Cholesterol Efflux and Atheroprotection

Name: Work Video:
Duration: 3 min 30 s
Robert S. Rosenson; H. Bryan Brewer; W. Sean Davidson; Zahi A. Fayad; Valentı́n Fuster; James Goldstein; Marc K. Hellerstein; Xian‐Cheng Jiang; Michael C. Phillips; Daniel J. Rader; Alan T. Remaley; George H. Rothblat; Alan R. Tall; Laurent Yvan‐Charvet
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Bryan Brewer', 'raw_affiliation_strings': ['From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...'], 'affiliations': [{'raw_affiliation_string': 'From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...', 'institution_ids': ['https://openalex.org/I177721651', 'https://openalex.org/I2801951336', 'https://openalex.org/I4210128757']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008316828', 'display_name': 'W. 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Sean Davidson', 'raw_affiliation_strings': ['From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...'], 'affiliations': [{'raw_affiliation_string': 'From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...', 'institution_ids': ['https://openalex.org/I177721651', 'https://openalex.org/I2801951336', 'https://openalex.org/I4210128757']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089434484', 'display_name': 'Zahi A. 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Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...'], 'affiliations': [{'raw_affiliation_string': 'From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...', 'institution_ids': ['https://openalex.org/I177721651', 'https://openalex.org/I2801951336', 'https://openalex.org/I4210128757']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040761622', 'display_name': 'James Goldstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177721651', 'display_name': 'Oakland University', 'ror': 'https://ror.org/01ythxj32', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I177721651']}, {'id': 'https://openalex.org/I2801951336', 'display_name': 'Washington Hospital', 'ror': 'https://ror.org/00jerb145', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801951336']}, {'id': 'https://openalex.org/I4210128757', 'display_name': 'Beaumont Hospital, Royal Oak', 'ror': 'https://ror.org/03artm726', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128757', 'https://openalex.org/I4392738273']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Goldstein', 'raw_affiliation_strings': ['From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...'], 'affiliations': [{'raw_affiliation_string': 'From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...', 'institution_ids': ['https://openalex.org/I177721651', 'https://openalex.org/I2801951336', 'https://openalex.org/I4210128757']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047114493', 'display_name': 'Marc K. 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Phillips', 'raw_affiliation_strings': ['From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...'], 'affiliations': [{'raw_affiliation_string': 'From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...', 'institution_ids': ['https://openalex.org/I177721651', 'https://openalex.org/I2801951336', 'https://openalex.org/I4210128757']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067149045', 'display_name': 'Daniel J. 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Rader', 'raw_affiliation_strings': ['From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...'], 'affiliations': [{'raw_affiliation_string': 'From Mount Sinai Heart (R.S.R., V.F.) and the Translational and Molecular Imaging Institute (Z.A.F.), Mount Sinai School of Medicine, New York, NY; Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC (H.B.B.); Center for Lipid and Arteriosclerosis Science, University of Cincinnati, Cincinnati, OH (W.S.D.); Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, MI (J.G.); University of California Berkeley,...', 'institution_ids': ['https://openalex.org/I177721651', 'https://openalex.org/I2801951336', 'https://openalex.org/I4210128757']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068951391', 'display_name': 'Alan T. 