Publication Information

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[2, 223], 'of': [3, 21, 38, 84, 147, 152, 163, 173, 184, 202, 224, 242, 259, 305, 368, 373, 384, 394, 405, 423, 448, 463, 468, 514, 546, 588, 601, 611, 634, 695, 710, 719, 755, 865, 874, 1033, 1059, 1093, 1100, 1205, 1261, 1408, 1435, 1443, 1480, 1486, 1546, 1552, 1632, 1675, 1807, 1815, 1878, 2033, 2058, 2196, 2257, 2265, 2347, 2362, 2373, 2389, 2396, 2412, 2430, 2456, 2509, 2535, 2544, 2584, 2604, 2611, 2630, 2646, 2667, 2701, 2845, 2957, 2963, 2987, 3103, 3109, 3117, 3159, 3172, 3177, 3180, 3188, 3199, 3209, 3222, 3274, 3304, 3325, 3333, 3356, 3378, 3388, 3428, 3455, 3508, 3548, 3562, 3620, 3665, 3696, 3731, 3756, 3766, 3888, 3946, 3987, 4062, 4073, 4129], 'fibronectin-containing': [4, 225], 'extracellular': [5, 206, 226, 427, 449, 544, 699, 763, 1001, 1063, 1355, 2696, 3770, 3892], 'matrices': [6, 227, 450], 'are': [7, 11, 43, 49, 228, 232, 264, 270, 1096, 1208, 3346, 3973], 'dynamic': [8, 229], 'processes': [9, 230], 'that': [10, 92, 113, 120, 145, 192, 200, 231, 313, 334, 341, 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3083, 3136, 3541, 3630, 3693], 'exchange.': [58, 279], 'Several': [59, 280], 'proteins': [60, 281, 1101, 2034, 2205, 2350, 2364, 2385, 2669, 2739, 2920, 2958, 3276, 3988, 3999], 'involved': [61, 282, 1055, 1102, 3885], 'exchange': [64, 285, 1020, 1105], 'reactions': [65, 286, 3089, 3236], 'contain': [66, 287, 1186, 1236, 3579, 3594, 3599], 'sequence': [68, 289, 1188, 1830, 1877, 2736], 'Cys-X-X-Cys': [69, 89, 290, 310, 1189, 2707, 3147, 3601, 3686], 'their': [71, 292, 1191, 1264], 'active': [72, 135, 293, 356, 1192, 2545, 3288, 3294, 3736, 3744], 'sites,': [73, 294], 'including': [74, 295, 466, 1107], 'thioredoxin': [75, 296, 1111, 1377, 2518, 2846, 3126, 3204, 3244, 3290], 'protein-disulfide': [77, 116, 149, 160, 195, 298, 337, 370, 381, 416, 1108, 1248, 1317, 1338, 2513, 2898, 3201, 3239, 3296, 3310, 3336, 3432, 3465, 3518, 3662, 3758, 3881, 3901, 3953, 3964], 'isomerase.': [78, 299, 3311, 3748], 'The': [79, 300, 509, 583, 629, 1194, 1388, 1431, 1469, 1540, 1646, 1678, 1744, 1772, 1979, 2255, 2309, 2617, 2639, 3157, 3220, 3235, 3344, 3363, 3394, 3491, 3588, 3615], 'twelfth': [80, 301, 1201], 'type': [81, 128, 302, 349, 1023, 1202, 3582], 'I': [82, 129, 303, 350, 1024, 1203, 3583], 'module': [83, 130, 304, 351, 1204], '(I12)': [86, 307, 1207], 'contains': [87, 194, 308, 415, 1245, 1315, 1337, 1823, 2705, 3135, 3623, 3674, 3684], 'a': [88, 212, 309, 433, 445, 457, 460, 531, 702, 1018, 1211, 1237, 1316, 1403, 1729, 2038, 2166, 2193, 2207, 2318, 2427, 2627, 2699, 2706, 3101, 3112, 3170, 3353, 3488, 3711, 3729, 3773, 3924], 'motif,': [90, 311, 3148, 3602], 'suggesting': [91, 312, 996, 1232], 'may': [94, 208, 315, 429, 1235, 1345, 3915], 'intrinsic': [97, 318, 1247], 'ability': [98, 319, 1265, 2956, 3158, 3198, 3221], 'catalyze': [100, 321, 1346, 2960, 3162, 3206, 3225], 'bond': [102, 323, 1348], 'rearrangement.': [103, 324], 'Using': [104, 325, 1272], 'an': [105, 137, 326, 358, 538, 1246, 1273, 1762, 1963, 2829], 'established': [106, 327, 1274, 1905, 2830], 'protein': [107, 328, 1275, 2628, 2831], 'refolding': [108, 329, 1276, 2030, 2355, 2414, 2500, 2684, 2832, 2962, 3108, 3164, 3208, 3227, 3306, 3318, 3441, 3494, 3720], 'assay,': [109, 330, 2356], 'we': [110, 331, 1251, 1311, 2827], 'demonstrate': [111, 332], 'here': [112, 333], 'has': [115, 336, 1009, 1747, 1761, 2730, 2823, 2836], 'isomerase': [117, 150, 161, 177, 196, 214, 338, 371, 382, 398, 417, 435, 1109, 1239, 1249, 1339, 1371, 2514, 2743, 2825, 2843, 2899, 3120, 3240, 3297, 3337, 3466, 3519, 3542, 3663, 3694, 3759, 3882, 3902, 3926, 3954, 3965], 'activity': [118, 122, 151, 162, 178, 197, 215, 339, 343, 372, 383, 399, 418, 436, 1321, 1325, 1340, 2276, 2342, 2744, 2844, 3151, 3179, 3190, 3543, 3568, 3604, 3651, 3664, 3695, 3760, 3883, 3903, 3914, 3927, 3955, 3966, 4067, 4072], 'this': [121, 342, 1013, 1094, 1324, 1638, 3153, 3570, 3653, 3913], 'is': [123, 154, 188, 344, 375, 409, 444, 603, 701, 855, 870, 1003, 1326, 1331, 1640, 2380, 2689, 3285, 3667, 3677, 3761, 3772, 3884, 3918, 3956], 'localized': [124, 155, 345, 376, 1327, 3668, 3703, 3762], 'carboxyl-terminal': [127, 348, 3581, 4059], 'I12.': [131, 157, 352, 378, 1329, 3764], 'I12': [132, 353, 1712, 1805, 1833, 1959, 2006, 2710, 3676, 3707, 3727], 'was': [133, 354, 1400, 1437, 1654, 1705, 1713, 1777, 1797, 1837, 1884, 1960, 1981, 2007, 2035, 2106, 2141, 2162, 2201, 2260, 2315, 2343, 2424, 2504, 2547, 2566, 2579, 2622, 2641, 3165, 3320, 3359, 3366, 3373, 3443, 3496, 3708, 3734], 'as': [134, 141, 355, 362, 530, 1254, 1256, 1412, 1447, 1501, 1564, 1728, 2111, 2220, 2277, 2357, 2698, 2733, 2991, 2993, 3085, 3087, 3138, 3140, 3348, 3368, 3408, 3467, 3520, 