Title: Expression of Erythropoietin and Erythropoietin Receptor in Vestibular Schwannoma
Abstract: Background: Expression of erythropoietin (Epo) is controlled by the transcription factor hypoxia-inducible factor-1α (HIF-1α). Epo signaling via erythropoietin receptor (EpoR) results in stimulation of cell proliferation and upregulation of the antiapoptotic protein bcl-2 followed by inhibition of apoptosis. Epo has previously been demonstrated to be associated with Schwann cell proliferation and a recent clinical case report suggested a role in vestibular schwannoma growth.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot