Role of a JAK3-dependent Biochemical Signaling Pathway in Platelet Activation and Aggregation

Name: Work Video:
Duration: 3 min 30 s
Heather Tibbles; Alexei Vassilev; Heather Wendorf; Dawn Schonhoff; Dan Zhu; David R. Lorenz; Barbara Waurzyniak; Xingping Liu; Fatih M. Uckun
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3556, 3568, 3576, 3588, 3610, 3616, 3625, 3635, 3644, 3658, 3663, 3674, 3697, 3759, 3771, 3774, 3792, 3905, 4005, 4022, 4044, 4050, 4066, 4080, 4096, 4099, 4132, 4176, 4191, 4220, 4224, 4254, 4266, 4338, 4348, 4406, 4427, 4441, 4456, 4462, 4477, 4513, 4520, 4536, 4599, 4603, 4616, 4640, 4645, 4656, 4661, 4671, 4700, 4772, 4796, 4829], 'regulators': [12, 175, 653], 'platelet': [14, 105, 109, 158, 177, 268, 272, 321, 427, 455, 615, 635, 655, 1735, 1753, 1848, 1862, 1881, 2658, 3689, 3775, 3825, 3854, 3910, 4072, 4143, 4197, 4248, 4260, 4306, 4561, 4678, 4718, 4752, 4756, 4835], 'function.': [15, 178, 656, 4679], 'Treatment': [16, 179], 'platelets': [18, 54, 84, 181, 217, 247, 1676, 1782, 1991, 2621, 2638, 2687, 2701, 2766, 3299, 3307, 3357, 3367, 3388, 3474, 3566, 3656, 3705, 3739, 3802, 3842, 3864, 3875, 3887, 3927, 3979, 3996, 4020, 4033, 4085, 4107, 4130, 4180, 4278, 4709, 4731], 'with': [19, 48, 55, 182, 211, 218, 1220, 1310, 1544, 1645, 1661, 1671, 1679, 1833, 1951, 1961, 1977, 2390, 2441, 2491, 2505, 2690, 2705, 2769, 2782, 2830, 2962, 2975, 2993, 3020, 3089, 3096, 3132, 3196, 3262, 3271, 3308, 3368, 3389, 3481, 3541, 3657, 3755, 3809, 3930, 3943, 3980, 3997, 4021, 4035, 4124, 4131, 4149, 4216, 4238, 4280, 4296, 4465, 4525, 4706, 4905], 'thrombin': [20, 81, 183, 244, 360, 409, 1680, 1850, 2506, 2618, 2706, 2783, 3287, 3311, 3344, 3371, 3435, 3456, 3478, 3599, 3631, 3681, 3701, 3798, 3828, 3844, 3944, 4038, 4100, 4140, 4239, 4297, 4569, 4728], 'induced': [21, 184, 3312, 3634], 'tyrosine': [22, 40, 74, 185, 203, 237, 762, 768, 774, 781, 3313, 3335, 3349, 3374, 3418, 3489, 4683, 4721], 'phosphorylation': [23, 41, 75, 186, 204, 238, 3291, 3314, 3336, 3350, 3375, 3419, 4684, 4722], 'target': [27, 190], 'substrates': [28, 191], 'STAT1': [29, 43, 77, 192, 206, 240, 2072, 3294, 3321, 3338, 3377, 3421, 4686, 4724], 'and': [30, 44, 70, 78, 132, 143, 193, 207, 233, 241, 295, 306, 339, 382, 435, 637, 643, 700, 883, 895, 910, 916, 999, 1010, 1065, 1147, 1228, 1256, 1286, 1307, 1325, 1384, 1448, 1476, 1511, 1589, 1626, 1675, 1779, 1797, 1819, 1823, 1839, 1868, 1914, 1943, 1990, 2034, 2040, 2071, 2118, 2133, 2145, 2311, 2313, 2318, 2330, 2363, 2394, 2430, 2463, 2503, 2517, 2520, 2585, 2748, 2779, 2862, 2874, 2876, 2901, 2910, 2913, 2949, 2992, 3015, 3046, 3118, 3204, 3215, 3239, 3250, 3269, 3273, 3295, 3324, 3339, 3378, 3383, 3414, 3422, 3425, 3484, 3558, 3561, 3580, 3606, 3622, 3640, 3671, 3691, 3722, 3734, 3761, 3783, 3791, 3817, 3879, 3919, 3940, 3985, 4000, 4088, 4159, 4235, 4270, 4293, 4390, 4416, 4433, 4435, 4450, 4481, 4563, 4574, 4648, 4687, 4697, 4720, 4725, 4781, 4792, 4800], 'STAT3.': [31, 45, 79, 194, 208, 242, 2138, 4726], 'Platelets': [32, 195, 1883, 1948, 1970, 2485], 'from': [33, 196, 1099, 1152, 1283, 1429, 1619, 1794, 1886, 2337, 2347, 2617, 3024, 3300, 3358, 3564, 3750, 3758, 3840, 4032, 4086, 4108, 4118, 4331, 4444, 4710], 'JAK3-deficient': [34, 197, 3356, 4711], 'mice': [35, 118, 127, 198, 281, 290, 1096, 1110, 1165, 1217, 1222, 1263, 1800, 1870, 3085, 3129, 3193, 3360, 4110, 4321, 4343, 4429, 4459, 4500, 4523, 4712, 4767, 4776], 'displayed': [36, 199, 4713], 'a': [37, 129, 137, 200, 292, 300, 365, 418, 546, 662, 670, 690, 1275, 1407, 1422, 1443, 1456, 1545, 1556, 1701, 1740, 1917, 2368, 2625, 2751, 2822, 2865, 2925, 2939, 2963, 3012, 3021, 3041, 3220, 3601, 3746, 3777, 3833, 3901, 3964, 3981, 4146, 4164, 4247, 4263, 4305, 4345, 4410, 4466, 4530, 4566, 4611, 4650, 4714, 4778, 4786, 4811, 4889, 4906], 'decrease': [38, 201, 4715], 'in': [39, 117, 128, 136, 202, 280, 291, 299, 454, 605, 613, 633, 705, 1291, 1334, 1353, 1412, 1427, 1555, 1700, 1773, 1866, 1877, 1924, 2426, 2436, 2804, 2844, 2856, 2864, 2884, 2906, 2917, 2924, 2983, 3011, 3040, 3104, 3110, 3244, 3252, 3298, 3355, 3548, 3575, 3587, 3624, 3650, 3688, 3770, 3820, 3853, 3921, 3963, 4004, 4070, 4093, 4145, 4232, 4246, 4285, 4289, 4304, 4344, 4409, 4447, 4497, 4510, 4559, 4653, 4716, 4766, 4777, 4785], 'In': [46, 209, 1273, 1767, 3785, 3807, 4122, 4206, 4422, 4549, 4704], 'accordance': [47, 210, 3808, 4123], 'these': [49, 212, 1789, 3352, 3893, 4125, 4516, 4707], 'data,': [50, 213], 'pretreatment': [51, 214, 3654, 4127], 'human': [53, 216, 606, 2686, 2765, 3366, 3387, 3704, 3926, 4129], 'inhibitor': [58, 221, 666, 683, 3392, 3660, 4134, 4193, 4222], 'WHI-P131': [59, 97, 114, 121, 150, 222, 260, 277, 284, 313, 684, 751, 834, 927, 1649, 1956, 2492, 2693, 2772, 2982, 3057, 3103, 3393, 3661, 3724, 3823, 3914, 3933, 4135, 4194, 4268, 4281, 4316, 4336, 4371, 4383, 4396, 4403, 4473, 4528, 4680, 4744, 4763, 4770, 4809, 4827, 4840, 4884], 'markedly': [60, 223, 3834], 'decreased': [61, 224, 3396], 'base-line': [63, 226, 2445, 3398], 'enzymatic': [64, 227, 3399, 3438], 'activity': [65, 228, 2414, 2425, 2451, 3400, 3439, 3453], 'constitutively': [67, 230, 603, 3402], 'active': [68, 231, 604, 3403], 'abolished': [71, 234, 3415], 'thrombin-induced': [73, 99, 236, 262, 426, 634, 3417, 3664, 3728, 3909, 3916, 4071, 4081, 4177, 4196, 4258, 4560, 4657, 4682, 4717, 4746], 'Following': [80, 243, 2047, 2351, 2821, 4727], 'stimulation,': [82, 245, 3436, 3600, 4729], 'WHI-P131-treated': [83, 246, 3801, 3841, 4011, 4730], 'did': [85, 248, 4173, 4732], 'not': [86, 249, 755, 3592, 4170, 4174, 4318, 4733], 'undergo': [87, 250, 4734], 'shape': [88, 251, 3690, 3748, 3815, 4735], 'changes': [89, 252, 3687, 3816, 3918, 4736], 'indicative': [90, 253, 3716, 4737], 'activation': [92, 255, 352, 428, 616, 636, 3679, 3718, 4562, 4739], 'such': [93, 256, 4740, 4882], 'pseudopod': [95, 258, 3729, 4742], 'formation.': [96, 259, 4743], 'inhibited': [98, 261, 3727, 3824, 4139, 4681, 4745], 'degranulation/serotonin': [100, 263, 4747], 'release': [101, 264, 4031, 4748], 'well': [103, 