Publication Information

{'id': 'https://openalex.org/W1989120365', 'doi': 'https://doi.org/10.1158/1535-7163.mct-06-0231', 'title': 'A novel class of pyranocoumarin anti–androgen receptor signaling compounds', 'display_name': 'A novel class of pyranocoumarin anti–androgen receptor signaling compounds', 'publication_year': 2007, 'publication_date': '2007-03-01', 'ids': {'openalex': 'https://openalex.org/W1989120365', 'doi': 'https://doi.org/10.1158/1535-7163.mct-06-0231', 'mag': '1989120365', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17363485'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-06-0231', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1158/1535-7163.mct-06-0231', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048078319', 'display_name': 'Junming Guo', 'orcid': 'https://orcid.org/0000-0003-2026-1075'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}, {'id': 'https://openalex.org/I109935558', 'display_name': 'Ningbo University', 'ror': 'https://ror.org/03et85d35', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I109935558']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Junming Guo', 'raw_affiliation_strings': ['1Hormel Institute, University of Minnesota, Austin, Minnesota;', 'Ningbo University'], 'affiliations': [{'raw_affiliation_string': '1Hormel Institute, University of Minnesota, Austin, Minnesota;', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}, {'raw_affiliation_string': 'Ningbo University', 'institution_ids': ['https://openalex.org/I109935558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061210080', 'display_name': 'Cheng Jiang', 'orcid': 'https://orcid.org/0000-0002-8735-1254'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cheng Jiang', 'raw_affiliation_strings': ['1Hormel Institute, University of Minnesota, Austin, Minnesota;'], 'affiliations': [{'raw_affiliation_string': '1Hormel Institute, University of Minnesota, Austin, Minnesota;', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100407553', 'display_name': 'Zhe Wang', 'orcid': 'https://orcid.org/0000-0001-5407-4230'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhe Wang', 'raw_affiliation_strings': ['1Hormel Institute, University of Minnesota, Austin, Minnesota;'], 'affiliations': [{'raw_affiliation_string': '1Hormel Institute, University of Minnesota, Austin, Minnesota;', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101970565', 'display_name': 'Hyo‐Jeong Lee', 'orcid': 'https://orcid.org/0000-0003-1946-7842'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hyo-Jeong Lee', 'raw_affiliation_strings': ['1Hormel Institute, University of Minnesota, Austin, Minnesota;'], 'affiliations': [{'raw_affiliation_string': '1Hormel Institute, University of Minnesota, Austin, Minnesota;', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065541374', 'display_name': 'Hongbo Hu', 'orcid': 'https://orcid.org/0000-0002-2780-5568'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hongbo Hu', 'raw_affiliation_strings': ['1Hormel Institute, University of Minnesota, Austin, Minnesota;'], 'affiliations': [{'raw_affiliation_string': '1Hormel Institute, University of Minnesota, Austin, Minnesota;', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071852497', 'display_name': 'Barbara Malewicz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Barbara Malewicz', 'raw_affiliation_strings': ['1Hormel Institute, University of Minnesota, Austin, Minnesota;'], 'affiliations': [{'raw_affiliation_string': '1Hormel Institute, University of Minnesota, Austin, Minnesota;', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101679500', 'display_name': 'Hyojung Lee', 'orcid': 'https://orcid.org/0000-0002-4991-0705'}, 'institutions': [{'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyo-Jung Lee', 'raw_affiliation_strings': ['2College of Oriental Medicine, Kyunghee University;'], 'affiliations': [{'raw_affiliation_string': '2College of Oriental Medicine, Kyunghee University;', 'institution_ids': ['https://openalex.org/I35928602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100376545', 'display_name': 'Jae Ho Lee', 'orcid': 'https://orcid.org/0000-0001-5076-4365'}, 'institutions': [{'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jae-Ho Lee', 'raw_affiliation_strings': ['2College of Oriental Medicine, Kyunghee University;'], 'affiliations': [{'raw_affiliation_string': '2College of Oriental Medicine, Kyunghee University;', 'institution_ids': ['https://openalex.org/I35928602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024239495', 'display_name': 'Nam‐In Baek', 'orcid': 'https://orcid.org/0000-0002-9438-2817'}, 'institutions': [{'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Nam-In Baek', 'raw_affiliation_strings': ['4Kyunghee University, Yongin, Republic of Korea; and'], 'affiliations': [{'raw_affiliation_string': '4Kyunghee University, Yongin, Republic of Korea; and', 'institution_ids': ['https://openalex.org/I35928602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101755851', 'display_name': 'Jin-Hyun Jeong', 'orcid': 'https://orcid.org/0000-0003-0216-2145'}, 'institutions': [{'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jin-Hyun