3743, 3745], 'on': [136, 357, 716, 2165], 'equal': [138, 359], 'molar': [139, 360], 'basis': [140, 361], 'intact': [142, 363, 1444, 3740, 3979, 4074], 'fibronectin,': [143, 364, 3200, 3429, 3458, 3511, 3545, 3621], 'indicating': [144, 365], 'most': [146, 367, 3567, 3753], 'Moreover,': [158, 379], 'appears': [165, 386], 'be': [167, 209, 388, 430, 606, 940, 1666, 2692, 3701, 3897, 3906, 3916, 3929], 'partially': [168, 389, 3930, 3957], 'cryptic': [169, 390], 'since': [170, 391, 2393], 'limited': [171, 392, 1440, 3959], 'proteolysis': [172, 393, 3960], 'I10–I12': [174, 395, 3585], 'increased': [175, 396], 'its': [176, 397, 1351, 3900, 3963], 'dramatically': [180, 401], 'enhanced': [181, 402, 3106, 3939, 3991, 4065], 'rate': [183, 404, 2411, 3113], 'RNase': [185, 406, 2029, 2105, 2137, 2161, 2191, 2258, 2275, 2326, 2341, 2354, 2375, 2413, 2499, 2522, 2546, 2595, 2613, 2683, 2967, 2988, 3110, 3163, 3226, 3300, 3305, 3317, 3329, 3440, 3451, 3493, 3504, 3719], 'refolding.': [186, 407], 'This': [187, 408, 597, 936, 1330, 2728, 2834], 'first': [190, 411, 1333], 'demonstration': [191, 412, 1334], 'suggests': [199, 420, 1342], 'cross-linking': [201, 422, 1014, 1058, 1095, 3887], 'matrix': [207, 428, 545, 700, 726, 764, 864, 1002, 1064, 2697, 3771], 'catalyzed': [210, 431, 3237], 'by': [211, 432, 1005, 1017, 1439, 2113, 2262, 2359, 2549, 2674, 3238, 3307, 3911, 3940, 3967], 'contained': [216, 437, 2386], 'within': [217, 438, 3544, 3679], 'molecule.': [220, 441, 3980], 'Multimeric': [442], 'major': [446], 'constituent': [447], 'found': [451, 1312], 'throughout': [452], 'body': [454], 'plays': [456], 'role': [458], 'wide': [461], 'variety': [462], 'biological': [464], 'events,': [465], 'maintenance': [467], 'endothelial': [469], 'cell': [470, 475, 3949], 'integrity,': [471], 'platelet': [472], 'adhesion,': [473], 'migration': [476], 'blood': [478], 'vessel': [479], 'repair': [480], '(1Hynes': [481, 555, 614, 879], 'R.O.': [482, 556, 615, 880, 893, 924, 953, 984], 'Fibronectins.': [483, 557, 616, 881], 'Springer-Verlag': [484, 558, 617, 882], 'New': [485, 488, 519, 559, 562, 593, 618, 621, 639, 883, 886, 1132, 1937, 2765], 'York': [486, 560, 619, 884], 'Inc.,': [487, 499, 561, 573, 620, 675, 885, 1131, 1226, 2722, 2764, 3643], 'York1990Crossref': [489, 563, 622, 887], 'Google': [490, 564, 623, 664, 742, 783, 798, 815, 833, 851, 888, 904, 919, 934, 964, 979, 994, 1050, 1087, 1154, 1169, 1184, 1295, 1309, 1429, 1467, 1516, 1538, 1588, 1603, 1627, 1742, 1858, 1940, 2103, 2134, 2239, 2253, 2291, 2307, 2664, 2787, 2802, 2817, 2864, 2878, 2896, 2916, 2933, 2951, 2982, 3015, 3038, 3051, 3064, 3079, 3796, 3813, 3829, 3861, 3877, 4024, 4047, 4100, 4123, 4161], 'Scholar,': [491, 504, 565, 578, 624, 642, 665, 784, 799, 816, 834, 889, 905, 920, 965, 980, 1135, 1155, 1170, 1296, 1517, 1589, 1604, 1919, 2240, 2292, 2768, 2788, 2803, 2865, 2879, 2934, 3039, 3052, 3065, 3797, 3814, 3830, 3862, 4025, 4101], '2Colvin': [492, 566], 'R.B.': [493, 567, 1417, 1454], 'Mosher': [494, 568, 670, 731, 771, 908, 968, 1038, 1071, 1221, 1451, 1505, 1733, 2717, 3638, 3785, 3802, 3817, 3865, 4008, 4084], 'D.F.': [495, 569, 671, 732, 772, 909, 969, 1039, 1072, 1222, 1415, 1452, 1506, 1734, 2718, 3639, 3786, 3803, 3818, 3866, 4009, 4085], 'Fibronectin.': [496, 570, 672, 1223, 2719, 3640], 'Academic': [497, 571, 673, 1224, 2720, 3641], 'Press,': [498, 518, 572, 592, 638, 674, 1225, 1936, 2721, 3642], 'San': [500, 574, 676, 1227, 1893, 2723, 3644], 'Diego,': [501, 575, 677, 1228, 1894, 2724, 3645], 'CA1989:': [502, 576, 678, 1229, 2725, 3646], '213-254Google': [503, 577], '3Clark': [505, 579, 625], 'R.A.F.': [506, 508, 580, 582, 626, 628], 'Clark': [507, 581, 627], 'Molecular': [510, 584, 630], 'Cellular': [512, 586, 632], 'Biology': [513, 587, 633], 'Wound': [515, 589, 635], 'Repair.': [516, 590, 636], 'Plenum': [517, 591, 637, 1935], 'York1995:': [520, 594, 640], '3-50Google': [521, 595, 641], 'Scholar).': [522, 596, 743, 852, 935, 1051, 1088, 1430, 1468, 1539, 1628, 1743, 1941, 2104, 2135, 2254, 2308, 2665, 2727, 2818, 2983, 3080, 3878, 4048, 4124], 'Fibronectin': [523, 853, 2704], 'circulates': [524], 'at': [525, 1671, 1752, 1767, 2158, 2183, 2192, 2269, 2312, 2555, 2574, 2626, 2636, 3100, 3111, 3169, 3728], 'high': [526, 756, 875], 'concentrations': [527, 2523, 2583, 3324], 'plasma': [529], 'soluble': [532, 711, 3935], 'dimeric': [533], 'molecule': [534, 613, 1035, 3554, 3937], 'exists': [536], 'insoluble': [539, 598], 'multimeric': [540, 599, 937], 'form': [541, 600, 610, 873, 2997], 'loose': [547], 'connective': [548], 'tissue,': [549, 551], 'granulation': [550], 'basement': [553], 'membranes': [554], 'primary': [608], 'functional': [609], '4Darribere': [643], 'R.': [644, 1139, 2090, 2094, 2772], 'Koteliansky': [645, 