266, 2373, 3530, 3584, 3766, 4691, 4750, 4902], 'aggregation.': [106, 269, 638, 1860, 4073, 4198, 4564, 4753], 'Highly': [107, 270, 4754], 'effective': [108, 271, 436, 4755], 'inhibitory': [110, 273, 3811, 4757], 'plasma': [111, 274, 334, 1615, 1725, 4212, 4758], 'concentrations': [112, 275, 1647, 1954, 4218, 4759], 'were': [115, 278, 835, 928, 962, 1097, 1150, 1166, 1218, 1235, 1250, 1351, 1521, 1565, 1601, 1643, 1659, 1668, 1677, 1755, 1884, 1949, 1971, 1992, 2062, 2164, 2335, 2345, 2355, 2384, 2489, 2567, 2590, 2639, 2688, 2702, 2721, 2767, 2790, 2828, 2841, 2882, 2895, 2922, 2935, 2959, 3009, 3049, 3086, 3130, 3194, 3206, 3241, 3267, 3789, 3856, 3928, 3951, 3961, 4214, 4353, 4508, 4764], 'achieved': [116, 279, 4765], 'without': [119, 282, 4529, 4540, 4768], 'toxicity.': [120, 283, 4769], 'prolonged': [122, 285, 4337, 4771], 'bleeding': [124, 287, 3005, 3017, 3047, 4340, 4351, 4773], 'time': [125, 288, 1997, 3006, 3176, 4469, 4480, 4774], 'dose-dependent': [130, 293, 4346, 4779], 'manner': [131, 294, 4780], 'improved': [133, 296, 4405, 4782], 'event-free': [134, 297, 4484, 4783], 'survival': [135, 298, 4407, 4468, 4479, 4485, 4784], 'mouse': [138, 301, 1285, 4411, 4787], 'model': [139, 302, 692, 4412, 4788], 'thromboplastin-induced': [141, 304, 4414, 4790], 'generalized': [142, 305, 4415, 4502, 4791], 'invariably': [144, 307, 4417], 'fatal': [145, 308, 678, 4418, 4793, 4821], 'thromboembolism.': [146, 309, 443, 4453, 4503], 'To': [147, 310, 4074, 4824], 'our': [148, 311, 658, 4551, 4825], 'knowledge,': [149, 312, 4826], 'is': [151, 314, 410, 1720, 1737, 1786, 3428, 3469, 3479, 3539, 4317, 4663, 4828, 4841], 'first': [153, 316, 3279, 3461, 4078, 4830], 'anti-thrombotic': [154, 317, 4831], 'agent': [155, 318, 673, 1719, 4814, 4832, 4849], 'prevents': [157, 320, 4834], 'aggregation': [159, 322, 618, 1690, 1699, 1754, 1769, 1780, 1863, 4144, 4178, 4243, 4261, 4275, 4301, 4719, 4836], 'by': [160, 323, 359, 1168, 1266, 1322, 1442, 1455, 1470, 1580, 1739, 1757, 1777, 1801, 1999, 2053, 2418, 2569, 2937, 3199, 3254, 3405, 3409, 3444, 3615, 3685, 3706, 3740, 3832, 4597, 4837], 'inhibiting': [161, 324, 4838], 'JAK3.': [162, 325, 4839], 'Janus': [326, 550], 'kinase': [327, 695, 763, 769, 775, 782, 785, 2143, 2353, 2413, 2424, 2456, 2469, 2477, 3490], 'polymerase': [328, 1268], 'chain': [329, 1269], 'reaction': [330, 1270], 'base': [331], 'pair': [332, 1107, 1405, 1420], 'platelet-rich': [333, 366, 1724, 4211], 'phosphate-buffered': [335, 3201, 4233], 'saline': [336, 1838, 3039], 'signal': [337, 4659], 'transducers': [338], 'activators': [340], 'transcription': [342], 'high-resolution': [343], 'low-voltage': [344], 'scanning': [345, 2389, 2438], 'electron': [346, 349, 2928, 3967], 'microscopy': [347, 350], 'transmission': [348], 'Platelet': [351, 1689, 1704, 2588, 3678, 4242, 4300], 'via': [353, 3137], 'cleavage': [354, 4622], 'protease-activated': [357, 4571, 4646], 'receptors': [358, 4572], 'leads': [361], 'to': [362, 374, 601, 627, 1237, 1245, 1252, 1629, 1722, 1727, 1826, 1858, 2064, 2365, 2386, 2633, 2716, 2817, 2953, 2991, 3124, 3217, 3282, 3347, 3477, 3533, 3609, 3643, 3673, 3753, 3779, 4049, 4064, 4320, 4333, 4639, 4669, 4699], 'formation': [363, 1731, 3730], 'thrombus,': [367], 'which': [368], 'can': [369], 'severely': [370], 'impair': [371], 'blood': [372, 1791, 1830, 1880], 'flow': [373], 'vital': [375], 'organs,': [376], 'including': [377], 'brain,': [379], 'heart,': [380, 3237, 4799], 'lungs,': [381, 4797], 'kidneys': [383], '(1Teng': [384, 3061], 'C.M.': [385, 3062], 'Wu': [386, 3063], 'C.C.': [387, 3064], 'Ko': [388, 3065], 'F.N.': [389, 3066], 'Lee': [390, 1897, 3067], 'F.Y.': [391, 3068], 'Kuo': [392, 3069], 'S.C.': [393, 3070], 'Eur.': [394, 3071, 3498], 'J.': [395, 471, 495, 516, 713, 792, 1040, 1049, 1073, 1154, 1892, 2096, 2175, 2201, 2228, 2249, 2258, 2277, 2537, 2554, 2598, 2798, 3072, 3164, 3499, 3517, 4586, 4864], 'Pharmacol.': [396, 3073, 3165], '1997;': [397, 519, 1908, 2538, 3074, 3501], '320:': [398, 3075], '161-166Crossref': [399, 3076], 'PubMed': [400, 482, 501, 527, 539, 562, 580, 594, 724, 803, 1060, 1084, 1140, 1209, 1911, 2107, 2186, 2212, 2235, 2269, 2292, 2541, 2563, 2611, 2679, 2743, 3077, 3169, 3504, 3526, 4592, 4631, 4875], 'Scopus': [401, 483, 502, 528, 540, 563, 581, 595, 725, 804, 1061, 1085, 1141, 1210, 2108, 2187, 2213, 2236, 2270, 2293, 2542, 2680, 2744, 3078, 3170, 3505, 4593, 4632, 4876], '(80)': [402, 3079], 'Google': [403, 485, 504, 530, 542, 565, 583, 597, 727, 749, 806, 828, 951, 1063, 1087, 1143, 1212, 1912, 2110, 2189, 2215, 2238, 2272, 2295, 2544, 2564, 2612, 2682, 2746, 3080, 3172, 3507, 3527, 4595, 4634, 4878], 'Scholar).': [404, 543, 750, 829, 952, 1213, 1348, 2111, 2296, 2565, 2613, 2683, 2811, 3081, 3173, 4635, 4879], 'Since': [405], 'serine': [407, 4567], 'protease': [408], 'most': [412], 'potent': [413], 'activator': [414], 'platelet-mediated': [416], 'coagulation,': [417], 'better': [419], 'understanding': [420], 'signaling': [423], 'pathways': [424], 'regulating': [425], 'may': [429, 4637, 4885], 'basis': [432], 'for': [433, 438, 450, 674, 693, 833, 926, 956, 1524, 1531, 1536, 1541, 1552, 1650, 1713, 1748, 1844, 1874, 1964, 2042, 2641, 2653, 2697, 2709, 2723, 2776, 2786, 2792, 2833, 2847, 2903, 2914, 3257, 3861, 3872, 3884, 3937, 3947, 3953, 4039, 4136, 4358, 4368, 4380, 4393, 4557, 4817, 4894, 4915], 'new': [434, 4890], 'strategies': [437], 'prevention': [439, 675, 4818], 'and/or': [440], 'treatment': [441, 3305, 4895], 'Recent': [444], 'studies': [445, 4666], 'have': [446], 'revealed': [447], 'important': [448], 'roles': [449], 'several': [451, 3233], 'protein-tyrosine': [452, 553], 'kinases': [453, 554], 'physiology': [456], '(2Pasquet': [457], 'J.M.': [458, 1121, 1190, 1894], 'Quek': [459], 'L.': [460, 1034, 2243], 'Pasquet': [461], 'S.': [462, 736, 738, 815, 817, 938, 940, 2093, 2198, 2222, 2275, 3512, 4851, 4853, 4859], 'Poole': [463], 'A.': [464, 2087, 2192, 2529, 2547], 'Matthews': [465], 'J.R.': [466], 'Lowell': [467], 'C.': [468, 740, 819, 942, 2091, 2196], 