [1627], 'during': [1630], 'sample': [1631], 'application': [1632], 'electron': [1635, 1676, 4888], 'grid': [1637], '(34Sharma': [1638], 'M.R.': [1639], 'Penczek': [1640, 1763, 1909], '273:': [1654, 4545, 4730, 4761], '18429-18434Google': [1655], 'Grids': [1657], 'blotted': [1659], 'Whatman': [1661], 'filter': [1662], 'paper': [1663], 'No.': [1664], '540.': [1665], 'performed': [1669, 1998], 'Philips': [1672], 'EM': [1673], '420': [1674], 'transmission': [1675], 'microscope': [1677], 'operated': [1678], '100': [1680], 'kV': [1681], 'dose': [1684], 'conditions': [1685], 'magnification': [1688], '×52,000,': [1690], 'micrographs': [1692, 1703, 1751, 1956], 'taken': [1694], '0°,': [1696], '30°,': [1697], '50°': [1699], 'tilt.': [1700], 'High': [1701], 'quality': [1702], '(71': [1704], '41': [1709], 'RyR1·apoCaM)': [1711, 1746], 'digitized': [1713], 'Hi-Scan': [1716], '(Eurocore)': [1717], 'densitometer': [1718], 'pixel': [1721], 'size': [1722, 2393], '3.8': [1724], 'Å,': [1725, 2190], 'binned': [1728], 'down': [1729], '7.7': [1731], 'Å': [1732, 2692, 3183], 'reconstruction.': [1736], 'Individual': [1737], 'particles': [1738, 1868], '(7814': [1739], '4887': [1744], 'selected': [1748], 'processed': [1753], 'using': [1754, 1805, 1812, 3126], 'SPIDER/WEB': [1756], 'software': [1757], 'package': [1758], '(35Frank': [1759], 'Li': [1767], 'Ladjadj': [1769], 'Leith': [1771], '116:': [1777], '190-199Google': [1778], '(36Samsó': [1783, 4655], 'Trujillo': [1785, 3586, 3713, 4657], 'Gurrola': [1787, 3588, 3715, 4659], 'G.B.': [1788, 3589, 3716, 4622, 4660], '146:': [1797, 3598, 3725, 4669], '493-499Google': [1798, 3599, 3726, 4670], '4-fold': [1800, 1860, 1987, 2001, 2427], 'two-dimensional': [1801, 2069, 2268, 2439, 2453], 'averages': [1802, 1879, 1997, 2070], 'generated': [1804], '900': [1806], 'particles.': [1807], 'Three-dimensional': [1808, 1932], 'computed': [1811, 2442], 'projection-matching': [1813], 'algorithms': [1814], '(37Penczek': [1815], 'P.A.': [1816], 'R.A.': [1818, 1916], 'Frank': [1819, 1839, 1923, 2045, 2229], 'Ultramicroscopy.': [1821], '53:': [1823], '251-270Google': [1824], 'existing': [1828], 'reconstruction': [1830, 1953, 2292], '(38Radermacher': [1833], 'Rao': [1835, 2041, 2225], '127:': [1851, 2057, 2241], '411-423Google': [1852, 2058, 2242], 'reference.': [1856], 'contribution': [1858], 'views': [1861, 2002], 'reduced': [1863], 'final': [1865], 'numbers': [1866], '2798': [1870], '2079': [1875], 'RyR1·apoCaM.': [1877], 'Two-dimensional': [1878, 1996], 'filtered': [1884], 'their': [1886, 1986, 2685, 2723, 2732, 4230], 'limiting': [1887], 'resolution': [1888, 2383, 2568], 'calculated': [1890], 'according': [1891, 2132], 'Fourier': [1894], 'ring': [1895], 'shell': [1897], 'correlation': [1898], 'criteria,': [1899], 'cutoff': [1903], 'value': [1904], '(39Malhotra': [1907], 'Agrawal': [1911], 'R.K.': [1912], 'Gabashvili': [1913], 'I.S.': [1914], 'Junemann': [1917], 'Burkhardt': [1919], 'Nierhaus': [1921], 'K.H.': [1922], '280:': [1929], '103-116Google': [1930], 'displayed': [1935], 'isosurface': [1937], 'representations': [1938], 'threshold': [1941], 'corresponds': [1943], 'midpoint': [1946], 'density': [1949, 2163], 'profile': [1950], 'boundary.': [1954], 'Electron': [1955], 'frozen': [1958], 'hydrated': [1959], 'specimens': [1960], 'show': [1961, 2192, 3016], 'fine': [1963], 'structure': [1964], 'indicative': [1967], 'preserved': [1970], '(Fig.1A)': [1973], 