Publication Information

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506, 560, 567, 613, 628, 677, 783, 785, 857, 988, 1107, 1319, 1361, 1387, 1424, 1470, 1563, 1724, 1956, 1964, 1972, 2087, 2183, 2213, 2234, 2239, 2284, 2300, 2355, 2400, 2457, 2498, 2542, 2547, 2584, 2597, 2627, 2666, 2674, 2689, 2710, 2714, 2846, 2869, 2882, 2902, 2910, 2976, 3039, 3047, 3065, 3077, 3133, 3168, 3237, 3308, 3335, 3367, 3417, 3514, 3619, 3656, 3687, 3702, 3721, 3731, 3779, 3803, 3816, 3888, 4032], 'wound': [33, 220, 563, 3283], 'healing': [34, 221], 'in': [35, 98, 162, 222, 285, 349, 499, 615, 1270, 1430, 1467, 1774, 1961, 2135, 2313, 2551, 2565, 2587, 2617, 2629, 2680, 2720, 2773, 2797, 2828, 2857, 3093, 3102, 3288, 3358, 3387, 3442, 3578, 3657, 3690, 3719, 3743, 3762, 3937, 3959, 3961], 'the': [36, 59, 65, 70, 73, 82, 122, 172, 223, 246, 252, 257, 260, 269, 309, 359, 481, 572, 658, 662, 673, 765, 774, 779, 786, 850, 855, 1008, 1021, 1108, 1182, 1262, 1378, 1556, 1681, 1761, 1834, 1951, 1962, 2041, 2046, 2111, 2310, 2314, 2358, 2375, 2391, 2395, 2403, 2458, 2580, 2592, 2611, 2630, 2650, 2655, 2695, 2778, 2789, 2885, 3008, 3022, 3063, 3068, 3097, 3128, 3143, 3177, 3282, 3322, 3351, 3364, 3388, 3396, 3399, 3402, 3414, 3448, 3520, 3537, 3587, 3634, 3640, 3695, 3706, 3722, 3800, 3840, 3860, 3863, 3885, 3927, 3953, 3969, 3984, 3994, 4017, 4052, 4059, 4066], 'adult,overexpression': [37, 224], 'leads': [38, 149, 225, 336, 2139, 2178, 3797], 'to': [39, 72, 150, 174, 179, 226, 259, 337, 361, 366, 490, 618, 621, 854, 864, 1015, 1184, 1311, 1316, 1464, 1641, 1701, 1715, 1771, 1872, 1878, 2039, 2043, 2071, 2081, 2121, 2140, 2152, 2179, 2216, 2274, 2384, 2788, 2973, 2978, 3018, 3034, 3082, 3202, 3205, 3210, 3304, 3363, 3510, 3534, 3550, 3584, 3638, 3664, 3735, 3771, 3858, 3867, 3879, 3983, 4007, 4039], 'excessive': [40, 227], 'deposition': [41, 228], 'matrix': [44, 231, 483], 'observedin': [45, 232], 'fibroproliferative': [47, 234], 'disorders.': [48, 235], 'We': [49, 78, 117, 236, 265, 304, 1143, 2029, 2168, 3572], 'previously': [50, 237, 2755, 2992, 3265, 3434, 3544, 3873], 'have': [51, 238, 1011, 2030, 3433, 3545, 3573, 3787, 3872], 'demonstrated': [52, 239, 1145, 3874], 'thatTGFβ-stimulated': [53, 240], 'induction': [55, 242, 1148, 2122, 3671, 3739, 3761, 3806, 3848], 'requires': [56, 243, 3883], 'activation': [57, 244, 1267, 1318, 1364, 2044, 2217, 4031], 'c-Jun': [60, 247, 411, 461, 1065], 'N-terminalkinase': [61, 248], '(JNK)': [62, 249], 'pathway;': [63, 250], 'however,': [64, 251, 4004], 'signaling': [66, 168, 253, 355, 500, 715, 1777, 3549, 3878], 'molecules': [67, 254], 'that': [68, 81, 109, 255, 268, 296, 502, 1146, 1272, 2032, 2113, 2127, 2171, 2194, 2578, 3410, 3436, 3508, 3691, 3693, 3754, 3766, 3789, 3804, 3949, 4026, 4033], 'link': [69, 256, 1697, 2040, 2208], 'TGFβreceptors': [71, 173, 258, 360, 2042], 'JNK': [74, 89, 181, 261, 276, 368, 1275, 1308, 1346, 2148, 2155, 2771, 2907, 3785, 3801, 3815, 3841, 3868, 3919, 3947, 3981, 4009, 4030, 4047], 'pathway': [75, 169, 262, 356, 1264, 1558, 3802], 'remain': [76, 263], 'unknown.': [77, 264], 'show': [79, 266, 1277], 'here': [80, 267, 2126], 'cytosolicadaptor': [83, 270], 'protein': [84, 128, 271, 315, 408, 458, 630, 727, 1685, 1709, 1954, 2813, 3138, 3711], 'disabled-2': [85, 272], '(Dab2)': [86, 273], 'directly': [87, 274, 1312, 1876, 2116, 2153, 3838, 4045], 'stimulates': [88, 121, 275, 308, 3980, 4046], 'activity,': [90, 277, 2119, 2156], 'whereasstable': [91, 278], 'small': [92, 279, 2129], 'interfering': [93, 280, 2130], 'RNA-mediated': [94, 281], 'ablation': [95, 282], 'Dab2': [97, 125, 175, 284, 312, 362, 1875, 2033, 2078, 2114, 2134, 2195, 2343, 2644, 3459, 3496, 3647, 3682, 3747, 3836, 3942, 4021, 4027, 4064], 'NIH3T3': [99, 286, 2136, 2583, 2659, 3099, 3334, 3618, 3652, 3736], 'mousefibroblasts': [100, 287], 'A10': [102, 289, 2561, 2585, 3621, 3724, 3744], 'rat': [103, 290, 3620], 'aortic': [104, 291, 3622], 'smooth': [105, 292, 3515, 3780], 'muscle': [106, 293, 3516, 3781], 'cells': [107, 294, 2562, 2577, 2586, 2660, 2794, 3100, 3170, 3287, 3307, 3337, 3400, 3409, 3624, 3653, 3663, 3745, 3796, 3914], 'demonstrates': [108, 295], 'itsexpression': [110, 297], 'is': [111, 160, 298, 347, 485, 556, 769, 1151, 1347, 1692, 1765, 2158, 2196, 3439, 3498, 3756, 3943, 4005, 4014], 'required': [112, 299, 851, 2197, 3499, 3757], 'TGFβ-mediated': [114, 301, 1147, 2147, 3501, 3688, 3759], 'induction.': [116, 154, 303, 341], 'demonstratethat': [118, 305], 'TGFβ': [119, 306, 416, 466, 663, 674, 698, 714, 1423, 2211, 2961, 3059, 3315, 3511, 3548, 3676, 3728, 3790, 3877], 'treatment': [120, 307, 3172], 'association': [123, 310, 1705], 'with': [126, 313, 849, 869, 1171, 1608, 1680, 2145, 2570, 2591, 2623, 2663, 2808, 2821, 2959, 2981, 3007, 3112, 3173, 3296, 3312, 3374, 3582, 3727, 3918, 3921], 'themitogen-activated': [127, 314, 726], 'kinase': [129, 130, 316, 317, 390, 440, 670, 728, 1374, 1381, 1382, 1384, 1390, 1394, 1417, 2829, 2860, 3963], 'kinase,': [131, 318, 1386], 'TAK1.': [132, 319, 1702], 'Attenuation': [133, 320], 'cellularTAK1': [135, 322], 'levels': [136, 