'Watson': [469, 514, 1905, 2599], 'S.P.': [470, 515, 1906, 2600], 'Biol.': [472, 517, 714, 793, 1050, 1074, 2097, 2176, 2202, 2259, 2288, 2555, 2602, 2674, 2738, 3518, 4865], 'Chem.': [473, 518, 715, 794, 1051, 1075, 2098, 2177, 2203, 2260, 2556, 3519, 4866], '2000;': [474, 591], '275:': [475], '28526-28531Abstract': [476], 'Full': [477, 479, 522, 524, 719, 721, 798, 800, 1055, 1057, 1079, 1081, 2102, 2104, 2181, 2183, 2207, 2209, 2264, 2266, 2560, 2606, 2608, 3523, 4870, 4872], 'Text': [478, 480, 523, 525, 720, 722, 799, 801, 1056, 1058, 1080, 1082, 2103, 2105, 2182, 2184, 2208, 2210, 2265, 2267, 2561, 2607, 2609, 3524, 4871, 4873], 'PDF': [481, 526, 723, 802, 1059, 1083, 2106, 2185, 2211, 2268, 2562, 2610, 3525, 4874], '(49)': [484], 'Scholar,': [486, 505, 531, 566, 584, 728, 807, 2190, 2216, 2239, 2273, 2545, 3508], '3Ezumi': [487], 'Y.': [488, 3152, 3160, 3162, 3495, 3510, 4857], 'Shindoh': [489], 'K.': [490, 586, 3150, 3493, 3514], 'Tsuji': [491], 'M.': [492, 509, 533, 1896, 2226, 2551, 4579, 4861], 'Takayama': [493], 'H.': [494, 572, 3158, 3497, 3516, 4583], 'Exp.': [496], 'Med.': [497], '1998;': [498, 716, 795, 1076, 2178, 2603, 2676, 2740, 3166], '188:': [499], '267-276Crossref': [500], '(181)': [503], '4Melford': [506], 'S.K.': [507], 'Turner': [508], 'Briddon': [510], 'S.J.': [511, 2283], 'Tybulewicz': [512], 'V.L.': [513], '272:': [520], '27539-27542Abstract': [521], '(53)': [529], '5Laffargue': [532], 'FEBS': [534, 557], 'Lett.': [535, 558], '1999;': [536, 577, 746, 825, 948, 2099, 2204, 4589, 4628, 4867], '443:': [537], '66-70Crossref': [538], '(33)': [541, 1062, 2271], 'Notably,': [544, 3304, 3630, 4402], 'JAK3,1': [545], 'member': [547], 'family': [551, 761, 767, 773, 780], '(6Rodriguez-Linares': [555], 'B.W.S.': [556], '1994;': [559, 3520], '352:': [560], '335-338Crossref': [561], '(48)': [564], '7Witthuhn': [567], 'B.A.': [568, 1127, 1196], 'Williams': [569], 'M.D.': [570], 'Kerawalla': [571], 'Uckun': [573, 711, 741, 790, 820, 943, 1071, 2094, 2173, 2199, 2672, 2736, 4862], 'F.M.': [574, 712, 742, 791, 821, 944, 1032, 1072, 1331, 2095, 2174, 2200, 2218, 2241, 2673, 2737, 4863], 'Leuk.': [575], 'Lymphoma.': [576], '32:': [578], '289-297Crossref': [579], '(32)': [582], '8Imada': [585], 'Leonard': [587], 'W.J.': [588], 'Mol.': [589, 2286], 'Immunol.': [590], '37:': [592], '1-11Crossref': [593], '(470)': [596], 'Scholar),': [598, 1064, 1144], 'was': [599, 626, 686, 1264, 1281, 1320, 1440, 1453, 1468, 1578, 1617, 1691, 1792, 1831, 1853, 1864, 1988, 2416, 2523, 2622, 2651, 2714, 2815, 3018, 3031, 3341, 3442, 3683, 4111, 4244, 4302, 4501], 'shown': [600, 3547, 3649, 4092, 4284], 'be': [602, 4886], 'platelets,': [607, 3822], 'but': [608, 754], 'its': [609, 3810], 'potential': [610], 'physiologic': [611], 'role': [612, 630, 3903, 4067, 4556, 4652], 'agonist-induced': [614, 1752], 'or': [617, 757, 777, 1432, 1957, 1979, 1983, 2080, 2499, 2509, 2694, 2773, 2978, 3099, 3184, 3275, 3934, 4228, 4291, 4322, 4547, 4910], 'remains': [619], 'unknown.': [620, 3471], 'The': [621, 681, 830, 922, 953, 1260, 1436, 1463, 1518, 1562, 1640, 1664, 1745, 1847, 2839, 2880, 3029, 3128, 3464, 3849, 4493, 4605], 'purpose': [622], 'this': [624, 1728, 2951, 3467, 4075, 4423, 4805], 'study': [625, 659, 4806], 'examine': [628, 3283, 4065], 'show': [641], 'genetic': [642], 'biochemical': [644, 4658], 'implicates': [647], 'Furthermore,': [657], 'uniquely': [660, 4807], 'small': [663], 'molecule': [664], 'chemical': [665], 'novel': [671, 4812], 'antiplatelet': [672, 4813], 'potentially': [677, 4820], 'thromboembolic': [679, 4822, 4916], 'events.': [680, 4823], '(4-(4′-hydroxylphenyl)amino-6,7-dimethoxyquinazoline)': [685], 'rationally': [687], 'designed': [688], 'using': [689, 1179, 1586, 1608, 1693, 1761, 2155, 2398, 2447, 2624, 2750, 2950, 3190, 4043], 'homology': [691], 'domain': [696], 'JAK3,': [698, 753, 2304, 2577, 3638, 3669, 4172], 'synthesized,': [699], 'characterized': [701], 'previously': [703, 1889, 2168, 2526, 2593, 2662, 2726, 2795, 3059, 3147], 'described': [704, 1890, 2167, 2527, 2594, 2727, 2796, 3060, 3148, 3956], 'detail': [706], '(9Goodman': [707, 786, 1067, 2169], 'P.A.': [708, 787, 1068, 2170], 'Niehoff': [709, 788, 1069, 2171], 'L.B.': [710, 789, 1070, 2172], '273:': [717, 796, 1077, 2179, 2233], '17742-17748Abstract': [718, 797, 1078, 2180], '(58)': [726, 805, 1086, 2188], '10Sudbeck': [729, 808], 'E.A.': [730, 809, 932, 4855], 'Liu': [731, 810, 933], 'X.P.': [732, 811, 934], 'Narla': [733, 812, 935], 'R.K.': [734, 813, 936], 'Mahajan': [735, 814, 937, 2092, 2197, 2221], 'Ghosh': [737, 816, 939, 4852], 'Mao': [739, 818, 941], 'Clin.': [743, 822, 945, 4587], 'Cancer': [744, 823, 946], 'Res.': [745, 824, 947], '5:': [747, 826, 949], '1569-1582PubMed': [748, 827, 950], 'inhibits': [752], 'JAK1': [756], 'JAK2,': [758], 'ZAP/SYK': [760], 'SYK,': [764, 3667], 'TEC': [766], 'BTK,': [770], 'SRC': [772], 'LYN,': [776], 'receptor': [779, 784, 4618, 4621, 4662], 'insulin': [783], 'physical': [831, 954], 'data': [832, 925, 955], 'follows:': [837, 964], 'm.p.': [838, 968], '245.0–248.0': [839], '°C;': [840, 970], '1H': [841, 971], 'NMR': [842, 972], '(Me2SO-d6)': [843, 973], 'δ': [844, 974], '11.21': [845], '(s,': [846, 850, 854, 858, 869, 880, 885, 976, 980, 984, 992, 996, 1001], '1H,': [847, 851, 855, 859, 870, 977, 981, 985, 993], '-NH),': [848, 978], '9.70': [849], '-OH),': [852], '8.74': [853], '2-H),': [856, 982], '8.22': [857], '5-H),': [860, 986], '7.40': [861], '(d,': [862, 873], '2H,J': [863, 874], '=': [864, 875, 1872, 2453, 2466, 3449, 3866, 3877, 3889, 4362, 4373, 4385, 4398], '8.9': [865, 876], 'Hz,': [866, 877], '2′,6′-H),': [867], '7.29': [868], '8-H),': [871, 994], '6.85': [872], '3′,5′-H),': [878], '3.98': [879], '3H,': [881, 886, 997, 1002], '-OCH3),': [882, 998], '3.97': [884], '-OCH3);': [887, 1003], 'IR': [888, 1004], '(KBr)': [889, 1005], '3428,': [890], '2836,': [891], '1635,': [892], '1516,': [893], '1443,': [894], '1234': [896], 'cm−1;': [897, 1012], 'gas': [898, 1013], 'chromatography/mass': [899, 1014], 