Publication Information

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'https://openalex.org/W2130234269', 'https://openalex.org/W2092574818', 'https://openalex.org/W2085109799', 'https://openalex.org/W2068905608', 'https://openalex.org/W2053622195', 'https://openalex.org/W1981680830', 'https://openalex.org/W1964986946'], 'abstract_inverted_index': {'The': [0, 160, 320, 512, 738, 917, 1112, 1193, 1226, 1587, 1857, 1877, 2120, 2293, 2306, 2371, 2417, 2448, 2590, 2838, 2856, 2909, 2933, 3070, 3125, 3163, 3296, 3305, 3489, 3519, 3550, 3749, 4342, 4502, 4513], 'p38': [1, 23, 120, 161, 183, 280, 717, 739, 922, 1115, 1197, 1224, 1699, 1779, 1813, 2222, 3569], 'MAP': [2, 162, 742, 825], 'kinase': [3, 52, 76, 163, 212, 236, 341, 520, 700, 736, 807, 826, 1198, 2400, 2544, 4328, 4338], 'signal': [4, 164, 328, 509], 'transduction': [5, 165, 329, 510], 'pathway': [6, 166], 'is': [7, 102, 115, 151, 167, 262, 275, 311, 367, 568, 1367, 1575, 1677, 1830], 'an': [8, 168, 685, 831, 847, 3248, 3689, 3756], 'important': [9, 169, 848, 3796], 'regulator': [10, 170], 'of': [11, 20, 60, 73, 90, 147, 171, 180, 220, 233, 250, 307, 323, 346, 351, 355, 363, 412, 419, 486, 490, 501, 518, 584, 601, 705, 709, 712, 716, 733, 741, 786, 850, 919, 931, 935, 1114, 1172, 1196, 1210, 1221, 1228, 1493, 1527, 1536, 1582, 1589, 1673, 1692, 1703, 1715, 1777, 1790, 1802, 1812, 1826, 1887, 2056, 2063, 2148, 2186, 2201, 2221, 2323, 2326, 2351, 2389, 2394, 2411, 2420, 2432, 2441, 2466, 2473, 2479, 2484, 2495, 2532, 2538, 2555, 2565, 2633, 2649, 2703, 2732, 2740, 2745, 2756, 2770, 2833, 2868, 2888, 2893, 2964, 3061, 3117, 3155, 3190, 3196, 3239, 3396, 3409, 3412, 3428, 3498, 3507, 3526, 3530, 3547, 3584, 3655, 3671, 3727, 3736, 3746, 3775, 3791, 3798, 3805, 3961, 3971, 4134, 4144, 4152, 4159, 4311, 4336, 4344, 4352, 4356, 4368, 4371, 4441, 4469, 4474, 4504, 4527, 4571], 'proinflammatory': [12, 172], 'cytokine': [13, 173], 'production': [14, 93, 174, 253, 2180], 'and': [15, 28, 94, 153, 175, 188, 254, 313, 475, 577, 792, 799, 836, 841, 852, 937, 1071, 1126, 1133, 1163, 1203, 1485, 1665, 1832, 1845, 1890, 2038, 2045, 2053, 2089, 2136, 2153, 2170, 2173, 2219, 2227, 2255, 2321, 2342, 2406, 2482, 2487, 2497, 2550, 2573, 2585, 2625, 2644, 2680, 2707, 2751, 2806, 2851, 2903, 2914, 2925, 2948, 2959, 2977, 3000, 3081, 3136, 3139, 3174, 3202, 3222, 3233, 3291, 3344, 3348, 3373, 3382, 3402, 3421, 3449, 3484, 3504, 3537, 3554, 3593, 3606, 3629, 3744, 3759, 3948, 3957, 3968, 3979, 3984, 4167, 4329, 4376, 4444, 4448], 'inflammation.': [16, 176], 'Defining': [17, 177], 'the': [18, 21, 58, 70, 148, 178, 181, 218, 230, 308, 352, 361, 416, 483, 502, 582, 599, 703, 710, 730, 806, 920, 1169, 1208, 1218, 1222, 1229, 1491, 1528, 1537, 1580, 1590, 1671, 1684, 1693, 1775, 1799, 1803, 1827, 1846, 2029, 2060, 2177, 2191, 2209, 2269, 2300, 2352, 2360, 2421, 2433, 2438, 2463, 2474, 2492, 2500, 2512, 2566, 2574, 2595, 2599, 2620, 2630, 2641, 2645, 2650, 2657, 2661, 2675, 2700, 2704, 2708, 2715, 2720, 2733, 2771, 2812, 2825, 2834, 2842, 2848, 2865, 2885, 2894, 2917, 2978, 2993, 3017, 3058, 3078, 3086, 3097, 3106, 3114, 3133, 3144, 3152, 3171, 3179, 3207, 3219, 3226, 3236, 3252, 3268, 3277, 3422, 3437, 3516, 3555, 3652, 3659, 3672, 3714, 3737, 3747, 3760, 3782, 3795, 3801, 3959, 3962, 3965, 3969, 4118, 4123, 4132, 4138, 4142, 4150, 4153, 4325, 4334, 4350, 4475, 4496, 4505, 4525, 4569], 'roles': [19, 179], 'various': [22, 182, 921, 2303, 2979], 'family': [24, 184, 418, 923], 'members,': [25, 185, 788], 'specifically': [26, 186], 'p38α': [27, 49, 84, 149, 187, 209, 244, 309, 697, 824, 1125, 1202, 1230, 1366, 1532, 1584, 1791, 1828, 1862, 3243, 3806, 3947, 4166, 4447], 'p38β,': [29, 189, 790], 'in': [30, 46, 83, 122, 129, 158, 190, 206, 243, 282, 289, 318, 326, 422, 592, 688, 713, 805, 838, 1160, 1232, 1241, 1490, 1531, 1593, 1650, 1660, 1708, 1712, 1725, 1734, 1788, 1837, 2026, 2030, 2048, 2086, 2106, 2109, 2116, 2210, 2499, 2525, 2603, 2639, 2719, 2841, 2937, 2992, 3002, 3187, 3257, 3455, 3511, 3543, 3574, 3598, 3624, 3665, 3807, 3954, 4115, 4174, 4315, 4339, 4349, 4436, 4456, 4472, 4478, 4522], 'these': [31, 74, 191, 234, 566, 734, 1211, 1778, 1817, 3101, 4160, 4320], 'processes': [32, 192], 'has': [33, 53, 193, 213, 925, 1893], 'been': [34, 54, 194, 214, 605, 926, 1119, 1894, 4181], 'difficult.': [35, 195], 'Here': [36, 196], 'we': [37, 197, 683, 1781, 4464], 'use': [38, 198, 1209, 4343], 'a': [39, 80, 125, 199, 240, 285, 519, 800, 929, 1488, 1720, 2087, 2096, 2110, 2117, 2125, 2149, 2215, 2327, 2338, 2366, 2381, 2385, 2390, 2398, 2402, 2407, 2428, 2454, 2518, 2522, 2528, 2533, 2542, 2546, 2551, 2604, 2612, 2635, 2665, 2671, 2686, 2726, 2736, 2741, 2747, 2752, 2814, 2871, 2898, 2904, 2965, 3074, 3082, 3129, 3137, 3140, 3167, 3175, 3199, 3215, 3258, 3499, 3544, 3568, 4346, 4353, 4437, 4466], 'chemical': [40, 200, 570], 'genetics': [41, 201], 'approach': [42, 202, 687, 4348], 'using': [43, 203, 493, 928, 2264, 2311, 2682, 2821, 2987, 3048, 3198, 3267, 3366, 3713], 'knock-in': [44, 204, 691, 723, 1783, 1818, 3112, 3150], 'mice': [45, 67, 123, 134, 205, 227, 283, 294, 692, 724, 1233, 1594, 1646, 1657, 1690, 1711, 1784, 1819, 2067, 2083, 2121, 2183, 2198, 2206, 3047, 3395, 3564, 3626, 3685, 4492, 4506, 4515, 4572], 'which': [47, 207, 572, 593, 689, 794, 1713, 2640, 3766], 'either': [48, 208, 2105], 'or': [50, 107, 210, 267, 698, 1792, 2115, 3312, 3354, 3577, 3633, 3695, 3721, 4365], 'p38β': [51, 65, 100, 132, 211, 225, 260, 292, 699, 1127, 1204, 1591, 1644, 1655, 1688, 1844, 2329, 2353, 2362, 2372, 2606, 2662, 2721, 3313, 3949, 4476], 'rendered': [55, 215], 'resistant': [56, 86, 216, 246, 701, 1808], 'to': [57, 68, 87, 119, 137, 217, 228, 247, 279, 297, 481, 564, 580, 597, 695, 702, 719, 728, 845, 1216, 1652, 1663, 1670, 1679, 1719, 1731, 1773, 1809, 1820, 2081, 2124, 2156, 2336, 2445, 2510, 2619, 2713, 2823, 2896, 3004, 3032, 3035, 3045, 3218, 3225, 3293, 3375, 3393, 3515, 3582, 3777, 3810, 4146, 4332, 4489, 4499], 'effects': [59, 219, 704, 711], 'specific': [61, 75, 145, 221, 235, 305, 365, 574, 602, 706, 