323, 2642, 3697], 'by': [137, 324, 771, 776, 795, 861, 1349, 1422, 1559, 2160, 2346, 2388, 2427, 2532, 2646, 2699, 2825, 2884, 2904, 3041, 3096, 3156, 3293, 3327, 3350, 3423, 3629, 3811, 3952], 'transient': [138, 325, 2775], 'double-stranded': [139, 326, 3079, 3117], 'RNA': [140, 327, 2131, 3080, 3087, 3118, 3161, 3189], 'oligonucleotide': [141, 328], 'transfection': [142, 329, 2776], 'aswell': [143, 330], 'as': [144, 331, 725, 875, 1415, 2035, 2353, 2406, 2609, 2677, 2754, 2915, 2991, 3135, 3264, 3986, 4019], 'overexpression': [145, 332, 2177, 3812], 'kinase-deficient': [147, 334, 401, 451, 2163, 2461], 'TAK1': [148, 335, 1412, 1460, 2462, 3075, 3083, 3154], 'abrogation': [151, 338, 2172], 'ofTGFβ-stimulated': [152, 339], 'Furthermore,': [155, 342, 1259], 'cell': [156, 185, 343, 372, 492, 504, 2657, 3146, 3344, 3445, 3452, 3506, 3553, 3580], 'migration,': [157, 344], 'anotherJNK-dependent': [158, 345], 'response,': [159, 346], 'attenuated': [161, 348, 3742], 'NIH3T3-siDab2-expressing': [163, 350], 'clones.': [164, 351], 'We,therefore,': [165, 352], 'delineate': [166, 353], 'a': [167, 354, 486, 497, 1353, 1416, 1695, 1758, 1766, 1826, 2072, 2085, 2188, 2201, 2207, 2634, 2678, 2703, 3197, 3297, 3371, 3443, 3456, 3530, 3551, 3658, 3679, 3880, 3991], 'proceeding': [170, 357], 'from': [171, 358, 1176, 2237, 2243, 2250, 2277, 2288, 2297, 2306, 2539, 3021, 3085, 3142, 3164, 3447], 'TAK1,': [177, 364, 388, 438, 2166, 2214, 2460], 'leading': [178, 365, 1315, 2120, 2215], 'TGFβ-stimulated': [180, 367, 2083, 2142, 2181, 2199, 3431, 3437, 3805, 3846], 'activation,': [182, 369, 3869], 'FNexpression,': [183, 370], 'migration.': [186, 373], 'Fibronectin': [374], '(FN),': [375], '1The': [376], 'abbreviations': [377, 427], 'used': [378, 428, 2365, 3017], 'are:': [379, 429], 'FN,': [380, 430], 'fibronectin;': [381, 431], 'ECM,': [382, 432], 'matrix;TGF,': [384, 434], 'factor;': [387, 437], 'TGFβ-activated': [389, 439, 1393], '1;': [391, 441], 'TAB1,TAK1-binding': [392, 442], 'protein;': [393, 443], 'PTB,': [394, 444], 'phosphotyrosine': [395, 445], 'binding': [396, 446, 872, 1830], 'domain;': [397, 447], 'si-,': [398, 448], 'smallinterfering;': [399, 449], 'TAKKW,': [400, 450], 'form': [402, 452, 2164, 3589, 3645], 'TAK1;': [404, 454], 'Dab2,': [405, 455, 1968, 2204, 3523, 3541, 3973, 3997], 'Disabled-2;': [406, 456], 'MAPK,mitogen-activated': [407, 457], 'kinase;': [409, 413, 459, 463], 'JNK,': [410, 460, 1269], 'N-terminal': [412, 462, 1066, 3886], 'TβRI': [414, 464], 'andTβRII,': [415, 465], 'type': [417, 420, 467, 470, 675, 1682, 1725], 'I': [418, 468, 1683, 1726], 'II,': [421, 471], 'respectively;': [422, 472], 'HA,': [423, 473], 'hemagglutinin;GST,': [424, 474], 'glutathione': [425, 475], 'S-transferase.1The': [426], 'S-transferase.a': [476], 'widely': [477, 1767], 'expressed': [478, 1768, 4015], 'component': [479], '(ECM),': [484], 'dimericglycoprotein': [487], 'whose': [488, 1418], 'ability': [489, 620, 1183, 3954], 'promote': [491], 'adhesion': [493, 626], 'migration': [495, 614, 3345], 'plays': [496], 'keyrole': [498], 'events': [501], 'regulate': [503], 'differentiation(1Geiger': [507], 'B.': [508, 2430, 2438], 'Bershadsky': [509], 'A.': [510, 634, 937, 1069, 1236, 1508, 1527, 1618], 'Pankov': [511], 'R.': [512, 542, 731, 950, 967, 1075, 1205, 1238, 2410, 2412], 'Yamada': [513, 543], 'K.M.': [514, 544, 1027, 3220], 'Nat.': [515], 'Rev.': [516, 531, 577, 648], 'Mol.': [517, 902, 1492, 2487], 'Cell': [518, 2298, 2545, 2707], 'Biol.': [519, 973, 1029, 1050, 1079, 1128, 1211, 1244, 1298, 1330, 1494, 1539, 1589, 1856, 1932, 2489, 2942, 3228], '2001;': [520, 837, 1213, 1788, 1800, 1893, 1979, 2058, 2099, 2330, 3470, 3564, 3903], '2:': [521, 905, 1801, 1894, 1980], '793-805Crossref': [522], 'PubMed': [523, 536, 550, 582, 600, 641, 653, 693, 738, 758, 820, 840, 887, 912, 941, 955, 983, 1002, 1039, 1060, 1089, 1104, 1138, 1167, 1221, 1254, 1302, 1340, 1407, 1455, 1498, 1519, 1549, 1599, 1633, 1670, 1753, 1791, 1803, 1818, 1866, 1896, 1911, 1942, 1982, 2002, 2024, 2061, 2102, 2333, 2417, 2452, 2493, 2525, 2767, 2952, 3004, 3232, 3259, 3277, 3473, 3488, 3567, 3605, 3828, 3906], 'Scopus': [524, 537, 551, 583, 642, 654, 694, 739, 759, 821, 841, 888, 913, 942, 956, 984, 1003, 1040, 1061, 1090, 1139, 1222, 1255, 1303, 1341, 1408, 1456, 1499, 1520, 1550, 1600, 1634, 1671, 1754, 1792, 1804, 1819, 1867, 1897, 1912, 1943, 1983, 2003, 2025, 2062, 2103, 2334, 2418, 2453, 2494, 2526, 2953, 3233, 3260, 3474, 3568, 3606, 3907], '(1814)': [525], 'Google': [526, 539, 553, 585, 601, 644, 656, 696, 741, 761, 823, 843, 890, 915, 944, 958, 986, 1005, 1042, 1063, 1092, 1105, 1141, 1168, 1224, 1257, 1305, 1343, 1410, 1458, 1501, 1522, 1552, 1602, 1636, 1673, 1756, 1794, 1806, 1821, 1869, 1899, 1914, 1945, 1985, 2005, 2027, 2064, 2105, 2336, 2420, 2455, 2496, 2528, 2768, 2955, 3005, 3235, 3262, 3278, 3476, 3489, 3570, 3608, 3829, 3909], 'Scholar,': [527, 540, 1502, 1523], '2Hynes': [528], 'R.O.': [529, 575, 595], 'Annu.': [530, 576, 647], 'CellBiol.': [532, 578, 649], '1985;': [533, 579], '1:': [534, 580], '67-90Crossref': [535, 