'spectrometry,': [900, 1015], 'm/z': [901, 1016], '298': [902], '(M+': [903, 912, 1018, 1026], '+': [904, 1019], '1,': [905, 914, 1020, 1028], '100),': [906, 1029], '297': [907], '(M+,': [908, 1023], '27),': [909], '296': [911], '−': [913, 1027], '12);': [915], 'analyzed': [917, 1089, 1602, 2568, 2749], '(C16H15N3O3·HCl),': [918], 'C,': [919, 1091, 4007, 4271], 'H,': [920, 1092], 'N.': [921, 1093, 1155, 2535], 'x-ray': [923], 'crystallographic': [924], 'recently': [929], 'published': [930, 1604], '(10Sudbeck': [931], 'parent': [958, 4225], 'compound,': [959], 'WHI-P258': [960, 4287], '(4-(phenyl)-amino-6,7-dimethoxyquinazoline),': [961], 'yield': [965], '88.26%;': [967], '258.0–260.0': [969], '11.41': [975], '8.82': [979], '8.32': [983], '7.70–7.33': [987], '(m,': [988], '5H,': [989], '2′,3′,4′,5′,6′-H),': [990], '7.36': [991], '4.02': [995], '4.00': [1000], '2852,': [1006], '1627,': [1007], '1509,': [1008], '1434,': [1009], '1248': [1011], '282': [1017], '11),': [1021], '281': [1022], '55),': [1024], '280': [1025], '264': [1030], '(16Uckun': [1031], 'Tuel-Ahlgren': [1033, 2242], 'Waddick': [1035, 2219, 2244], 'K.G.': [1036, 2220, 2245], 'Jun': [1037, 2223, 2246], 'X.': [1038, 2224, 2247], 'Jin': [1039, 2248], 'Myers': [1041, 2250], 'D.E.': [1042, 2251], 'Rowley': [1043, 2252], 'R.B.': [1044, 2253], 'Burkhardt': [1045, 2254, 2278], 'A.L.': [1046, 2255, 2279], 'Bolen': [1047, 2227, 2256, 2284, 2597], 'J.B.': [1048, 2257, 2285], '1996;': [1052, 2232, 2261], '271:': [1053, 2262], '6389-6397Abstract': [1054, 2263], '207': [1066], 'Scholar);': [1088], '(C16H15N3O2),': [1090], 'Control': [1094, 1656], 'C57BL/6': [1095, 1113, 1221, 1238, 1246, 1799, 3302], 'purchased': [1098, 1618, 2336, 2346], 'Taconic': [1100], 'Farms': [1101], 'Inc.': [1102], '(Germantown,': [1103], 'NY).': [1104], 'A': [1105, 2411, 3721, 4158, 4187], 'breeder': [1106], 'Jak3knockout': [1109, 3359, 4089], '(Jak3': [1111, 3361], '−/−,': [1112], '×': [1114, 1921, 2056, 2487], '129/Sv,': [1115], 'H-2b': [1116], '(11Nosaka': [1117, 1186], 'T.': [1118, 1187, 2230, 2533, 3154], 'van': [1119, 1188], 'Deursen': [1120, 1189], 'Tripp': [1122, 1191], 'R.A.': [1123, 1192], 'Thierfelder': [1124, 1193], 'W.E.': [1125, 1194], 'Witthuhn': [1126, 1195], 'McMickle': [1128, 1197], 'A.P.': [1129, 1198], 'Doherty': [1130, 1199], 'P.C.': [1131, 1200], 'Grosveld': [1132, 1201], 'G.C.': [1133, 1202], 'Ihle': [1134, 1156, 1203], 'J.N.': [1135, 1204], 'Science.': [1136, 1205, 2231], '1995;': [1137, 1206, 2289], '270:': [1138, 1207], '800-802Crossref': [1139, 1208], '(568)': [1142, 1211], 'A011': [1145], '(male)': [1146], 'A1038': [1148], '(female))': [1149], 'obtained': [1151], 'Dr.': [1153], '(St.': [1157], 'Jude': [1158], "Children's": [1159], 'Research': [1160], 'Hospital,': [1161], 'Memphis,': [1162], 'TN).': [1163], 'These': [1164, 1214], 'created': [1167], 'targeted': [1170], 'disruption': [1171], 'Jak3': [1174, 1465, 1605, 1795, 4116, 4119], 'gene': [1175, 1183], 'through': [1176, 3208, 3219, 3223], 'homologous': [1177], 'recombination': [1178], 'hygromycin': [1181], 'resistance': [1182], '(Hyg)': [1184], 'cassette': [1185], 'founderJak3': [1215], '−/−': [1216, 1255, 1415, 1451], 'bred': [1219], '(Jackson': [1223], 'Laboratory,': [1224], 'Bar': [1225], 'Harbor,': [1226], 'ME),': [1227], 'offspring': [1230, 1249], 'F1': [1233], 'generation': [1234], 'back-crossed': [1236], 'mice.': [1239, 1259, 1416, 1435, 3303, 4090, 4121, 4517], 'After': [1240], 'three': [1241, 2854], 'generations': [1242], 'back-crossing': [1244], 'mice,': [1247], 'intercrossed': [1251], 'produce': [1253], 'homozygousJak3': [1254, 1430, 1437, 1450], 'wild-typeJak3': [1257], '+/+': [1258, 1431, 1438, 4106], 'genotype': [1261, 1439, 1452, 1467], 'confirmed': [1265, 3567], 'multiplex': [1267], '(PCR)': [1271], 'tests.': [1272], 'brief,': [1274], '0.5-inch': [1276], '(1.27-cm)': [1277], 'tail': [1278, 3016, 3027, 3030, 3144, 4339, 4350], 'tissue': [1279, 3265], 'section': [1280], 'taken': [1282], 'each': [1284, 1507, 1875, 2943], 'digested': [1287], 'at': [1288, 1653, 1841, 1855, 1916, 1967, 1974, 1994, 2756, 2836, 2850, 2859, 2930, 2942, 3051, 3187, 3431, 3708, 3742, 3969, 4182, 4327, 4913], '55': [1289], '°C': [1290, 1523, 1530, 1535, 1540, 1551, 1843, 1976, 3043], '600': [1292], 'μl': [1293, 1312, 2970, 2985, 3091, 3106], 'lysis': [1295, 2005], 'buffer': [1296, 1488, 1809, 1927, 2006], '(50': [1297], 'mmTris': [1298], '(pH': [1299, 1946, 2038], '8.0),': [1300], '100': [1301, 1304, 2691, 2770, 3931, 4183, 4334], 'mm': [1302, 1305, 1500, 1929, 1932, 1935, 1938, 1941, 2008, 2011, 2022, 2026, 2036], 'EDTA,': [1303], 'NaCl,': [1306, 1930, 2009], '1%': [1308, 1962, 2845, 2907], 'SDS)': [1309], '50': [1311, 2035], 'proteinase': [1314], 'K': [1315], '(10': [1316, 2511], 'mg/ml).': [1317], 'Genomic': [1318], 'DNA': [1319, 1594, 1599, 1606], 'purified': [1321], 'phenol/chloroform': [1323], 'extractions': [1324], 'ethanol': [1326, 2867, 2912], 'precipitation': [1327], '(12Treco': [1328], 'D.A.': [1329], 'Ausubel': [1330], 'Current': [1332], 'Protocols': [1333], 'Molecular': [1335, 1503, 2399], 'Biology.': [1336], '5th': [1337], 'Ed.': [1338], '1.': [1339], 'John': [1340], 'Wiley': [1341], '&': [1342], 'Sons,': [1343], 'Inc.,': [1344, 1399, 1596, 1684, 2323, 2807], 'New': [1345, 2808], 'York1995:': [1346], '2.1.1-2.1.8Google': [1347], 'Three': [1349], 'primers': [1350, 1592], 'employed': [1352], 'PCR': [1355, 1403, 1410, 1418, 1425, 1446, 1459, 1478, 1482, 1487, 1519, 1563, 1582], 'tests:': [1356], '30-base': [1358, 1371, 1386], 'primerJak3-S': [1359], '(5′-ACC': [1360], 'TAG': [1361], 'TCC': [1362], 'CCA': [1363, 1380], 'GCT': [1364], 'TGG': [1365, 1392], 'CTG': [1366], 'TCA': [1367], 'CTT': [1368], 'GGG-3′),': [1369], 'primer': [1372, 1387, 1404, 1419], 'Jak3-AS': [1373], '(5′-CAA': [1374], 'AGC': [1375], 'GGT': [1376], 'GAC': [1377], 'ATG': [1378], 'TCT': [1379], 'GCC': [1381], 'CAA': [1382], 'ACC-3′),': [1383], 'Jak3-Hyg(5′-ATG': [1388], 'GTT': [1389], 'TTT': [1390], 'GGA': [1391, 1396], 'CCT': [1393], 'GGG': [1394], 