769], 'V.': [646], 'Chernousov': [647], 'M.A.': [648, 766], 'Akiyama': [649], 'S.K.': [650], 'Yamada': [651], 'K.M.': [652, 836], 'Thiery': [653], 'J.P.': [654], 'Boucaut': [655], 'J.C.': [656], 'Dev.': [657], 'Dyn.': [658], '1993;': [659, 1736, 3822], '194:': [660], '63-70Crossref': [661], 'Scopus': [662, 740, 796, 813, 917, 932, 977, 992, 1085, 1167, 1182, 1293, 1307, 1427, 1514, 1586, 1601, 1625, 1740, 1856, 2101, 2132, 2237, 2251, 2289, 2305, 2662, 2800, 2815, 2862, 2876, 2931, 2949, 2980, 3013, 3036, 3049, 3062, 3077, 3794, 3811, 3859, 4045, 4121, 4159], '(34)': [663], '5Hedman': [666], 'D.': [667], 'Vaheri': [668], 'A.': [669, 786, 1288, 1612, 1851, 1929, 2127, 2232, 2857, 2885, 2905, 3008, 3031], '123-137Google': [679], 'Scholar),': [680, 995, 1185, 1231, 1310, 2897, 2917, 3648], 'mediating': [681], 'adhesive': [682], 'migratory': [684], 'events': [685], 'associated': [686], 'with': [687, 947, 1668, 1708, 1715, 1889, 1969, 1983, 1995, 2075, 2171, 2203, 2417, 2624, 2643, 3997, 4070], 'repair,': [689], 'neovascularization,': [690], 'embryonic': [692], 'development.': [693], 'Deposition': [694, 3765], 'into': [697, 761, 1353, 1660, 1799, 1886, 2009, 2013, 3768], 'cell-mediated,': [703], 'multistep': [704], 'process': [705, 2986, 3776], 'involves': [707], 'binding': [709, 746, 3945], 'specific': [714], 'sites': [715, 728], 'surface': [718], 'substrate-attached': [720], 'cells': [721, 866, 1888, 1944], 'termed': [725], 'assembly': [727], '(6McKeown-Longo': [729, 1503], 'P.J.': [730, 805, 822, 907, 967, 1037, 1504], 'J.': [733, 773, 789, 806, 820, 823, 841, 894, 910, 954, 970, 1040, 1073, 1144, 1457, 1507, 1528, 1574, 1594, 1732, 2300, 2655, 2777, 2881, 2886, 2901, 2906, 2975, 3055, 3787, 3819, 3847, 3867, 4005, 4015, 4018, 4081, 4091, 4094, 4150], 'Cell': [734, 790, 807, 911, 971, 1508, 3788, 4019, 4095], 'Biol.': [735, 774, 791, 808, 824, 842, 895, 912, 955, 972, 1041, 1074, 1145, 1458, 1509, 1529, 1575, 1596, 2778, 2887, 2907, 3057, 3789, 3805, 3820, 3848, 3868], '1985;': [736, 1510], '100:': [737, 1511], '364-374Crossref': [738, 1512], 'PubMed': [739, 782, 795, 812, 832, 850, 903, 916, 931, 963, 976, 991, 1049, 1084, 1153, 1166, 1181, 1292, 1306, 1426, 1466, 1513, 1537, 1585, 1600, 1624, 1739, 1855, 2100, 2131, 2236, 2250, 2288, 2304, 2786, 2799, 2814, 2861, 2875, 2895, 2915, 2930, 2948, 2979, 3012, 3035, 3048, 3061, 3076, 3793, 3810, 3828, 3858, 3876, 4044, 4120, 4158], '(247)': [741, 1515], 'Subsequent': [744], 'homophilic': [745], 'interactions': [747], 'between': [748, 2434], 'molecules': [750], 'lead': [751], 'molecular': [757, 876], 'mass,': [758], '(7Chernousov': [765], 'Fogerty': [767], 'F.J.': [768], 'V.E.': [770], 'Chem.': [775, 825, 843, 896, 956, 1042, 1075, 1146, 1459, 1530, 1576, 2657, 2779, 2888, 2908, 3821, 3849, 3869], '1991;': [776, 3045], '266:': [777], '10851-10858Abstract': [778], 'Full': [779, 829, 847, 900, 960, 1046, 1079, 1081, 1150, 1463, 1534, 1580, 1582, 2783, 2892, 2912, 3825, 3853, 3855, 3873, 4155], 'Text': [780, 830, 848, 901, 961, 1047, 1080, 1082, 1151, 1464, 1535, 1581, 1583, 2784, 2893, 2913, 3826, 3854, 3856, 3874, 4156], 'PDF': [781, 831, 849, 902, 962, 1048, 1083, 1152, 1465, 1536, 1584, 2785, 2894, 2914, 3827, 3857, 3875, 4157], '8Morla': [785], 'Ruoslahti': [787], 'E.': [788, 1523, 1610, 3019], '1992;': [792, 1147, 2780, 2889, 2909], '118:': [793, 2098], '421-429Crossref': [794], '(145)': [797], '9Hocking': [800], 'D.C.': [801, 818], 'Smith': [802, 1909], 'R.K.': [803], 'McKeown-Longo': [804, 821, 1489], '1996;': [809, 1076, 1163, 2796, 4021, 4097], '133:': [810], '431-444Crossref': [811], '(115)': [814], '10Hocking': [817], 'Sottile': [819, 4014, 4090], '1994;': [826, 844, 1597, 2945, 3790, 4152], '269:': [827, 845], '19183-19191Abstract': [828], '11Aguirre': [835], 'McCormick': [837], 'R.J.': [838], 'Schwarzbauer': [839], 'J.E.': [840], '27863-27868Abstract': [846], 'deposited': [856], 'tissues': [858], 'vivo': [860], 'cultured': [867], 'vitro': [869], 'mass': [877], '12Choi': [890], 'M.G.': [891, 951], 'Hynes': [892, 923, 952, 983], '1979;': [897, 957, 1531, 3058], '254:': [898, 958, 1532], '12050-12055Abstract': [899, 959], '13McKeown-Longo': [906, 966], '1983;': [913, 973, 1423], '97:': [914, 974], '466-472Crossref': [915, 975], '(200)': [918, 978], '14Ali': [921, 981], 'I.U.': [922, 982], 'Biochim.': [925, 985], 'Biophys.': [926, 986, 2942], 'Acta.': [927, 987], '1978;': [928, 988], '510:': [929, 989], '140-150Crossref': [930, 990], '(32)': [933, 993], 'can': [939, 3989], 'converted': [941], 'monomeric': [943], 'upon': [945, 3944], 'treatment': [946], 'disulfide-reducing': [948], 'agents': [949], '(12Choi': [950], 'stabilized': [1004, 2693], 'cross-linking.': [1007, 2703], 'It': [1008, 2379], 'postulated': [1011], 