581], '(443)': [538, 584], '3Pankov': [541], 'J.Cell': [545], 'Sci.': [546, 749, 934], '2002;': [547, 1999, 2021, 2414], '115:': [548], '3861-3863Crossref': [549], '(1424)': [552], 'Scholar).Fibronectin': [554], 'embryogenesis': [559], 'angiogenesis': [561], 'andmodulates': [562], 'healing,': [564], 'host': [565], 'defense,': [566], 'maintenance': [568], 'tissue': [570], 'homeostasisin': [571], 'adult': [573], '(2Hynes': [574], 'Scholar,4George': [586], 'E.L.': [587], 'Georges-Labouesse': [588], 'E.N.': [589], 'Patel-King': [590], 'R.S.': [591], 'Rayburn': [592], 'H.': [593, 1112, 1122, 1438, 1485, 1531, 1537, 1581, 1612, 1662, 1745, 2480, 2517, 2934], 'Hynes': [594], 'Development.': [596], '1993;': [597], '119:': [598], '1079-1091Crossref': [599], 'Scholar).': [602, 697, 762, 844, 1142, 1169, 1258, 1411, 1459, 1603, 1674, 1822, 2028, 2065, 2106, 2337, 2421, 2769, 3490, 3571, 3609, 3830, 3910], 'transforminggrowth': [605], '(TGFβ)': [608], 'controls': [609], 'cellular': [610], 'growth,': [611], 'proliferation,adhesion,': [612], 'part': [616], 'due': [617], 'modulate': [622], 'ofcell': [624], 'surface': [625, 3404], 'receptors': [627, 2212], 'ECM': [629], 'expression,': [631], 'FN(5Leask': [633], 'Abraham': [635], 'D.J.': [636], 'FASEBJ.': [637], '2004;': [638, 750, 1541], '18:': [639, 1102, 1165, 1668, 1751, 2523, 2765, 3002, 3275, 3486, 3826], '816-827Crossref': [640], '(1944)': [643], 'Scholar,6Massague': [645], 'J.': [646, 683, 836, 963, 972, 1028, 1049, 1078, 1100, 1114, 1120, 1127, 1163, 1195, 1210, 1243, 1295, 1329, 1477, 1481, 1489, 1504, 1510, 1529, 1538, 1588, 1650, 1666, 1733, 1749, 1787, 1810, 1814, 1848, 1855, 1903, 1907, 1922, 1928, 1930, 1931, 2013, 2057, 2098, 2329, 2472, 2476, 2484, 2505, 2521, 2763, 2941, 3000, 3248, 3273, 3469, 3484, 3563, 3824, 3902], '1990;': [650], '6:': [651], '597-641Crossref': [652], '(2995)': [655], 'Scholar).TGFβ,': [657], 'founding': [659], 'member': [660, 1759], 'superfamily,': [664], 'mediates': [665], 'itseffects': [666], 'two': [668, 3504, 3763], 'Ser/Thr': [669], 'receptors,': [671], 'termed': [672], 'I(TβRI)': [676], 'II': [678, 2294], '(TβRII)': [679], 'receptors(7Shi': [680], 'Y.': [681, 946, 961, 1289, 1571, 1579, 1620, 2924, 2932], 'Massague': [682], 'Cell.': [684, 811, 903, 1398, 1493, 2445, 2488], '2003;': [685, 735, 1299, 1495, 1858, 2490], '113:': [686], '685-700Abstract': [687], 'Full': [688, 690, 753, 755, 815, 817, 907, 909, 978, 980, 1034, 1036, 1055, 1057, 1084, 1086, 1133, 1135, 1216, 1218, 1249, 1251, 1335, 1337, 1402, 1404, 1544, 1546, 1594, 1596, 1861, 1863, 1937, 1939, 2449, 2947, 2949, 3600, 3602], 'Text': [689, 691, 754, 756, 816, 818, 908, 910, 979, 981, 1035, 1037, 1056, 1058, 1085, 1087, 1134, 1136, 1217, 1219, 1250, 1252, 1336, 1338, 1403, 1405, 1545, 1547, 1595, 1597, 1862, 1864, 1938, 1940, 2450, 2948, 2950, 3601, 3603], 'PDF': [692, 757, 819, 911, 982, 1038, 1059, 1088, 1137, 1220, 1253, 1339, 1406, 1548, 1598, 1865, 1941, 2451, 2951, 3604], '(4737)': [695], 'ligand': [699], 'bindingto': [700], 'TβRII': [701], 'triggers': [702], 'recruitment': [703], 'TβRI,': [705], 'thereby': [706], 'forming': [707], 'an': [708, 2036, 3375, 3960], 'activereceptor': [709], 'complex.': [710], 'Further': [711], 'propagation': [712], 'can': [716, 793, 1368, 1554, 3767, 4028, 4036], 'then': [717], 'beinitiated': [718], 'Smad-dependent': [720, 2069], 'or': [721, 825, 866, 2175, 2605, 2637, 3052, 3313, 3390], 'Smad-independent': [722, 1155, 2088], 'pathways,': [723], 'such': [724, 874], '(MAPK)': [729], 'pathway(8Derynck': [730], 'Zhang': [732, 1843], 'Y.E.': [733], 'Nature.': [734, 883, 951, 1515], '425:': [736], '577-584Crossref': [737], '(4199)': [740], 'Scholar,9ten': [742], 'Dijke': [743], 'P.': [744, 1232], 'Hill': [745], 'C.S.': [746], 'Trends': [747], 'Biochem.': [748, 1813, 1906], '29:': [751], '265-273Abstract': [752], '(1039)': [760], 'Signaling': [763], 'Smadfamily': [766], 'proteins': [768], 'triggered': [770, 1348], 'phosphorylation': [772, 792, 1351, 1431, 1560], 'receptor-activatedSmads': [775], 'TβRI.': [777], 'In': [778, 2076], 'case': [780], 'Smad2': [782, 1279], 'Smad3': [784], 'TGFβ-': [787], 'andactivin-specific': [788], 'receptor-activated': [789], 'Smads,': [790], 'this': [791, 1704, 3575, 4034], 'befacilitated': [794], 'SARA': [796], '(Smad': [797], 'anchor': [798], 'receptor': [800, 1686, 1699, 1883], 'activation)(10Tsukazaki': [801], 'T.': [802, 969, 1285, 1291, 1446, 1473, 1565, 1575, 1852, 2436, 2440, 2468, 2918, 2928], 'Chiang': [803], 'T.A.': [804], 'Davison': [805], 'A.F.': [806], 'Attisano': [807, 900], 'L.': [808, 901, 1525, 1840, 3212, 3246], 'Wrana': [809, 898, 1239], 'J.L.': [810, 899, 1240], '1998;': [812, 904, 952, 999], '95:': [813], '779-791Abstract': [814], '(784)': [822], 'Scholar)': [824, 2529, 2956, 3236, 3263], 'Disabled-2': [826], '(Dab2)(11Hocevar': [827], 'B.A.': [828, 1094, 1157, 1779, 2049, 2090, 2321, 2757, 2994, 3267, 3461, 3478, 3555, 3818, 3894], 'Smine': [829, 1780, 2050, 2091, 2322, 3462, 3556, 3895], 'A': [830, 1781, 2051, 2092, 2323, 3463, 3557, 3896, 3933], 'Xu': [831, 1782, 2052, 2093, 2324, 3464, 3558, 3897], 'X.