'CAT': [1395], 'CCG-3′)': [1397], '(Biosynthesis': [1398], 'Lewisville,': [1400], 'TX).': [1401], 'TheJak3-AS/Jak3-Hyg': [1402], 'yielded': [1406, 1421], '620-bp': [1408, 1458, 1477], 'mutant': [1409], 'product': [1411, 1426, 1460], 'tissues': [1413, 1428, 3235], 'fromJak3': [1414], 'TheJak3-AS/Jak3-S': [1417], '720-bp': [1423, 1445], 'wild-type': [1424, 1867, 3301, 4087, 4109], 'heterozygousJak3': [1433], '+/−': [1434, 1466], 'documented': [1441, 1454, 1469], 'single': [1444, 1457, 2964], 'product,': [1447], '(Fig.': [1461, 3331, 3411, 3458, 3719, 3731, 3781, 3803, 3846, 4185, 4420, 4491], '1).': [1462], 'heterozygous': [1464], 'presence': [1472, 3569], 'both': [1474, 2114, 2129, 2309, 2316], '720-': [1475], 'products.': [1479], 'Each': [1480], '50-μl': [1481], 'medium': [1483], 'consisted': [1484], '1×': [1486], 'II': [1489], 'containing': [1490, 1806, 1810], '2.5': [1491, 1512, 4471], 'mmMgCl2': [1492], '(AmpliTaq': [1493], 'Gold': [1494, 1516], 'kit,': [1495], 'PerkinElmer': [1496], 'Life': [1497], 'Sciences),': [1498], '0.2': [1499], 'dNTP': [1501], '(Roche': [1502], 'Biochemicals),': [1504], '0.4': [1505], 'μm': [1506, 2692, 2771, 3932, 4156, 4184], 'primer,': [1508], '6%': [1509], 'Me2SO,': [1510], 'units': [1513, 2428, 2439], 'AmpliTaq': [1515], 'enzyme.': [1517], 'conditions': [1520], '94': [1522], '10': [1525, 1553, 1980, 2710, 2787, 2904, 2915, 3035, 3948, 4438], 'min,': [1526, 1533, 1538, 2496], '30': [1527, 1965, 2058, 2495, 2698, 2777, 2988, 3052, 3114, 3938, 4137, 4488], 'cycles': [1528], '(94': [1529], '1': [1532, 1537, 1542, 1856, 2043, 2848, 4036, 4332, 4573], '57': [1534], '72': [1539, 1550], 'min': [1543, 1554, 1652, 1857, 1966, 2778, 2835, 2905, 2916, 2989, 3002, 3053, 3115, 3120, 3939, 4138, 4357, 4367, 4379, 4392, 4439], '5': [1546, 1714, 1845, 3001, 3119, 3847], 'sec': [1547], 'extension),': [1548], 'then': [1549, 1972, 2703, 2780, 2842, 3941, 4236, 4294, 4608], 'Touchdown': [1557], 'thermocycler': [1558], '(Hybaid,': [1559], 'Potomac,': [1560], 'MD).': [1561], 'products': [1564], 'cloned': [1566], 'into': [1567, 1804, 3034, 3142], 'original': [1569], 'TA': [1570], 'cloning': [1571], 'vector': [1572], '(Invitrogen,': [1573], 'Carlsbad,': [1574], 'CA).': [1575], 'Sequence': [1576], 'analysis': [1577, 1760, 2572, 3554], 'accomplished': [1579], 'ThermoSequenase': [1581], '(Amersham': [1583, 2161], 'Pharmacia': [1584, 2162], 'Biotech)': [1585, 2163], 'Cy5-labeled': [1587], 'T3': [1588], 'T7': [1590], 'sequencing': [1591], '(Integrated': [1593], 'Technologies,': [1595], 'Coralville,': [1597], 'IA).': [1598], 'sequences': [1600], 'against': [1603, 2069, 2302, 2576], 'sequence': [1607], 'Lasergene': [1609], 'software': [1610, 2403], '(DNASTAR,': [1611], 'Madison,': [1612], 'WI).': [1613], 'Platelet-rich': [1614], '(PRP)': [1616], 'Memorial': [1621], 'Blood': [1622, 1703], 'Bank': [1623], '(Minneapolis,': [1624], 'MN)': [1625], 'used': [1627, 2300, 2640], 'according': [1628, 1726, 2632, 4048], 'guidelines': [1631], 'Parker': [1634], 'Hughes': [1635], 'Institute': [1636], 'Human': [1637], 'Subjects': [1638], 'Committee.': [1639], 'PRP': [1641, 1657, 1666, 1887], 'samples': [1642, 1658, 1667, 2061, 2589, 2840, 2881, 4213], 'treated': [1644, 1660, 1665, 2490, 2960, 3087, 4215, 4279, 4524], 'varying': [1646, 2979, 3100, 4217], '20': [1651, 3870, 4369, 4457, 4521], '37': [1654, 1842, 1968, 1975, 2497, 3042], '°C.': [1655, 1969], 'vehicle': [1662, 1958, 2500, 2695, 2774, 2972, 2987, 3093, 3108, 3935, 4229, 4292], 'alone.': [1663], 'diluted': [1669, 1832], '1:4': [1670], 'sterile': [1672], 'normal': [1673, 3038], 'saline,': [1674], 'stimulated': [1678, 1973, 2504, 2704, 2781, 3942, 4034, 4237, 4295], '(0.1': [1681, 1851, 2507, 2619, 2707, 2784, 3702, 3945, 4101, 4141, 4240, 4298], 'unit/ml;': [1682], 'Chronolog': [1683, 1711], 'Philadelphia,': [1685], 'PA)': [1686], 'under': [1687, 3957], 'stirring.': [1688], 'monitored': [1692, 4245, 4303], 'Born': [1695], 'method': [1696], 'turbidimetric': [1698], 'Whole': [1702], 'Aggregometer': [1705], '(Model': [1706], '560': [1707], 'dual': [1708], 'chamber': [1709], 'instrument,': [1710], 'Inc.)': [1712], 'min.': [1715, 1846, 2699, 4472], 'When': [1716], 'aggregating': [1718], 'added': [1721, 1854, 2715, 2816], 'method,': [1729], 'large': [1734], 'aggregate': [1736], 'accompanied': [1738, 3684], 'clearing': [1741], 'plasma.': [1744], 'IC50': [1746, 4152], 'values': [1747, 3852], 'WHI-P131-mediated': [1749], 'inhibition': [1750], 'calculated': [1756], 'nonlinear': [1758], 'regression': [1759], 'GraphPAD': [1762], 'Prism': [1763], 'Version': [1764, 2401], '2.0': [1765], 'software.': [1766], 'impedance': [1768, 1775], 'studies,': [1770, 1790], 'increase': [1772], 'electrical': [1774], 'caused': [1776], 'adherence': [1778], 'on': [1783, 2045, 2147, 2367, 2376, 2898, 2946, 3289, 3813, 3915, 4195], 'an': [1784, 1834, 2395, 2757, 2994, 3138, 4150, 4483, 4554, 4846], 'electrode': [1785], 'measured.': [1787], 'For': [1788, 2297], 'extracted': [1793], 'knockout': [1796, 1869, 4120], 'control': [1798, 2483, 3863, 3977, 4256, 4522], 'eye': [1802], 'bleeds': [1803], 'tubes': [1805], '15%': [1807, 4490], '(v/v)': [1808], '0.8%': [1811], '(w/v)': [1812, 1816, 1821], 'citric': [1813], 'acid,': [1814], '2.2%': [1815], 'trisodium': [1817], 'citrate,': [1818], '2.45%': [1820], 'dextrose': [1822], 'mixed': [1824], 'gently': [1825], 'prevent': [1827], 'coagulation.': [1828], 'Citrated': [1829], 'equal': [1835], 'volume': [1836], 'prewarmed': [1840], 'agonist': [1849], 'unit/ml)': [1852, 2508, 2708, 2785, 3946], 'induce': [1859, 3348], 'Thrombin-induced': [1861, 3334], 'measured': [1865, 2623, 3408, 3850, 4042], '(n': [1871, 3865, 3876, 3888, 4361, 4372, 4384, 4397], '3': [1873, 1920, 2021, 2025, 2360, 3550, 3652], 'type)': [1876], 'whole': [1879], 'aggregometer.': [1882, 4249], 'isolated': [1885], '(13Asselin': [1891], 'Gibbins': [1893], 'Achison': [1895], 'Y.H.': [1898], 'Morton': [1899], 'L.F.': [1900], 'Farndale': [1901], 'R.W.': [1902], 'Barnes': [1903], 'M.J.': [1904, 2671, 2735, 4581], 