'event': [1015], 'occurs': [1016], 'mechanism': [1021, 3910], 'involving': [1022], 'II': [1026], 'modules': [1027, 3584], '70-kDa': [1030, 1476, 3591], 'amino': [1031], 'terminus': [1032, 1674], '(15McKeown-Longo': [1036], '1984;': [1043], '259:': [1044], '12210-12215Abstract': [1045], 'However,': [1052], 'regions': [1054], 'not': [1066, 2377, 2408, 2420, 3128, 3192, 3246, 3259, 3598], 'identified': [1068, 2437, 2732], '(16Chen': [1069], 'H.': [1070, 2064, 4031, 4107], '271:': [1077], '9084-9089Abstract': [1078], '(41)': [1086], 'In': [1089, 3922, 4125], 'addition,': [1090, 4126], 'A': [1098, 1629, 2138, 2563, 3130], 'number': [1099], 'reactions,': [1106], '(17Chivers': [1112, 2745], 'P.T.': [1113, 1172, 2746, 2805], 'Laboissiere': [1114, 2747], 'M.C.A.': [1115, 2748], 'Raines': [1116, 1175, 2749, 2808], 'R.T.': [1117, 1176, 2750, 2809], 'Guzman': [1118, 2751], 'N.A.': [1119, 2752], 'Prolyl': [1120, 2753], '4-Hydroxylase,': [1121, 2754], 'Protein-disulfide': [1122, 1370, 2755], 'isomerase,': [1123, 2756, 3202], 'Other': [1125, 2758], 'Structurally': [1126, 2759], 'Related': [1127, 2760], 'Proteins.': [1128, 2761], 'Marcel': [1129, 2762], 'Dekker,': [1130, 2763], 'York1996:': [1133, 2766], '487-505Google': [1134, 2767], '18Vuori': [1136, 2769], 'K.': [1137, 1218, 1220, 2714, 2716, 2770, 3635, 3637, 4037, 4113], 'Myllya': [1138, 2771], 'Pihlajaniemi': [1140, 2773], 'T.': [1141, 2774, 4033, 4039, 4109, 4115, 4169], 'Kivirikko': [1142, 2775], 'K.I.': [1143, 2776], '267:': [1148, 2781, 2890, 2910], '7211-7214Abstract': [1149, 2782], '19Walker': [1156, 2789], 'K.W.': [1157, 2790], 'Lyles': [1158, 2791], 'M.M.': [1159, 2792, 3041], 'Gilbert': [1160, 2793, 3042], 'H.F.': [1161, 2794, 3043], 'Biochemistry.': [1162, 1177, 1735, 2068, 2795, 2810, 3044, 3072, 4040, 4116], '35:': [1164, 2797], '1972-1980Crossref': [1165, 2798], '(142)': [1168, 2801], '20Chivers': [1171, 2804], 'Prehoda': [1173, 2806], 'K.E.': [1174, 2807], '1997;': [1178, 1577, 2811, 3807], '36:': [1179, 2812], '4061-4066Crossref': [1180, 2813], '(234)': [1183, 2816], 'sites.': [1193], 'fifth': [1195], 'sixth': [1197], 'cysteines': [1198], 'arranged': [1209], 'similar': [1212, 3114], 'sequence,': [1213], 'Cys-Asp-Asn-Cys': [1214], '(21Petersen': [1215, 2711, 3632], 'T.E.': [1216, 2712, 3054, 3633], 'Skorstengaard': [1217, 2713, 3634], 'Vibe-Pedersen': [1219, 2715, 3636], '1-24Google': [1230, 2726, 3647], 'activity.': [1240, 3560], 'To': [1241, 2492, 2819, 3194, 3538], 'determine': [1242, 2487, 2820, 3264, 3477, 3530, 3690], 'whether': [1243, 2821, 3691], 'activity,': [1250, 2826], 'assayed': [1252, 3558], 'well': [1255, 2992, 3086, 3139], 'proteolytic': [1257, 1433, 3546, 3985, 4127], 'recombinant': [1259, 1958, 3706], 'fragments': [1260, 1479, 1545, 1635, 3547, 3970, 3986, 4061, 4128], 'for': [1263, 1826, 2581, 2589, 2633, 3272, 3559], 'reactivate': [1267], 'reduced': [1268, 2107, 2401, 2964, 3210, 3326, 3414, 3448, 3501], 'denatured': [1270, 2109, 2190, 2966, 3212, 3328, 3416, 3450, 3503], 'RNase.': [1271, 2586], 'assay': [1277, 2320, 2501, 2835, 3154, 3319, 3399, 3442, 3495, 3571, 3654], '(22Pigiet': [1278, 2117, 2222, 2847, 2998], 'V.P.': [1279, 2092, 2118, 2223, 2848, 2999], 'Schuster': [1280, 2116, 2119, 2224, 2849, 3000], 'B.J.': [1281, 2120, 2225, 2850, 3001], 'Proc.': [1282, 1845, 2121, 2226, 2851, 3002, 3025], 'Natl.': [1283, 1846, 2122, 2227, 2852, 3003, 3026], 'Acad.': [1284, 1421, 1847, 2123, 2228, 2853, 3004, 3027], 'Sci.': [1285, 1422, 1848, 2124, 2229, 2854, 3005, 3028, 4020, 4096], 'U.': [1286, 1849, 2125, 2230, 2855, 3006, 3029], 'S.': [1287, 1571, 1842, 1850, 2126, 2231, 2856, 3007, 3030, 3842, 3846], '1986;': [1289, 1621, 2128, 2233, 2858, 3009], '83:': [1290, 2129, 2234, 2859, 3010], '7643-7647Crossref': [1291, 2130, 2235, 2860, 3011], '(123)': [1294, 2133, 2238, 2863, 3014], '23Boniface': [1297, 2241, 2866], 'J.J.': [1298, 2242, 2280, 2867, 2922], 'Reichert': [1299, 2243, 2281, 2868, 2923], 'Jr.,': [1300, 2244, 2282, 2869, 2924, 3023], 'L.E.': [1301, 2245, 2283, 2870, 2925], 'Science.': [1302, 2246, 2284, 2871, 2926], '1990;': [1303, 2247, 2285, 2872, 2927], '247:': [1304, 2248, 2286, 2873, 2928], '61-64Crossref': [1305, 2249, 2287, 2874, 2929], '(86)': [1308, 2252, 2290, 2877, 2932], 'isomerase-': [1318], 'thioredoxin-like': [1320], 'rearrangement': [1349], 'incorporation': [1352], 'matrix.': [1356], 'Gelatin-Sepharose,': [1357], 'Sephadex': [1358, 1362, 1965, 2167], 'G-25,': [1359], 'SP': [1361, 1964], 'C-25': [1363, 1966], 'were': [1364, 1380, 1391, 1482, 1499, 1548, 1562, 1694, 1866, 1902, 1945, 2177, 2436, 2447, 2462, 2484, 2539, 2599, 2670, 3218, 3261, 3402, 3474, 3527, 3557, 3572], 'obtained': [1365], 'from': [1366, 1382, 1393, 1402, 2525, 2601, 2608, 3375, 3385, 3975], 'Amersham': [1367], 