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56, 63, 66, 70, 79, 83], 'Zahi': [49, 503], 'A.': [50, 504, 506], 'Fayad,': [51], 'Valentin': [53, 640], 'Fuster,': [54], 'James': [57, 775], 'Goldstein,': [58], 'Marc': [60, 910], 'Hellerstein,': [61], 'Xian-Cheng': [64, 1045], 'Jiang,': [65], 'Michael': [67, 1180], 'C.': [68, 1181, 1183], 'Phillips,': [69], 'Daniel': [71, 1317], 'J.': [72, 1318, 1320], 'Rader,': [73], 'Alan': [75, 84, 1454, 1728], 'T.': [76, 1455, 1457], 'Remaley,': [77], 'George': [80, 1591], 'Rothblat,': [82], 'R.': [85, 1729, 1731], 'Tall,': [86], 'MD': [87, 212, 349, 486, 623, 758, 893, 1028, 1163, 1300, 1437, 1574, 1711, 1848, 1983], 'Laurent': [89, 1865], 'Yvan-Charvet,': [90], 'PhD': [91], 'RosensonRobert': [94], 'Rosenson': [96], 'From': [97, 234, 371, 508, 643, 778, 913, 1048, 1185, 1322, 1459, 1596, 1733, 1868, 2104], 'Mount': [98, 111, 235, 248, 372, 385, 509, 522, 644, 657, 779, 792, 914, 927, 1049, 1062, 1186, 1199, 1323, 1336, 1460, 1473, 1597, 1610, 1734, 1747, 1869, 1882], 'Sinai': [99, 112, 236, 249, 373, 386, 510, 523, 645, 658, 780, 793, 915, 928, 1050, 1063, 1187, 1200, 1324, 1337, 1461, 1474, 1598, 1611, 1735, 1748, 1870, 1883], 'Heart': [100, 237, 374, 511, 646, 781, 916, 1051, 1188, 1325, 1462, 1599, 1736, 1871], '(R.S.R.,': [101, 238, 375, 512, 647, 782, 917, 1052, 1189, 1326, 1463, 1600, 1737, 1872], 'V.F.)': [102, 239, 376, 513, 648, 783, 918, 1053, 1190, 1327, 1464, 1601, 1738, 1873], 'Translational': [105, 242, 379, 516, 651, 786, 921, 1056, 1193, 1330, 1467, 1604, 1741, 1876], 'Molecular': [107, 217, 244, 354, 381, 491, 518, 628, 653, 763, 788, 898, 923, 1033, 1058, 1168, 1195, 1305, 1332, 1442, 1469, 1579, 1606, 1716, 1743, 1853, 1878, 1988], 'Imaging': [108, 245, 382, 519, 654, 789, 924, 1059, 1196, 1333, 1470, 1607, 1744, 1879], 'Institute': [109, 246, 383, 520, 655, 790, 925, 1060, 1197, 1334, 1471, 1608, 1745, 1880], '(Z.A.F.),': [110, 247, 384, 521, 656, 791, 926, 1061, 1198, 1335, 1472, 1609, 1746, 1881], 'School': [113, 147, 250, 284, 387, 421, 524, 558, 659, 693, 794, 828, 929, 963, 1064, 1098, 1201, 1235, 1338, 1372, 1475, 1509, 1612, 1646, 1749, 1783, 1884, 1918], 'Medicine,': [115, 149, 167, 218, 252, 286, 304, 355, 389, 423, 441, 492, 526, 560, 578, 629, 661, 695, 713, 764, 796, 830, 848, 899, 931, 965, 983, 1034, 1066, 1100, 1118, 1169, 1203, 1237, 1255, 1306, 1340, 1374, 1392, 1443, 1477, 1511, 1529, 1580, 1614, 1648, 1666, 1717, 1751, 1785, 1803, 1854, 1886, 1920, 1938, 1989], 'New': [116, 223, 253, 360, 390, 497, 527, 634, 662, 769, 797, 904, 932, 1039, 1067, 1174, 1204, 1311, 1341, 1448, 1478, 1585, 1615, 1722, 1752, 1859, 1887, 1994], 'York,': [117, 224, 254, 361, 391, 498, 528, 635, 663, 770, 798, 905, 933, 1040, 1068, 1175, 1205, 1312, 1342, 1449, 1479, 1586, 1616, 1723, 1753, 1860, 1888, 1995], 'NY;': [118, 255, 392, 529, 664, 799, 934, 1069, 1206, 1343, 1480, 1617, 1754, 1889], 'Cardiovascular': [119, 256, 393, 530, 665, 800, 935, 1070, 1207, 1344, 1481, 1618, 1755, 1890], 'Research': [120, 123, 257, 260, 394, 397, 531, 534, 666, 669, 801, 804, 936, 939, 1071, 1074, 1208, 1211, 1345, 1348, 1482, 1485, 1619, 1622, 1756, 1759, 1891, 1894], 'Institute,': [121, 124, 206, 258, 261, 343, 395, 398, 480, 532, 535, 617, 667, 670, 752, 802, 805, 887, 937, 940, 1022, 1072, 1075, 1157, 1209, 1212, 1294, 1346, 1349, 1431, 1483, 1486, 1568, 1620, 1623, 1705, 1757, 1760, 1842, 1892, 1895, 1977], 'MedStar': [122, 259, 396, 533, 668, 803, 938, 1073, 1210, 1347, 1484, 1621, 1758, 1893], 'Washington': [125, 262, 399, 536, 671, 806, 941, 1076, 1213, 1350, 1487, 1624, 1761, 1896], 'Hospital': [126, 187, 263, 324, 400, 461, 537, 598, 672, 733, 807, 868, 942, 1003, 1077, 1138, 1214, 1275, 1351, 1412, 1488, 1549, 1625, 1686, 1762, 1823, 1897, 1958], 'Center,': [127, 179, 222, 264, 316, 359, 401, 453, 496, 538, 590, 633, 673, 725, 768, 808, 860, 903, 943, 995, 1038, 1078, 1130, 1173, 1215, 1267, 1310, 1352, 1404, 1447, 1489, 1541, 1584, 1626, 1678, 1721, 1763, 1815, 1858, 1898, 1950, 1993], 'Washington,': [128, 265, 402, 539, 674, 809, 944, 1079, 1216, 1353, 1490, 1627, 1764, 1899], 'DC': [129, 266, 403, 540, 675, 810, 945, 1080, 1217, 1354, 1491, 1628, 1765, 1900], '(H.B.B.);': [130, 267, 404, 541, 676, 811, 946, 1081, 1218, 1355, 1492, 1629, 1766, 1901], 'Center': [131, 268, 405, 542, 677, 812, 947, 1082, 1219, 1356, 1493, 1630, 1767, 1902], 'for': [132, 269, 406, 543, 678, 813, 948, 1083, 1220, 1357, 1494, 1631, 1768, 1903, 2109, 2128, 2155, 2259, 2542, 2569, 2614, 2626, 2754, 2866, 2908, 2974, 3158, 3189, 3204, 3412, 3424, 3497, 3760, 3776], 'Lipid': [133, 270, 407, 544, 679, 814, 949, 1084, 1221, 1358, 1495, 1632, 1769, 1904, 3500], 'Arteriosclerosis': [135, 272, 409, 546, 681, 816, 951, 1086, 1223, 1360, 1497, 1634, 1771, 1906], 'Science,': [136, 273, 410, 547, 682, 817, 952, 1087, 1224, 1361, 1498, 1635, 1772, 1907], 'University': [137, 144, 157, 168, 190, 196, 220, 274, 281, 294, 305, 327, 333, 357, 411, 418, 431, 442, 464, 470, 494, 548, 555, 568, 579, 601, 607, 631, 683, 690, 703, 714, 736, 742, 766, 818, 825, 838, 849, 871, 877, 901, 953, 960, 973, 984, 1006, 1012, 1036, 1088, 1095, 1108, 1119, 1141, 1147, 1171, 1225, 1232, 1245, 1256, 1278, 