735, 1219, 1824, 2111, 2158, 4323], 'inhibitors': [62, 121, 222, 281, 342, 366, 603, 718, 1116, 1155, 1199, 3813, 4156, 4322], 'along': [63, 223], 'with': [64, 124, 224, 284, 515, 528, 1128, 1246, 1598, 1687, 1785, 2050, 2095, 2847, 3100, 3300, 3310, 3323, 3333, 3351, 3425, 3458, 3523, 3567, 3692, 4137, 4169, 4518, 4524], 'knock-out': [66, 133, 226, 293, 1585, 1645, 1656, 1710, 1736], 'dissect': [69, 229, 729], 'biological': [71, 231, 484, 731], 'function': [72, 232, 485, 732, 918, 1776], 'isoforms.': [77, 237, 737, 1225, 1700], 'Mice': [78, 238, 2076, 3418], 'harboring': [79, 239], 'T106M': [81, 126, 241, 286, 2523, 2575, 2727, 2826, 3145, 3180, 3952], 'mutation': [82, 128, 242, 288, 2524, 2576, 2597, 2728, 2827, 2895, 3963, 4143], 'are': [85, 245, 405, 496, 595, 693, 1121, 4162], 'pharmacological': [88, 248, 578, 1072, 4347], 'inhibition': [89, 146, 249, 306, 530, 1073, 1825], 'LPS-induced': [91, 111, 251, 271, 2178, 3383], 'TNF': [92, 112, 252, 272, 2179, 3384], 'collagen': [95, 255, 751, 2192], 'antibody-induced': [96, 256, 752, 2193], 'arthritis,': [97, 257], 'indicating': [98, 258], 'that': [99, 144, 259, 304, 526, 833, 1117, 1365, 1823, 2348, 3015, 3246, 4179, 4493], 'activity': [101, 261, 1130, 1159], 'not': [103, 263, 406, 497, 1206, 1596, 1797, 3104], 'required': [104, 264, 1368], 'for': [105, 155, 265, 315, 335, 409, 504, 1200, 1369, 1695, 1834, 2028, 2208, 2943, 2951, 3009, 3022, 3077, 3085, 3132, 3143, 3170, 3178, 3251, 3317, 3357, 3400, 3443, 3662, 3755, 4165, 4324, 4374], 'acute': [106, 266], 'chronic': [108, 268], 'inflammatory': [109, 138, 269, 298], 'responses.': [110, 270], 'production,': [113, 273], 'however,': [114, 274], 'still': [116, 276, 1666], 'completely': [117, 277], 'sensitive': [118, 278, 1730], 'point': [127, 287, 1786], 'p38β.': [130, 290, 1793], 'Similarly,': [131, 291], 'respond': [135, 295], 'normally': [136, 296, 4357], 'stimuli.': [139, 299, 1654], 'These': [140, 300, 1152, 1362, 1794], 'results': [141, 301, 1685], 'demonstrate': [142, 302, 1821], 'conclusively': [143, 303, 1822], 'isoform': [150, 310, 1829], 'necessary': [152, 312, 1831], 'sufficient': [154, 314, 1833], 'anti-inflammatory': [156, 316, 1158], 'efficacy': [157, 317, 1836], 'vivo.': [159, 319, 1838], 'ubiquitous': [321], 'involvement': [322], 'protein': [324, 359, 2270, 3283], 'kinases': [325, 421, 594, 784, 939, 1804, 4178, 4359], 'cellular': [327], 'pathways': [330], 'makes': [331], 'them': [332, 1807], 'attractive': [333], 'targets': [334], 'pharmacologic': [336, 529], 'intervention.': [337], 'Low': [338], 'molecular': [339, 586], 'weight': [340, 587], 'enable': [343, 598], 'titratable': [344], 'control': [345], 'signaling': [347, 854, 1649], 'pathways.': [348, 511], 'However,': [349, 1675], 'because': [350, 500, 1691], 'high': [353, 764, 796], 'degree': [354], 'structural': [356], 'conservation': [357], 'within': [358, 506, 3800, 4122], 'kinases,': [360], 'generation': [362, 4570], 'truly': [364], 'very': [368], 'challenging': [369], '(1Fischer': [370], 'P.M.': [371], 'Curr.': [372, 1140], 'Med.': [373, 1036, 1142, 1298, 1421, 1939, 2013, 4029, 4103, 4226, 4300], 'Chem.': [374, 973, 999, 1143, 1940, 2014, 3836, 3870, 3893, 4030, 4104, 4227, 4301], '2004;': [375, 461, 1000], '11:': [376, 648], '1563-1583Crossref': [377], 'PubMed': [378, 397, 439, 464, 557, 633, 655, 675, 819, 895, 912, 960, 982, 1008, 1040, 1066, 1087, 1107, 1147, 1188, 1279, 1302, 1331, 1357, 1402, 1425, 1454, 1480, 1519, 1569, 1634, 1763, 1945, 2018, 2248, 2288, 2799, 3845, 3878, 3901, 3939, 4035, 4108, 4232, 4305, 4563], 'Scopus': [379, 398, 440, 465, 558, 634, 656, 676, 820, 896, 913, 961, 983, 1009, 1041, 1067, 1088, 1108, 1148, 1189, 1280, 1303, 1332, 1358, 1403, 1426, 1455, 1481, 1520, 1570, 1635, 1764, 1946, 2019, 2249, 2289, 2800, 3846, 3879, 3902, 3940, 4036, 4109, 4233, 4306, 4564], '(127)': [380], 'Google': [381, 400, 442, 467, 560, 636, 658, 678, 822, 898, 915, 963, 985, 1011, 1043, 1069, 1090, 1110, 1150, 1191, 1282, 1305, 1334, 1360, 1405, 1428, 1457, 1483, 1522, 1572, 1637, 1766, 1948, 2021, 2251, 2291, 2802, 3848, 3881, 3904, 3942, 4038, 4111, 4235, 4308, 4566], 'Scholar,': [382, 443, 637, 659, 899, 964, 986, 1044, 1091, 1283, 1306, 1335, 1406, 1429, 1458, 1949, 3849, 3882, 3905, 4039, 4236], '2Vieth': [383], 'M.': [384, 534, 610, 1256, 1285, 1289, 1347, 1379, 1408, 1412, 1470, 1509, 1546, 1609, 1611, 1745, 1753, 1991, 2001, 3886, 3892, 4081, 4091, 4278, 4288, 4538, 4540], 'Sutherland': [385], 'J.J.': [386, 536, 612], 'Robertson': [387], 'D.H.': [388], 'Campbell': [389], 'R.M.': [390, 1929, 4019, 4216], 'Drug': [391, 1082, 1183], 'Discov.': [392, 1083, 1184], 'Today.': [393], '2005;': [394, 1037, 1144, 1631, 1760, 4560], '10:': [395], '839-846Crossref': [396], '(160)': [399, 1042], 'Scholar).': [401, 468, 561, 679, 823, 916, 1111, 1151, 1192, 1361, 1523, 1638, 1767, 2022, 2252, 2292, 3943, 4112, 4309, 4567], 'In': [402, 680, 2176, 2190], 'addition,': [403], 'tools': [404, 727, 1215], 'readily': [407], 'available': [408, 1578], 'comprehensive': [410], 'assessment': [411], 'inhibitor': [413, 3570], 'specificity': [414, 1195], 'across': [415], 'large': [417], '>500': [420], 'mammalian': [423], 'species': [424], '(3Manning': [425], 'G.': [426, 447, 453, 1254, 1377, 1544, 1625, 1739, 3915, 4554], 'Whyte': [427], 'D.B.': [428], 'Martinez': [429], 'R.': [430, 1266, 1345, 1389, 1468, 1507, 1556, 1931, 4021, 4218], 'Hunter': [431, 450], 'T.': [432, 451, 966, 1339, 1462, 1501], 'Sudarsanam': [433, 448], 'S.': [434, 445, 449, 459, 864, 955, 1075, 1095, 1097, 1176, 1260, 1318, 1326, 1383, 1441, 1449, 1550, 1901, 1917, 1995, 2786, 2794, 3819, 3857, 3924, 3991, 4007, 4085, 4188, 4204, 4282], 'Science.': [435, 908], '2002;': [436], '298:': [437], '1912-1934Crossref': [438], '(6259)': [441], '4Caenepeel': [444], 'Charydczak': [446], 'Manning': [452], 'Proc.': [454, 950, 1321, 1444, 2789], 'Natl.': [455, 951, 1322, 1445, 2790], 'Acad.': [456, 952, 1323, 1446, 2791], 'Sci.': [457, 666, 953, 1324, 1447, 2792], 'U.': [458, 663, 954, 1325, 1341, 1448, 1464, 1503, 2793], 