'Pharmacia': [1368], 'Biotech.': [1369], '(107': [1372], 'kDa)': [1373, 1379], '(EC': [1374], '5.3.4.1)': [1375], '(11.7': [1378], 'purchased': [1381, 1392], 'Calbiochem-Novabiochem': [1383], 'Corp.': [1384], '(La': [1385], 'Jolla,': [1386], 'CA).': [1387, 2479], 'remaining': [1389], 'chemicals': [1390], 'Sigma': [1394], 'unless': [1395], 'otherwise': [1396], 'indicated.': [1397], 'Human': [1398], 'purified': [1401, 2164, 2349, 2363, 2384], 'fibrinogen-rich': [1406], 'by-product': [1407], 'factor': [1409], 'VIII': [1410], 'production': [1411], 'described': [1413, 1448, 1502, 1565, 2112, 2221, 2278, 2561, 3369, 3400, 3409, 3468, 3521], '(24Mosher': [1414], 'Johnson': [1416, 1453], 'Ann.': [1418], 'N.': [1419, 4173], 'Y.': [1420, 4035, 4111, 4136, 4146, 4171], '408:': [1424], '583-594Crossref': [1425], '(55)': [1428], '160/180-kDa': [1432], 'fragment': [1434, 2621, 3619, 3672, 3682, 3699, 4054], 'generated': [1438, 2567, 2596, 3396, 3709], 'trypsin': [1441], 'digestion': [1442], 'essentially': [1446, 2110], '(25Smith': [1449], 'D.E.': [1450, 2652], 'Furcht': [1455], 'L.T.': [1456], '1982;': [1460], '257:': [1461], '5831-5838Abstract': [1462], '40-kDa': [1470, 2620, 4052], '(cathepsin': [1471], 'trypsin)': [1473], 'gelatin-binding': [1474, 4053], '(cathepsin)': [1477], 'amino-terminal': [1478], 'generous': [1484, 1550], 'gifts': [1485, 1551], 'Drs.': [1487], 'Paula': [1488], 'Denise': [1491], 'Hocking': [1492], '(Albany': [1493], 'Medical': [1494], 'College,': [1495], 'Albany,': [1496], 'NY)': [1497], 'made': [1500], '26Balian': [1518], 'G.E.': [1519, 1910], 'Click': [1520], 'E.M.': [1521, 2294, 2969], 'Couch': [1522], 'Davidson': [1524], 'J.M.': [1525], 'Bornstein': [1526], 'P.': [1527, 1608, 1923], '1429-1432Abstract': [1533], '110-': [1541], '19-kDa': [1543, 3576, 3671, 3681, 3698], 'thermolysin': [1544], 'Dr.': [1553], 'Ken': [1554], 'Ingham': [1555, 1592], '(American': [1556], 'Red': [1557], 'Cross,': [1558], 'Bethesda,': [1559], 'MD)': [1560], 'prepared': [1563, 1903], '(27Ingham': [1566], 'K.C.': [1567, 1593], 'Brew': [1568], 'S.A.': [1569], 'Huff': [1570], 'Litvinovich': [1572], 'S.V.': [1573], '272:': [1578], '1718-1724Abstract': [1579], '(107)': [1587], '28Novokhatny': [1590], 'V.V.': [1591], 'Mol.': [1595, 3056, 3804], '238:': [1598], '833-844Crossref': [1599], '(15)': [1602], '29Borsi': [1605], 'L.': [1606, 1618, 4134], 'Castellani': [1607], 'Balza': [1609], 'Siri': [1611], 'Pellecchia': [1613], 'C.': [1614, 3832, 3836, 4138], 'DeScalzi': [1615], 'F.': [1616, 1840], 'Zardi': [1617], 'Anal.': [1619, 2095], 'Biochem.': [1620, 2096, 2299, 2941, 2974], '155:': [1622], '335-345Crossref': [1623], '(51)': [1626], 'schematic': [1630], 'diagram': [1631], 'various': [1633, 2204, 2270, 2531, 2582, 3323], 'used': [1636, 2043, 2351, 2485, 2828, 2839, 3262, 3475, 3528], 'study': [1639], 'shown': [1641, 3280, 3723, 3983], 'Fig.': [1643, 3725], '3': [1644, 3173, 3340, 3456, 3509], '(inset).': [1645], 'baculovirus': [1647, 1801, 3712], 'expression': [1648, 3713], 'vector': [1649, 1802], 'pVL1392': [1650, 1703, 1881], '(Invitrogen,': [1651], 'Carlsbad,': [1652], 'CA)': [1653, 1895], 'modified': [1655, 1880], 'so': [1656], 'genes': [1658], 'cloned': [1659], 'multiple': [1662, 2442], 'cloning': [1663], 'site': [1664, 1751, 1766, 1786, 1810], 'would': [1665, 3896, 3904, 3928], 'produced': [1667], 'six': [1669], 'histidines': [1670], 'carboxyl': [1673], 'protein.': [1677], 'complementary': [1679], 'oligonucleotides': [1680], '5′-AATTCTTCACCATCACCATCACCATTGATCAG-3′': [1681], '5′-GATCCTGATCAATGGTGATGGTGATGGTGAAG-3′': [1683], '(encoding': [1684], 'histidine': [1686], 'tag': [1687], 'containing': [1689, 1957, 2149, 2210], 'EcoRI': [1690, 1709, 1763, 1785, 1809], 'BamHI': [1692], 'overhangs)': [1693], 'hybridized': [1695], 'each': [1697, 3273], 'other': [1698, 2738, 2919], 'then': [1700, 1993, 2163, 2181, 3894], 'ligated': [1701], 'previously': [1706], 'digested': [1707, 2668], 'BamHI.': [1711], 'amplified': [1714], 'sense': [1717, 1745], 'primer': [1718, 1723, 1746, 1760, 1782], '5′-CCCAGATCTACTCTCCTCCCATCCACTCAAG-3′': [1719], 'antisense': [1722, 1759, 1781], '5′-CCCGAATTC': [1724], 'CAGCCCCAGGTCTGCGGCAG-3′': [1725], 'using': [1726, 1904, 1950, 2037, 2426, 2438, 2449, 2468, 2521, 3322, 3361, 3445, 3498, 3710], 'I12/GE-1': [1727], 'template': [1730], '(30Sottile': [1731], '32:': [1737], '1641-1647Crossref': [1738], '(25)': [1741], 'aBglII': [1748], 'restriction': [1749, 1764], 'enzyme': [1750, 1765], '5′-end': [1754, 1769], '(underlined': [1755, 1770], 'letters),': [1756], 'letters).': [1771], 'base': [1773], 'boldface': [1775], '(C)': [1776], 'added': [1778, 2374], 'following': [1783, 1896], 'maintain': [1788], 'correct': [1790], 'reading': [1791], 'frame.': [1792], 'Polymerase': [1793], 