1284, 1308, 1362, 1369, 1382, 1393, 1415, 1421, 1445, 1499, 1506, 1519, 1530, 1552, 1558, 1582, 1636, 1643, 1656, 1667, 1689, 1695, 1719, 1773, 1780, 1793, 1804, 1826, 1832, 1856, 1908, 1915, 1928, 1939, 1961, 1967, 1991], 'Cincinnati,': [139, 140, 276, 277, 413, 414, 550, 551, 685, 686, 820, 821, 955, 956, 1090, 1091, 1227, 1228, 1364, 1365, 1501, 1502, 1638, 1639, 1775, 1776, 1910, 1911], 'OH': [141, 278, 415, 552, 687, 822, 957, 1092, 1229, 1366, 1503, 1640, 1777, 1912], '(W.S.D.);': [142, 279, 416, 553, 688, 823, 958, 1093, 1230, 1367, 1504, 1641, 1778, 1913], 'Oakland': [143, 280, 417, 554, 689, 824, 959, 1094, 1231, 1368, 1505, 1642, 1779, 1914], 'William': [145, 150, 282, 287, 419, 424, 556, 561, 691, 696, 826, 831, 961, 966, 1096, 1101, 1233, 1238, 1370, 1375, 1507, 1512, 1644, 1649, 1781, 1786, 1916, 1921], 'Beaumont': [146, 151, 283, 288, 420, 425, 557, 562, 692, 697, 827, 832, 962, 967, 1097, 1102, 1234, 1239, 1371, 1376, 1508, 1513, 1645, 1650, 1782, 1787, 1917, 1922], 'Hospital,': [152, 289, 426, 563, 698, 833, 968, 1103, 1240, 1377, 1514, 1651, 1788, 1923], 'Royal': [153, 290, 427, 564, 699, 834, 969, 1104, 1241, 1378, 1515, 1652, 1789, 1924], 'Oak,': [154, 291, 428, 565, 700, 835, 970, 1105, 1242, 1379, 1516, 1653, 1790, 1925], 'MI': [155, 292, 429, 566, 701, 836, 971, 1106, 1243, 1380, 1517, 1654, 1791, 1926], '(J.G.);': [156, 293, 430, 567, 702, 837, 972, 1107, 1244, 1381, 1518, 1655, 1792, 1927], 'California': [159, 170, 296, 307, 433, 444, 570, 581, 705, 716, 840, 851, 975, 986, 1110, 1121, 1247, 1258, 1384, 1395, 1521, 1532, 1658, 1669, 1795, 1806, 1930, 1941], 'Berkeley,': [160, 297, 434, 571, 706, 841, 976, 1111, 1248, 1385, 1522, 1659, 1796, 1931], 'Berkeley': [161, 165, 298, 302, 435, 439, 572, 576, 707, 711, 842, 846, 977, 981, 1112, 1116, 1249, 1253, 1386, 1390, 1523, 1527, 1660, 1664, 1797, 1801, 1932, 1936], '(M.H.);': [162, 166, 175, 299, 303, 312, 436, 440, 449, 573, 577, 586, 708, 712, 721, 843, 847, 856, 978, 982, 991, 1113, 1117, 1126, 1250, 1254, 1263, 1387, 1391, 1400, 1524, 1528, 1537, 1661, 1665, 1674, 1798, 1802, 1811, 1933, 1937, 1946], 'KineMed,': [163, 300, 437, 574, 709, 844, 979, 1114, 1251, 1388, 1525, 1662, 1799, 1934], 'Inc,': [164, 301, 438, 575, 710, 845, 980, 1115, 1252, 1389, 1526, 1663, 1800, 1935], 'San': [171, 173, 308, 310, 445, 447, 582, 584, 717, 719, 852, 854, 987, 989, 1122, 1124, 1259, 1261, 1396, 1398, 1533, 1535, 1670, 1672, 1807, 1809, 1942, 1944], 'Francisco,': [172, 309, 446, 583, 718, 853, 988, 1123, 1260, 1397, 1534, 1671, 1808, 1943], 'Francisco': [174, 311, 448, 585, 720, 855, 990, 1125, 1262, 1399, 1536, 1673, 1810, 1945], 'SUNY': [176, 313, 450, 587, 722, 857, 992, 1127, 1264, 1401, 1538, 1675, 1812, 1947], 'Downstate': [177, 314, 451, 588, 723, 858, 993, 1128, 1265, 1402, 1539, 1676, 1813, 1948], 'Medical': [178, 221, 315, 358, 452, 495, 589, 632, 724, 767, 859, 902, 994, 1037, 1129, 1172, 1266, 1309, 1403, 1446, 1540, 1583, 1677, 1720, 1814, 1857, 1949, 1992], 'Brooklyn,': [180, 317, 454, 591, 726, 861, 996, 1131, 1268, 1405, 1542, 1679, 1816, 1951], 'NY': [181, 225, 318, 362, 455, 499, 592, 636, 727, 771, 862, 906, 997, 1041, 1132, 1176, 1269, 1313, 1406, 1450, 1543, 1587, 1680, 1724, 1817, 1861, 1952, 1996], '(X.-C.J.);': [182, 319, 456, 593, 728, 863, 998, 1133, 1270, 1407, 1544, 1681, 1818, 1953], 'Department': [183, 320, 457, 594, 729, 864, 999, 1134, 1271, 1408, 1545, 1682, 1819, 1954], 'Pediatrics,': [185, 322, 459, 596, 731, 866, 1001, 1136, 1273, 1410, 1547, 1684, 1821, 1956], "Children's": [186, 323, 460, 597, 732, 867, 1002, 1137, 1274, 1411, 1548, 1685, 1822, 1957], 'Philadelphia,': [189, 326, 463, 600, 735, 870, 1005, 1140, 1277, 1414, 1551, 1688, 1825, 1960], 'Pennsylvania,': [192, 198, 329, 335, 466, 472, 603, 609, 738, 744, 873, 879, 1008, 1014, 1143, 1149, 1280, 1286, 1417, 1423, 1554, 1560, 1691, 1697, 1828, 1834, 1963, 1969], 'Philadelphia': [193, 199, 330, 336, 467, 473, 604, 610, 739, 745, 874, 880, 1009, 1015, 1144, 1150, 1281, 1287, 1418, 1424, 1555, 1561, 1692, 1698, 1829, 1835, 1964, 1970], '(M.C.P.,': [194, 331, 468, 605, 740, 875, 1010, 1145, 1282, 1419, 1556, 1693, 1830, 1965], 'G.H.R.);': [195, 332, 469, 606, 741, 876, 1011, 1146, 1283, 1420, 1557, 1694, 1831, 1966], '(D.J.R.);': [200, 337, 474, 611, 746, 881, 1016, 1151, 1288, 1425, 1562, 1699, 1836, 1971], 'National': [201, 207, 338, 344, 475, 481, 612, 618, 747, 753, 882, 888, 1017, 1023, 1152, 1158, 1289, 1295, 1426, 1432, 1563, 1569, 1700, 1706, 1837, 1843, 1972, 1978], 'Heart,': [202, 339, 476, 613, 748, 883, 1018, 1153, 1290, 1427, 1564, 1701, 1838, 1973], 'Lung,': [203, 340, 477, 614, 749, 884, 1019, 1154, 1291, 1428, 1565, 1702, 