-X.': [832, 1783, 2053, 2094, 2325, 3465, 3559, 3898], 'Howe': [833, 1097, 1160, 1784, 2054, 2095, 2326, 2760, 2997, 3270, 3466, 3481, 3560, 3593, 3821, 3899], 'P.H.': [834, 1098, 1161, 1785, 2055, 2096, 2327, 2761, 2998, 3271, 3467, 3482, 3561, 3594, 3822, 3900], 'EMBO': [835, 1099, 1162, 1665, 1748, 1786, 2056, 2097, 2328, 2520, 2762, 2999, 3272, 3468, 3483, 3562, 3823, 3901], '20:': [838, 1789, 2059, 2100, 2331, 3471, 3565, 3904], '2789-2801Crossref': [839, 1790, 2060, 2101, 2332, 3472, 3566, 3905], '(200)': [842, 1793, 2063, 2104, 2335, 3475, 3569, 3908], 'After': [845, 2791, 3123, 3395], 'phosphorylation,receptor-activated': [846], 'Smads': [847], 'dimerize': [848], 'co-Smad,': [852], 'Smad4,translocate': [853], 'nucleus,': [856], 'activate': [858, 1555, 3839], 'gene': [859, 1763], 'transcription': [860], 'either': [862], 'directlybinding': [863], 'DNA': [865, 871, 3253], 'cooperation': [868], 'other': [870], 'transcriptionfactors': [873], 'FAST-1': [876], '(12Chen': [877], 'X.': [878, 924, 990, 992], 'Rubock': [879], 'M.J.': [880, 1991], 'Whitman': [881], 'M.': [882, 1118, 1201, 1281, 1293, 1322, 1324, 1483, 1535, 1587, 1652, 1735, 1838, 1916, 1918, 2432, 2442, 2478, 2507, 2940], '1996;': [884, 1052, 1591, 1630, 2944], '383:': [885], '691-696Crossref': [886], '(625)': [889], 'Scholar),FAST-2': [891], '(13Labbe': [892], 'E.': [893, 1073, 1126, 1191, 1448, 1585, 1626, 1660, 1743, 2515, 2938], 'Silvestri': [894], 'C.': [895, 926, 1077, 1203, 1226, 1230, 3592], 'Hoodless': [896, 1233], 'P.A.': [897, 1234, 1989], '109-120Abstract': [906], '(460)': [914], 'Scholar),': [916, 959, 987, 1064, 1106, 1306, 1637, 1870, 1946, 2456, 2497, 3006], 'c-Jun(14Liberati': [917], 'N.T.': [918], 'Datto': [919], 'M.B.': [920], 'Frederick': [921], 'J.P.': [922, 2017], 'Shen': [923], 'Wong': [925], 'Rougier-Chapman': [927], 'E.M.': [928], 'Wang': [929], 'X-F.': [930], 'Proc.': [931], 'Natl.': [932], 'Acad.': [933], 'U.': [935], 'S.': [936, 965, 971, 1071, 1228, 1475, 1648, 1731, 2470, 2503, 3214, 3218, 3242], '1999;': [938, 975, 1101, 1130, 1164, 1332, 1516, 1667, 1750, 2522, 2764, 3001, 3274, 3485, 3825], '96:': [939], '4844-4849Crossref': [940], '(271)': [943], 'Scholar,15Zhang': [945], 'Feng': [947], 'X-H.': [948], 'Derynck': [949], '394:': [953], '909-913Crossref': [954], '(679)': [957], 'ATF-2(16Sano': [960], 'Harada': [962], 'Tashiro': [964], 'Gotoh-Mandeville': [966], 'Maekawa': [968], 'Ishii': [970], 'Chem.': [974, 1030, 1051, 1080, 1129, 1212, 1245, 1331, 1540, 1590, 1857, 1933, 2943, 3596], '274:': [976, 1131, 1333], '8949-8957Abstract': [977], '(314)': [985], 'TFE3(17Hua': [989], 'Liu': [991], 'Ansari': [993], 'D.O.': [994], 'Lodish': [995], 'H.F.': [996], 'Genes': [997], 'Dev.': [998], '12:': [1000], '3084-3095Crossref': [1001], '(257)': [1004], 'Scholar).Members': [1006], 'MAPK': [1009, 1358, 1373], 'family': [1010, 1824, 1884], 'also': [1012, 1639, 2169, 3704, 3717], 'been': [1013, 1677, 2318], 'shown': [1014, 1463, 1678, 1770, 2151, 3435, 3546, 3628, 3936], 'be': [1016, 1369, 1465, 1772, 3768, 3809, 4037], 'activated': [1017], 'afterTGFβ': [1018, 1188, 3774], 'stimulation,': [1019, 3512], 'signal-regulated': [1023, 1380], 'kinase(18Hartsough': [1024], 'M.T.': [1025], 'Mulder': [1026], '1995;': [1031, 1452], '270:': [1032, 1453], '7117-7124Abstract': [1033], '(273)': [1041, 1091], 'Scholar,19Mucsi': [1043], 'I.': [1044, 1442], 'Skorecki': [1045], 'K.L.': [1046], 'Goldberg': [1047], 'H.J.': [1048], '271:': [1053, 1592, 2945], '16567-16572Abstract': [1054], '(169)': [1062], 'kinase(JNK)': [1067], '(20Atfi': [1068], 'Djelloul': [1070], 'Chastre': [1072], 'Davis': [1074, 2443], 'Gespach': [1076], '1997;': [1081, 3229], '272:': [1082, 1631], '1429-1432Abstract': [1083], 'Scholar,21Hocevar': [1093, 3477], 'Brown': [1095, 1158, 2758, 2995, 3223, 3268, 3479, 3819], 'T.L.': [1096, 1159, 2759, 2996, 3269, 3480, 3820], '1345-1356Crossref': [1103, 1166, 2766, 3003, 3276, 3487, 3827], 'p38': [1109, 1557], 'kinasepathways': [1110], '(22Hanafusa': [1111], 'Ninomiya-Tsuji': [1113, 1488, 1649, 1732, 2483, 2504], 'Masuyama': [1115], 'N.': [1116, 1444, 1479, 1567, 1622, 1658, 1741, 2474, 2513, 2920], 'Nishita': [1117, 1651, 1734, 2506], 'Fujisawa': [1119], 'Shibuya': [1121, 1437, 1484, 1580, 1661, 1744, 2479, 2516, 2933], 'Matsumoto': [1123, 1449, 1490, 1513, 1582, 1627, 1663, 1746, 2485, 2518, 2935], 'K.': [1124, 1283, 1287, 1434, 1436, 1440, 1450, 1491, 1506, 1514, 1569, 1573, 1577, 1583, 1614, 1616, 1624, 1628, 1646, 1654, 1656, 1664, 1729, 1737, 1739, 1747, 2486, 2501, 2509, 2511, 2519, 2922, 2926, 2930, 2936], 'Nishida': [1125, 1447, 1584, 1625, 1659, 1742, 2514, 2937], '27161-27167Abstract': [1132], '(378)': [1140], 'previouslyhave': [1144], 'mediated': [1152, 1370, 1959], 'througha': [1153], 'JNK-dependent,': [1154], 'pathway(21Hocevar': [1156], 'Consistent': [1170], 'thisobservation,': [1172], 'mouse': [1173, 2137, 2256, 2261, 2282, 2385, 3616], 'fibroblasts': [1174, 2138], 'derived': [1175], 'Smad2-,': [1177], 'Smad3-,': [1178], 'andSmad4-deficient': [1179], 'embryos': [1180], 