'A.': [460, 532, 538, 608, 614, 949, 956, 1099, 1252, 1262, 1327, 1375, 1385, 1450, 1542, 1552, 1757, 1969, 2005, 2795, 3909, 3926, 4059, 4095, 4256, 4292], '101:': [462], '11707-11712Crossref': [463], '(249)': [466], 'Genetic': [469], 'techniques,': [470, 932], 'such': [471, 4312, 4345], 'as': [472, 830, 1213, 2146, 2229, 2261, 2268, 2333, 2415, 2559, 2760, 2990, 3732, 3734], 'gene': [473, 1231, 1592, 2569, 2774, 3099], 'knock-outs': [474], 'RNA': [476, 3203], 'interference,': [477], 'offer': [478], 'alternative': [479, 686], 'ways': [480], 'study': [482, 1217, 1774], 'kinases.': [487], 'Nevertheless,': [488, 4141], 'interpretations': [489], 'data': [491, 2308], 'generated': [492, 1782, 2581, 3095, 3230, 3256], 'genetic': [494, 516, 575, 590, 690], 'techniques': [495, 579], 'always': [498], 'straightforward': [499], 'potential': [503, 1694], 'compensation': [505, 1696, 1704], 'highly': [507, 4163], 'adaptable': [508], 'phenotypes': [513], 'associated': [514, 527, 1245, 1597], 'deletion': [517, 1227, 1588, 4468], 'can': [521], 'be': [522, 846, 2157, 3094], 'quite': [523], 'distinct': [524, 3974], 'from': [525, 1643, 1683, 1852, 1864, 1873, 1883, 2070, 2453, 2611, 2674, 2695, 2880, 2922, 2974, 3051, 3096, 3391, 3436], '(5Jaeschke': [531, 607], 'Karasarides': [533, 609], 'Ventura': [535, 611], 'Ehrhardt': [537, 613], 'Zhang': [539, 615, 1932, 4022, 4219], 'C.': [540, 616, 941, 1607, 1621, 3921, 4536, 4550], 'Flavell': [541, 617], 'R.A.': [542, 618], 'Shokat': [543, 619, 642], 'K.M.': [544, 620, 643, 1903, 3993, 4190], 'Davis': [545, 621], 'R.J.': [546, 622, 907, 3815], 'Mol.': [547, 623, 1269, 1392, 1559, 1628, 4557], 'Cell.': [548, 624, 1270, 1348, 1393, 1471, 1510, 1560], '2006;': [549, 625, 1942, 4032, 4229], '23:': [550, 626], '899-911Abstract': [551, 627], 'Full': [552, 554, 628, 630, 650, 652, 670, 672, 977, 979, 1003, 1005, 1274, 1276, 1352, 1354, 1397, 1399, 1475, 1477, 1514, 1516, 1564, 1566, 3840, 3842, 3875, 3898], 'Text': [553, 555, 629, 631, 651, 653, 671, 673, 978, 980, 1004, 1006, 1275, 1277, 1353, 1355, 1398, 1400, 1476, 1478, 1515, 1517, 1565, 1567, 3841, 3843, 3876, 3899], 'PDF': [556, 632, 654, 674, 981, 1007, 1278, 1356, 1401, 1479, 1518, 1568, 3844, 3877, 3900], '(132)': [559, 635], 'One': [562, 2356], 'way': [563], 'overcome': [565], 'difficulties': [567], 'through': [569], 'genetics,': [571], 'combines': [573], 'mutations': [576, 1787, 1795, 3953], 'manipulate': [581], 'selectivity': [583], 'low': [585], 'inhibitors.': [588, 707, 1814], 'Chemical': [589], 'approaches': [591], 'mutated': [596, 2621, 2849, 2858], 'binding': [600, 3803, 4125, 4133], 'have': [604, 1118, 1156, 1166, 3793, 4180], 'described': [606, 1120, 1707, 1895, 2230, 2263, 2991], '6Bishop': [638], 'A.C.': [639], 'Buzko': [640], 'O.': [641, 1056], 'Trends': [644, 664], 'Cell': [645, 1629, 1865, 3380, 4558], 'Biol.': [646, 972, 998, 1630, 3835, 3871, 3894, 4559], '2001;': [647, 816, 1063], '167-172Abstract': [649], '(202)': [657, 1636, 4565], '7Crews': [660], 'C.M.': [661, 1927, 4017, 4214], 'Splittgerber': [662], 'Biochem.': [665], '1999;': [667, 1104, 2015, 4105, 4302], '24:': [668, 1761], '317-320Abstract': [669], '(117)': [677], 'this': [681, 1732], 'report,': [682], 'describe': [684], 'used': [694, 745, 1816, 2207, 2332, 2712, 3021, 3044, 4488], 'render': [696, 1806], 'Comparisons': [708], 'vivo': [714, 1661, 2211, 4340], 'administration': [715], 'wild-type': [720, 936, 1726, 2601, 3079, 3098, 3134, 3172, 3227, 4139, 4327, 4375], 'versus': [721], 'drug-resistant': [722], 'provide': [725], 'powerful': [726], 'subfamily': [740], '2The': [743], 'abbreviations': [744], 'are:': [746], 'MAP,': [747], 'mitogen-activated': [748], 'protein;': [749], 'CAIA,': [750], 'arthritis;': [753], 'Me2SO,': [754], 'dimethyl': [755], 'sulfoxide;': [756], 'ELISA,': [757], 'enzyme-linked': [758], 'immunosorbent': [759], 'assay;': [760], 'LPS,': [761], 'lipopolysaccharide;': [762], 'HPLC,': [763], 'performance': [765], 'liquid': [766], 'chromatography;': [767], 'HRP,': [768], 'horseradish': [769], 'peroxidase;': [770], 'neo,': [771], 'neomycin': [772, 2403, 2547, 2688, 2748, 2873], 'resistance;': [773], 'TK,': [774], 'thymidine': [775, 2399, 2543], 'kinase;': [776], 'TNF,': [777], 'tumor': [778], 'necrosis': [779], 'factor;': [780], 'GST,': [781], 'glutathione': [782], 'S-transferase.': [783], 'consists': [785], '4': [787, 2572, 2731, 2769], 'p38α,': [789], 'p38γ,': [791], 'p38δ,': [793], 'share': [795], 'sequence': [797, 2364, 2588, 2602, 2854, 3221, 3228, 3254], 'homology': [798, 2395, 2412, 2539, 2556, 2757], 'signature': [801], 'TGY': [802], 'phosphorylation': [803, 1714], 'motif': [804], 'activation': [808], 'loop': [809], '(8Kyriakis': [810], 'J.M.': [811, 1617, 4546], 'Avruch': [812], 'J.': [813, 901, 971, 997, 1032, 1077, 1137, 1178, 1291, 1293, 1296, 1310, 1414, 1416, 1419, 1433, 1613, 1615, 1747, 1759, 1897, 1993, 2003, 2012, 2778, 3834, 3907, 3932, 3987, 4083, 4093, 4102, 4184, 4280, 4290, 4299, 4542, 4544], 'Physiol.': [814], 'Rev.': [815, 1081, 1182], '81:': [817], '807-869Crossref': [818], '(2885)': [821], 'was': [827, 834, 842, 1234, 1244, 1595, 1705, 1717, 1863, 1872, 1882, 2296, 2374, 2413, 2424, 2451, 2489, 2557, 2580, 2627, 2668, 2697, 2711, 2758, 2804, 2819, 2845, 2862, 2882, 2972, 3040, 3043, 3204, 3229, 3247, 3255, 3494, 3513, 3552, 3558, 3609, 3648, 3676, 3697, 3753, 3764], 'originally': [828], 'identified': [829, 2999], 'enzyme': [832], 'phosphorylated': [835], 'activated': [837, 2228], 'LPS-stimulated': [839], 'monocytes': [840], 'subsequently': [843], 'shown': [844, 4114], 'mediator': [849], 'TNFα': [851, 3556, 3608], 'IL-1': [853], '(9Lee': [855], 'J.C.': [856, 1079, 1093, 1180, 3825], 'Laydon': [857], 'J.T.': [858], 'McDonnell': [859], 'P.C.': [860], 'Gallagher': [861], 'T.F.': [862], 'Kumar': [863, 1096, 1916, 3818, 4006, 4203], 'Green': [865], 'D.': [866, 868], 'McNulty': [867], 'Blumenthal': [869], 'M.J.': [870, 3823, 3863], 'Heys': [871], 'J.R.': [872, 886, 1022], 'Landvatter': [873], 'S.W.': [874], 'Strickler': [875], 'J.E.': [876, 1905, 