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'present': [40], 'work,': [41], 'a': [42, 57, 62, 138], 'G-quadruplex-based,': [43], 'fluorescent': [44, 112], 'has': [49], 'been': [50], 'developed': [51], 'with': [52], 'protoporphyrin': [53], 'IX': [54], '(PPIX)': [55], 'signal': [58], 'reporter.': [59], 'S1': [60, 88, 128, 179, 200], 'nuclease,': [61], 'single': [63], 'strand': [64], 'DNA': [65, 78, 93, 185], '(ssDNA)-specific': [66], 'endonuclease,': [67], 'employed': [69], 'model': [71], 'system.': [72], '"on"': [75], 'state,': [76], 'G-quadruplex': [77, 92, 184], 'can': [79, 120], 'greatly': [80], 'enhance': [81], 'fluorescence': [83], 'PPIX.': [85, 110], 'if': [87], 'nuclease': [89, 119, 180, 201], 'could': [90], 'cleave': [91], 'into': [94], 'small': [95], 'fragments,': [96], 'there': [97], 'would': [98], 'be': [99, 121], 'no': [100], 'formation': [101], 'G-quadruplexes,': [103], 'accompanied': [104], 'by': [105, 118], 'low': [106], 'emission': [107], 'response': [108], 'This': [111, 130], 'discrimination': [113], 'before': [114], 'or': [115, 156], 'after': [116], 'digestion': [117], 'used': [122, 194], 'to': [123, 173, 212], 'monitor': [124], 'nuclease.': [129], 'simple': [133], 'design': [135], 'offers': [137, 161], 'convenient': [139], 'protocol': [140], 'homogeneous,': [142], 'rapid': [143], 'high-throughput': [145], 'detection.': [146], 'addition,': [148], 'proposed': [150], 'strategy': [151], 'avoids': [152], 'complicated': [153], 'covalent': [154], 'modifications': [155], 'chemical': [157], 'labeling,': [158], 'thus': [160, 189], 'advantages': [162], 'simplicity': [164], 'cost': [166], 'efficiency.': [167], 'More': [168], 'importantly,': [169], 'K+': [170, 208], 'found': [172], 'well': [174], 'inhibit': [175], 'when': [181], 'using': [182], 'certain': [183], 'substrate,': [187], 'this': [190], 'system': [191], 'further': [193], 'turn-on': [196], 'detection': [197, 206], 'K+.': [199], 'critical': [203], 'since': [209], 'it': [210], 'helps': [211], 'reduce': [213], 'background': [215], 'signal.': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1989057809', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-08-21T15:21:52.847580', 'created_date': '2016-06-24'}