'retain': [1181], 'induce': [1185], 'synthesis': [1187, 3139, 3674], 'stimulation': [1189, 2958, 3677, 3726, 3791], '(23Piek': [1190], 'Ju': [1192], 'W.J.': [1193], 'Heyer': [1194], 'Escalante-Alcalde': [1196], 'D.': [1197, 2799], 'Stewart': [1198], 'C.L.': [1199, 3222], 'Weinstein': [1200], 'Deng': [1202, 2439], 'Kucherlapati': [1204], 'Bottinger': [1206], 'E.P.': [1207], 'Roberts': [1208, 2010], 'A.B.': [1209], '276:': [1214], '19945-19953Abstract': [1215], '(355)': [1223], 'Scholar,24Sirard': [1225], 'Kim': [1227], 'Mirtsos': [1229], 'Tadich': [1231], 'Itié': [1235], 'Maxson': [1237], 'Mak': [1241], 'T.W.': [1242], '2000;': [1246, 1399, 1815, 1908, 1934], '275:': [1247, 1935], '2063-2070Abstract': [1248], '(150)': [1256], 'efficientactivation': [1260], 'Smad': [1263, 2047], 'may': [1265, 1706], 'require': [1266], 'thatfibroblasts': [1271], 'express': [1273, 3694, 3772], 'antisense': [1274], 'oligonucleotides': [1276], 'decreasedTGFβ-stimulated': [1278], 'phosphorylation(25Utsugi': [1280], 'Dobashi': [1282], 'Ishizuka': [1284], 'Masubuchi': [1286], 'Shimizu': [1288], 'Nakazawa': [1290], 'Mori': [1292], 'Am.': [1294], 'Respir.': [1296], 'CellMol.': [1297], '28:': [1300], '754-761Crossref': [1301], '(77)': [1304], 'whereas': [1307, 1363, 1947, 3145], 'has': [1309, 1461, 1676, 2317], 'beenshown': [1310], 'phosphorylate': [1313, 3957], 'Smad3,': [1314], 'nuclearaccumulation': [1320], '(26Engel': [1321], 'McDonnell': [1323], 'Law': [1325], 'B.K.': [1326], 'Moses': [1327], 'H.L.': [1328], '37413-37420Abstract': [1334], '(432)': [1342], 'Scholar).Activation': [1344], 'dual': [1350], 'TPY': [1354], 'motif': [1355], 'bythe': [1356], 'upstream': [1357], 'kinases': [1359, 1375], 'MKK7': [1360], 'MKK4,': [1362], 'these': [1366, 3669], 'MAPKkinases': [1367], 'multiple': [1372], 'membersof': [1377], 'MAPK/extracellular': [1379], '(MEK)': [1383], '(MEKK),mixed-lineage': [1385], 'apoptosis': [1388, 1691, 1723], 'signal-regulating': [1389], 'families,': [1391], 'Tpl2,and': [1392], '1': [1395, 2624, 2690, 2740, 2826, 2863], '(TAK1)(27Davis': [1396], 'R.J.': [1397, 2444, 3250], '103:': [1400], '239-252Abstract': [1401], '(3593)': [1409], 'was': [1413, 1420, 2079, 2224, 2241, 2286, 2295, 2305, 2425, 2537, 2751, 2781, 2913, 3131, 3140, 3162, 3195, 3325, 3338, 3625, 3636, 3716, 3740, 3849, 3950], 'initiallyidentified': [1414], 'activity': [1419, 3948, 3982, 4010, 4035], 'stimulated': [1421, 3770], 'BMP4,': [1425], 'aTGFβ': [1426], 'superfamily': [1427], 'member,': [1428], 'resulting': [1429], 'MKK4(28Yamaguchi': [1433], 'Shirakabe': [1435, 1576, 1615, 2929], 'Irie': [1439, 1572, 1623, 1655, 1738, 2510, 2925], 'Oishi': [1441], 'Ueno': [1443, 1478, 1621, 1657, 1740, 2473, 2512], 'Taniguchi': [1445], 'Science.': [1451, 1629, 2413], '2008-2011Crossref': [1454], '(1169)': [1457], 'subsequentlybeen': [1462], 'involved': [1466, 1773], 'interleukin': [1468], '1-': [1469], 'Wnt-mediated': [1471], 'signaltransduction(29Ishitani': [1472], 'Kishida': [1474, 2469], 'Hyodo-Miura': [1476, 2471], 'Yasuda': [1480, 2475], 'Waterman': [1482, 2477], 'Moon': [1486, 2481], 'R.T.': [1487, 2482], '23:': [1496, 2491], '131-139Crossref': [1497, 2492], '(469)': [1500, 2495], '30Ninomiya-Tsuji': [1503], 'Kishimoto': [1505], 'Hiyama': [1507], 'Inoue': [1509], 'Cao': [1511], 'Z.': [1512], '398:': [1517], '252-256Crossref': [1518], '(1010)': [1521], '31Smit': [1524], 'Baas': [1526], 'Kuipers': [1528], 'Korswagen': [1530], 'van': [1532], 'de': [1533], 'Wetering': [1534], 'Clevers': [1536], '279:': [1542], '17232-17240Abstract': [1543], '(94)': [1551], 'Scholar)and': [1553], 'MKK3': [1562], 'MKK6(32Moriguchi': [1564], 'Kuroyanagi': [1566, 2919], 'Yamaguchi': [1568, 1613, 2921], 'Gotoh': [1570, 1619, 2923], 'Kano': [1574, 2927], 'Muro': [1578, 2931], 'Hagiwara': [1586, 2939], '13675-13679Abstract': [1593, 2946], '(406)': [1601, 2954], 'Activation': [1604], 'TAK1requires': [1606], 'interaction': [1607, 1718], 'TAB1': [1609, 1675], '(TAK1-binding': [1610], 'protein)(33Shibuya': [1611], 'Tonegawa': [1617], '1179-1182Crossref': [1632], '(516)': [1635], 'which': [1638, 2157, 3454, 3542, 3776], 'binds': [1640, 1877], 'theX-linked': [1642, 1688], 'inhibitor': [1643, 1689, 1721, 2746], 'apoptosis(34Yamaguchi': [1645], 'Nagai': [1647, 1730, 2502], 'Tamai': [1653, 1736, 2508], '179-187Crossref': [1669, 1752, 2524], '(324)': [1672, 1755, 2527], 'toassociate': [1679], 'bone-morphogenetic': [1684], 'when': [1687], 'co-expressed,': [1693], 'suggesting': [1694, 2193], 'possible': [1696], 'ofthe': [1698, 3612], 'complex': [1700], 'However,': [1703], 'involve': [1707], 'anotherinteracting': [1708], 'since': [1710, 3843], 'yeast': [1711], 'two-hybrid': [1712], 'analysis': [1713, 2648, 2701, 2980, 3207, 3631], 'failed': [1714], 'demonstrate': [1716, 3705, 3753, 4025], 'adirect': [1717], 'between': [1719, 2209], 'X-linked': [1720], 'BMPreceptor': [1727], '(34Yamaguchi': [1728, 2500], 'Scholar).Dab2,': [1757], 'Disabled': [1762, 1823], 'family,': [1764], 'adaptormolecule': [1769], 'several': [1775, 1879, 3302, 3579], 'receptor-mediated': [1776, 1973], 'pathways(11Hocevar': [1778], 