Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1988829843', 'doi': 'https://doi.org/10.1002/(sici)1097-0169(1999)43:3<232::aid-cm6>3.0.co;2-7', 'title': 'Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons', 'display_name': 'Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons', 'publication_year': 1999, 'publication_date': '1999-01-01', 'ids': {'openalex': 'https://openalex.org/W1988829843', 'doi': 'https://doi.org/10.1002/(sici)1097-0169(1999)43:3<232::aid-cm6>3.0.co;2-7', 'mag': '1988829843', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10401579'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-0169(1999)43:3<232::aid-cm6>3.0.co;2-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S67371178', 'display_name': 'Cell Motility and the Cytoskeleton', 'issn_l': '0886-1544', 'issn': ['0886-1544', '1097-0169'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013086594', 'display_name': 'Can-wen A. Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Can-wen A. Liu', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, Harvard University, Cambridge Massachusetts, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biology, Harvard University, Cambridge Massachusetts, USA.', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013812266', 'display_name': 'Gloria Lee', 'orcid': 'https://orcid.org/0000-0002-8633-1534'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gloria Lee', 'raw_affiliation_strings': ["Center for Neurologic Diseases Brigham and Women's Hospital, Harvard Medical School, Boston Massachusetts"], 'affiliations': [{'raw_affiliation_string': "Center for Neurologic Diseases Brigham and Women's Hospital, Harvard Medical School, Boston Massachusetts", 'institution_ids': ['https://openalex.org/I1283280774']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017883303', 'display_name': 'Daniel G. Jay', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel G. Jay', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts', 'Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111.', 'institution_ids': ['https://openalex.org/I121934306']}, {'raw_affiliation_string': 'Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts', 'institution_ids': ['https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.203, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 90, 'citation_normalized_percentile': {'value': 0.907312, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '43', 'issue': '3', 'first_page': '232', 'last_page': '242'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12061', 'display_name': 'Axon Guidance and Neuronal Signaling', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurite', 'display_name': 'Neurite', 'score': 0.9704559}, {'id': 'https://openalex.org/keywords/growth-cone', 'display_name': 'Growth cone', 'score': 0.92745626}, {'id': 'https://openalex.org/keywords/dorsal-root-ganglion', 'display_name': 'Dorsal root ganglion', 'score': 0.5621023}], 'concepts': [{'id': 'https://openalex.org/C113246987', 'wikidata': 'https://www.wikidata.org/wiki/Q1534415', 'display_name': 'Neurite', 'level': 3, 'score': 0.9704559}, {'id': 'https://openalex.org/C135903288', 'wikidata': 'https://www.wikidata.org/wiki/Q559423', 'display_name': 'Growth cone', 'level': 3, 'score': 0.92745626}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.80236006}, {'id': 'https://openalex.org/C58207958', 'wikidata': 'https://www.wikidata.org/wiki/Q33596', 'display_name': 'Motility', 'level': 2, 'score': 0.64926445}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.64785147}, {'id': 'https://openalex.org/C2779530196', 'wikidata': 'https://www.wikidata.org/wiki/Q178999', 'display_name': 'Axon', 'level': 2, 'score': 0.5840694}, {'id': 'https://openalex.org/C2776281502', 'wikidata': 'https://www.wikidata.org/wiki/Q1395415', 'display_name': 'Dorsal root ganglion', 'level': 3, 'score': 0.5621023}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.53735554}, {'id': 'https://openalex.org/C20418707', 'wikidata': 'https://www.wikidata.org/wiki/Q189933', 'display_name': 'Microtubule', 'level': 2, 'score': 0.46156612}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.43079126}, {'id': 'https://openalex.org/C94487597', 'wikidata': 'https://www.wikidata.org/wiki/Q11101', 'display_name': 'Sensory system', 'level': 2, 'score': 0.31500563}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.22662061}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11774796}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.098855376}], 'mesh': [{'descriptor_ui': 'D020439', 'descriptor_name': 'Growth Cones', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D016501', 'descriptor_name': 'Neurites', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009475', 'descriptor_name': 'Neurons, Afferent', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002452', 'descriptor_name': 'Cell Count', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D002452', 'descriptor_name': 'Cell Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048429', 'descriptor_name': 'Cell Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048429', 'descriptor_name': 'Cell Size', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005727', 'descriptor_name': 'Ganglia, Spinal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005727', 'descriptor_name': 'Ganglia, Spinal', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005727', 'descriptor_name': 'Ganglia, Spinal', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D020439', 