Publication Information

{'id': 'https://openalex.org/W1989815568', 'doi': 'https://doi.org/10.1056/nejm196802152780702', 'title': "Prevention of Wilson's Disease in Asymptomatic Patients", 'display_name': "Prevention of Wilson's Disease in Asymptomatic Patients", 'publication_year': 1968, 'publication_date': '1968-02-15', 'ids': {'openalex': 'https://openalex.org/W1989815568', 'doi': 'https://doi.org/10.1056/nejm196802152780702', 'mag': '1989815568', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/5635646'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1056/nejm196802152780702', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063095063', 'display_name': 'Irmin Sternlieb', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800364127', 'display_name': 'Jacobi Medical Center', 'ror': 'https://ror.org/05hcfns23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800364127']}, {'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Irmin Sternlieb', 'raw_affiliation_strings': ['Associate professor of medicine, Albert Einstein College of Medicine: attending physician, Bronx Municipal Hospital Center.'], 'affiliations': [{'raw_affiliation_string': 'Associate professor of medicine, Albert Einstein College of Medicine: attending physician, Bronx Municipal Hospital Center.', 'institution_ids': ['https://openalex.org/I2800364127', 'https://openalex.org/I129975664']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071983021', 'display_name': 'I. Herbert Scheinberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1289079397', 'display_name': 'Bronx-Lebanon Hospital Center', 'ror': 'https://ror.org/0107ygt22', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289079397']}, {'id': 'https://openalex.org/I2800364127', 'display_name': 'Jacobi Medical Center', 'ror': 'https://ror.org/05hcfns23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800364127']}, {'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'I. Herbert Scheinberg', 'raw_affiliation_strings': ['Professor of medicine, Albert Einstein College of Medicine', 'attending physician, Bronx Municipal Hospital Center.'], 'affiliations': [{'raw_affiliation_string': 'attending physician, Bronx Municipal Hospital Center.', 'institution_ids': ['https://openalex.org/I1289079397', 'https://openalex.org/I2800364127']}, {'raw_affiliation_string': 'Professor of medicine, Albert Einstein College of Medicine', 'institution_ids': ['https://openalex.org/I129975664']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 18.251, 'has_fulltext': False, 'cited_by_count': 307, 'citation_normalized_percentile': {'value': 0.998332, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '278', 'issue': '7', 'first_page': '352', 'last_page': '359'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10915', 'display_name': 'Trace Elements in Health', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10915', 'display_name': 'Trace Elements in Health', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10790', 'display_name': 'Heavy Metal Exposure and Toxicity', 'score': 0.9884, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12211', 'display_name': 'Aluminum toxicity and tolerance in plants and animals', 'score': 0.9726, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pathognomonic', 'display_name': 'Pathognomonic', 'score': 0.83084345}, {'id': 'https://openalex.org/keywords/penicillamine', 'display_name': 'Penicillamine', 'score': 0.608163}, {'id': 'https://openalex.org/keywords/regimen', 'display_name': 'Regimen', 'score': 0.44695082}, {'id': 'https://openalex.org/keywords/subclinical-infection', 'display_name': 'Subclinical infection', 'score': 0.4223441}], 'concepts': [{'id': 'https://openalex.org/C2777910003', 'wikidata': 'https://www.wikidata.org/wiki/Q1707292', 'display_name': 'Asymptomatic', 'level': 2, 'score': 0.9378209}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.92519}, {'id': 'https://openalex.org/C2776407475', 'wikidata': 'https://www.wikidata.org/wiki/Q1981783', 'display_name': 'Pathognomonic', 'level': 3, 'score': 0.83084345}, {'id': 'https://openalex.org/C2779348387', 'wikidata': 'https://www.wikidata.org/wiki/Q421239', 'display_name': 'Penicillamine', 'level': 2, 'score': 0.608163}, {'id': 'https://openalex.org/C163276114', 'wikidata': 'https://www.wikidata.org/wiki/Q484591', 'display_name': 'Natural history', 'level': 2, 'score': 0.5691154}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.50512296}, {'id': 'https://openalex.org/C2781413609', 'wikidata': 'https://www.wikidata.org/wiki/Q7308373', 'display_name': 'Regimen', 'level': 2, 'score': 0.44695082}, {'id': 'https://openalex.org/C2775934546', 'wikidata': 'https://www.wikidata.org/wiki/Q179991', 'display_name': 'Biopsy', 'level': 2, 'score': 0.42358238}, {'id': 'https://openalex.org/C113280763', 'wikidata': 'https://www.wikidata.org/wiki/Q2326546', 'display_name': 'Subclinical