'chain': [1794, 1870], 'reaction-amplified': [1795], 'DNA': [1796, 1822, 1836, 1864, 1891], 'subcloned': [1798], 'pVL1392/His6.': [1803], 'Cloning': [1804], 'upstream': [1806], 'resulted': [1811], 'addition': [1814, 2395, 2645], 'Gly-Ile-Leu': [1816], 'before': [1817], 'six-histidine': [1819], 'tag.': [1820], 'Amplified': [1821], 'sequences': [1824], 'coding': [1825, 1834], 'signal': [1829], 'sequence.': [1835], 'sequenced': [1838], '(31Sanger': [1839], 'Nicklen': [1841], 'Coulson': [1843], 'S.R.': [1844], '1977;': [1852], '74:': [1853, 2302, 2977], '5463-5467Crossref': [1854], '(52674)': [1857], 'Scholar)': [1859, 2072, 2952, 4162], 'ensure': [1861], 'no': [1863, 3629], 'mutations': [1865], 'introduced': [1867], 'polymerase': [1869], 'reaction': [1871, 2208, 2267, 2537, 2640], 'amplification': [1872], 'verify': [1875], 'vector.': [1882], 'I12/pVL1392/His6': [1883], 'cotransfected': [1885], 'insect': [1887, 1943], 'Baculogold': [1890], '(Pharmingen,': [1892], "manufacturer's": [1898], 'instructions.': [1899], 'Recombinant': [1900], 'viruses': [1901], 'methods': [1906], '(32Summers': [1907], 'M.D.': [1908], 'Tex.': [1911], 'Agric.': [1912], 'Exp.': [1913], 'Stn.': [1914], 'Bull.': [1915], '1987;': [1916, 2069, 3870], '1555:': [1917], '1-55Google': [1918], '33Miller': [1920], 'D.W.': [1921], 'Safer': [1922], 'Miler': [1924], 'L.K.': [1925], 'Setlow': [1926], 'J.A.': [1927, 2936, 3844], 'Hollaender': [1928], 'Genetic': [1930], 'Engineering:': [1931], 'Principles': [1932], 'Methods.': [1934], 'York1986:': [1938], '277-298Crossref': [1939], 'SF21': [1942], 'grown': [1946], 'under': [1947, 3370, 3410, 3469, 3522], 'serum-free': [1948], 'conditions': [1949], 'SF900-II': [1951], '(Life': [1952], 'Technologies,': [1953], 'Inc.).': [1954], 'Conditioned': [1955], 'medium': [1956], 'applied': [1961], 'column': [1967, 1980, 2169], 'equilibrated': [1968, 2170], '60': [1970], 'mm': [1971, 1975, 1985, 1997, 2001, 2015, 2018, 2218, 2329, 2400, 2648], 'NaCl': [1972, 1986, 1998], '100': [1974, 1988, 2000], 'Tris,': [1976, 2002, 2155, 2213], 'pH': [1977, 1990, 2003, 2156, 2214, 2337], '6.2.': [1978, 2004], 'washed': [1982], '250': [1984], 'mmTris,': [1989], '6.2,': [1991], 'eluted': [1994], '350': [1996], 'Purified': [2005], 'dialyzed': [2008], 'phosphate-buffered': [2010], 'saline': [2011], '30': [2014, 3124, 3459, 3512], 'NaCl,': [2016], '1': [2017, 2217, 2634, 3118, 3746], 'EDTA,': [2019], '0.1': [2021, 2153, 2211, 2334], 'm': [2022, 2146, 2154, 2212, 2335, 2490, 3216, 3270, 3384], 'Tris': [2023], 'prior': [2024, 2678], 'use': [2026, 2680], 'assay.': [2031, 2685, 2833, 3721], 'Purity': [2032], 'assessed': [2036, 2358], 'discontinuous': [2039], 'Tricine': [2040], '1The': [2041], 'abbreviations': [2042], 'are:': [2044], 'Tricine,': [2045], 'N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine;': [2046], 'MOPS,': [2047, 2336], '3-(N-morpholino)propanesulfonic': [2048], 'acid': [2049], 'SDS-polyacrylamide': [2050], 'gel': [2051, 2676], 'electrophoresis': [2052, 2677], 'system': [2053, 3714], 'according': [2054], 'method': [2057], 'Schagger': [2059], 'von': [2061, 2065], 'Jagow': [2062, 2066], '(34Schagger': [2063], 'G.': [2067, 2883, 2903, 3838], '166:': [2070], '368-379Google': [2071], 'visualized': [2074], 'either': [2076], '0.025%': [2077], 'Serva': [2078], 'blue': [2079], 'G': [2080], '(Serva,': [2081], 'Paramus,': [2082], 'NJ)': [2083], 'silver': [2085], 'nitrate': [2086], '(35Wray': [2087], 'W.': [2088], 'Boulikas': [2089], 'Wray': [2091], 'Hancock': [2093], '1981;': [2097], '197-203Crossref': [2099], '(2501)': [2102], 'Pigiet': [2114], 'Briefly,': [2136], '(30': [2139, 2199, 2519], 'mg)': [2140], 'incubated': [2142, 2623], 'overnight': [2143], '6': [2145], 'guanidine': [2147], 'HCl': [2148], '0.15m': [2150], 'dithiothreitol': [2151, 2406], '8.6,': [2157], 'room': [2159], 'temperature.': [2160], 'G-25': [2168], '0.1%': [2172], 'acetic': [2173], 'acid.': [2174], 'Peak': [2175], 'samples': [2176], 'pooled,': [2178], 'nitrogen-sparged,': [2179], 'stored': [2182], '−80': [2184], '°C': [2185], 'until': [2186], 'use.': [2187], 'Reduced': [2188], 'final': [2194, 2319], 'concentration': [2195, 2458, 2614, 3102, 3171, 3730], '400': [2197], 'μg/ml': [2198], 'μm)': [2200, 2520], 'mixed': [2202], 'mixture': [2209, 2268, 2321, 2538], '7.4,': [2215], 'EDTA': [2219], 'extent': [2256], 'reactivation': [2259], 'determined': [2261, 2548], 'removing': [2263], 'aliquots': [2264, 2534], 'time': [2271, 2532, 2559, 2578], 'intervals': [2272], 'measuring': [2274, 2550], '(23Boniface': [2279, 2921], '36Crook': [2293], 'Mathias': [2295, 2970], 'A.P.': [2296, 2971, 4013, 4089], 'Rabin': [2297, 2972], 'B.R.': [2298, 2973], '1960;': [2301, 2976], '234-238Crossref': [2303, 2978], '(355)': [2306, 2981], 