'proportion': [1977], '4-fold-symmetric': [1979], 'views,': [1980], 'lying': [1984], 'symmetry': [1988, 2428], 'axes': [1989, 2670], 'normal': [1990, 2424], 'carbon': [1993], 'support': [1994], 'film.': [1995], 'such': [2000, 2793, 3176, 3270, 3683, 4333], '(resolution': [2003], '28': [2005, 2187], 'Å),': [2006], 'apoCaM,': [2014, 2077], 'display': [2015, 2273, 2519], 'typical': [2017], 'square': [2018, 2194, 2330], 'shape': [2019, 2391], 'protruding': [2021], 'corners': [2022], '(clamps)': [2023], 'central': [2026], 'cross': [2027], '38Radermacher': [2039, 2223], '(Fig.': [2060, 2084, 2121, 2180, 2316, 2444, 2455, 2664, 2682, 2706, 3244, 3318, 3376, 3465, 4683], '1,B': [2061], 'C).': [2063], 'Direct': [2064], 'comparison': [2065], 'reveals': [2071], 'small': [2079, 2093], 'domain': [2082, 2282, 2607, 3298, 3668, 4258, 4352, 4697], '1C,': [2085], 'arrows)': [2086], 'increased': [2088], 'density,': [2090], 'protuberance': [2094], 'external': [2098], 'side.': [2099], 'Subtraction': [2100, 2307], 'average': [2105], 'yields': [2111, 2312], 'difference': [2113, 2276, 2400, 2417, 2502, 2507], 'map': [2114, 2401, 2418, 2508], 'showing': [2115, 3473, 3883], 'discrete': [2117], 'positive': [2118, 2497], '(white)': [2119], 'densities': [2120, 2500], '1D)': [2122], 'statistically': [2125], 'significant': [2126, 2521], '99.9%': [2129], 'confidence': [2130], 't': [2135], 'test': [2136], '(40Armitage': [2137], 'Berry': [2139], 'Statistical': [2141], 'Methods': [2142], 'Medical': [2144], 'Research.3rd': [2145], 'Ed.': [2146], 'Blackwell': [2147], 'Scientific': [2148], 'Publications,': [2149], 'Cambridge,': [2150], 'MA1994:': [2151], '99-103Google': [2152], 'It': [2154], 'highly': [2156], 'likely': [2157], 'regions': [2160, 4691], 'excess': [2162], 'correspond': [2164], 'without': [2177, 3555, 3950], '(control)': [2178], '2,': [2181, 2304], 'andB)': [2183], 'resolutions': [2185], '26': [2189], 'prism-shaped': [2195], 'distinguishable': [2200], 'domains': [2201, 2660, 3292, 3367, 4651], 'differentiated': [2204], 'smaller': [2205, 2556], 'transmembrane': [2206, 3657, 3672], 'region,': [2207, 3658], '41Serysheva': [2244], 'I.I.': [2245], 'Orlova': [2246], 'E.V.': [2247], 'Chiu': [2248], 'W.': [2249], 'Sherman': [2250], 'van': [2254], 'Heel': [2255], '2:': [2261], '18-24Google': [2262], 'anticipated': [2265], 'analysis,': [2269], 'major': [2275, 2321, 2669, 3291], 'outer': [2279], 'face': [2280, 2637], '3:': [2283], 'concave': [2285], 'present': [2287, 3800], 'protuberant': [2294], 'when': [2295], 'added': [2298, 3556], '(compare': [2299], 'boxed': [2300], 'areas': [2301], 'Fig.': [2303, 2747, 4340], 'andB).': [2306, 2667], 'volumes': [2311, 2698], 'ellipsoidal-shaped': [2314, 2395], 'masses': [2315, 2341, 2396, 2532], '2C),': [2317], 'each': [2318, 2338, 2610, 2654, 3018, 3783], 'having': [2319], 'axis': [2322, 2429], 'approximately': [2323], 'perpendicular': [2324], 'plane': [2327, 2423], 'defined': [2331], 'assembly.': [2335], 'attribute': [2337], 'subunit).': [2351], 'Consistent': [2352], 'interpretation,': [2355], 'peptide·apoCaM': [2364], 'complex': [2365, 2744, 4080], '(42Houdusse': [2366], 'Silver': [2368], 'Cohen': [2370], 'Structure.': [2372], '4:': [2374], '1475-1490Google': [2375], 'following': [2377], 'pass': [2379], 'filtration': [2380], 'our': [2385, 2410], 'reconstructions,': [2387], 'closely': [2388, 4768], 'matches': [2389], '(not': [2402], 'shown).': [2403], 