1839, 1974], 'Blood': [205, 342, 479, 616, 751, 886, 1021, 1156, 1293, 1430, 1567, 1704, 1841, 1976], 'Institutes': [208, 345, 482, 619, 754, 889, 1024, 1159, 1296, 1433, 1570, 1707, 1844, 1979], 'Health,': [210, 347, 484, 621, 756, 891, 1026, 1161, 1298, 1435, 1572, 1709, 1846, 1981], 'Bethesda,': [211, 348, 485, 622, 757, 892, 1027, 1162, 1299, 1436, 1573, 1710, 1847, 1982], '(A.T.R.);': [213, 350, 487, 624, 759, 894, 1029, 1164, 1301, 1438, 1575, 1712, 1849, 1984], 'Division': [215, 352, 489, 626, 761, 896, 1031, 1166, 1303, 1440, 1577, 1714, 1851, 1986], 'Columbia': [219, 356, 493, 630, 765, 900, 1035, 1170, 1307, 1444, 1581, 1718, 1855, 1990], '(A.R.T.,': [226, 363, 500, 637, 772, 907, 1042, 1177, 1314, 1451, 1588, 1725, 1862, 1997], 'L.-Y.C.).': [227, 364, 501, 638, 773, 908, 1043, 1178, 1315, 1452, 1589, 1726, 1863, 1998], ',': [228, 365, 502, 639, 774, 909, 1044, 1179, 1316, 1453, 1590, 1727], 'BrewerJrH.': [231], 'BrewerJr': [233], 'DavidsonW.': [368], 'Davidson': [370], 'FayadZahi': [505], 'Fayad': [507], 'FusterValentin': [641], 'Fuster': [642], 'GoldsteinJames': [776], 'Goldstein': [777], 'HellersteinMarc': [911], 'Hellerstein': [912], 'JiangXian-Cheng': [1046], 'Jiang': [1047], 'PhillipsMichael': [1182], 'Phillips': [1184], 'RaderDaniel': [1319], 'Rader': [1321], 'RemaleyAlan': [1456], 'Remaley': [1458], 'RothblatGeorge': [1593], 'Rothblat': [1595], 'TallAlan': [1730], 'Tall': [1732], 'Yvan-CharvetLaurent': [1866], 'Yvan-Charvet': [1867], 'Originally': [1999], 'published17': [2000], 'Apr': [2001], '2012https://doi.org/10.1161/CIRCULATIONAHA.111.066589Circulation.': [2002], '2012;125:1905–1919IntroductionHigh-density': [2003], 'lipoprotein': [2004, 2313, 2317, 2374, 2637, 2868], '(HDL)': [2005], 'has': [2006, 2122, 2780, 3171, 3177, 3616], 'been': [2007, 2123, 2781, 3172, 3178, 3617, 3679], 'proposed': [2008, 2107, 2649], 'have': [2010, 2877, 3300, 3678], 'several': [2011], 'antiatherosclerotic': [2012], 'properties,': [2013, 2025], 'including': [2014, 2803], 'ability': [2016, 2030], 'mediate': [2018], 'macrophage': [2019, 2080, 2159, 2197, 2440, 2544, 2615, 2708, 2766], 'cholesterol': [2020, 2046, 2058, 2081, 2086, 2111, 2117, 2134, 2140, 2147, 2198, 2251, 2262, 2290, 2344, 2393, 2441, 2444, 2473, 2496, 2510, 2526, 2545, 2576, 2597, 2616, 2620, 2629, 2658, 2696, 2714, 2731, 2748, 2755, 2761, 2773, 2933, 3578, 3606, 3633, 3667, 3734, 3775, 3780], 'efflux,': [2021, 2527], 'antioxidant': [2022], 'capacity,': [2023], 'antiinflammatory': [2024], 'nitric': [2026], 'oxide–promoting': [2027], 'activity,': [2028], 'transport': [2032, 2240, 2577, 2595, 2922], 'proteins': [2033, 2095, 3210, 3307, 3351, 3366, 3389], 'with': [2034, 2204, 2796, 2843, 2979, 2998, 3014, 3037, 3043, 3057, 3085, 3124, 3196, 3290, 3310, 3374, 3391, 3543, 3549], 'their': [2035, 3518, 3574], 'own': [2036], 'intrinsic': [2037], 'biological': [2038], 'activities.1': [2039], 'HDL': [2040, 2120, 2150, 2181, 2185, 2210, 2213, 2216, 2272, 2411, 2456, 2464, 2471, 2721, 2734, 2747, 2777, 2882, 2978, 3031, 3044, 3064, 3087, 3136, 3197, 3275, 3285, 3331, 3375, 3397, 3403, 3437, 3471, 3535, 3541, 3599, 3765, 3787], 'particles': [2041, 2121, 2208, 2993, 3065, 3358, 3371, 3376], 'are': [2042, 2512, 2839, 3378, 3429, 3627, 3710, 3736], 'critical': [2043, 2566, 2941], 'acceptors': [2044], 'from': [2047, 2158, 2270, 2475, 2631, 2659, 2757, 2763, 2825, 2924, 3047, 3074, 3607, 3669, 3674, 3782], 'lipid-laden': [2048, 2253, 2765, 2925], 'macrophages': [2049, 3672, 3677], 'thereby': [2051, 2293], 'participate': [2052], 'in': [2053, 2060, 2065, 2119, 2241, 2252, 2261, 2281, 2303, 2439, 2463, 2495, 2515, 2654, 2685, 2713, 2735, 2966, 3018, 3101, 3114, 3160, 3180, 3278, 3308, 3457, 3489, 3505, 3512, 3517, 3546, 3568, 3576, 3597, 3612, 3634, 3694], 'maintenance': [2055], 'net': [2057], 'balance': [2059], 'arterial': [2062, 2072, 2476, 2504, 2525, 2584, 2588, 2633], 'wall': [2063, 2477, 2480, 2505, 2509, 2585, 2589, 2592], 'reduction': [2067], 'proinflammatory': [2069], 'responses': [2070], 'by': [2071, 2149, 2273, 2835, 3071, 3414, 3462, 3630, 3640], 'cholesterol-loaded': [2073, 3675, 3695, 3724], 'macrophages.': [2074, 2254], 'The': [2075, 3384, 3660], 'pathways': [2076, 2309, 2437, 3629, 3665, 3709, 3732], 'that': [2077, 2236, 2279, 2310, 2466, 2488, 2523, 2532, 2703, 2915, 2950, 3011, 3029, 3133, 3211, 3334, 3341, 3372, 3434, 3448, 3469, 3479, 3515], 'regulate': [2078, 2311], 'HDL-mediated': [2079, 2110, 2543, 2571], 'efflux': [2082, 2157, 2199, 2394, 2442, 2474, 2497, 2506, 2511, 2546, 2586, 2590, 2593, 2630, 2697, 2715, 2756, 2762, 3668, 3708, 3735, 3749], 'disposition': [2084, 2291], 'involve': [2087], 'cell': [2088, 2683], 