1935, 3995, 4025, 4192, 4222], 'McLaughlin': [877, 3816], 'M.M.': [878, 1320, 1443, 2788, 3817], 'Siemens': [879], 'I.R.': [880], 'Fisher': [881], 'S.M.': [882, 1963, 4053, 4250], 'Livi': [883, 3828], 'G.P.': [884, 3829], 'White': [885], 'Adams': [887, 1100, 3826], 'J.L.': [888, 1101, 3827], 'Young': [889, 3832], 'P.R.': [890, 3833, 3865], 'Nature.': [891, 1062], '1994;': [892, 909], '372:': [893], '739-746Crossref': [894], '(3138)': [897], '10Han': [900], 'Lee': [902, 1078, 1179, 3824], 'J.D.': [903, 2241, 2281], 'Bibbs': [904], 'L.': [905, 988, 1264, 1287, 1312, 1316, 1387, 1410, 1435, 1439, 1554, 1623, 1907, 1975, 2780, 2784, 3997, 4065, 4194, 4262, 4552], 'Ulevitch': [906], '265:': [910], '808-811Crossref': [911], '(2413)': [914], 'members': [924], 'investigated': [927], 'variety': [930, 3790], 'including': [933], 'overexpression': [934, 1672], 'mutant': [938, 3253, 3946, 4313, 4377], '(11Lechner': [940], 'Zahalka': [942], 'M.A.': [943, 3867], 'Giot': [944], 'J.F.': [945], 'Moller': [946], 'N.P.': [947], 'Ullrich': [948], '1996;': [957], '93:': [958], '4355-4359Crossref': [959], '(276)': [962], '12Efimova': [965], 'Broome': [967], 'A.M.': [968, 1343, 1466, 1505, 2237, 2277], 'Eckert': [969], 'R.L.': [970], '2003;': [974, 1084, 1185], '278:': [975], '34277-34285Abstract': [976], '(128)': [984], '13Wang': [987], 'Kwak': [989], 'J.H.': [990, 1018], 'Kim': [991], 'S.I.': [992], 'He': [993], 'Y.': [994, 1048, 1743, 2007, 4097, 4294], 'Choi': [995], 'M.E.': [996], '279:': [1001], '33213-33219Abstract': [1002], '(60)': [1010], 'Scholar),': [1012, 1070, 1573], 'antisense': [1013], 'knockdowns': [1014], '(14Duan': [1015], 'W.': [1016], 'Chan': [1017], 'McKay': [1019], 'K.': [1020, 1139, 1258, 1337, 1381, 1460, 1499, 1548, 1977, 3855, 4067, 4264], 'Crosby': [1021], 'Choo': [1023], 'H.H.': [1024], 'Leung': [1025], 'B.P.': [1026], 'Karras': [1027], 'J.G.': [1028], 'Wong': [1029], 'W.S.': [1030], 'Am.': [1031], 'Respir.': [1033], 'Crit.': [1034], 'Care': [1035, 2037], '171:': [1038], '571-578Crossref': [1039], '15Bulavin': [1045], 'D.V.': [1046], 'Higashimoto': [1047], 'Popoff': [1049], 'I.J.': [1050], 'Gaarde': [1051], 'W.A.': [1052, 1985, 4075, 4272], 'Basrur': [1053], 'V.': [1054, 1749, 3859], 'Potapova': [1055], 'Appella': [1057], 'E.': [1058, 3955], 'Fornace': [1059], 'Jr.,': [1060, 1136], 'A.J.': [1061, 1979, 4069, 4266], '411:': [1064], '102-107Crossref': [1065], '(460)': [1068], '(16Kumar': [1074, 1175], 'Boehm': [1076, 1177], 'Nat.': [1080, 1181], '2:': [1085, 1186], '717-726Crossref': [1086, 1187], '(1071)': [1089, 1190], '17Lee': [1092], 'Kassis': [1094], 'Badger': [1098], 'Pharmacol.': [1102], 'Ther.': [1103], '82:': [1105], '389-397Crossref': [1106], '(334)': [1109], 'majority': [1113], 'active': [1122, 4358], 'against': [1123, 1131, 1843, 1861, 4176], 'both': [1124, 1201], 'minimal': [1129], 'p38γ': [1132, 1709, 1735], 'p38δ': [1134], '(18Hynes': [1135], 'Leftheri': [1138], 'Top.': [1141], '5:': [1145, 3896], '967-985Crossref': [1146], '(65)': [1149], 'dual': [1153, 1194, 1721, 4321], 'p38α/β': [1154, 1722, 3975], 'potent': [1157], 'preclinical': [1161], 'models,': [1162], 'several': [1164, 2343], 'compounds': [1165, 1212, 4161], 'advanced': [1167], 'into': [1168, 2437, 2462, 2491, 2629, 2660, 2670, 2729, 2808, 2864, 2916, 2961, 3024, 3235, 3496, 3631, 3651], 'early': [1170, 1496], 'stages': [1171], 'clinical': [1173], 'development': [1174, 1371, 1497], 'does': [1205], 'allow': [1207, 4330], 'definitive': [1214], 'functions': [1220], 'individual': [1223, 2962], 'reported': [1235], 'by': [1236, 2160, 2298, 2376, 2397, 2426, 2541, 2582, 2587, 2691, 2853, 2876, 2983, 3231, 3327, 3441, 3560, 3611, 3618, 3701, 4453, 4509], 'four': [1237, 3770], 'separate': [1238], 'groups': [1239, 3636], 'and,': [1240], 'all': [1242, 2042, 2483, 3769], 'cases,': [1243], 'embryonic': [1247, 1640], 'lethality': [1248], '(19Adams': [1249, 1372, 1539], 'R.H.': [1250, 1373, 1540], 'Porras': [1251, 1374, 1541], 'Alonso': [1253, 1376, 1543], 'Jones': [1255, 1378, 1545], 'Vintersten': [1257, 1380, 1547], 'Panelli': [1259, 1382, 1549], 'Valladares': [1261, 1384, 1551], 'Perez': [1263, 1386, 1553], 'Klein': [1265, 1388, 1555], 'Nebreda': [1267, 1390, 1557], 'A.R.': [1268, 1391, 1558], '2000;': [1271, 1299, 1328, 1349, 1394, 1422, 1451, 1472, 1511, 1561, 2796], '6:': [1272, 1395, 1562], '109-116Abstract': [1273, 1396, 1563], '(451)': [1281, 1404, 1571], '20Allen': [1284, 1407], 'Svensson': [1286, 1409], 'Roach': [1288, 1411], 'Hambor': [1290, 1413], 'McNeish': [1292, 1415], 'Gabel': [1294, 1417], 'C.A.': [1295, 1418], 'Exp.': [1297, 1420], '191:': [1300, 1423], '859-870Crossref': [1301, 1424], '(252)': [1304, 1427], '21Mudgett': [1307, 1430], 'J.S.': [1308, 1431, 1627, 1741, 2776, 4556], 'Ding': [1309, 1432, 2777], 'Guh-Siesel': [1311, 1434, 2779], 'Chartrain': [1313, 1436, 2781], 'N.A.': [1314, 1437, 1755, 2782], 'Yang': [1315, 1438, 2783], 'Gopal': [1317, 1440, 2785], 'Shen': [1319, 1442, 2787], '97:': [1329, 1452, 2797], '10454-10459Crossref': [1330, 1453, 2798], '(329)': [1333, 1456, 2801], '22Tamura': [1336, 1459], 'Sudo': [1338, 1461, 1500], 'Senftleben': [1340, 1463, 1502], 'Dadak': [1342, 1465, 1504], 'Johnson': [1344, 1467, 1506], 'Karin': [1346, 1469, 1508], '102:': [1350, 1473, 1512], '221-231Abstract': [1351, 1474, 1513], '(321)': [1359, 1482, 1521], 'studies': [1363, 3792], 'revealed': [1364], 'placental': [1370, 1529], 'Scholar)': [1484, 2803], 'may': [1486, 3093], 'play': [1487], 'role': [1489, 3797, 4335], 'expression': [1492], 'erythropoietin': [1494], 'during': [1495], '(22Tamura': [1498], 'While': [1524], 'tetraploid': [1525], 'rescue': [1526], 'defect': [1530], 'knockouts': [1533], 'enabled': [1534], 'survival': [1535], 'embryos': [1538], 'there': [1574], 'little': [1576], 'information': [1577], 'on': [1579, 2102, 2214, 2365, 2927, 3287, 3637, 3678, 3964, 4131], 'phenotype': [1581, 1601, 4521], 'adult': [1583], 'mice.': [1586, 3667], 'any': [1599, 4362], 'known': [1600], '(23Beardmore': [1602, 4531], 'V.A.': [1603, 4532], 'Hinton': [1604, 4533], 