'Blood.': [1907], '89:': [1909], '1235-1242Crossref': [1910], 'Scholar)': [1913, 2747, 3528, 4596], 'resuspended': [1915], 'concentration': [1918, 4201], '109': [1922], 'cells/ml': [1923], 'modified': [1925], "Tyrode's": [1926], '(137': [1928], '2.7': [1931], 'KCl,': [1933], '0.9': [1934], 'MgCl2,': [1936], '5.5': [1937], 'glucose,': [1939], '3.3': [1940], 'NaH2PO4,': [1942], '3.8': [1944], 'mmHepes': [1945], '7.4)).': [1947], 'incubated': [1950, 2689, 2768, 3929], 'indicated': [1953, 1996], '(PBS': [1959, 2973, 3094], 'supplemented': [1960, 2974, 3095], 'Me2SO)': [1963, 2502, 2977, 3098], '2': [1978, 2761, 3332, 3412, 3459], 'μg/ml': [1981, 2029, 2032], 'collagen': [1982, 2510], '0.1': [1984, 3309, 3369, 4356], 'unit/ml': [1985, 3310, 3370, 4037], 'thrombin.': [1986], 'Stimulation': [1987], 'stopped,': [1989], 'lysed': [1993], 'points': [1998], 'adding': [2000], 'ice-cold': [2001], '3×': [2002], 'Triton': [2003, 2014, 2518, 3535, 3559, 3577, 3589, 3627, 3645, 3675, 4701], 'X-100': [2004], '(150': [2007], '15': [2010], 'EGTA,': [2012], '3%': [2013, 2016, 2712, 2831], 'X-100,': [2015], 'sodium': [2017], 'deoxycholate,': [2018], '0.3%': [2019], 'SDS,': [2020], 'phenylmethylsulfonyl': [2023], 'fluoride,': [2024], 'Na3VO4,': [2027], '60': [2028, 2031, 2931, 3432, 3596, 3970, 4040], 'leupeptin,': [2030], 'aprotinin,': [2033], 'Tris-HCl': [2037], '7.4))': [2039], 'incubating': [2041], 'h': [2044, 2849, 3189], 'ice.': [2046], 'removal': [2048], 'membranous': [2051], 'fraction': [2052, 3537, 3579], 'centrifugation': [2054], '(12,000': [2055], 'g,': [2057], 'min),': [2059], 'subjected': [2063, 2364, 2385], 'immunoprecipitation': [2065], 'utilizing': [2066, 2573], 'antibodies': [2067, 2301, 2334, 2344, 2574], 'raised': [2068, 2575], '(E23,': [2073], 'Santa': [2074, 2077, 2348], 'Cruz': [2075, 2349, 2581], 'Biotechnology,': [2076], 'Cruz,': [2078], 'CA)': [2079], 'STAT3': [2081, 3296, 3330, 3340, 3379, 3423, 3672, 4688], '(Transduction': [2082], 'Laboratories,': [2083], 'Lexington,': [2084], 'KY)': [2085], '(14Vassilev': [2086], 'Ozer': [2088, 2193], 'Z.': [2089, 2194, 2669, 2733], 'Navara': [2090, 2195], '274:': [2100, 2205, 4868], '1646-1656Abstract': [2101, 2206], '(120)': [2109, 2214], 'E23': [2112], 'recognizes': [2113, 2128], 'α': [2116, 2131, 3317], '(p91)': [2117, 3319], 'β': [2119, 2134, 3326], '(p84)': [2120], 'isoforms': [2121, 2136], 'STAT1.': [2123], 'Similarly,': [2124, 2378, 3363], 'anti-STAT3': [2126], 'antibody': [2127], '(p92)': [2132], '(p83)': [2135, 3328], 'Immunoprecipitations,': [2139], 'immune': [2140], 'complex': [2141], 'protein': [2142, 2434, 2460, 2473, 2481], 'assays,': [2144], 'immunoblotting': [2146], 'polyvinylidene': [2148], 'difluoride': [2149], 'membranes': [2150], '(Millipore': [2151], 'Corp.,': [2152], 'Bedford,': [2153], 'MA)': [2154], 'ECL': [2157], 'chemiluminescence': [2158], 'detection': [2159, 2627, 3619, 4046], 'system': [2160], 'conducted': [2165], '14Vassilev': [2191], '15Uckun': [2217], 'Takata': [2225], 'Kurosaki': [2229], '1096-1100Crossref': [2234], '(166)': [2237], '16Uckun': [2240], '17Mahajan': [2274], 'Fargnoli': [2276], 'Kut': [2280], 'S.A.': [2281], 'Saouaf': [2282], 'Cell.': [2287], '15:': [2290], '5304-5311Crossref': [2291], '(134)': [2294], 'immunoblotting,': [2298], 'phosphotyrosine,': [2303], 'STAT1,': [2305, 2578, 3670], 'STAT3,': [2306, 2583], 'phospho-STAT1': [2307], '(recognizes': [2308, 2315], 'STAT1α': [2310], 'STAT1β),': [2312], 'phospho-STAT3': [2314], 'STAT3α': [2317], 'STAT3β)': [2319], '(New': [2320], 'England': [2321], 'Biolabs': [2322], 'Beverly,': [2324], 'MA).': [2325], 'Horseradish': [2326, 2340], 'peroxidase-conjugated': [2327, 2341], 'sheep': [2328, 2342], 'anti-mouse': [2329], 'donkey': [2331], 'anti-rabbit': [2332], 'secondary': [2333], 'Transduction': [2338], 'Laboratories.': [2339], 'anti-goat': [2343], 'Biotechnology.': [2350], 'electrophoresis,': [2352], 'gels': [2354], 'dried': [2356], 'onto': [2357], 'Whatman': [2358], 'No.': [2359], 'Filter': [2361], 'Paper': [2362], 'phosphorimaging': [2366], 'molecular': [2369, 2392, 4672], 'imager': [2370, 2393], '(Bio-Rad)': [2371], 'autoradiography': [2375], 'film.': [2377], 'all': [2379, 3192], 'chemiluminescent': [2380], 'Western': [2382, 2570, 3552, 3617], 'blots': [2383], 'three-dimensional': [2387], 'densitometric': [2388, 2437], 'imaging': [2396, 2655, 3695], 'densitometer': [2397], 'Analyst/Macintosh': [2400], '2.1': [2402], 'following': [2404, 2449], 'specifications': [2406], 'manufacturer': [2409], '(Bio-Rad).': [2410], 'index': [2415, 2452, 2465, 3454], 'determined': [2417, 2936, 3050], 'comparing': [2419], 'ratios': [2421], 'PhosphorImager': [2427], '(PIU)': [2429], 'density': [2431], 'bands': [2435], '(DSU)': [2440], 'those': [2442], 'sample': [2446, 2826], 'formulas:': [2450], '(PIU': [2454, 2467], 'band/DSU': [2457, 2470, 2478], 'band)test': [2461, 2474], 'sample;': [2462], 'stimulation': [2464, 3288, 3345, 3364, 3632, 3682, 3799, 3829], 'sample/(PIU': [2475], 'band)base-line': [2482], 'sample.': [2484], '(1': [2486], '108/ml)': [2488], '(100': [2493, 3394, 3725, 4282], 'μm,': [2494], '°C)': [2498], '(1%': [2501, 4230], 'μg/ml).': [2512], 'Isolation': [2513], 'cytoplasmic': [2516, 3557, 4641], 'X-100-soluble': [2519, 3560, 3590], '-insoluble': [2521, 3562], 'fractions': [2522, 3563], 'performed': [2524, 3019], '(18Hirao': [2528], 'Hamaguchi': [2530], 'I.': [2531], 'Suda': [2532], 'Yamaguchi': [2534], 'EMBO': [2536], '16:': [2539], '2342-2351Crossref': [2540], '(66)': [2543], '19Oda': [2546], 'Druker': [2548], 'B.J.': [2549], 'Smith': [2550], 'Salzman': [2552], 'E.W.': [2553], '1992;': [2557], '267:': [2558], '20075-20081Abstract': [2559], 'Fractions': [2566], 'blot': [2571, 3553, 3618], 'SYK': [2579, 3491, 3582, 3605, 3621, 4696], '(Santa': [2580], 'Biotechnology),': [2582], 'tubulin,': [2584, 3668], 'actin': [2586, 3482, 3543, 3574], '(Sigma).': [2587], 'prepared': [2591, 2722, 2791, 3268, 3952], '(20Quek': [2595], 'L.S.': [2596], 'Curr.': [2601], '8:': [2604], '1137-1140Abstract': [2605], 'Release': [2614], 