'membrane–bound': [2089], 'transporters,': [2090, 2930], 'plasma': [2091, 2094, 2980, 3049, 3075, 3135, 3783], 'lipid': [2092, 2239, 3001, 3446, 3519, 3527], 'acceptors,': [2093], 'enzymes,': [2097], 'hepatic': [2099, 2371, 2932], 'cellular': [2100, 2436], 'receptors': [2101, 2983], '(Figure': [2102, 2202, 3033, 3624, 3645], '1).': [2103, 2501, 3034, 3625], 'earliest': [2106], 'concept': [2108, 2651, 3621], 'efflux,2,3': [2112], 'concentration': [2114, 2750], 'content': [2118, 2249, 2732, 2774, 3565], 'considered': [2124], 'a': [2125, 2142, 2233, 2540, 2624, 2650, 2724, 2752, 2768, 2811, 2818, 2912, 2940, 2999, 3025, 3077, 3090, 3163, 3361, 3440, 3450], 'surrogate': [2126, 2613], 'measurement': [2127, 2879], 'efficiency': [2130], '"reverse': [2133], 'transport"': [2135], '(RCT)': [2136], 'process;': [2137], 'however,': [2138, 3296], 'macrophage-derived': [2139, 3608], 'represents': [2141], 'minor': [2143, 2769, 3350, 3388, 3525], 'component': [2144], 'transported': [2148], 'particles.4–7': [2151], 'One': [2152, 3324], 'important': [2153, 2295, 3495], 'pathway': [2154, 3690, 3740, 3753], 'cholesterol-mediated': [2156], 'foam': [2160, 3609, 3635], 'cells': [2161, 3610, 3636], 'involves': [2162, 2264, 2916], 'interaction': [2163, 2976], 'between': [2164, 2705, 3117], 'ATP-binding': [2166, 2191, 2352, 2396], 'cassette': [2167, 2192, 2353, 2397, 2426], 'transporter': [2168, 2193, 2354, 2398, 2427], 'A1': [2169, 2355], '(ABCA1)': [2170, 2356], 'cholesterol-deficient': [2172], 'phospholipid-depleted': [2174], 'apolipoprotein': [2175], '(apo)': [2176], 'A-I': [2177], 'complexes': [2178], '(pre-β': [2179], 'migrating': [2180], 'or': [2182, 2681, 2982, 2984], 'very': [2183, 2219, 2385, 2420, 3250], 'small': [2184, 2604, 2819, 3260], '[HDL-VS];': [2186], 'Figure': [2187, 3658], '2).1,8': [2188], 'Subsequently,': [2189], 'G1': [2194, 2399], '(ABCG1)': [2195], 'mediates': [2196, 2237], 'through': [2200, 2482, 2956], 'interactions': [2201, 3148, 3428], '3)': [2203], 'spherical,': [2205], 'cholesterol-containing': [2206], 'α-HDL': [2207], '(small': [2209], '[HDL-S],': [2211], 'medium': [2212, 3257], '[HDL-M],': [2214], 'large': [2215, 2220, 3251, 3254], '[HDL-L],': [2217], '(HDL-VL).1': [2221], 'In': [2222, 3097, 3683, 3723], 'contrast,': [2223], 'scavenger': [2225, 2321, 2401], 'receptor': [2226, 2235, 2302, 2322, 2402], 'class': [2227, 2323, 2403], 'B': [2228, 2324, 2404], 'type': [2229, 2325, 2405], 'I': [2230, 2406], '(SR-BI)': [2231], 'is': [2232, 2245, 2537, 2578, 2608, 2621, 2672, 2823, 2861, 2903, 2939, 3288, 3333, 3406, 3410, 3422, 3466, 3502, 3537, 3691, 3754, 3768, 3770, 3789], 'multifunctional': [2234], 'bidirectional': [2238], 'macrophage,': [2243], 'which': [2244, 3019, 3631], 'dependent': [2246], 'on': [2247, 2729, 2885, 3144], 'A': [2255], 'more': [2256, 2844, 2848, 3756], 'established': [2257, 2845], 'role': [2258, 3575], 'SR-BI': [2260, 2282, 3752], 'trafficking': [2263], 'selective': [2265], 'uptake': [2266, 2598], 'cholesteryl': [2268, 2334, 3270], 'esters': [2269], 'mature': [2271], 'liver.': [2275], 'Recent': [2276], 'studies': [2277, 2530, 3127], 'suggest': [2278], 'polymorphisms': [2280], 'contribute': [2283, 3747], 'functional': [2286], 'capacity': [2287], 'this': [2289, 2301, 2429, 2516, 2550, 2686, 3122], 'pathway,9': [2292], 'providing': [2294], 'insights': [2296], 'into': [2297, 2603, 3024, 3052, 3619], 'involvement': [2299], 'RCT.Download': [2304], 'figureDownload': [2305, 2346, 2387], 'PowerPointFigure': [2306, 2347, 2388], '1.': [2307, 2573], 'Metabolic': [2308], 'high-density': [2312, 2377, 2413, 2636, 3247], '(HDL).': [2314], 'LRP': [2315], 'indicates': [2316, 2359, 2412, 2635, 3132, 3246], 'receptor-related': [2318], 'protein;': [2319, 2337], 'SR-BI,': [2320, 3648, 3721], 'I;': [2326], 'LDL,': [2327], 'low-density': [2328, 2360, 2867], 'lipoprotein;': [2329, 2361, 2369, 2378, 2414, 3248], 'LDLR,': [2330, 2362], 'LDL': [2331, 2358, 2363, 2869], 'receptor;': [2332, 2364], 'CETP,': [2333], 'ester': [2335, 3002], 'transfer': [2336, 3781], 'Tg': [2338], 'TG,': [2340, 3264], 'triglycerides;': [2341, 2366, 3265], 'CE,': [2343, 3269], 'efflux.Download': [2345], '2.': [2348, 3217], 'Schematic': [2349, 2390], 'diagram': [2350, 2391], 'transporter.': [2357], 'Tg,': [2365], 'VLDL,': [2367], 'very-low-density': [2368], 'HL,': [2370], 'lipase;': [2372, 2375], 'LPL,': [2373], 'HDL,': [2376, 3309, 3364], 'M,': [2379, 2415], 'medium;': [2380], 'L,': [2381], 'large;': [2382], 'VL,': [2384], 'large.Download': [2386], '3.': [2389, 3758], 'via': [2395], '(ABCG1),': [2400], '(SRB1),': [2407], 'passive': [2409, 2921], 'diffusion.': [2410], 'medium,': [2416], 'S,': [2417], 'small;': [2418, 2421], 