'H.J.': [1605, 4534], 'Eftychi': [1606, 4535], 'Apostolaki': [1608, 4537], 'Armaka': [1610, 4539], 'Darragh': [1612, 4541], 'McIlrath': [1614, 4543], 'Carr': [1616, 1746, 4545], 'Armit': [1618, 4547], 'L.J.': [1619, 4548], 'Clacher': [1620, 4549], 'Malone': [1622, 4551], 'Kollias': [1624, 4553], 'Arthur': [1626, 1740, 4555], '25:': [1632, 4561], '10454-10464Crossref': [1633, 4562], 'Mouse': [1639], 'fibroblast': [1641, 2930], 'cells': [1642, 1727, 1737, 3387, 3520, 4480], 'displayed': [1647], 'normal': [1648, 1659], 'response': [1651], 'stress': [1653], 'had': [1658, 2122, 3016, 4127], 'responses': [1662, 1669], 'LPS': [1664, 3531, 3562, 3587], 'showed': [1667], 'pathological': [1668], 'TNFα.': [1674], 'it': [1676, 2626], 'difficult': [1678], 'draw': [1680], 'firm': [1681], 'conclusions': [1682], 'obtained': [1686, 2069, 2610, 2694, 2879], 'knockout': [1689], 'between': [1697, 2677], 'different': [1698], 'This': [1701], 'type': [1702, 4367], 'previously': [1706, 2231, 2262], 'SAP97': [1716], 'insensitive': [1718], 'inhibitor,': [1723], 'SB203850,': [1724], 'but': [1728, 1805, 3103, 3785], 'became': [1729], 'compound': [1733, 3614, 3696], '(24Sabio': [1738], 'Kuma': [1742], 'Peggie': [1744], 'Murray-Tait': [1748], 'Centeno': [1750], 'F.': [1751], 'Goedert': [1752, 3891], 'Morrice': [1754, 3887], 'Cuenda': [1756], 'EMBO': [1758], '1134-1145Crossref': [1762], '(195)': [1765], 'To': [1768, 2379, 2516, 2655, 2724, 2810, 4460], 'generate': [1769, 2380, 2446, 2511, 2517, 2897, 4461, 4490], 'better': [1770], 'animal': [1771, 2043], 'models': [1772], 'isoforms,': [1780], 'Thr106': [1789, 3776, 3799, 4145], 'do': [1796], 'affect': [1798], 'kinetic': [1800, 4372], 'properties': [1801], 'certain': [1810], 'classes': [1811], 'We': [1815, 3944], 'antiinflammatory': [1835], 'Antibodies—The': [1839], 'murine': [1840, 2328, 2567, 2772, 2929, 4457], 'monoclonal': [1841, 1879, 3641, 3673], 'antibody': [1842, 1850, 1860, 1871, 1880, 3642, 3674], 'goat': [1847], 'anti-mouse': [1848, 3355], 'HRP-conjugated': [1849, 1870, 3352], 'were': [1851, 2024, 2046, 2068, 2077, 2143, 2154, 2188, 2203, 2213, 2224, 2259, 2309, 2331, 2346, 2503, 2507, 2617, 2653, 2912, 2935, 2957, 2981, 2998, 3020, 3030, 3064, 3120, 3158, 3185, 3264, 3285, 3298, 3308, 3364, 3389, 3419, 3434, 3521, 3565, 3601, 3616, 3627, 3686, 3710, 3772, 4451, 4487, 4507, 4516], 'Invitrogen': [1853], '(Zymed': [1854], 'Laboratories': [1855], 'Inc.).': [1856], 'rabbit': [1858], 'polyclonal': [1859], 'Signaling': [1866], 'Technology.': [1867], 'Donkey': [1868], 'anti-rabbit': [1869, 3353], 'Santa': [1874], 'Cruz': [1875], 'Biotechnology.': [1876], 'Arthrogen': [1878], 'mixture': [1881, 3643, 3675], 'Chemicon/Millipore.': [1884], 'Compounds—The': [1885], 'synthesis': [1886], 'MRK': [1888, 1891, 3508, 3977, 3980], '4g': [1889, 3509, 3978, 4422], '48': [1892, 3981, 4399], '(29Bao': [1896, 4183], 'Hunt': [1898, 3988, 4185], 'J.A.': [1899, 3989, 4186], 'Miao': [1900, 3990, 4187], 'Rupprecht': [1902, 3992, 4189], 'Stelmach': [1904, 3994, 4191], 'Liu': [1906, 3996, 4193], 'Ruzek': [1908, 3998, 4195], 'R.D.': [1909, 3999, 4196], 'Sinclair': [1910, 4000, 4197], 'P.J.': [1911, 4001, 4198], 'Pivnichny': [1912, 4002, 4199], 'J.V.': [1913, 4003, 4200], 'Hop': [1914, 4004, 4201], 'C.E.': [1915, 4005, 4202], 'Zaller': [1918, 4008, 4205], 'D.M.': [1919, 2009, 4009, 4099, 4206, 4296], 'Shoop': [1920, 4010, 4207], 'W.L.': [1921, 4011, 4208], "O'Neill": [1922, 1996, 2242, 2282, 3912, 4012, 4086, 4209, 4283], 'E.A.': [1923, 1997, 2243, 2283, 3913, 4013, 4087, 4210, 4284], "O'Keefe": [1924, 2010, 2238, 2278, 3916, 4014, 4100, 4211, 4297], 'S.J.': [1925, 1989, 2011, 2239, 2279, 3917, 4015, 4079, 4101, 4212, 4276, 4298], 'Thompson': [1926, 1934, 4016, 4024, 4213, 4221], 'Cubbon': [1928, 4018, 4215], 'Wang': [1930, 3820, 4020, 4217], 'W.X.': [1933, 4023, 4220], 'Doherty': [1936, 4026, 4223], 'J.B.': [1937, 4027, 4224], 'Bioorg.': [1938, 4028, 4225], 'Lett.': [1941, 4031, 4228], '16:': [1943, 4033, 4230], '64-68Crossref': [1944, 4034, 4231], '(11)': [1947, 4037, 4234], '30Liverton': [1950, 4040, 4237], 'N.J.': [1951, 4041, 4238], 'Butcher': [1952, 4042, 4239], 'J.W.': [1953, 4043, 4240], 'Claiborne': [1954, 4044, 4241], 'C.F.': [1955, 1987, 4045, 4077, 4242, 4274], 'Claremon': [1956, 4046, 4243], 'D.A.': [1957, 4047, 4244], 'Libby': [1958, 3927, 4048, 4245], 'B.E.': [1959, 4049, 4246], 'Nguyen': [1960, 4050, 4247], 'K.T.': [1961, 4051, 4248], 'Pitzenberger': [1962, 4052, 4249], 'Selnick': [1964, 4054, 4251], 'H.G.': [1965, 4055, 4252], 'Smith': [1966, 3925, 4056, 4253], 'G.R.': [1967, 4057, 4254], 'Tebben': [1968, 3908, 4058, 4255], 'Vacca': [1970, 4060, 4257], 'J.P.': [1971, 4061, 4258], 'Varga': [1972, 4062, 4259], 'S.L.': [1973, 4063, 4260], 'Agarwal': [1974, 4064, 4261], 'Dancheck': [1976, 4066, 4263], 'Forsyth': [1978, 4068, 4265], 'Fletcher': [1980, 4070, 4267], 'D.S.': [1981, 4071, 4268], 'Frantz': [1982, 2234, 2274, 3910, 4072, 4269], 'B.': [1983, 2235, 2275, 3911, 3919, 3928, 4073, 4270], 'Hanlon': [1984, 4074, 4271], 'Harper': [1986, 4076, 4273], 'Hofsess': [1988, 4078, 4275], 'Kostura': [1990, 4080, 4277], 'Lin': [1992, 4082, 4279], 'Luell': [1994, 4084, 4281], 'Orevillo': [1998, 4088, 4285], 'C.J.': [1999, 4089, 4286], 'Pang': [2000, 4090, 4287], 'Parsons': [2002, 4092, 4289], 'Rolando': [2004, 2236, 2276, 4094, 4291], 'Sahly': [2006, 4096, 4293], 'Visco': [2008, 4098, 4295], '42:': [2016, 4106, 4303], '2180-2190Crossref': [2017, 4107, 4304], '(207)': [2020, 4110, 4307], 'Compounds': [2023], 'dissolved': [2025, 3510], 'Me2SO': [2027, 3512], 'vitro': [2031, 3003], 'experiments.': [2032], 'Mice—The': [2033, 4446], 'Merck': [2034], 'Institutional': [2035], 'Animal': [2036], 'Use': [2039], 'Committee': [2040], 'approved': [2041], 'procedures': [2044], 'performed': [2047, 2260, 4465], 'accordance': [2049], 'institutional': [2051], 'policy': [2052], 'National': [2054], 'Institutes': [2055], 'Health': [2057], 'guidelines': [2058], 'governing': [2059], 'humane': [2061], 'treatment': [2062, 3635], 'vertebrate': [2064], 