'To': [2404, 3787], 'check': [2405], 'internal': [2407], 'consistency': [2408], 'results,': [2411, 3177], 'projected': [2420], 'onto': [2421], 'simulate': [2434], 'analysis.': [2440], 'These': [2441, 4319], 'projections': [2443], '1,': [2445, 2456], 'E–G)': [2446], 'reproduce': [2447], 'features': [2450], 'analysis': [2454], 'B–D).': [2457], 'An': [2458], 'alternative': [2459], 'unlikely': [2461, 2805, 3624], 'interpretation': [2462], 'differences': [2466, 2489, 2563, 3447, 3607], 'they': [2473, 3792], 'due': [2475, 2806], 'changes': [2478, 2553], 'induced': [2481, 3634], 'However,': [2487, 2616], 'should': [2490], 'result': [2491, 3629], 'comparable': [2493], 'levels': [2494], 'negative': [2499, 2522], 'images,': [2503], 'whereas': [2504, 2650], 'obtained': [2509, 3678], 'does': [2517, 2546], 'not': [2518, 2547, 2560, 3301], 'any': [2520], 'density.': [2523], 'Therefore,': [2524, 2708], 'conclude': [2526], 'additional': [2530, 4690], 'ellipsoidal': [2531], 'arise': [2533], 'molecules': [2536, 2676, 2818], 'surface': [2542, 2646, 3639], 'preclude': [2548, 3763], 'possibility': [2550, 3529], 'scale,': [2557], 'might': [2559, 3198, 4802], 'produce': [2561], 'detectable': [2562], 'attained.': [2569], 'compared': [2571], 'already': [2579], 'Both': [2602], 'subunits.': [2615], 'depending': [2617], 'locates': [2623], 'ApoCaM': [2630, 2716], 'closer': [2633], 'T-tubule': [2636], 'protrudes': [2641], 'lateral': [2645], 'structure,': [2649], 'crevices': [2657, 4647], 'formed': [2658, 4648], '6/8': [2663, 4654], '3,': [2665, 2748, 4684], 'angle': [2679], '∼140°': [2681], '3C),': [2683], 'geometric': [2686], 'centers': [2687, 2772, 3187, 3218], '33': [2689, 2775, 3180], '±': [2690, 2776, 3181], '5': [2691, 2777, 3182], 'apart.': [2693], 'If': [2694], 'simultaneously,': [2696], 'would': [2703, 2801, 3870, 3966, 4183], 'interpenetrate': [2704], '3D).': [2707], 'simultaneous': [2709, 2795], 'occupation': [2710], 'seems': [2714], 'unlikely.': [2715], 'differ': [2720], 'substantially': [2721], 'physicochemical': [2726], 'properties': [2727, 4320], 'biological': [2733], 'effects,': [2734], 'spatially': [2737], 'localized': [2738], 'intact': [2741], '(summarized': [2745], 'B).': [2751], 'distinct,': [2768], 'overlapping': [2769, 3159, 4678], 'separated': [2773], 'Å.': [2778], 'sufficiently': [2783, 3758], 'close,': [2784], 'orientations': [2787], 'appear': [2802, 3871], 'steric': [2808], 'interference.': [2809], 'evidence': [2813, 3882, 4125], 'only': [2815, 3022, 4256], 'given': [2827], 'time,': [2828], 'regardless': [2829], 'concentration.': [2833], 'nine': [2835], 'potential': [2836], 'identified': [2843, 4472], 'within': [2844, 3236, 4645, 4696], 'polypeptide': [2850], '(21Takeshima': [2851], '43Menegazzi': [2912], 'Larini': [2914], 'Guerrini': [2918], 'Quadroni': [2920], '9078-9084Google': [2927], 'conflicting': [2929], 'appeared': [2932], 'regarding': [2933], 'actual': [2935], 'Our': [2984, 3164, 3810], 'findings,': [2985, 3811], 'based': [2986, 4109], 'upon': [2987, 4110], 'determination,': [2990], 'agree': [2991], 'Bound': [3031], 'protects': [3035], 'peptide': [3039, 3071, 3375, 3396, 4597], 'bonds': [3040], '(between': [3041], 'residues': [3042, 3074, 3234], '3630–3631': [3043], '3637–3638)': [3045], 'proteolysis': [3047], 'trypsin': [3049], 'further,': [3068], 'synthetic': [3070], 'containing': [3072], '(amino': [3079], 'acids': [3080], '3614–3643)': [3081], 