'VS,': [2419], 'ABCA1,': [2423, 3713], 'APT': [2424], 'binding': [2425, 3413, 3425, 3557, 3590, 3778], 'A1.In': [2428], 'review,': [2430], 'we': [2431, 2459, 2699], 'discuss': [2432], 'molecular': [2434, 3181], 'involved': [2438, 2494, 2712], 'disposition,': [2445], 'as': [2446, 2448, 2723, 2751, 2810, 3201, 3203, 3316, 3337, 3382, 3459, 3711], 'well': [2447, 3202], 'recent': [2449, 2528, 3297], 'clinical': [2450, 2837], 'trials': [2451], 'aimed': [2452], 'at': [2453], 'better': [2454], 'understanding': [2455, 2520], 'function.': [2457], 'Specifically,': [2458], 'address': [2460], 'new': [2461, 2551, 2945], 'advances': [2462], 'biology': [2465], 'challenge': [2467], 'longstanding': [2468], 'misperceptions': [2469], 'about': [2470, 2695], 'nonarterial': [2479, 2508], 'sites': [2481, 2711], 'use': [2484, 2745, 2892, 3059], 'specific': [2486, 2679, 2682, 2701, 2881, 3470], 'terminology': [2487, 2702], 'addresses': [2489], 'various': [2491, 2707], 'tissue': [2492], 'locations': [2493], 'elimination': [2499, 2717], '(Table': [2500, 2718, 2988, 3521, 3655, 3681], 'However,': [2502, 2890, 3417], 'nonmacrophage': [2503, 2710], 'not': [2513, 2538, 2609, 2622, 3746], 'addressed': [2514], 'review.': [2517], 'Critical': [2518], 'processes': [2522], 'facilitate': [2524], 'experimental': [2529], 'establish': [2531], 'increased': [2533, 3582], 'fecal': [2534, 2669], 'sterol': [2535], 'excretion': [2536, 2602, 2618], 'necessarily': [2539, 2610, 2623], 'prerequisite': [2541, 2625], 'atheroprotection.10,11': [2548], 'Thus,': [2549], 'information': [2552, 2953, 3123], 'necessitates': [2553], 'revision': [2554], 'initial': [2556, 2739], 'models': [2557, 3039, 3185], 'RCT': [2559, 2641, 2653, 2671, 2876, 2958, 3623], 'foster': [2561], 'accurate': [2562, 2841], 'description': [2563], 'steps': [2567, 2680], 'required': [2568], 'effective': [2570], 'atheroprotection.Table': [2572], 'Key': [2574], 'ConceptsReverse': [2575], 'composed': [2579], 'multiple': [2581, 2894, 3628], 'components': [2582], 'Macrophage-specific': [2583], 'Nonmacrophage': [2587], 'Nonarterial': [2591], 'Lipoprotein': [2594, 3221], 'Hepatic': [2596], '(hepatobiliary': [2599], 'excretion)': [2600], 'Direct': [2601], 'intestine': [2605], 'Fecal': [2606], 'excretionHDL-C': [2607], 'an': [2611, 2905, 3338, 3581], 'adequate': [2612], 'effluxFecal': [2617], 'assessing': [2627], 'wallHDL-C': [2634], 'cholesterol.Evolution': [2638], 'ConceptNearly': [2642], '50': [2643, 3304], 'years': [2644], 'ago,': [2645], 'Glomset': [2646, 2736], 'Wright2,3': [2648], 'overall': [2655], 'flux': [2656, 2919, 2955], 'entire': [2661], 'periphery': [2662], 'liver': [2665], 'its': [2667, 3508], 'ultimate': [2668], 'excretion.': [2670], 'also': [2673, 3041, 3213, 3430, 3503], 'sometimes': [2674, 2689], 'used': [2675, 2834], 'refer': [2677], 'types': [2684], 'process,': [2687], 'thus': [2688], 'causing': [2690], 'confusion.': [2691], 'To': [2692, 3156], 'enhance': [2693], 'communication': [2694], 'pathways,': [2698], 'propose': [2700], 'distinguishes': [2704], '1).Emergence': [2719], 'Biomarker': [2725], 'RCTThe': [2727], 'emphasis': [2728], "Wright's": [2738], 'model': [2740, 3017], 'RCT2,3': [2742], 'promulgated': [2743], '(HDL-C)': [2749], 'biomarker': [2753, 2812], 'tissues.3': [2758], 'Even': [2759], 'though': [2760], 'contributes': [2767], 'amount': [2770], 'particles,': [2778], 'HDL-C': [2779, 2809, 2822, 2831, 2902], 'found': [2782], 'be': [2784, 2793, 2814, 2970, 3141, 3638], 'inversely': [2785], 'related': [2786], 'cardiovascular': [2788, 2858, 3490], 'disease': [2789, 3491], 'risk12': [2790], 'positively': [2794], 'correlated': [2795], 'beneficial': [2798], 'effect': [2799], 'lipid-modifying': [2801], 'therapies,': [2802], 'statins.13': [2804], 'Yet,': [2805], 'value': [2807], 'may': [2813, 2969, 3212, 3359, 3454, 3484, 3572], 'limited': [2815], 'because': [2816, 3426], '(1)': [2817], 'percentage': [2820], 'derived': [2824], 'peripheral': [2826], 'tissues,': [2827], '(2)': [2828], 'direct': [2830], 'measurements': [2832], 'routinely': [2833], 'most': [2836], 'laboratories': [2838], 'less': [2840, 3305], 'compared': [2842, 3548], 'but': [2846, 3453, 3743], 'technically': [2847], 'demanding': [2849], 'analytical': [2850], 'methods,': [2851], '(3)': [2853], 'potential': [2854], 'confounding': [2855], 'risk': [2859], 'relationships': [2860], 'possible': [2862], 'after': [2863], 'statistical': [2864], 'adjustment': [2865], 'particle': [2870, 3102, 3137, 3161, 3215, 3404, 3420, 3536], 'concentration.1Efforts': [2871], 'refine': [2873], 'biomarkers': [2874, 2949], 'encompassed': [2878], 'subclasses': [2883], 'based': [2884, 3142], 'physical': [2886], 'chemical': [2888], 