'absorbance': [2310, 2554, 2573], 'change': [2311, 2552, 2571], '284': [2313, 2556, 2575], 'nm': [2314, 2557, 2576], 'recorded': [2316, 2580], 'included': [2323], '1.4': [2324], 'μm': [2325, 2404, 3105, 3125, 3174, 3182, 3335, 3341, 3447, 3457, 3460, 3464, 3500, 3510, 3513, 3517, 3733, 3739], '0.44': [2328], 'cytidine': [2330, 2367], '2′:3′-cyclic': [2331, 2368], 'monophosphate': [2332, 2369], '7.0.': [2338], 'No': [2339], 'contaminating': [2340, 2390], 'detected': [2344], 'any': [2346], 'inability': [2361], 'hydrolyze': [2366], 'absence': [2372], '(data': [2376, 2419, 3127, 3191, 3245], 'shown).': [2378, 2421, 3129, 3193], 'also': [2381, 3248, 3905], 'unlikely': [2382], 'small': [2387], 'amounts': [2388], 'redox': [2391], 'reagents': [2392], '5': [2397], 'μmto': [2398], '2': [2399, 2647, 3184, 3256], '4–100': [2403], 'oxidized': [2405], 'did': [2407], 'accelerate': [2409], 'comparison': [2416], 'controls': [2418], 'Statistical': [2422], 'analysis': [2423, 2429, 3303], 'performed': [2425, 2448, 2505, 3321, 3444, 3497], 'one-way': [2428], 'variance.': [2431], 'Significant': [2432], 'differences': [2433], 'groups': [2435], 'Tukey': [2440], 'HSD': [2441], 'comparisonpost': [2443], 'hoc': [2444], 'test.': [2445], 'Statistics': [2446], 'Statistica': [2450], 'software': [2451], '(StatSoft,': [2452], 'Tulsa,': [2453], 'OK).': [2454], 'Plots': [2455], 'substrate': [2457], 'versus': [2459, 2615, 3350], 'initial': [2460, 3364], 'velocity': [2461, 3365], 'fit': [2463, 3355], 'Michaelis-Menten': [2466, 2591, 3230, 3251, 3406], 'equation': [2467, 3407], 'Enzfitter': [2470], 'program': [2471], '(Biosoft,': [2472], 'Ferguson,': [2473], 'MO)': [2474], 'DeltaGraph': [2476], '(Deltapoint,': [2477], 'Monterey,': [2478], 'Lineweaver-Burk': [2480, 3253, 3314, 3472, 3525], 'plots': [2481, 2592, 3254, 3473, 3526], 'thus': [2482], 'derived': [2483, 2607], 'Vmaxand': [2488], 'K': [2489, 2495, 3215, 3383, 3478, 3531], 'values.': [2491], 'determineVmax': [2493], 'm,': [2496, 3267, 3479, 3532], 'standard': [2498, 2564, 3439, 3492], '(described': [2502], 'above)': [2503], 'presence': [2508, 3332, 3454, 3507], '(3': [2511], 'μm),': [2512, 2516], '(1.5': [2515], 'ranging': [2524], '15': [2526], '75': [2528], 'μm.': [2529], 'At': [2530], 'intervals,': [2533], 'removed,': [2540], 'amount': [2543], 'over': [2558, 2577], '(as': [2560], 'above).': [2562], 'curve': [2565], 'which': [2569, 3134, 3578, 3593, 3622, 3912], 'native': [2585, 2594, 2612, 2994, 3095, 3934, 3998], 'Initial': [2587], 'velocities': [2588], '(μm': [2593], 'per': [2597], 'min)': [2598], 'calculated': [2600, 3360, 3367, 3374], 'slope': [2603], 'line': [2606], 'plot': [2610], 'time.': [2616], '19-': [2618], 'α-chymotrypsin': [2625], 'ratio': [2629], '1:200': [2631], '(w/w)': [2632], 'h': [2635], '37': [2637], '°C.': [2638], 'terminated': [2642], 'phenylmethylsulfonyl': [2649], 'fluoride': [2650], '(37Fahrney': [2651], 'Gold': [2653], 'A.M.': [2654, 4011, 4017, 4087, 4093], 'Am.': [2656], 'Soc.': [2658], '1963;': [2659], '85:': [2660], '997-1000Crossref': [2661], '(509)': [2663], 'Samples': [2666], 'removed': [2671], 'analyzed': [2673], 'Tricine/SDS-polyacrylamide': [2675], 'Soluble': [2686], 'protomeric': [2687], 'believed': [2690], 'result': [2700], 'motif': [2708, 2729], 'active-site': [2735], 'exhibit': [2741], 'widely': [2838], 'assess': [2841], '38Lundstrom': [2880], 'Krause': [2882, 2902], 'Holmgren': [2884, 2904, 4133], '9047-9052Abstract': [2891, 2911], '(38Lundstrom': [2900], '39Koedam': [2935], 'van': [2937], 'den': [2938], 'Brande': [2939], 'J.L.': [2940], 'Res.': [2943], 'Commun.': [2944], '198:': [2946], '1225-1231Crossref': [2947], '(9)': [2950], 'measures': [2954], '(36Crook': [2968], 'During': [2984], 'refolding,': [2989], 'non-native': [2990], 'bonds': [2996, 3137, 3631], 'Scholar,40Anfinsen': [3016], 'C.B.': [3017], 'Haber': [3018], 'Sela': [3020], 'M.': [3021, 3840, 4029, 4105, 4142], 'White': [3022], 'F.H.': [3024], '1961;': [3032], '47:': [3033], '1309-1314Crossref': [3034], '(892)': [3037], '41Lyles': [3040], '30:': [3046], '613-619Crossref': [3047], '(351)': [3050], '42Creighton': [3053], '129:': [3059], '411-431Crossref': [3060], '(148)': [3063], '43Hantgan': [3066], 'R.G.': [3067], 'Hammes': [3068], 'G.G.': [3069], 'Scheraga': [3070], 'H.A.': [3071], '1974;': [3073], '13:': [3074], '3421-3431Crossref': [3075], '(112)': [3078], 'Therefore,': [3081, 3688], 'both': [3082], 'oxidation': [3084], 'isomerization': [3088], 'must': [3090], 'occur': [3091], 'achieve': [3093], 'folded': [3096], 'state.': [3097], 'Intact': [3098, 3167], '4': [3104, 3181, 3732, 3738], 'μmprotein-disulfide': [3119, 3747], '(Fig.': [3121, 3155, 3232, 3241, 3255, 3555, 3586, 3613, 3655], '1)': [3122], 'control': [3131, 3610], 'protein,': [3132, 