'capable': [3086, 4226], 'affinity': [3091, 4033, 4185, 4192, 4613], 'Additional': [3117], 'experiments': [3118, 3125], 'employing': [3119], 'related': [3121, 3256], 'peptides,': [3122], 'together': [3123, 4779], 'single': [3127, 4212], 'point': [3128], 'mutants': [3130], '(25Yamaguchi': [3131, 3845], 'interpreted': [3145, 3522], 'supporting': [3147], 'peptide.': [3163], 'spatial': [3165], 'localizations': [3166], 'compatible': [3174], 'although': [3178], 'distance': [3184, 3618], 'somewhat': [3195], 'greater': [3196], 'than': [3197, 4616, 4815], 'expected.': [3201], 'modes': [3205], '∼33-Å': [3214], 'separation': [3215, 3456], 'while': [3223], 'still': [3228], 'preserve': [3229], '4).': [3245], '(i)': [3246], 'instance,': [3248], 'translation': [3259, 3352], 'linear': [3265], '"protected': [3273], 'region"': [3274], 'immediate': [3281], 'neighborhood': [3282], '(Fig.4A).': [3295], '(ii)': [3296], 'interacting': [3302, 3397], 'protected': [3305], 'even': [3308, 4083], 'non-contiguous': [3312], '4B),': [3319], 'situation': [3321], 'reminiscent': [3324], 'recently': [3327], 'mode': [3329], 'target': [3335, 3374, 3384, 3638], '(30Schumacher': [3337], '(iii)': [3350], 'involve': [3356], 'polarity': [3361], 'carboxyl': [3366], 'respect': [3371], '4C).': [3377], 'interacts': [3380, 4146, 4793], 'predominantly': [3381], 'antiparallel': [3388], 'terminus': [3393], 'C-lobe': [3400], 'opposite': [3404, 4372], 'orientation': [3405], '(29Osawa': [3410], '44Zhang': [3433], 'Yuan': [3435], '76:': [3441], '313-323Google': [3442], '(iv)': [3444], 'Alternatively,': [3445], 'RyR1·Ca2+-CaM': [3451], 'contribute': [3453, 4322], '4D).': [3466], 'sensitive': [3470], 'bell-shaped': [3475], 'curve': [3477], 'maximum': [3480], '4.': [3483], 'Interestingly,': [3484], 'counteracts': [3489], 'partially,': [3492], 'millimolar': [3497], 'submicromolar': [3504], 'concentrations.': [3506], 'Because': [3507], 'affected': [3513], 'RyR1-CaM': [3517], 'need': [3519], 'context.': [3525], 'explored': [3527], 'Ca2+-induced': [3532, 4328], 'cause': [3537], 'comparing': [3550], '>6': [3560], '4': [3564], '36Samsó': [3584, 3711], 'minor': [3605], 'vicinity': [3610], 'regions,': [3614], 'relatively': [3616, 3915], 'large': [3617], 'solely': [3627], 'Ca2+.': [3636], '∼10': [3647], 'nm': [3648], 'away': [3649], 'Ca2+-conducting': [3652], 'pore': [3653], 'suggesting': [3659], 'long': [3663], 'range': [3664, 4046], 'allosteric': [3665], 'domain.': [3673], 'Similar': [3674], 'modulators,': [3682], 'FK-506': [3685], '(IpTxa)': [3691], 'Tripathy': [3728, 4088], 'et': [3729, 3818, 3843, 4089], 'al.': [3730, 3819, 3844, 4090], '(15Tripathy': [3731, 4091], 'kinetics': [3748, 4113], 'RyR1-enriched': [3755], 'vesicles': [3756], 'slow': [3759, 4112], 'modulation': [3767], 'dissociates': [3773, 4117], 'reassociates': [3778], 'cycle': [3784], 'contraction.': [3786], 'result,': [3791], 'postulated': [3793], 'occupied': [3804], 'Yamaguchi': [3842], 'argue': [3858], 'strongly': [3859, 4561], 'Thus,': [3868, 4358], 'if': [3873], 'kinetic': [3878], 'studies': [3879], 'apply': [3892], 'vivo': [3896], 'situation,': [3897], 'then': [3898], 'must': [3907], 'non-dissociative': [3909, 4208], 'nature.': [3911], 'Based': [3912], 'positioning': [3917], 'switches': [3932], 'responsible': [3941], 'cycles': [3944], 'contraction-relaxation': [3946], 'dissociation': [3951], 'necessity': [3956], 'capture': [3958], 'another': [3959], 