'properties.1': [2889], 'static': [2895], 'measures': [2896], 'pool': [2899, 3773], 'size': [2900, 3103], 'likely': [2904], 'inadequate': [2906], 'approach': [2907], 'characterization': [2910], 'dynamic': [2913], 'process': [2914], 'active': [2918], 'mechanisms': [2923], 'macrophages,': [2926, 3686, 3696, 3726], 'HDL-modifying': [2927], 'enzymes': [2928, 2981], 'receptors.1': [2934], 'For': [2935], 'these': [2936, 3038, 3349, 3387, 3482, 3664, 3731], 'reasons,': [2937], 'there': [2938, 3109], 'need': [2942], 'identify': [2944], 'clinically': [2947], 'measurable': [2948], 'accurately': [2951], 'relay': [2952], 'concerning': [2954], 'pathway.HDL': [2959], 'Structure': [2960], 'CompositionHDL': [2962, 3501], 'StructureLocalized': [2963], 'conformational': [2964], 'features': [2965], 'apoA-I': [2967, 3021, 3068, 3092, 3105, 3169, 3190, 3289, 3335], 'structure': [2968, 3028, 3138], 'key': [2972], 'importance': [2973], 'exposure': [2985], 'oxidants': [2987], '2).': [2989, 3522], 'Analysis': [2990], 'spherical': [2992], 'different': [2995], 'sizes': [2996], 'reconstituted': [2997, 3086, 3598], 'neutral': [3000], 'core': [3003], 'revealed': [3004], 'almost': [3005], 'identical': [3006], 'patterns,': [3007], 'suggesting': [3008], 'similar': [3009, 3091, 3174, 3451], 'structures14': [3010], 'were': [3012, 3040, 3110], 'consistent': [3013, 3036], '"trefoil"': [3016], '3': [3020, 3656], 'molecules': [3022, 3106, 3170], 'arrange': [3023], '3-dimensional': [3026], 'cage': [3027], 'stabilizes': [3030, 3342], 'lipids': [3032, 3343], 'Data': [3035], 'obtained': [3042], 'isolated': [3045, 3070], 'directly': [3046], 'human': [3048, 3134, 3676, 3725], 'separated': [3051], '5': [3053], 'distinct': [3054, 3443, 3513], 'density': [3055, 3061, 3119], 'subfractions': [3056], 'gradient': [3062], 'ultracentrifugation.15': [3063], 'containing': [3066], 'predominantly': [3067], '[lipoprotein(A-I)]': [3069], 'immunoaffinity': [3072], 'chromatography': [3073], 'showed': [3076], 'striking': [3078], 'similarity': [3079], 'cross-linking': [3082, 3115], 'pattern': [3083], 'observed': [3084], 'forms,': [3088], 'indicating': [3089], 'secondary': [3093], 'tertiary': [3095], 'structure.': [3096], 'addition,': [3098], 'despite': [3099], 'variations': [3100], 'per': [3107, 3534], 'particle,': [3108], 'no': [3111], 'systematic': [3112], 'changes': [3113, 3159], 'patterns': [3116], 'subfractions.': [3120, 3554], 'Combining': [3121], 'detailed': [3125], 'compositional': [3126], 'lipoprotein(A-I)': [3130], 'subpopulations': [3131, 3472, 3514], 'appears': [3139], 'primarily': [3143], 'common': [3146], 'intermolecular': [3147], 'inherent': [3149], 'double-belt': [3152], 'trefoil': [3154], 'models.': [3155], 'account': [3157], 'size,': [3162], 'twisting': [3164], 'motion': [3165], 'resident': [3168], 'postulated,': [3173], 'what': [3176], 'described': [3179], 'dynamics': [3182], 'studies.16': [3183], 'These': [3184], 'hold': [3186], 'interesting': [3187], 'implications': [3188], 'conformation': [3191], 'how': [3193], 'it': [3194, 3465], 'interacts': [3195], 'plasma-remodeling': [3199], 'factors,': [3200], 'association': [3206], 'other': [3208, 3365], 'HDL-associated': [3209], 'alter': [3214], 'function.Table': [3216], 'Composition': [3218], 'High-Density': [3220], 'AcceptorsHDL-VL': [3222], '(HDL2b)HDL-L': [3223], '(HDL2a)HDL-M': [3224], '(HDL3a)HDL-S': [3225], '(HDL3b)HDL-VSFree': [3226], 'Apolipoprotein': [3227], '(ApoA-I)HDL3cPre-β–HDLDensity,': [3228], 'g/mL1063–10901090–11201120–11501150–11801180–1210xxComposition,': [3229], '%': [3230], 'TG4432100': [3231], 'FC43210.10.10': [3232], 'CE292725231700': [3233], 'PL3033292416160': [3234], 'Proteins333441506684100Apolipoproteins': [3235], 'ApoA-I,': [3236], 'mol/mol': [3237, 3240], 'HDL3.64.14.43.7311': [3238], 'ApoA-II,': [3239], 'HDL0.81.11.410.400': [3241], 'OtherApoC,': [3242], 'apoD,': [3243], 'apoEApoC,': [3244], 'apoDxApoEHDL': [3245], 'HDL-VL,': [3249], 'HDL;': [3252, 3255, 3258, 3261, 3561], 'HDL-L,': [3253, 3551], 'HDL-M,': [3256, 3550], 'HDL-S,': [3259], 'apo,': [3262], 'apolipoprotein;': [3263], 'FC,': [3266], 'free': [3267], 'cholesterol;': [3268], 'ester;': [3271], 'PL,': [3273], 'phospholipid.': [3274], 'nomenclature': [3276], 'reviewed': [3277], 'Reference': [3279], '1.HDL': [3280], 'Protein': [3281], 'CompositionApproximately': [3282], '65%': [3283], 'protein': [3286, 3444], 'mass': [3287], 'another': [3291], '12%': [3292], '15%': [3294], 'apoA-II;': [3295], 'proteomic': [3298], 'studies17–20': [3299], 'identified': [3301], 'up': [3302], 'abundant': [3306], 'many': [3311], 'linked': [3312], 'functions': [3314], 'such': [3315], 'complement': [3317], 'regulation,': [3318], 