Jeong', 'raw_affiliation_strings': ['4Kyunghee University, Yongin, Republic of Korea; and', 'Department of Pharmacy'], 'affiliations': [{'raw_affiliation_string': '4Kyunghee University, Yongin, Republic of Korea; and', 'institution_ids': ['https://openalex.org/I35928602']}, {'raw_affiliation_string': 'Department of Pharmacy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113465333', 'display_name': 'Dae-Keun Kim', 'orcid': None}, 'institutions': [], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Dae-Keun Kim', 'raw_affiliation_strings': ['5Wouseok University, Chunju, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': '5Wouseok University, Chunju, Republic of Korea', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013654282', 'display_name': 'Kyung‐Sun Kang', 'orcid': 'https://orcid.org/0000-0002-9322-741X'}, 'institutions': [{'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kyung-Sun Kang', 'raw_affiliation_strings': ['3Seoul National University, Seoul, Republic of Korea;'], 'affiliations': [{'raw_affiliation_string': '3Seoul National University, Seoul, Republic of Korea;', 'institution_ids': ['https://openalex.org/I139264467']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100429324', 'display_name': 'Sung‐Hoon Kim', 'orcid': 'https://orcid.org/0000-0002-1570-3230'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}, {'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Sung-Hoon Kim', 'raw_affiliation_strings': ['1Hormel Institute, University of Minnesota, Austin, Minnesota;', '2College of Oriental Medicine, Kyunghee University;'], 'affiliations': [{'raw_affiliation_string': '1Hormel Institute, University of Minnesota, Austin, Minnesota;', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}, {'raw_affiliation_string': '2College of Oriental Medicine, Kyunghee University;', 'institution_ids': ['https://openalex.org/I35928602']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010296048', 'display_name': 'Junxuan Lü', 'orcid': 'https://orcid.org/0000-0002-2354-7186'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Junxuan Lu', 'raw_affiliation_strings': ['1Hormel Institute, University of Minnesota, Austin, Minnesota;'], 'affiliations': [{'raw_affiliation_string': '1Hormel Institute, University of Minnesota, Austin, Minnesota;', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.933, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.917354, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '6', 'issue': '3', 'first_page': '907', 'last_page': '917'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13971', 'display_name': 'Synthesis and Biological Activity', 'score': 0.9826, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11973', 'display_name': 'Plant chemical constituents analysis', 'score': 0.9769, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.850525}], 'concepts': [{'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.850525}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.8414153}, {'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.78994524}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.61998975}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.5421113}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.54080284}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.47274837}, {'id': 'https://openalex.org/C1292079', 'wikidata': 'https://www.wikidata.org/wiki/Q3817769', 'display_name': 'Transactivation', 'level': 4, 'score': 0.4633826}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.42947263}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.42787594}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4232457}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40955815}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37958723}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3686689}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26145726}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23852664}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.21892369}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.18187371}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.09716478}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.046687722}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D059002', 'descriptor_name': 'Androgen Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001578', 'descriptor_name': 'Benzopyrans', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002087', 'descriptor_name': 'Butyrates', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029969', 'descriptor_name': 'Angelica', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D029969', 'descriptor_name': 'Angelica', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001578', 'descriptor_name': 'Benzopyrans', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001578', 'descriptor_name': 'Benzopyrans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002087', 'descriptor_name': 'Butyrates', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002087', 'descriptor_name': 'Butyrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-06-0231', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17363485', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-06-0231', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.4, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1533310838', 'https://openalex.org/W1749733472', 'https://openalex.org/W1968434687', 'https://openalex.org/W1968992705', 'https://openalex.org/W1974810481', 'https://openalex.org/W1976449876', 'https://openalex.org/W1986568749', 'https://openalex.org/W2003955264', 'https://openalex.org/W2010397777', 'https://openalex.org/W2064293531', 'https://openalex.org/W2074022118', 'https://openalex.org/W2074955198', 'https://openalex.org/W2079039801', 'https://openalex.org/W2081305758', 'https://openalex.org/W2088590359', 'https://openalex.org/W2092612351', 'https://openalex.org/W2115023106', 'https://openalex.org/W2122028337', 'https://openalex.org/W2122680090', 'https://openalex.org/W2126238138', 'https://openalex.org/W2130973373', 'https://openalex.org/W2131899125', 'https://openalex.org/W2140559258', 'https://openalex.org/W2140675573', 'https://openalex.org/W2141813746', 'https://openalex.org/W2144941480', 'https://openalex.org/W2152286177', 'https://openalex.org/W2153010844', 'https://openalex.org/W2170395586', 'https://openalex.org/W2188526507', 'https://openalex.org/W2370454378'], 'related_works': ['https://openalex.org/W4361805108', 'https://openalex.org/W2772229485', 'https://openalex.org/W2541857854', 'https://openalex.org/W24268339', 'https://openalex.org/W2168187995', 'https://openalex.org/W2076586151', 'https://openalex.org/W2063882679', 'https://openalex.org/W2058568096', 'https://openalex.org/W2042646980', 'https://openalex.org/W1606103292'], 'abstract_inverted_index': {'Androgen': [0], 'and': [1, 22, 33, 70, 75, 80, 98, 101, 123, 132, 136, 144, 164, 189, 192, 197, 204, 210, 230, 244, 248], 'the': [2, 28, 35, 46, 51, 61, 67, 71, 85, 118, 154, 160, 184, 241, 245], 'androgen': [3, 163], 'receptor': [4], '(AR)-mediated': [5], 'signaling': [6, 19, 203], 'are': [7, 25, 213], 'crucial': [8], 'for': [9, 27, 34, 170, 239], 'prostate': [10, 31, 39, 89], 'cancer': [11, 90], 'development.': [12], 'Novel': [13], 'agents': [14], 'that': [15, 45, 222], 'can': [16], 'inhibit': [17], 'AR': [18, 120, 126, 202, 232], 'in': [20, 84, 159], 'ligand-dependent': [21, 229], 'ligand-independent': [23, 231], 'manners': [24], 'desirable': [26], 'chemoprevention': [29], 'of': [30, 37, 78, 112, 157, 162, 215, 219, 227], 'carcinogenesis': [32], 'treatment': [36], 'advanced': [38], 'cancer.': [40], 'We': [41], 'have': [42], 'shown': [43], 'recently': [44], 'pyranocoumarin': [47], 'compound': [48], 'decursin': [49, 79, 209], 'from': [50, 60], 'herb': [52], 'Angelica': [53], 'gigas': [54], 'possesses': [55], 'potent': [56, 167], 'anti-AR': [57, 68, 242], 'activities': [58, 69, 191, 243], 'distinct': [59], 'anti-androgen': [62], 'bicalutamide.': [63], 'Here,': [64], 'we': [65], 'compared': [66], 'cell': [72, 91, 173, 205], 'cycle': [73], 'arrest': [74, 135, 247], 'apoptotic': [76, 190, 249], 'effects': [77], 'two': [81], 'natural': [82], 'analogues': [83], 'androgen-dependent': [86], 'LNCaP': [87], 'human': [88], 'culture': [92], 'model': [93], 'to': [94], 'identify': [95], 'structure-activity': [96], 'relationships': [97], 'mechanisms.': [99], 'Decursin': [100], 'its': [102], 'isomer': [103], 'decursinol': [104, 211], 'angelate': [105, 212], 'decreased': [106, 125], 'prostate-specific': [107], 'antigen': [108], 'expression': [109], 'with': [110], 'IC(50)': [111], 'approximately': [113], '1': [114], 'mumol/L.': [115], 'Both': [116], 'inhibited': [117], 'androgen-stimulated': [119, 172], 'nuclear': [121], 'translocation': [122], 'transactivation,': [124], 'protein': [127], 'abundance': [128], 'through': [129], 'proteasomal': [130], 'degradation,': [131], 'induced': [133, 141], 'G(0/1)': [134], 'morphologic': [137], 'differentiation.': [138], 'They': [139], 'also': [140], 'caspase-mediated': [142], 'apoptosis': [143], 'reactive': [145, 185], 'oxygen': [146, 186], 'species': [147, 187], 'at': [148], 'higher': [149], 'concentrations.': [150], 'Furthermore,': [151], 'they': [152], 'lacked': [153, 183], 'agonist': [155], 'activity': [156], 'bicalutamide': [158, 169], 'absence': [161], 'were': [165], 'more': [166], 'than': [168], 'suppressing': [171], 'growth.': [174, 206], 'Decursinol,': [175], 'which': [176], 'does': [177], 'not': [178], 'contain': [179], 'a': [180, 198, 216, 224], 'side': [181, 235], 'chain,': [182], 'induction': [188], 'exerted': [193], 'paradoxically': [194], 'an': [195], 'inhibitory': [196], 'stimulatory': [199], 'effect': [200], 'on': [201], 'In': [207], 'conclusion,': [208], 'members': [214], 'novel': [217], 'class': [218], 'nonsteroidal': [220], 'compounds': [221], 'exert': [223], 'long-lasting': [225], 'inhibition': [226], 'both': [228], 'signaling.': [233], 'The': [234], 'chain': [236], 'is': [237], 'critical': [238], 'sustaining': [240], 'growth': [246], 'effects.': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1989120365', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-11T05:40:44.128550', 'created_date': '2016-06-24'}