'Scholar,35Morris': [1795], 'S.M.': [1796, 1889, 1975, 2007], 'Cooper': [1797, 1890, 1976, 2014], 'J.A.': [1798, 1891, 1924, 1977, 2015], 'Traffic.': [1799, 1892, 1978, 2020], '111-123Crossref': [1802, 1895, 1981], '(217)': [1805, 1898, 1984], 'Scholar,36Oleinikov': [1807, 1900], 'A.V.': [1808, 1901], 'Zhao': [1809, 1902], 'Makker': [1811, 1904], 'S.P.': [1812, 1905], '347:': [1816, 1909], '613-621Crossref': [1817, 1910], '(131)': [1820, 1913], 'memberspossess': [1825], 'highly': [1827], 'conserved': [1828], 'N-terminalphosphotyrosine-interacting/phosphotyrosine': [1829], 'domain': [1831, 4041], '(PID/PTB),': [1832], 'recentlyrenamed': [1833], 'DAB': [1835], 'homology': [1836], 'domain(37Yun': [1837], 'Keshvara': [1839], 'Park': [1841, 1853], 'C-G.': [1842], 'Y.-M.': [1844], 'Dickerson': [1845], 'J.B.': [1846], 'Zheng': [1847], 'Rock': [1849], 'C.O.': [1850], 'Curran': [1851], 'H.-W.': [1854], '278:': [1859], '36572-36581Abstract': [1860], '(104)': [1868], 'linked': [1871], 'divergentC-terminal': [1873], 'sequences.': [1874], 'members': [1880], 'thelipoprotein': [1882], 'PTB': [1887, 3887], 'domain(35Morris': [1888], 'Scholar,38Gotthardt': [1915], 'Tromsdorff': [1917], 'Nevitt': [1919], 'M.F.': [1920], 'Shelton': [1921], 'Richardson': [1923], 'Stockinger': [1925], 'W.': [1926], 'Nimpf': [1927], 'Herz': [1929], '25616-25624Abstract': [1936], '(393)': [1944, 3234], 'associationwith': [1949], 'clathrin,': [1950], 'clathrin': [1952], 'adaptor': [1953, 2037], 'AP2,': [1955], 'myosin': [1957], 'VI,': [1958], 'bysequences': [1960], 'linker': [1963], 'C-terminal': [1965, 3889, 3970], 'regions': [1966], 'facilitatesclathrin-coated': [1969], 'pit': [1970], 'assembly': [1971], 'endocytosis(35Morris': [1974], 'Scholar,39Mishra': [1986], 'S.K.': [1987], 'Keyel': [1988], 'Hawryluk': [1990], 'Agostinelli': [1992], 'N.R.': [1993], 'Watkins': [1994], 'S.C.': [1995], 'Traub': [1996], 'L.M.': [1997], 'EMBOJ.': [1998], '21:': [2000], '4915-4926Crossref': [2001], '(249)': [2004], 'Scholar,40Morris': [2006], 'Arden': [2008], 'S.D.': [2009], 'R.C.': [2011], 'Kendrick-Jones': [2012], 'Luzio': [2016], 'Buss': [2018], 'F.': [2019], '3:': [2022], '331-341Crossref': [2023], '(198)': [2026], 'recentlydemonstrated': [2031], 'serves': [2034], 'molecule': [2038], 'pathway(11Hocevar': [2048], 'Expression': [2066, 2641, 2693, 3427, 3989], 'Dab2restored': [2068], 'responses': [2070], 'TGFβ-signaling-deficient': [2073, 3444, 3881], 'mutantcell': [2074], 'line.': [2075], 'addition,': [2077], 'found': [2080], 'augment': [2082], 'FNinduction,': [2084, 2143, 3689], 'JNK-dependent': [2086, 2202], 'response(11Hocevar': [2089], 'We,': [2107, 3491, 3831], 'therefore,': [2108, 3492, 3832], 'wished': [2109, 3493, 3833, 3857], 'toexplore': [2110], 'possibility': [2112], 'could': [2115, 3837], 'mediate': [2117], 'TGFβ-stimulatedJNK': [2118], 'FN.We': [2124], 'report': [2125, 2170], 'stable': [2128, 2376, 3527], '(siRNA)-mediated': [2132], 'silencingof': [2133], 'decreased': [2141, 2146, 2180], 'concomitant': [2144], 'activation.': [2149], 'Dab2is': [2150], 'stimulate': [2154, 4008], 'blocked': [2159, 3810], 'ofa': [2162], 'TAKKW.': [2167], 'TAK1expression': [2174], 'TAKKW': [2176, 2696], 'FNprotein': [2182], 'mRNA': [2184], 'induction,': [2185], 'respectively.': [2186], 'At': [2187], 'biological': [2189], 'level': [2190], 'we': [2191, 3524, 3543, 3844, 3856, 3871], 'provideevidence': [2192], 'cellularmigration,': [2200], 'response.': [2203], 'thus,': [2205, 3752], 'provides': [2206], 'theactivated': [2210], 'theJNK-signaling': [2219], 'pathway.MATERIALS': [2220], 'AND': [2221], 'METHODSReagents—Recombinant': [2222], 'TGFβ2': [2223], 'generously': [2225], 'provided': [2226, 2426, 2531, 3095], 'byGenzyme': [2227], '(Cambridge,': [2228], 'MA).': [2229], 'SP600125': [2230], '(JNK': [2231], 'Inhibitor': [2232], 'II)': [2233], 'SB203580': [2235, 3050], 'werepurchased': [2236, 3084], 'Calbiochem,': [2238], 'PD98059': [2240, 3053], 'purchased': [2242, 2249, 2296, 2538], 'Alexis.': [2244], 'Thefollowing': [2245], 'primary': [2246], 'antibodies': [2247], 'were': [2248, 2344, 2397, 2530, 2549, 2563, 2661, 2795, 2806, 2818, 2855, 2896, 2967, 3016, 3056, 3151, 3291, 3300, 3361, 3407, 3421, 3915], 'Santa': [2251], 'Cruz': [2252], 'Biotechnology:mouse': [2253], 'α-HA': [2254], '(sc-7392),': [2255], 'α-myc': [2257], '(sc-40),': [2258], 'rabbit': [2259, 2264, 2301], 'α-TAK1(sc-7162),': [2260], 'α-TAK1': [2262], '(sc-7967),': [2263], 'α-HSP': [2265], '90': [2266], '(sc-7947),': [2267], 'andrabbit': [2268], 'α-JNK1': [2269], '(sc-474).': [2270], 'Mouse': [2271], 'monoclonal': [2272, 2651, 2704], 'antibody': [2273, 2293, 2304, 2810, 2984], 'Disabled-2/p96': [2275], 'waspurchased': [2276], 'BD': [2278], 'Transduction': [2279], 'Laboratories.': [2280], 'α-FLAG-M2antibody': [2283], 'gelatin-agarose': [2285, 3013], 'obtained': [2287], 'Sigma.': [2289], 'Rabbit': [2290], 'polyclonalphospho-c-Jun': [2291], '(Ser63)': [2292], 'SignalingTechnology,': [2299], 'α-rat': [2302], 'Invitrogen.Plasmid': [2307], 'Construction—Construction': [2308], 'FLAG-tagged': [2311, 2423], 