infection', 'level': 2, 'score': 0.4223441}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.40998557}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39574838}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.3728314}], 'mesh': [{'descriptor_ui': 'D006527', 'descriptor_name': 'Hepatolenticular Degeneration', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D010396', 'descriptor_name': 'Penicillamine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001706', 'descriptor_name': 'Biopsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002570', 'descriptor_name': 'Ceruloplasmin', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D002570', 'descriptor_name': 'Ceruloplasmin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003300', 'descriptor_name': 'Copper', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D003300', 'descriptor_name': 'Copper', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006527', 'descriptor_name': 'Hepatolenticular Degeneration', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006527', 'descriptor_name': 'Hepatolenticular Degeneration', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D006527', 'descriptor_name': 'Hepatolenticular Degeneration', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006527', 'descriptor_name': 'Hepatolenticular Degeneration', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006527', 'descriptor_name': 'Hepatolenticular Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006527', 'descriptor_name': 'Hepatolenticular Degeneration', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007223', 'descriptor_name': 'Infant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008854', 'descriptor_name': 'Microscopy, Electron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010396', 'descriptor_name': 'Penicillamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1056/nejm196802152780702', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/5635646', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.77, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1972898946', 'https://openalex.org/W1973385829', 'https://openalex.org/W1979600756', 'https://openalex.org/W1980498693', 'https://openalex.org/W1995996350', 'https://openalex.org/W2007030387', 'https://openalex.org/W2066524910', 'https://openalex.org/W2067965621', 'https://openalex.org/W2068900026', 'https://openalex.org/W2069457793', 'https://openalex.org/W2070094044', 'https://openalex.org/W2081433242', 'https://openalex.org/W2094549059', 'https://openalex.org/W2129958911', 'https://openalex.org/W2319457182', 'https://openalex.org/W2327276531', 'https://openalex.org/W2333056508', 'https://openalex.org/W2746559983', 'https://openalex.org/W4247165955', 'https://openalex.org/W575151623'], 'related_works': ['https://openalex.org/W4206182164', 'https://openalex.org/W272938725', 'https://openalex.org/W2621389486', 'https://openalex.org/W2511485561', 'https://openalex.org/W2417403314', 'https://openalex.org/W2333305249', 'https://openalex.org/W2314178239', 'https://openalex.org/W2032455296', 'https://openalex.org/W2016369437', 'https://openalex.org/W2001746178'], 'abstract_inverted_index': {'A': [0], 'biochemical': [1], 'diagnosis': [2], 'of': [3, 27, 32, 52, 69, 80, 82, 93, 106, 119], "Wilson's": [4, 94], 'disease': [5, 95], 'was': [6, 39], 'established': [7], 'in': [8, 13, 45, 96, 115], '53': [9], 'asymptomatic': [10, 76], 'subjects,': [11], 'ranging': [12], 'age': [14], 'from': [15], '15': [16], 'months': [17], 'to': [18, 113], '31': [19, 46], 'years.': [20, 85], 'None': [21], 'had': [22], 'any': [23], 'pathognomonic': [24], 'physical': [25], 'sign': [26], 'the': [28, 64, 90, 107], 'disease.': [29], 'In': [30], '36': [31], 'these': [33, 53, 120], 'patients': [34, 54], 'a': [35, 59, 78], 'liver': [36], 'biopsy': [37], 'specimen': [38], 'examined': [40], 'by': [41], 'light': [42], 'microscopy,': [43], 'and': [44, 66, 73], 'histologic': [47], 'changes': [48], 'were': [49], 'found.': [50], 'Forty-two': [51], 'have': [55, 74, 110], 'been': [56, 111], 'treated': [57], 'with': [58], 'de-copperizing': [60], 'regimen,': [61], 'based': [62, 88], 'on': [63, 89], 'continued': [65], 'daily': [67], 'administration': [68], 'D,L-penicillamine': [70], 'or': [71], 'D-penicillamine,': [72], 'remained': [75], 'during': [77, 102], 'period': [79], 'observation': [81], '142': [83], 'patient': [84], 'An': [86], 'estimate,': [87], 'natural': [91], 'history': [92], '121': [97], 'symptomatic': [98], 'patients,': [99], 'suggests': [100], 'that': [101], 'this': [103], 'interval': [104], 'symptoms': [105], 'disorder': [108], 'could': [109], 'expected': [112], 'develop': [114], 'at': [116], 'least': [117], 'eight': [118], 'subjects.': [121]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1989815568', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-06T04:51:32.603191', 'created_date': '2016-06-24'}