'animals.': [2065], '129/SvEv': [2066], 'Taconic': [2071], 'Farms,': [2072], 'Inc.': [2073], '(Germantown,': [2074], 'NY).': [2075], 'housed': [2078], 'at': [2079, 2103, 2302, 2699, 2884, 3320, 3360, 3446, 3451, 3540, 4170], 'up': [2080], 'ten': [2082], 'per': [2084, 3193], 'cage': [2085], 'temperature-': [2088], 'humidity-controlled': [2090], 'room': [2091, 3321, 3361], '(21': [2092], '°C,': [2093], '50%)': [2094], '12': [2097, 4408], 'h': [2098, 3319, 3359, 3580, 3706], 'light/dark': [2099], 'cycle': [2100], '(lights': [2101], '0700)': [2104], 'microisolator': [2107], 'cages': [2108], 'pathogen-free': [2112, 2159], 'barrier': [2113], 'facility': [2114], 'conventional': [2118], 'facility.': [2119], 'access': [2123], 'standard': [2126], 'rodent': [2127], 'laboratory': [2128], 'diet': [2129], '(Harland': [2130], 'Teklad': [2131], 'Laboratory': [2132, 2163], 'Rodent': [2133], 'Diet': [2134], '7012)': [2135], 'reverse-osmosis': [2137], 'water': [2138], 'ad': [2139], 'libitum.': [2140], 'Sentinel': [2141], 'animals': [2142, 4316], 'evaluated': [2144], 'quarterly': [2145], 'part': [2147, 2478], 'health': [2150], 'surveillance': [2151], 'program': [2152], 'determined': [2155, 2297, 3559, 3958, 4508], 'Charles': [2161], 'River': [2162], 'Assessment': [2164], 'Plus': [2165], 'profile': [2166], '(Wilmington,': [2167], 'MA),': [2168], 'endo-': [2169], 'ectoparasite': [2171], 'examinations,': [2172], 'gross': [2174], 'necropsy.': [2175], 'experiments,': [2181, 2196], 'male': [2182], '12–15': [2184], 'weeks': [2185, 2200], 'age': [2187, 2202, 3401], 'used.': [2189, 2204, 3108], 'arthritis': [2194, 3663], '(CAIA)': [2195], 'female': [2197], '11–15': [2199], 'All': [2205], 'experiments': [2212], '129S6': [2216], 'background.': [2217], 'Cloning': [2218], 'Expression': [2220, 4310], 'Proteins—Proteins': [2223], 'expressed,': [2225], 'purified,': [2226], '(47LoGrasso': [2232, 2272], 'P.V.': [2233, 2273], 'Hermes': [2240, 2280, 3931], 'Biochemistry.': [2244, 2284, 3935], '1997;': [2245, 2285, 3872], '36:': [2246, 2286], '10422-10427Crossref': [2247, 2287], '(102)': [2250, 2290], 'Kinase': [2253], 'Assays': [2254], 'Km': [2256, 2295, 3784, 3967, 4389], 'Determinations—Kinase': [2257], 'assays': [2258, 3263], '2': [2265, 2681, 3392, 3505], 'μm': [2266, 3486], 'GST-ATF2': [2267], 'substrate': [2271], 'ATP': [2294, 2304, 3783, 3802, 3966, 4124, 4135], 'measuring': [2299], 'rate': [2301], 'concentrations.': [2305], 'resulting': [2307, 2709, 2857], 'fit': [2310], 'Grafit': [2312], 'software': [2313], 'version': [2314], '4.3': [2315], '(Erithacus': [2316], 'Software).': [2317], 'Construction': [2318], 'Targeting': [2319], 'Vectors': [2320], 'Transfection': [2322], 'ES': [2324, 2919, 2955, 2975, 3013, 4458, 4479], 'Cells—Portions': [2325], 'cDNA': [2330], 'hybridization': [2334], 'probes': [2335, 2989], 'screen': [2337], 'mouse': [2339], 'genomic': [2340, 2354, 2363, 2607, 2623, 2663, 2722, 2765, 2817, 2860], 'library,': [2341], 'phage': [2344, 2357], 'clones': [2345, 2498, 2934, 2980, 2997, 3014, 4484], 'isolated': [2347, 2805, 3050, 3205], 'contained': [2349, 2359], 'fragments': [2350, 2506], 'sequence.': [2355, 2723], 'clone': [2358, 2436], 'entire': [2361, 3738], 'single': [2367, 3216], '12.2-kb': [2368], 'EcoRI': [2369, 2608], 'fragment.': [2370], 'allele': [2373, 2520, 3080, 3135, 3173, 4498], 'confirmed': [2375, 2586, 2852], 'DNA': [2377, 2971, 2988, 3049], 'sequencing.': [2378], 'MAPK11': [2382, 2434, 2475], '(p38β)-null': [2383], 'allele,': [2384], 'targeting': [2386, 2422, 2514, 2529, 2737, 2910], 'vector': [2387, 2423, 2530, 2638, 2652, 2738], 'consisting': [2388, 2531, 2739], '5.4-kb': [2391], '5′': [2392, 2418, 2536, 2900], 'arm': [2393, 2410, 2419, 2450, 2537, 2554, 2744, 2755, 2902], 'preceded': [2396, 2540], 'cassette,': [2401, 2545], 'resistance': [2404, 2548, 2749], 'cassette': [2405, 2549, 2643, 2659, 2689, 2750, 2874], '3-kb': [2408], '3′': [2409, 2449, 2553, 2906], 'constructed': [2414, 2452, 2558, 2759], 'follows:': [2416, 2560, 2761], 'created': [2425, 2820], 'inserting': [2427], '5.4': [2429], 'BamHI': [2430], 'fragment': [2431, 2457, 2472, 2564, 2593, 2609, 2673, 2718, 2766, 2818, 2840, 2850, 2861], 'cosmid': [2435, 2456, 2476, 2613], 'BglII': [2439], 'site': [2440, 2494, 2632, 2648, 2667, 2702, 2867, 2887, 3804], 'pKO': [2442, 2467], 'Scrambler': [2443, 2468], 'NKTV-1901': [2444], 'pKOp38βRIKpn.': [2447], 'KpnI-EcoRI': [2455, 2464], 'containing': [2458, 2477, 2521, 2570, 2594, 2767, 2939, 3214, 3335, 3951], 'exons': [2459, 2485, 2678, 4470], '10–12': [2460], 'inserted': [2461, 2698, 2883], 'sites': [2465, 2693, 2878, 3238], 'NTKV-1902.': [2469], 'A': [2470, 2561, 2762, 3089, 3210, 3241], 'KpnI': [2471, 2493, 2836], 'exon': [2480, 2526, 2571, 2730, 2768], '7': [2481], '8': [2486], '9': [2488], 'ligated': [2490, 2508], 'pKOp38βRIKpn,': [2496], 'correct': [2501, 3018], 'orientation': [2502], 'selected.': [2504], 'NotI-XhoI': [2505], 'together': [2509], 'completed': [2513], 'vector.': [2515], 'Mapk11': [2519, 2568], '4,': [2527, 3742], '4.2': [2534], 'kb': [2535], '5kb': [2552], '333-bp': [2562, 2591], 'Sse83871': [2563, 2592], '(ACG': [2577], '→': [2578, 2829], 'ATG)': [2579, 2830], 'site-directed': [2583], 'mutagenesis': [2584], 'analysis.': [2589, 2855], 'T-M': [2596], 'replaced': [2598, 2846], 'corresponding': [2600, 2716, 2839], '9.2-kb': [2605, 2622], 'clone.': [2614], 'XhoI': [2615, 2631], 'linkers': [2616], 'added': [2618, 3514], 'fragment,': [2624, 2706, 2813], 'subcloned': [2628, 2807, 2863], 'pKI-TK3988,': [2634], 'modified': [2636], 'pKOScramber-NTKV-1901': [2637], 'neo': [2642, 2658], 'unique': [2646], 'NotI': [2647, 2666, 2701], 'parental': [2651], 'removed.': [2654], 'introduce': [2656, 2725], 'segment,': [2664], 'introduced': [2669], 'BsmBI-BspEI': [2672, 2705, 2717], 'intron': [2676], '1': [2679, 3188, 3318, 3358, 3410, 3474, 3983], 'PCR': [2683, 2822, 3042, 3062, 3071, 3118, 3126, 3156, 3164, 3232, 4510], 'mutagenesis.': [2684], 'Finally,': [2685], '1.8-kb': [2687, 2815, 2872], 'flanked': [2690, 2875], 'loxP': [2692, 2877], 