'humanDab2': [2312], 'RK5': [2315, 2359], 'plasmid': [2316], 'described': [2319, 2916, 3136], 'previously(11Hocevar': [2320], 'various': [2339, 2963, 3178, 3924, 4053], 'domainconstructs': [2340], 'human': [2342, 3449, 3793], 'generated': [2345], 'standard': [2347], 'PCR': [2348, 2367], 'methods': [2349], 'using': [2350, 2671, 3036, 3181], 'thefull-length': [2351], 'construct': [2352, 2594, 3614, 3966, 3992], 'template': [2354], 'inserted': [2356], 'into': [2357, 2402, 3321, 3615], 'vector': [2360, 2405, 2536, 3577], 'containinga': [2361], 'FLAG': [2362], 'epitope.': [2363], 'Sequences': [2364], 'amplification': [2368], 'available': [2370], 'uponrequest.': [2371], 'For': [2372, 2770], 'construction': [2373], 'siDab2': [2377, 2581, 2593, 3613], 'construct,': [2378, 2582], 'forward': [2379], 'andcomplementary': [2380], 'reverse': [2381], 'primers': [2382], 'corresponding': [2383], 'p96(5′-CAAATGGAGTCACCTCCTG-3′)': [2386], 'flanked': [2387], 'AA': [2389], 'at': [2390, 2394, 2876, 3062, 3425, 4016], '5′-end': [2392], 'andTT': [2393], '3′-end': [2396], 'synthesized,': [2398], 'annealed,': [2399], 'ligated': [2401], 'pSUPERexpression': [2404], 'described(41Brummelkamp': [2407], 'T.R.': [2408], 'Bernards': [2409], 'Agami': [2411], '296:': [2415], '550-553Crossref': [2416], '(3942)': [2419], 'JNKconstruct': [2424], 'Roger': [2428], 'Davis(42Derijard': [2429], 'Hibi': [2431], 'Wu': [2433], 'I.-H.': [2434], 'Barrett': [2435], 'Su': [2437], 'Karin': [2441], '1994;': [2446], '76:': [2447], '1025-1037Abstract': [2448], '(2949)': [2454], 'HA-taggedwild-type': [2459], '(TAKK63W),': [2463], 'constitutively': [2464], 'active': [2465], 'TAK1(TAK1dN)': [2466], '(29Ishitani': [2467], 'Myc-taggedTAB1': [2499], 'E.Nishida.': [2533], 'pPur': [2535, 2598, 2667], 'Clontech.Cell': [2540], 'Culture': [2541], 'Generation': [2543], 'Lines—NIH3T3': [2546], 'COS7cells': [2548], 'cultured': [2550, 2564], "Dulbecco's": [2552, 2566, 2619, 2681], 'modified': [2553, 2567, 2620, 2682], "Eagle's": [2554, 2621, 2683], 'medium': [2555, 2684], 'supplemented': [2556, 2569], 'with10%': [2557], 'newborn': [2558], 'calf': [2559, 2573, 2687], 'serum.': [2560, 2574], "Eagle'smedium": [2568], '10%': [2571], 'fetal': [2572], 'To': [2575, 3518, 3911], 'generate': [2576], 'stablyexpress': [2579], '100-mm-diameter': [2588], 'plateswere': [2589], 'transfected': [2590, 3917], '(10': [2595, 3045, 3054], 'μg)': [2596, 2665, 2669, 2805, 3191], '(2': [2599, 2668, 3060, 3105], 'μg)utilizing': [2600], 'FuGENE': [2601, 2672, 2783], '6': [2602, 2673, 2784], '(Roche': [2603, 2785], 'Diagnostics)': [2604, 2786], 'Lipofectamine': [2606], 'PLUS': [2607], '(Invitrogen),respectively,': [2608], 'per': [2610, 3120, 3185], "manufacturer's": [2612, 3121], 'instructions.': [2613, 3122, 3187], 'Stable': [2614, 3610], 'transfectantswere': [2615], 'selected': [2616, 2675], 'serum-containing': [2618, 3385], 'mediumsupplemented': [2622], 'μg/ml': [2625, 2691], 'puromycin': [2626], 'maintained': [2628, 3066], 'same': [2631, 3149], 'media': [2632, 3023, 3311, 3360, 3386], 'eitheras': [2633], 'pool': [2635, 2679, 3659], '(A10)': [2636], 'individual': [2638, 3078, 3649, 3864], 'clones': [2639, 2912, 3650, 3692], '(NIH3T3).': [2640], 'wereassessed': [2645], 'Western': [2647, 2700, 2715, 3157, 3630], 'utilizing': [2649, 2702, 3208, 3340], 'α-p96': [2652], 'antibody.': [2653], 'Togenerate': [2654], '3T3-TAKKW': [2656, 3169], 'line,': [2658, 3453], 'co-transfected': [2662], 'TAKKW(10': [2664], 'constructs': [2670, 2780, 3925, 4054, 4062], 'andmaintained': [2676], 'containing': [2685, 2862, 3926, 4065], '10%newborn': [2686], 'serum': [2688], 'puromycin.': [2692], 'constructwas': [2697], 'verified': [2698], 'α-HAantibody.Preparation': [2705], 'Lysates,': [2708], 'Immunoprecipitation,': [2709], 'Protein': [2711, 2986], 'KinaseAssays—For': [2712], 'immunoprecipitation': [2713], 'blot': [2716], 'analysis,': [2717], 'cellswere': [2718], 'lysed': [2719, 2796], 'buffer': [2721, 2798, 2822, 2831, 2861], 'D': [2722, 2823], '(20': [2723], 'mm': [2724, 2733, 2736, 2741, 2837, 2842], 'Tris,': [2725], 'pH': [2726, 2834], '7.5,': [2727, 2835], '1%': [2728], 'Triton': [2729], 'X-100,': [2730], '10%glycerol,': [2731], '137': [2732], 'NaCl,': [2734], '2': [2735, 2841, 2870, 3354], 'EDTA,': [2737], '25': [2738, 2836], 'mmβ-glycerophosphate,': [2739], 'Na3V04,': [2742], 'andComplete': [2743], 'EDTA-free': [2744, 2848], 'protease': [2745], 'mixture;': [2747, 2850], 'Roche': [2748, 2851], 'Diagnostics),': [2749], 'andimmunoprecipitation': [2750], 'carried': [2752], 'out': [2753], 'described(21Hocevar': [2756, 2993, 3266], 'assays': [2772, 3012], 'COS7cells,': [2774], 'indicated': [2779, 3180], 'performedutilizing': [2782], 'according': [2787], "manufacturer'sprotocols.": [2790], '48': [2792, 3124], 'h': [2793, 3125, 3381], 'Equal': [2800], 'amounts': [2801], 'cellularprotein': [2803], '(250': [2804], 'immunoprecipitated': [2807], 'α-FLAG': [2809], 'andcaptured': [2811], 'on': [2812, 2898, 2969, 3029, 3401, 3851], 'G-Sepharose': [2814], 'beads.': [2815], 'beads': [2817, 3014], 'subsequently': [2819], 