'protease': [3319], 'inhibition,': [3320], 'innate': [3322], 'immunity.1': [3323], 'view': [3325], 'complexity': [3328], 'proteome': [3332], 'acts': [3336], 'organizing': [3339], 'scaffold': [3340], 'allows': [3345], 'attachment': [3347], 'onto': [3352], 'particles.': [3354], 'Alternatively,': [3355], 'although': [3356], 'apoA-I–containing': [3357], 'represent': [3360, 3494], 'majority': [3362, 3385], 'could': [3367], 'potentially': [3368], 'generate': [3369], 'independent': [3370], 'coisolate': [3373], 'therefore': [3379, 3493], 'similarly': [3380], 'classified': [3381], 'HDL.': [3383], 'associate': [3390], 'densest': [3393], '(and': [3394], 'hence': [3395], 'smallest)': [3396], 'populations.21': [3398], 'About': [3399], '13%': [3400], 'surface': [3405, 3421], 'phospholipid': [3407], 'covered': [3408], 'available': [3411, 3423], 'protein-lipid': [3415], 'interaction.': [3416], 'complete': [3419], 'protein–apoA-I': [3427], 'possible.': [3431], 'This': [3432], 'suggests': [3433], 'term': [3436], 'refers': [3438], 'constellation': [3441], 'constructs': [3447], 'share': [3449], 'density20,21': [3452], 'vary': [3455], 'widely': [3456], 'function,22': [3458], 'originally': [3460], 'suggested': [3461], 'Alaupovic.23': [3463], 'Indeed,': [3464], 'now': [3467], 'recognized': [3468], 'serve': [3473], 'highly': [3474], 'specialized': [3475], 'functions.22': [3476], 'It': [3477], 'follows': [3478], 'some': [3480], 'subspecies': [3483], 'play': [3485], 'particularly': [3486], 'protective': [3487], 'roles': [3488], 'targets': [3496], 'mechanistic': [3498], 'investigations.HDL': [3499], 'heterogeneous': [3504], 'regard': [3506], 'lipidome': [3509], 'exists': [3511], 'differ': [3516], 'content1,15,24–26': [3520], 'Among': [3523], 'bioactive': [3526], 'components,': [3528], 'abundance': [3530], 'sphingosine-1': [3532], 'phosphate': [3533], 'asymmetrical': [3538], 'across': [3539], 'spectrum,': [3542], 'preferential': [3544], 'enrichment': [3545], 'HDL-S': [3547], 'HDL-VL': [3553, 3571], 'Sphingomyelin': [3555], 'decreases': [3556], 'apoE': [3559, 3654], 'thus,': [3562], 'reduced': [3564], 'sphingomyelin': [3567, 3585], 'HDL-L': [3569], 'explain': [3573], 'apoE-mediated': [3577], 'efflux.': [3579], 'Additionally,': [3580], 'ratio': [3583], 'phosphatidylcholine': [3587], 'decreased': [3588], 'activity': [3592], 'lecithin–cholesterol': [3594], 'acyltransferase': [3595], '(LCAT)': [3596], 'particles.27–29Cellular': [3600], 'EffluxThe': [3602], 'removal': [3603], 'excess': [3605, 3632], 'present': [3611], 'atherosclerotic': [3614], 'plaque2': [3615], 'incorporated': [3618], 'There': [3626], 'can': [3637], 'removed': [3639], 'HDL:': [3641], 'aqueous': [3642, 3688, 3715], 'diffusion,': [3643, 3716], 'ABCA1': [3644, 3739], '2),': [3646], 'ABCG1,': [3647, 3718], 'endogenous': [3650], 'production': [3651], 'lipid-poor': [3653], '3).30': [3659], 'relative': [3661, 3728], 'contributions': [3662, 3698, 3705, 3729], 'mouse': [3670], 'peritoneal': [3671], 'determined': [3680], '3).31,32': [3682], 'normal-cholesterol': [3684], 'murine': [3685], 'diffusion': [3689], 'predominant,': [3692, 3742], 'whereas': [3693], 'ABC': [3701], 'transporters': [3702], 'predominate.31': [3703], 'Relative': [3704], 'follows:': [3712], '35%;': [3714, 3717], '21%;': [3719], '9%.': [3722], 'different;': [3737], 'remains': [3741], 'ABCG1': [3744], 'does': [3745], 'relatively': [3755], 'important.32Table': [3757], 'Pathways': [3759], 'Macrophage-Specific': [3761], 'EffluxEfflux': [3763], 'PathwayEnergeticsPreferred': [3764], 'AcceptorCharacteristicsAqueous': [3766], 'diffusionPassiveHDL-L∼HDL-M∼HDL-SProcess': [3767], 'bidirectionalSR-BIPassiveHDL-L>HDL-M>HDL-SProcess': [3769], 'bidirectionalCreates': [3771], 'labile': [3772], 'effluxHigh-affinity': [3777], 'permits': [3779], 'membrane': [3784], 'bound': [3786], 'particlesABCG1ActiveHDL-L∼HDL-M∼HDL-SProcess': [3788], 'unidirectionalNo': [3790], 'high-affinity': [3791], 'bindingE-': [3792]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1989242866', 'counts_by_year': [{'year': 2024, 'cited_by_count': 40}, {'year': 2023, 'cited_by_count': 61}, {'year': 2022, 'cited_by_count': 49}, {'year': 2021, 'cited_by_count': 73}, {'year': 2020, 'cited_by_count': 55}, {'year': 2019, 'cited_by_count': 56}, {'year': 2018, 'cited_by_count': 67}, {'year': 2017, 'cited_by_count': 73}, {'year': 2016, 'cited_by_count': 58}, {'year': 2015, 'cited_by_count': 90}, {'year': 2014, 'cited_by_count': 88}, {'year': 2013, 'cited_by_count': 93}, {'year': 2012, 'cited_by_count': 21}], 'updated_date': '2024-12-16T04:47:10.091604', 'created_date': '2016-06-24'}
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