'pBS246neoTK': [2696, 2881], 'product': [2710, 3076, 3084, 3092, 3131, 3142, 3169, 3177], 'replace': [2714], 'Mapk14': [2734, 2773, 2889], 'gene,': [2735], '4.2-kb': [2742, 2899], 'long': [2743, 2901], 'homology,': [2746], '2.3-kb': [2753, 2905], 'short': [2754, 2907], '6.5-kb': [2763, 2859], 'HindIII': [2764, 2866], '(21Mudgett': [2775], 'pBS-KS.': [2809, 2869], 'mutate': [2811], 'KpnI-HindIII': [2816], 'insert': [2824], '(ACC': [2828], 'just': [2831], 'downstream': [2832], '5′-terminal': [2835], 'site.': [2837], 'original': [2843], 'subclone': [2844], 'Last,': [2870], 'PsiI': [2886], 'located': [2890], '0.74-kb': [2891], 'upstream': [2892], 'arm.': [2908], 'vectors': [2911], 'linearized': [2913], 'electroporated': [2915], 'CMTI-1': [2918], 'line': [2920], '(obtained': [2921], 'CMTI,': [2923], 'Inc.)': [2924], 'seeded': [2926], 'irradiated': [2928], 'feeder': [2931], 'cells.': [2932, 4459], 'selected': [2936], 'medium': [2938, 3416], '300': [2940], 'μg/ml': [2941, 2950, 3528], 'G418': [2942], '3': [2944, 3394, 3404, 3572, 3683], 'days': [2945, 3405], 'following': [2946, 3059, 3115, 3153, 3206, 3276, 3658, 3715], 'electroporation': [2947], '150': [2949], 'routine': [2952], 'culture.': [2953], 'G418-resistant': [2954], 'colonies': [2956], 'picked': [2958], 'placed': [2960, 3630], 'wells': [2963, 3497], '96-well': [2966, 3500], 'tissue': [2967, 3197, 3501], 'culture': [2968, 3502], 'plate.': [2969], 'Genomic': [2970], 'prepared': [2973], 'cells,': [2976], 'screened': [2982], 'Southern': [2984], 'blot': [2985], 'analysis': [2986], 'figure': [2994], 'legends.': [2995], 'Positive': [2996, 3012, 4483], 'cultured': [3001], 'obtain': [3005], 'adequate': [3006], 'cell': [3007, 3517], 'numbers': [3008], 'blastocyst': [3010], 'injections.': [3011, 3708], 'karyotype': [3019], 'injection': [3023, 3583, 3691], 'C57BL/6': [3025, 3033, 3666], 'blastocysts.': [3026], 'Coat': [3027], 'color': [3028], 'chimeras': [3029], 'mated': [3031], 'females': [3034], 'determine': [3036], 'if': [3037], 'germline': [3038], 'transmission': [3039], 'achieved.': [3041], 'genotype': [3046, 3398], 'tail': [3052, 3657], 'snips.': [3053], 'For': [3054, 3109, 3147, 4568], 'genotyping': [3055, 3110, 3148], 'p38β-null': [3056, 4445, 4462], 'mice,': [3057, 3113, 3151, 4463], 'set': [3060, 3116, 3154], 'primers': [3063, 3102, 3119, 3157], 'used:': [3065, 3121, 3159], '5′-CCACCCACCTCCACCCCAGAAGTTACTTAGACATT-3′,': [3066, 3122], '5′-CCTTCCCAGCCTCTGAGCCCAGAAA-3′,': [3067], '5′-GATCCTCCCTTAGGAGACCCCTTTGAGTGGACAA-3′,': [3068, 3123], '5′-AATCCTTCCTGTGAGCCTGGGGAGG-3′.': [3069], 'reaction': [3072, 3127, 3165], 'produces': [3073, 3128, 3166], '1004-bp': [3075], '749-bp': [3083], 'null': [3087, 4497], 'allele.': [3088, 3146, 3181], 'second': [3090], '2.5-kb': [3091], 'under': [3105], 'conditions': [3107], 'p38β(T106M)': [3111, 3212, 3220], '5′-TCACGAGGCCCTTTCGTCTTCAAGAATTCAAGTT-3′.': [3124], '1000-bp': [3130], '714-': [3138], '1200-bp': [3141, 3168], 'p38α(T106M)': [3149], '5′-TCCTTCCTTTAAGGGAGAGCAGGATAGTACTCAT-3′,': [3160], '5′-CGAGGCTAGAGCGGCCATCAAGCTTAGGATC-3′,': [3161], '5′-TCAGCTTCTGGCACTTCACGATGTTGTTCA-3′.': [3162], '941-bp': [3176], 'RPA': [3182, 3269], 'Assay—Tissue': [3183], 'samples': [3184], 'homogenized': [3186], 'ml': [3189, 3411, 3427, 3670], 'TRIzol': [3191], 'reagent': [3192, 3369], '50–100': [3194], 'mg': [3195], 'Polytron': [3200], 'homogenizer,': [3201], "manufacturer's": [3208, 3278, 3660], 'instructions.': [3209, 3279], '307-bp': [3211], 'probe': [3213, 3245, 4333], 'mismatch': [3217], 'two': [3223, 3722, 3730, 3972, 4154], 'mismatches': [3224], 'cloned': [3234], 'KpnI/PstI': [3237], 'pGEM3Z.': [3240], '250-bp': [3242], '(T106M)': [3244], 'exact': [3249], 'match': [3250], 'similar': [3259], 'fashion.': [3260], 'Ribonuclease': [3261, 3271], 'protection': [3262], 'carried': [3265], 'out': [3266], 'III™': [3270], 'Protection': [3272], 'Assay': [3273], 'kit': [3274], '(Ambion)': [3275], 'Western': [3280, 3367], 'Blot': [3281], 'Analysis—Soluble': [3282], 'extracts': [3284], 'run': [3286], '4–20%': [3288], 'polyacrylamide': [3289], 'gels': [3290], 'transferred': [3292], 'nitrocellulose': [3294], 'membranes.': [3295], 'membranes': [3297, 3307], 'blocked': [3299, 3306], '5%': [3301, 3548], 'skim': [3302], 'milk': [3303], 'overnight.': [3304], 'incubated': [3309, 3350, 3538], 'anti-p38α': [3311], 'antibodies': [3314, 3356], '(1:1000': [3315], 'dilution)': [3316], 'temperature': [3322], 'gentle': [3324], 'agitation': [3325], 'followed': [3326], 'three': [3328], 'washes': [3329], '(10': [3330], 'min': [3331, 3445, 3604], 'each)': [3332], 'buffer': [3334], '10': [3336, 3426, 3444, 3485, 3585], 'mm': [3337, 3342, 3475], 'Tris,': [3338], 'pH': [3339], '7.5,': [3340], '50': [3341], 'NaCl,': [3343], '0.1%': [3345], 'Tween': [3346], '20': [3347, 3524], 'then': [3349], 'temperature.': [3362], 'Blots': [3363], 'developed': [3365], 'chemiluminescent': [3368], '(PerkinElmer': [3370], 'Life': [3371], 'Sciences)': [3372], 'exposed': [3374], 'x-ray': [3376], 'film.': [3377], 'Peritoneal': [3378], 'Exudate': [3379], 'Preparation': [3381], 'Assay—Peritoneal': [3385], 'exudate': [3386], '(PECs)': [3388], 'harvested': [3390], 'each': [3397, 3656, 3687, 4337], 'matched': [3399], 'gender': [3403], 'after': [3406], 'intraperitoneal': [3407, 3690], 'inoculation': [3408], '8%': [3413], 'Brewer': [3414], 'thioglycollate': [3415], '(Sigma).': [3417], 'euthanized': [3420, 3602], 'abdomens': [3423], 'flushed': [3424], 'phosphate-buffered': [3429], 'saline': [3430], 'plus': [3431], 'heparin.': [3432], 'Cells': [3433], 'collected': [3435], 'peritoneal': [3438], 'lavage': [3439], 'fluid': [3440], 'centrifugation': [3442], '1200': [3447], 'rpm,': [3448], 'resuspended': [3450], '5.56': [3452], '×': [3453], '105/ml': [3454], 'RPMI': [3456], 'supplemented': [3457], '10%': [3459], 'fetal': [3460], 'calf': [3461], 'serum': [3462], '(Hyclone),': [3463], '100': [3464, 3467], 'units/ml': [3465, 3468], 'penicillin,': [3466], 'streptomycin,': [3469], '0.3': [3470], 'mg/ml': [3471], 'l-glutamine': [3472], '(Invitrogen),': [3473, 