'pool': [3965], 'avoided,': [3968], 'fast': [3971], 'response': [3972], '(13Fuentes': [3977], 'Given': [3993], '(2': [3998], '(45Klee': [4003], 'Vanaman': [4005], 'T.C.': [4006], 'Adv.': [4007], 'Protein': [4008, 4243], '1982;': [4010], '35:': [4011], '213-321Google': [4012], '50': [4015], 'Scholar))': [4029], '(Kd': [4040], 'values': [4041], 'nanomolar': [4045], 'Scholar)),': [4073], 'exist': [4076], 'primarily': [4077], 'resting': [4085], 'levels.': [4087], 'suggested': [4106], 'scenario': [4108, 4325], 'relative': [4120], 'contraction/relaxation': [4122], 'Recent': [4124], 'supports': [4126], 'preassociation': [4128], 'voltage-gated': [4132], 'including': [4140], 'L-type': [4142], '(DHPR)': [4144], 'triad': [4150], 'junctions': [4151], '(47Erickson': [4152], 'M.G.': [4153, 4404], 'Alseikhan': [4154, 4405], 'B.A.': [4155, 4406, 4734], 'Peterson': [4156, 4407], 'B.Z.': [4157, 4408], 'Yue': [4158, 4409], 'D.T.': [4159, 4410], '31:': [4162, 4413], '973-985Google': [4163, 4414], 'pCa>6,': [4169], 'apoCaM-binding': [4175], 'After': [4179], 'release,': [4181], 'lose': [4184], 'neighboring': [4195], 'Several': [4200], 'characteristics': [4201], 'consistent': [4205], 'sites:': [4220], 'functional': [4224], 'modules': [4225, 4301], 'targets': [4231], 'independently': [4232], 'affinities': [4236], '(46Bayley': [4237], 'P.M.': [4238], 'Findlay': [4239], 'W.A.': [4240], 'Martin': [4241], 'Sci.': [4244, 4429], '5:': [4246], '1215-1228Google': [4247], 'ability': [4250], 'stable': [4253], '(28Elshorst': [4260], 'flexibility': [4292], 'tether': [4295], 'connects': [4298], '(e.g.': [4332], 'models': [4337], 'depicted': [4338], '4A-C)': [4341], 'achieved': [4343], 'two-step': [4346], 'process': [4347], 'time.': [4357], 'act': [4361], 'producing': [4369], 'alternative,': [4371], 'modulatory': [4373], 'effects.': [4374], 'Such': [4375], 'coordinated': [4376], 'parallel': [4382], '47Erickson': [4403], '48Qin': [4416], 'Olcese': [4418], 'Bransby': [4420], 'Lin': [4422], 'Birnbaumer': [4424], 'Proc.': [4426], 'Natl.': [4427], 'Acad.': [4428], 'U.': [4430], '96:': [4434], '2435-2438Google': [4435], 'currently': [4438], 'favored': [4439], 'E-C': [4442, 4571, 4813], 'first': [4447], 'Schneider': [4450], 'Chandler': [4452, 4455], '(49Schneider': [4453], 'M.F.': [4454], 'W.K.': [4456], '1973;': [4458], ':': 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'IpTxa': [4640], 'near': [4674], 'perhaps': [4677], 'E': [4685], 'F).': [4687], 'Most': [4688], 'likely,': [4689], 'clamps': [4701], '(domains': [4702], '5–10),': [4703], '55Block': [4733], 'Imagawa': [4735], 'Campbell': [4737], 'K.P.': [4738], 'Franzini-Armstrong': [4739], '1988;': [4744], '107:': [4745], '2587-2600Google': [4746], 'Scholar,56Nakai': [4747], 'Sekiguchi': [4749], 'Rando': [4751], 'T.A.': [4752], 'Allen': [4753], 'P.D.': [4754], 'Beam': [4755], 'K.G.': [4756], '13403-13406Google': [4762], 'existence': [4765], 'spaced': [4769], 'proximity': [4782], 'potentially': [4792], 'leads': [4796], 'us': [4797], 'speculate': [4799], 'molecular': [4810], 'considered': [4817], 'Scholar,57Fruen': [4854], 'B.R.': [4855], 'Bardy': [4856], 'J.M.': [4857], 'Byrem': [4858], 'T.M.': [4859], 'Louis': [4862], 'C.F.': [4863], 'Am.': [4864], '279:': [4870], 'C724-C733Google': [4871], 'thank': [4874], 'technical': [4878], 'assistance,': [4879], 'grateful': [4883], 'Wadsworth': [4886], 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