'serotonin': [2616, 2626, 2646, 3838, 3851, 4030, 4045], 'unit/ml)-stimulated': [2620, 3703], 'kit': [2628, 4047], '(Immunotech,': [2629], 'Marseilles,': [2630], 'France)': [2631], "manufacturer's": [2635, 4051], 'specifications.': [2636], 'Sonicated': [2637], 'measurement': [2642], 'total': [2645], 'content': [2647], 'platelets.': [2649, 3922], 'HR-LVSEM': [2650, 2724, 3707], 'utilized': [2652], 'topographical': [2654], 'surface': [2659, 3698, 3760], 'membrane': [2660, 3699], 'reported': [2663], "(21D'Cruz": [2664, 2728], 'O.J.': [2665, 2729], 'Venkatachalam': [2666, 2730], 'T.K.': [2667, 2731], 'Zhu': [2668, 2732], 'Shih': [2670, 2734], 'Reprod.': [2675, 2739], '59:': [2677, 2741], '503-515Crossref': [2678, 2742], '(55)': [2681, 2745], 'Aliquots': [2684, 2763], 'alone': [2696, 2775, 3936], 'Treated': [2700], 's.': [2711, 2788, 3949], 'glutaraldehyde': [2713, 2814, 2832], 'stop': [2717, 2818], 'reaction.': [2719, 2820], 'Samples': [2720, 2789, 3950], 'Hitachi': [2752], 'S-900': [2753], 'SEM': [2754], 'instrument': [2755], 'accelerating': [2758], 'voltage': [2759], 'kV.': [2762, 2932], 'TEM': [2793, 3741, 3954, 3972, 3991, 4008, 4015], '(22White': [2797], 'Harker': [2799], 'L.A.': [2800], 'Zimmerman': [2801], 'T.S.': [2802], 'Methods': [2803], 'Hematology.': [2805], 'Churchhill-Livingston,': [2806], 'York1983:': [2809], '1-25Google': [2810], 'Briefly,': [2812], '0.1%': [2813], 'brief': [2823], 'centrifugation,': [2824], 'pellets': [2827], 'layered': [2829], '40': [2834, 4381], 'room': [2837, 2860], 'temperature.': [2838], 'post-fixed': [2843], 'OsO4': [2846], '4': [2851, 4575], '°C,': [2852], 'rinsed': [2853], 'times': [2855, 3048, 4341, 4352], 'distilled': [2857], 'water': [2858, 3044], 'temperature,': [2861], 'dehydrated': [2863], 'graded': [2866], 'series': [2868], '(25,': [2869], '50,': [2870], '75,': [2871], '90,': [2872], '95,': [2873], '100%)': [2875], '100%': [2877, 4425], 'propylene': [2878], 'oxide.': [2879], 'embedded': [2883, 3251], 'Embed': [2885], '812': [2886], '(Electron': [2887], 'Microscopy': [2888], 'Sciences,': [2889], 'Fort': [2890], 'Washington,': [2891], 'PA).': [2892], 'Silver': [2893], 'sections': [2894, 3266], 'picked': [2896], 'up': [2897], 'mesh': [2899], 'grids': [2900], 'stained': [2902, 3270], 'uranyl': [2908], 'acetate': [2909], '70%': [2911], "Reynold's": [2918], 'lead': [2919], 'citrate.': [2920], 'Sections': [2921, 3960], 'viewed': [2923, 3962], 'Jeol': [2926, 3965], '100×': [2927, 3966], 'microscope': [2929, 2948, 3968], 'True': [2933], 'magnifications': [2934], 'photographing': [2938], 'calibration': [2940], 'grid': [2941], 'magnification': [2944, 3710, 3744], 'step': [2945], 'scale': [2952], 'determine': [2954], 'final': [2955], 'print': [2956], 'enlargements.': [2957], 'Mice': [2958, 3008], 'intravenously': [2961, 3088], 'intraperitoneal': [2965], 'bolus': [2966, 2996, 3112, 3140], 'injection': [2967, 3055, 3141, 3183], '200': [2969, 2984, 3090, 3105], '10%': [2976, 3097, 3245], 'doses': [2980, 3101], 'prior': [2990, 3123], 'intravenous': [2995, 3139], 'same': [2999], 'dose': [3000, 4328], 'before': [3003, 3455], 'measurements.': [3007], 'placed': [3010, 3032], 'tube': [3013], 'holder,': [3014], '2-mm': [3022], 'cut': [3023], 'protruding': [3026], 'tip.': [3028], 'vertically': [3033], 'ml': [3036], 'bath,': [3045], 'post-intraperitoneal': [3054], '4–6-week-old': [3082], 'male': [3083], 'ICR': [3084], 'administered': [3109, 4325], 'two': [3111, 4207], 'injections': [3113], '(intraperitoneal': [3116], 'bolus)': [3117, 3122], '(intravenous': [3121], 'thromboplastin': [3126, 3135, 3182, 4442, 4463, 4532], 'challenge.': [3127], 'challenged': [3131, 4428], '25': [3133], 'mg/kg': [3134, 4370, 4382, 4395, 4527], '(Sigma)': [3136], 'vein': [3145], '(23Sato': [3149], 'Taniuchi': [3151], 'Kawasaki': [3153], 'Hirayama': [3155], 'F.': [3156], 'Koshio': [3157], 'Matsumoto': [3159], 'Iizumi': [3161], 'Jpn.': [3163], '78:': [3167], '191-197Crossref': [3168], '(30)': [3171], 'At': [3174], 'thromboembolism-related': [3178], 'death': [3179, 4496], 'after': [3180, 3434, 3475, 3598, 3680, 3797, 3827, 3843, 4440, 4461], 'elective': [3185], 'sacrifice': [3186], '48': [3188], 'ketamine/xylazine,': [3191], 'perfused': [3195], 'PBS,': [3197], 'followed': [3198], '4%': [3200], 'Formalin.': [3202], 'PBS': [3203], 'Formalin': [3205], 'pumped': [3207], 'left': [3210], 'ventricle': [3211], 'heart': [3214], 'allowed': [3216], 'exit': [3218], '3-mm': [3221], 'incision': [3222], 'anterior': [3225], 'wall': [3226], 'right': [3229], 'ventricle.': [3230], 'During': [3231], 'necropsy,': [3232], 'selected': [3234], '(brain,': [3236], 'liver,': [3238, 4798], 'lungs)': [3240], 'harvested,': [3242], 'fixed': [3243], 'neutral': [3246], 'buffered': [3247], 'Formalin,': [3248], 'dehydrated,': [3249], 'paraffin': [3253], 'routine': [3255], 'methods': [3256], 'histopathological': [3258], 'examination.': [3259], 'Glass': [3260], 'slides': [3261], 'affixed': [3263], '6-μm': [3264], 'hematoxylin': [3272], 'eosin': [3274], "Masson's": [3276], 'trichrome.': [3277], 'We': [3278, 4061], 'set': [3280], 'out': [3281], 'effects': [3285, 3812], 'status': [3292, 4546], 'proteins': [3297, 3354, 3380, 3642, 4689], 'isoform': [3318, 3327], '(Fig.2': [3322], 'A)': [3323], 'B).': [3333, 3723, 3784, 4160], 'JAK3-dependent': [3342], 'because': [3343], 'failed': [3346], 'STAT': [3353], '−/−).': [3362], 'enhanced': [3372], '(Fig.2,': [3381], 'C': [3382, 3733, 3805], 'D).': [3384, 3735], 'Pretreatment': [3385], 'μm)': [3395, 3726, 4761], '81%': [3406], 'autophosphorylation': [3410], 'E)': [3413], '(F': [3424], 'G).': [3426], 'It': [3427], 'noteworthy': [3429], 's': [3433, 3597, 4041], 'reduced': [3443, 3835], '41%': [3445], '(activity': [3446], 'index:': [3447], '0.35': [3448], '59%': [3450], 'stimulation)': [3457], 'E,': [3460, 4029], 'andsecond': [3462], 'lanes).': [3463], 'significance': [3465], 'observation': [3468, 4538], 'currently': [3470], 'Activation': [3472], 'exposure': [3476], 'associated': [3480, 3540], 'polymerization': [3483], 