Title: α<sub>2</sub>‐Macroglobulin A Multifunctional Binding and Targeting Protein with Possible Roles in Immunity and Autoimmunitya
Abstract: Annals of the New York Academy of SciencesVolume 737, Issue 1 p. 267-272 α2-Macroglobulin A Multifunctional Binding and Targeting Protein with Possible Roles in Immunity and Autoimmunitya WOLFGANG BORTH, WOLFGANG BORTH Department of Medicine Division of Hematology Mount Sinai School of Medicine New York, New York 10029Search for more papers by this author WOLFGANG BORTH, WOLFGANG BORTH Department of Medicine Division of Hematology Mount Sinai School of Medicine New York, New York 10029Search for more papers by this author First published: September 1994 https://doi.org/10.1111/j.1749-6632.1994.tb44317.xCitations: 36 a This study was supported by a grant (No. 4162) from the Austrian Nationalbank. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Sottrup-jensen, L. 1987. α2-Macroglobulin and related thiol ester plasma proteins. In The Plasma Proteins. Volume 5. F. Putnam: 191– 291. Academic Press. New York . 2 Borth, W. 1992. α2-Macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J. 6: 3345– 3353. 3 Gonias, S. L. 1992. α2-Macroglobulin: a protein at the interface of fibrinolysis and cellular growth regulation. Exp. Hematol. 20: 302– 311. 4 Hubbard, W. J., A. D. Hess, S. Hsia & D B. Amos 1981. 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Immunol. 142: 629– 635. 9 Roche, P. A., M. R. Hoffman & S. V. Pizzo 1990. Effect of interferon-γ and human α2-macroglobulin on peritoneal macrophage morphology and Ia antigen expression. Biochim. Biophys. Acta 1051: 166– 174. 10 Chu, C. T. & S. V. Pizzo 1993. Receptor-mediated antigen delivery into macrophages: complexing antigen to α2-macroglobulin enhances presentation to T cells. J. Immunol. 150: 48– 58. 11 Borth, W. & M. Teodorescu 1986. Inactivation of human interleukin-2 (IL-2) by α2-macroglobulin-trypsin complexes. Immunology 57: 367– 371. 12 Jacquier, M. R., F. M. Gabert, C. L. Villiers & M. G. Colomb 1993. Disulfide linkage between C3b and tetanus toxin on tetanus-specific EBV-transformed B cells. J. Immunol. 150: 4253– 4260. 13 Borth, W., A. Dunky & K. Kleesiek 1986. α2-Macroglobulin-proteinase complexes as correlated with α1-proteinase-inhibitor-elastase complexes in synovial fluids of rheumatoid arthritis patients. Arthritis Rheum. 29: 319– 325. 14 Borth, W., A. Urbansky, R. Prohaska, M. Susani & T. A. Luger 1990. Binding of recombinant interleukin-1β to the third complement component and α2-macroglobulin after activation of serum by immune complexes. Blood 75: 2388– 2395. 15 Borth, W. & J. E. Menzel 1984. Association of C1q- and conglutinin-binding immune complexes with high consumption of alpha2-macroglobulin in synovial fluids of patients with rheumatoid arthritis. Int. Arch. Allergy Appl. Immunol. 75: 92– 96. 16 Kaye, J., S. Porcelli, J. Tite, B. Jones & C. A. Janeway, Jr. 1983. Both a monoclonal antibody and antisera specific for determinants unique to individual cloned T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J. Exp. Med. 158: 836– 856. 17 Harpel, P. C., V. T. Chang & W. Borth 1992. Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism. Proc. Natl. Acad. Sci. U.S.A. 89: 10193– 10197. 18 Mccaffrey, T. A., D. J. Falcone, D. Baoheng, S. Consigli, D. Vicente & W. Borth 1994. Protection of transforming growth factor-β1 activity by heparin and fucoidan. J. Cell. Physiol. 159: 51– 59. 19 Crookston, K. P., D. J. Webb, B. B. Wolf & S. L. Gonias 1994. Classification of α2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions. J. Biol. Chem. 269: 1533– 1540. Citing Literature Volume737, Issue1Biology of 2‐Macroglobulin, Its Receptor, and Related ProteinsSeptember 1994Pages 267-272 ReferencesRelatedInformation
Publication Year: 1994
Publication Date: 1994-09-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 46
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