3478, 3483], 'sodium': [3476], 'pyruvate': [3477], '1×': [3479], 'non-essential': [3480], 'amino': [3481], 'acids': [3482], '2-mercaptoethanol': [3487], '(BioRad).': [3488], 'PEC': [3490], 'suspension': [3491], '(180': [3492], 'μl)': [3493], 'dispensed': [3495], 'plate': [3503], 'μl': [3506, 3525], 'suspension.': [3518], 'stimulated': [3522], 'a1': [3527], 'solution': [3529], '(Salmonella': [3532], 'minnesota': [3533], 'Re': [3534], '595,': [3535], 'Sigma)': [3536, 3592], 'overnight': [3539], '37': [3541], '°C': [3542], 'humidified': [3545], 'atmosphere': [3546], 'CO2.': [3549], 'supernatant': [3551], 'harvested,': [3553], 'concentration': [3557], 'ELISA.': [3561, 3612], 'Challenge—12-week-old': [3563], 'dosed': [3566], '(p.o.,': [3571], 'mg/kg': [3573, 3595], '0.5%': [3575], 'methylcellulose)': [3576], 'vehicle': [3578, 3632], '2.5': [3579], 'prior': [3581], 'μg/mouse': [3586], '(Escherichia': [3588], 'coli': [3589, 3956], 'Serotype': [3590], '0111:B4,': [3591], '800': [3594], 'd-galactosamine': [3596], '(Sigma)': [3597], 'saline.': [3599], 'Animals': [3600], '90': [3603], 'later,': [3605], 'plasma': [3607], 'measured': [3610, 3617], 'Plasma': [3613], 'levels': [3615], 'HPLC.': [3619], 'Collagen': [3620], 'Antibody': [3621], 'Arthritis': [3622], 'Induction': [3623], 'Mice—Female': [3625], 'weighed': [3628], 'drug': [3634], 'day': [3638, 3679, 3682], '0.': [3639, 3680], 'Arthritis-inducing': [3640], '(Chemicon': [3644], 'International,': [3645], 'ECM': [3646], '1400)': [3647], 'injected': [3649, 3677], 'intravenously': [3650], 'caudal': [3653], 'portion': [3654], 'protocol': [3661], 'induction': [3664], 'Briefly,': [3668], '0.8': [3669], 'On': [3681], 'postinoculation,': [3684], 'given': [3688, 3698], 'LPS.': [3693], 'Vehicle': [3694], 'once': [3699], 'daily': [3700, 3712], 'oral': [3702], 'gavage': [3703], 'beginning': [3704], '24': [3705], 'post-LPS': [3707], 'Limbs': [3709], 'scored': [3711], 'system:': [3716], '0,': [3717], 'normal;': [3718], '1,': [3719, 4117], 'one': [3720, 4473], 'swollen': [3723], 'digits;': [3724], '2,': [3725], 'swelling': [3726, 3735], 'more': [3728], 'than': [3729], 'digits': [3731], 'well': [3733], 'carpus/tarsus;': [3739], '3,': [3740], 'deformity;': [3741], 'rigidity': [3743], 'immobility': [3745], 'joints.': [3748], 'lowest': [3750], 'possible': [3751, 3762, 4363], 'score': [3752, 3763], '0': [3754], 'asymptomatic': [3757], 'mouse,': [3758], 'highest': [3761], '16,': [3765], 'would': [3767, 4317, 4360], 'indicate': [3768], 'limbs': [3771], 'rigid.': [3773], 'Mutation': [3774], 'Methionine': [3778], 'Does': [3779, 3786], 'Not': [3780], 'Affect': [3781], 'Decrease': [3787], 'Inhibitor': [3788], 'Potency—A': [3789], 'demonstrated': [3794], 'determining': [3808], 'sensitivity': [3809], 'pyridinyl': [3811], 'imidazole': [3812], '(25Gum': [3814], 'Z.': [3821], 'Bower': [3822], 'Goldsmith': [3830], 'E.J.': [3831], '1998;': [3837, 3895, 3936], '273:': [3838], '15605-15610Abstract': [3839], '(230)': [3847], '26Wilson': [3850], 'K.P.': [3851], 'McCaffrey': [3852], 'P.G.': [3853], 'Hsiao': [3854], 'Pazhanisamy': [3856], 'Galullo': [3858], 'Bemis': [3860], 'G.W.': [3861], 'Fitzgibbon': [3862], 'Caron': [3864], 'Murcko': [3866], 'Su': [3868], 'M.S.': [3869], '4:': [3873], '423-431Abstract': [3874], '(282)': [3880], '27Eyers': [3883], 'P.A.': [3884], 'Craxton': [3885], 'N.': [3888, 3930], 'Cohen': [3889], 'P.': [3890, 3934], '321-328Abstract': [3897], '(280)': [3903], '28Lisnock': [3906], 'Croft': [3914], 'Li': [3918], 'Hacker': [3920], 'de': [3922], 'Laszlo': [3923], 'Liverton': [3929], 'LoGrasso': [3933], '37:': [3937], '16573-16581Crossref': [3938], '(112)': [3941], 'expressed': [3945], 'proteins': [3950, 4314], 'effect': [3960, 4130], 'IC50': [3970, 4400, 4423], 'structurally': [3973], 'inhibitors,': [3976], '(Fig.': [3982, 4481, 4485, 4511], 'Refs.': [3985], '29Bao': [3986], 'As': [4113], 'Table': [4116], 'mutations,': [4119], 'even': [4120], 'though': [4121], 'site,': [4126], 'no': [4128, 4519], 'significant': [4129], 'compared': [4136], 'proteins.': [4140], 'Met': [4147], 'dramatically': [4148], 'decreased': [4149], 'potency': [4151, 4175], 'tested': [4155, 4182], '200–1000-fold.': [4157], 'Both': [4158], 'selective': [4164], 'β': [4168, 4449], 'least': [4171], '500-fold': [4172], 'decrease': [4173], 'other': [4177, 4366], 'essentially': [4318], 'make': [4319], 'remaining': [4326], 'us': [4331], 'pharmacologically.': [4341], 'presence': [4351], 'complete': [4354], 'complement': [4355], 'eliminate': [4361], 'developmental': [4364], 'compensation.TABLE': [4369], '1Comparison': [4370], 'parameters': [4373], 'enzymesWild-type(α)αT106MWild-type(β)βT106MVmax': [4378], '(arbitrary': [4379], 'units)19': [4380], '±': [4381, 4383, 4385, 4387, 4391, 4393, 4395, 4397, 4402, 4407, 4412, 4417], '0.158': [4382], '0.289': [4384], '1465': [4386], '9ATP': [4388], '(μm)128': [4390], '2.472': [4392], '4.869': [4394], '2535': [4396], '13MRK': [4398], '(nm)0.08': [4401], '0.03': [4403], '(n': [4404, 4409, 4414, 4419, 4425, 4428, 4431], '=': [4405, 4410, 4415, 4420, 4426, 4429, 4432], '4)28': [4406], '5)0.25': [4411], '0.1': [4413], '5)260': [4416], '30': [4418], '5)MRK': [4421], '(nm)0.1': [4424], '1)34': [4427], '1)0.1': [4430], '1)': [4433], 'Open': [4434], 'table': [4435], 'new': [4438], 'tab': [4439], 'Generation': [4440], 'p38α(T106M)-,': [4442], 'p38β(T106M)-,': [4443], 'loci': [4450], 'targeted': [4452, 4467], 'homologous': [4454], 'recombination': [4455], '1–7': [4471], 'alleles': [4477], '2A).': [4482], '2B)': [4486], 'chimeric': [4491], 'successfully': [4494], 'transmitted': [4495], 'their': [4500], 'offspring.': [4501], 'genotypes': [4503], '2C).': [4512], 'p38β–/–': [4514], 'fertile': [4517], 'apparent': [4520], 'agreement': [4523], 'observations': [4526], 'Beardmore': [4528], 'et': [4529], 'al.': [4530], 'expressing': [4573], 'p38β(T106M),': [4574]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1989729292', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-13T12:01:00.188904', 'created_date': '2016-06-24'}