'descriptor_name': 'Growth Cones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007834', 'descriptor_name': 'Lasers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008870', 'descriptor_name': 'Microtubules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008870', 'descriptor_name': 'Microtubules', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016501', 'descriptor_name': 'Neurites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016501', 'descriptor_name': 'Neurites', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D009475', 'descriptor_name': 'Neurons, Afferent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009475', 'descriptor_name': 'Neurons, Afferent', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-0169(1999)43:3<232::aid-cm6>3.0.co;2-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S67371178', 'display_name': 'Cell Motility and the Cytoskeleton', 'issn_l': '0886-1544', 'issn': ['0886-1544', '1097-0169'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10401579', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1490295223', 'https://openalex.org/W1515728609', 'https://openalex.org/W1663825042', 'https://openalex.org/W1925288097', 'https://openalex.org/W1965404941', 'https://openalex.org/W1966614543', 'https://openalex.org/W1971165215', 'https://openalex.org/W1973512372', 'https://openalex.org/W1974340985', 'https://openalex.org/W1976663562', 'https://openalex.org/W1987683665', 'https://openalex.org/W1989623765', 'https://openalex.org/W1991623867', 'https://openalex.org/W1994336523', 'https://openalex.org/W1995562130', 'https://openalex.org/W1995877869', 'https://openalex.org/W2000303735', 'https://openalex.org/W2003084435', 'https://openalex.org/W2015645618', 'https://openalex.org/W2026823930', 'https://openalex.org/W2027105301', 'https://openalex.org/W2028869988', 'https://openalex.org/W2035339007', 'https://openalex.org/W2036806199', 'https://openalex.org/W2039270622', 'https://openalex.org/W2051358675', 'https://openalex.org/W2057898633', 'https://openalex.org/W2064244929', 'https://openalex.org/W2072982648', 'https://openalex.org/W2088849282', 'https://openalex.org/W2093157615', 'https://openalex.org/W2102701929', 'https://openalex.org/W2113394908', 'https://openalex.org/W2122694225', 'https://openalex.org/W2126787718', 'https://openalex.org/W2127229268', 'https://openalex.org/W2127728252', 'https://openalex.org/W2128635872', 'https://openalex.org/W2131832714', 'https://openalex.org/W2144925005', 'https://openalex.org/W2157124870', 'https://openalex.org/W2157601680', 'https://openalex.org/W2170345361', 'https://openalex.org/W2182661714', 'https://openalex.org/W2188467511', 'https://openalex.org/W2189214793', 'https://openalex.org/W2345662142', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W4211170404', 'https://openalex.org/W2993335338', 'https://openalex.org/W2143653341', 'https://openalex.org/W2141562672', 'https://openalex.org/W2080491833', 'https://openalex.org/W2016400499', 'https://openalex.org/W1999779256', 'https://openalex.org/W1988829843', 'https://openalex.org/W1968181667', 'https://openalex.org/W1586509210'], 'abstract_inverted_index': {'The': [0], 'role': [1, 36, 43], 'of': [2, 44, 65, 82, 95, 112, 116], 'the': [3, 42, 60, 141, 145, 149, 174], 'microtubule-associated': [4], 'protein': [5], '(MAP)': [6], 'tau': [7, 18, 33, 45, 66, 83, 96, 113, 159, 167], 'in': [8, 37, 46, 67, 74, 97, 125, 140, 162, 170], 'axon': [9, 22], 'growth': [10, 51, 117, 175], 'remains': [11], 'controversial.': [12], 'Antisense': [13], 'experiments': [14], 'have': [15, 30, 55], 'suggested': [16, 31], 'that': [17, 32, 85, 158, 166], 'is': [19, 86, 160], 'required': [20, 161], 'for': [21], 'outgrowth,': [23], 'whereas': [24, 148], 'genetic': [25], 'knockout': [26], 'and': [27, 50, 104, 109, 165], 'immunodepletion': [28], 'studies': [29], 'plays': [34], 'no': [35], 'this': [38], 'process.': [39], 'To': [40], 'investigate': [41], 'both': [47], 'neurite': [48, 107, 126, 163], 'outgrowth': [49, 164], 'cone': [52, 176], 'motility,': [53], 'we': [54], 'used': [56], 'a': [57, 123, 136], 'different': [58], 'approach,': [59], 'chromophore-assisted': [61], 'laser': [62], 'inactivation': [63, 146], '(CALI)': [64], 'chick': [68], 'dorsal': [69], 'root': [70], 'ganglion': [71], '(DRG)': [72], 'neurons': [73, 100], 'culture.': [75], 'This': [76], 'approach': [77], 'generates': [78], 'an': [79], 'acute': [80], 'loss': [81], 'function': [84], 'not': [87, 153], 'subject': [88], 'to': [89], 'compensation': [90], 'by': [91, 129], 'other': [92], 'MAPs.': [93], 'Inactivation': [94, 111], 'whole': [98], 'DRG': [99], '(including': [101], 'cell': [102], 'body': [103], 'neurites)': [105], 'reduced': [106], 'number': [108], 'length.': [110], 'within': [114, 144], 'regions': [115], 'cones': [118], 'using': [119], 'micro-scale': [120], 'CALI': [121], 'caused': [122, 135], 'decrease': [124, 139], 'extension': [127], 'rate': [128], 'approximately': [130, 137], '2-fold.': [131], 'Surprisingly,': [132], 'it': [133], 'also': [134, 168], '20%': [138], 'lamellipodial': [142, 171], 'size': [143], 'region,': [147], 'filopodial': [150], 'motility': [151, 172], 'was': [152], 'affected.': [154], 'These': [155], 'results': [156], 'suggest': [157], 'functions': [169], 'at': [173], 'leading': [177], 'edge.': [178]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1988829843', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-11T14:24:36.230201', 'created_date': '2016-06-24'}