3611], 'ovalbumin,': [3133], 'free': [3141, 3625], 'sulfhydryl': [3142, 3626], 'residues,': [3143], 'but': [3144, 3596, 3628], 'lacks': [3145], 'showed': [3149], 'little': [3150, 3650], '1).': [3156], 'concentration-dependent.': [3166], 'had': [3175, 3186, 3603, 3649], '∼84%': [3176], 'fibronectin;': [3183], 'μmfibronectin': [3185], '∼74%': [3187], 'directly': [3195], 'compare': [3196], 'RNase,kcat': [3213], 'values': [3217, 3271], 'determined.': [3219], 'followed': [3228, 3249], 'typical': [3229, 3250], 'kinetics': [3231], '2B,': [3233], 'inset).': [3234], '2A,inset)': [3242], 'shown)': [3247, 3260], 'kinetics.': [3252], 'data': [3258, 3345, 3358, 3395, 3658, 3750], 'Vmax,K': [3266], 'kcat/K': [3269], 'these': [3275], '(Table': [3277], 'I).': [3278], 'As': [3279, 3722], 'Table': [3282], 'I,': [3283], '∼9-fold': [3286], 'more': [3287, 3735], 'than': [3289, 3295, 3608, 3737], '9-fold': [3292], 'less': [3293], 'catalyzing': [3299], 'refolding.Figure': [3301], '2Kinetic': [3302], 'For': [3312, 4049], 'plots,': [3315], '1.5': [3334, 3463, 3516], '(A)': [3338], '(B).': [3343], 'plotted': [3347], '1/v': [3349], '1/[S],': [3351], 'linear': [3354], 'DeltaGraph.': [3362], '“Experimental': [3371, 3411, 3470, 3523], 'Procedures.”Vmax': [3372], 'reciprocal': [3377, 3387], 'y': [3380], 'intercept,': [3381], 'x': [3390], 'intercept.': [3391], 'Insets,Michaelis-Menten': [3392], 'plots.': [3393], 'above': [3401], 'fitted': [3403], 'Procedures.”': [3412, 3471, 3524], 'rdRNase,': [3413], 'RNase.View': [3417], 'Large': [3418], 'Image': [3419], 'Figure': [3420], 'ViewerDownload': [3421], 'Hi-res': [3422], 'image': [3423], 'Download': [3424], '(PPT)Table': [3425], 'IEnzymatic': [3426], 'parameters': [3427], 'thioredoxin,': [3430, 3461, 3514], 'isomerasekcatK': [3433], 'mkcat/K': [3434], 'mμm': [3435], 'min−1/μmenzymeμmm−1': [3436], 'min−1Fibronectin0.001762.527.2Thioredoxin0.000266.52.9Protein-disulfide': [3437], 'isomerase0.006727.7241.9The': [3438], '15–75': [3446, 3499], 'Vmax,': [3480, 3533], 'kcat': [3482, 3535], '(Vmax/enzyme': [3483, 3536], 'concentration).': [3484, 3537], 'Open': [3485], 'table': [3486], 'new': [3489], 'tab': [3490], 'localize': [3539], 'encompassing': [3550], 'entire': [3552], '3,inset)': [3556], 'Fragments': [3561], 'demonstrated': [3565], '160/180-': [3574], 'fragments,': [3577, 3592], '3).': [3587, 3614, 3656], '40-': [3589], 'disulfides,': [3595], 'do': [3597], 'only': [3605], 'slightly': [3606], 'higher': [3607], 'ovalbumin': [3612], 'central': [3616], '110-kDa': [3617], 'cell-binding': [3618], 'one': [3624], 'residue,': [3627], 'These': [3657, 3749], 'indicate': [3659], 'I10–I12.': [3675], 'located': [3678], 'motif.': [3687], 'could': [3700], 'further': [3702], 'I12,': [3705], 'tested': [3716], '4,': [3726], 'suggest': [3751], 'all': [3755], "fibronectin's": [3757, 3880, 3952], 'highly': [3774], 'regulated': [3775, 3917], '(44Zhang': [3777], 'Q.': [3778, 3799], 'Checovich': [3779], 'W.J.': [3780], 'Peters': [3781], 'D.M.': [3782], 'Albrecht': [3783], 'R.M.': [3784], '127:': [3791], '1447-1459Crossref': [3792], '(95)': [3795], '45Zhang': [3798], 'Magnusson': [3800], 'M.K.': [3801], 'Cell.': [3806, 4151], '8:': [3808], '1415-1425Crossref': [3809], '(171)': [3812], '46Sommers': [3815], 'C.E.': [3816], '268:': [3823], '22277-22280Abstract': [3824], '47Wu': [3831], 'Keightley': [3833], 'S.Y.': [3834], 'Leung-Hagesteijn': [3835], 'Radeva': [3837], 'Coppolino': [3839], 'Goicoechea': [3841], 'McDonald': [3843], 'Dedhar': [3845], '1998;': [3850], '273:': [3851], '528-536Abstract': [3852], '(252)': [3860], '48Allen-Hoffmann': [3863], 'B.L.': [3864], '262:': [3871], '14361-14365Abstract': [3872], 'If': [3879, 3951], 'matrix,': [3893], 'it': [3895], 'expected': [3898], 'tightly': [3907], 'regulated.': [3908], 'One': [3909], 'conformation-induced': [3920], 'activation.': [3921], 'such': [3923], 'model,': [3925], 'masked': [3931], 'conformational': [3941], 'changes': [3942], 'induced': [3943], 'surfaces.': [3950], 'cryptic,': [3958], 'might': [3961], 'enhance': [3962], 'generating': [3968], 'smaller': [3969], 'whose': [3971], 'conformations': [3972], 'distinct': [3974], 'those': [3976], 'Others': [3981], 'novel': [3993], 'activities': [3994], 'when': [3995, 4068], 'compared': [3996, 4069], '(49Schor': [4000, 4076], 'S.L.': [4001, 4077], 'Ellis': [4002, 4078], 'I.': [4003, 4079], 'Banyard': [4004, 4080], 'Humphries': [4006, 4082], 'M.J.': [4007, 4083], 'Grey': [4010, 4086], 'Mould': [4012, 4088], 'Schor': [4016, 4092], '109:': [4022, 4098], '2581-2590PubMed': [4023, 4099], '50Fukai': [4026, 4102], 'G.F.': [4027, 4103], 'Ohataki': [4028, 4104], 'Yajima': [4030, 4106], 'Ishii': [4032, 4108], 'Nishizawa': [4034, 4110], 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