'rapid': [3485, 3747], 'translocation': [3486, 3636, 4694], '(24Sada': [3492], 'Minami': [3494], 'Yamamura': [3496, 3515], 'Biochem.': [3500], '248:': [3502], '827-833Crossref': [3503], '(24)': [3506], '25Tohyama': [3509], 'Yanagi': [3511], 'Sada': [3513], '269:': [3521], '32796-32799Abstract': [3522], 'tubulin': [3532, 3586, 3607, 3623, 4698], 'X-100-insoluble': [3536, 3578, 3628, 3646, 3676, 4702], 'filament': [3544], 'network.': [3545], 'As': [3546, 3648, 4091, 4565], 'Fig.': [3549, 3651, 4094], 'A,': [3551, 4199], 'unstimulated': [3565, 3976, 4012], 'abundant': [3571], 'amounts': [3572], '(but': [3591], '-insoluble)': [3593], 'fraction.': [3594, 3647, 4703], 'Within': [3595], 'significant': [3602], 'amount': [3603, 3836], 'translocated': [3608], 'membrane-associated': [3611], 'cytoskeleton': [3612], 'evidenced': [3614, 3831], 'actin-containing': [3626], 'fractions.': [3629, 3677], 'also': [3633, 4404, 4842], 'STAT1α/β,': [3639], 'STAT3β': [3641], 'B,': [3653, 3990], 'prevented': [3662], 'relocalization': [3665], 'marked': [3686], 'ultrastructural': [3692, 3917], 'organization.': [3693], 'Topographical': [3694], '40×': [3709], 'showed': [3711, 3745], 'development': [3712], 'pseudopodious': [3714], 'extensions': [3715], '4,': [3720, 3732], 'Examination': [3736], 'thrombin-stimulated': [3738, 3821, 3874, 3886, 3995, 4019], '40,000×': [3743], 'change': [3749], 'discoidal': [3751], 'cells': [3752], 'spheres': [3754], 'pseudopods': [3756, 3788], 'extending': [3757], 'coalescence': [3762, 4001], 'granules': [3764, 3793, 4003], 'canalicular': [3768], 'cisternae': [3769], 'center': [3772], 'prelude': [3778], 'degranulation': [3780, 3826, 3920], '5,A': [3782], 'contrast,': [3786], 'no': [3787], 'observed,': [3790], 'remained': [3794], 'uniformly': [3795], 'dispersed': [3796], '5,': [3804], 'andD).': [3806], 'activation-associated': [3814, 4693], 'granule': [3818], 'migration': [3819], 'secreted': [3839], 'challenge': [3845, 4443, 4533], 'E).': [3848], 'supernatants': [3855], '157': [3857], '±': [3858, 3869, 3881, 4355, 4365, 4489], '26': [3859], 'nm': [3860, 3871, 3883], 'vehicle-treated': [3862, 4359, 4458], '4),': [3867, 3878], '907': [3868], 'vehicle-treated,': [3873, 3994], '313': [3880], '19': [3882], 'WHI-P131-treated,': [3885, 4018], '4).': [3890], 'Taken': [3891], 'together,': [3892], 'results': [3894], 'unprecedented': [3896], 'plays': [3900], 'critical': [3902], 'during': [3904], 'earliest': [3906], 'events': [3907], 'activation.Figure': [3911], '5Effects': [3912], 'A–C,': [3923], 'aliquots': [3924], '"Experimental': [3958], 'Procedures."': [3959], 'kV.A,': [3971], 'images': [3973, 3992, 4009, 4016], 'untreated': [3975], '(CON)': [3978], 'typical': [3982], 'discoid': [3983, 4024], 'appearance': [3984, 4025], 'disperse': [3986], 'distribution': [3987], 'granules;': [3989], 'spike-like': [3998], 'pseudopodia': [3999], 'center;': [4006], 'platelets;': [4013, 4028], 'D,': [4014], 'largely': [4023], 'resting': [4027], 'specifications.View': [4052], 'Large': [4053, 4308], 'Image': [4054, 4309], 'Figure': [4055, 4310], 'ViewerDownload': [4056, 4311], 'Hi-res': [4057, 4312], 'image': [4058, 4313], 'Download': [4059, 4314], '(PPT)': [4060, 4315], 'next': [4062], 'sought': [4063], 'end,': [4076], 'compared': [4079], 'aggregatory': [4082, 4103], 'responses': [4083], '6,': [4095], 'magnitude': [4097], 'unit/ml)-induced': [4102, 4142], 'response': [4104], 'ofJak3': [4105], 'greater': [4112], 'than': [4113, 4475], '−/−platelets': [4117], 'results,': [4126, 4708], 'concentration-dependent': [4147], 'fashion,': [4148], 'average': [4151, 4349], 'value': [4153], '1.5': [4155, 4354], '(Fig.7,': [4157], 'By': [4161], 'comparison,': [4162], 'WHI-P258,': [4163, 4227], 'structurally': [4165], 'similar': [4166], 'compound': [4167, 4226], 'does': [4169], 'inhibit': [4171], 'affect': [4175], 'even': [4181], '7,': [4186], 'andC).Figure': [4188], '7Effects': [4189], 'composite': [4200], 'effect': [4202], 'curve': [4203], 'WHI-P131.': [4205], 'independent': [4208, 4619], 'experiments,': [4209], 'triplicate': [4210], 'WHI-P131,': [4223], 'Me2SO': [4231], 'saline)': [4234], 'unit/ml).': [4241, 4299], 'Results': [4250], 'are': [4251, 4667], 'expressed': [4252], 'percent': [4255], 'maximum': [4259], 'function': [4264], 'applied': [4267], 'concentration.B': [4269], 'representative': [4272], 'traces': [4273], 'curves': [4276], 'μm;': [4283], 'B),': [4286], '(shown': [4288], 'C),': [4290], 'aggregometer.View': [4307], 'toxic': [4319, 4506], 'monkeys': [4323], 'when': [4324], 'systemically': [4326], 'levels': [4329], 'ranging': [4330], 'mg/kg.': [4335], 'manner:': [4347], 'controls': [4360], '12),': [4363], '9.4': [4364], '0.6': [4366], '5;': [4374], 'p': [4375, 4387], '<': [4376, 4388, 4400], '0.001),': [4377, 4389], '>10': [4378, 4391], '10;': [4386], '80': [4394, 4526], '10;p': [4399], '0.001).': [4401], 'outcome': [4408, 4486], 'thromboembolism': [4419], '8).': [4421, 4492], 'model,': [4424], 'develop': [4430], 'dyspnea,': [4431], 'ataxia,': [4432], 'seizures': [4434], 'die': [4436], 'within': [4437], 'widespread': [4445], 'thrombosis': [4446], 'multiple': [4448], 'organs': [4449, 4514], 'massive': [4451], 'pulmonary': [4452], 'All': [4454, 4518], 'died': [4460], 'challenge,': [4464], 'median': [4467, 4478], 'more': [4474], 'doubled': [4476], 'produced': [4482], 'cause': [4494], 'WHI-P131-pretreated': [4498], 'thromboplastin-challenged': [4499], 'No': [4504], 'drug-related': [4505], 'lesions': [4507], 'detected': [4509], 'any': [4511, 4541], 'subsequent': [4531], 'survived': [4534], 'beyond': [4535], '48-h': [4537], 'period': [4539], 'impaired': [4544], 'health': [4545], 'bleeding.': [4548], 'summary,': [4550], 'findings': [4552], 'reveal': [4553], 'essential': [4555], 'protease,': [4568], 'activates': [4570, 4615], '(26Kahn': [4576], 'M.L.': [4577], 'Nakanishi-Matsui': [4578], 'Shapiro': [4580], 'Ishihara': [4582], 'Coughlin': [4584, 4625], 'S.R.': [4585, 4624, 4626], 'Invest.': [4588], '103:': [4590], 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