'washedtwice': [2820], 'followed': [2824], 'wash': [2827], 'assay': [2830, 2908, 3130, 3346], '(25mm': [2832], 'HEPES,': [2833], 'β-glycerophosphate,': [2838], '25mm': [2839], 'MgCl2,': [2840], 'dithiothreitol,': [2843], '0.1mm': [2844], 'Na3VO4,': [2845], 'Complete': [2847], 'proteaseinhibitor': [2849], 'Diagnostics).': [2852], 'Kinase': [2853], 'reactions': [2854], 'performed': [2856, 2914, 3134, 3326], '30μl': [2858], 'μg': [2864], 'GST-c-Jun': [2865, 3958], '(Stratagene),': [2866], '50μm': [2867], 'ATP,': [2868], 'μCi': [2871], '[γ-32P]ATP.': [2873], 'Reactionswere': [2874], 'incubated': [2875], '30': [2877], '°C': [2878], '20': [2880], 'min': [2881], 'terminated': [2883], 'addition': [2886], 'anequal': [2888], 'volume': [2889], '2×': [2891], 'Laemmli': [2892], 'sample': [2893, 3194], 'buffer.': [2894], 'Samples': [2895, 3027], 'resolved': [2897, 2968], '10%SDS/PAGE': [2899, 2970], 'gels,': [2900, 2971, 3032], 'dried,': [2901], 'visualized': [2903, 3040], 'autoradiography.': [2905, 3042], 'inNIH3T3': [2909], '3T3-siDab2': [2911, 3336], 'previously(32Moriguchi': [2917], 'after': [2957, 3171, 3329, 3675], '5ng/ml': [2960], 'times.': [2964], 'Reaction': [2965], 'products': [2966], 'transferred': [2972, 3201], 'Immobilon': [2974], 'membranes,': [2975], 'subjected': [2977, 3033], 'Westernblot': [2979], 'α-phospho-c-Jun': [2982], '(Ser-63)': [2983], 'II.Fibronectin': [2985], 'Assay—TGFβ-stimulated': [2987], 'inductionwas': [2989], 'determined': [2990], 'exception': [3009], 'thatin': [3010], 'some': [3011], '(Sigma)': [3015], 'precipitate35S-labeled': [3019], 'labeled': [3025], 'cells.': [3026, 3517], 'wereresolved': [3028], '6%': [3030], 'SDS/PAGE': [3031], 'fluorography': [3035], 'Enhance(Amersham': [3037], 'Biosciences),': [3038], 'inhibitorsSP600125': [3044], 'μm': [3046], '50': [3048], 'μm),': [3049], '(10μm),': [3051], 'μm)': [3055], 'added': [3057, 3362], 'simultaneouslywith': [3058], 'ng/ml)': [3061], 'initiation': [3064], 'throughout': [3067], 'FNassay.Transient': [3069], 'siRNA-mediated': [3070], 'Silencing': [3071], 'TAK1—The': [3073], 'negativecontrol,': [3074], 'pool,': [3076], 'oligos': [3081], 'Dharmacon': [3086], 'Technologies': [3088], '(SMARTpool': [3089], 'Plus,': [3090], 'Q-004500-00-09)': [3091], 'andresuspended': [3092], 'reagents': [3094], 'manufacturer.': [3098, 3352], 'weretransfected': [3101], '6-well': [3103], 'plates': [3104, 3290], '×': [3106, 3355], '105': [3107, 3356], 'cells/well)': [3108], 'usingOligofectamine': [3109], 'reagent': [3110, 3183], '(Invitrogen)': [3111, 3184], '200': [3113], 'nm': [3114], 'concentrations': [3115], 'eachof': [3116], 'oligo': [3119], 'ofsiRNA': [3126], 'treatment,': [3127, 3775], 'initiated': [3132], 'above.FN': [3137], 'analyzed': [3141, 3152], 'media,': [3144], 'lysates': [3147], 'fromthe': [3148], 'wells': [3150], 'analysis.Northern': [3158], 'Blot': [3159], 'Analysis—Total': [3160], 'isolated': [3163], 'NIH3T3,3T3-siDab2': [3165], 'clone': [3166, 3700], '8,': [3167], '5': [3174, 3393, 3418], 'ng/ml': [3175], 'TGFβfor': [3176], 'times': [3179, 3303], 'TRIzol': [3182], "themanufacturer's": [3186], 'Total': [3188], '(40': [3190], 'each': [3193], 'resolvedin': [3196], '1.2%': [3198], 'formaldehyde/agarose': [3199], 'gel,': [3200], 'nitrocellulose,': [3203], 'andsubjected': [3204], 'Northern': [3206], 'probes': [3209], 'FN(45Tong': [3211], 'Pav': [3213], 'White': [3215], 'D.M.': [3216], 'Rogers': [3217], 'Crane': [3219], 'Cywin': [3221], 'M.L.': [3224], 'Pargellis': [3225], 'C.A.': [3226], 'Nat.Struct.': [3227], '4:': [3230], '311-316Crossref': [3231], 'cyclophilin': [3238], '(1B15)(43Danielson': [3239], 'P.E.': [3240], 'Forss-Petter': [3241], 'Brow': [3243], 'M.A.': [3244], 'Calavetta': [3245], 'Douglass': [3247], 'Milner': [3249], 'Sutcliffe': [3251], 'J.G.': [3252], '(N.': [3254], 'Y.).': [3255], '1988;': [3256], '7:': [3257], '261-267Crossref': [3258], '(1032)': [3261], 'Scholar).Wound': [3279], 'Closure': [3280], 'Assay—For': [3281], 'closure': [3284], 'assay,': [3285], 'confluentmonolayer': [3286], '60-mm': [3289], 'wounded': [3292, 3323], 'manual': [3294], 'scraping': [3295], 'pipettetip.': [3298], 'Plates': [3299], 'washed': [3301], 'remove': [3305], 'non-adherent': [3306], 'placedin': [3309], 'complete': [3310], 'without': [3314], '(5': [3316], 'ng/ml).': [3317], 'Assessment': [3318], 'cellmigration': [3320], 'area': [3324], 'microscopy': [3328, 3424], '24': [3330, 3732], 'h.': [3331, 3733], 'Cellmigration': [3332], 'quantitated': [3339], 'theQCM™': [3341], '24-well': [3342], 'colorimetric': [3343], '(Chemicon': [3347], 'International)as': [3348], 'suggested': [3349], 'Briefly,': [3353], 'cellsresuspended': [3357], 'serum-free': [3359], 'upper': [3365, 3403], 'chamber': [3366], 'allowed': [3368], 'tomigrate': [3369], 'membrane': [3372, 3415], 'insert': [3373], '8-μm': [3376], 'pore': [3377], 'size': [3378], '4': [3380, 3730], 'toward': [3382], '10%fetal': [3383], 'bovine': [3384], 'absence': [3389], 'presence': [3391], 'ng/mlTGFβ.': [3394], 'incubation': [3397], 'period,': [3398], 'themembrane': [3406], 'removed,': [3408], 'had': [3411], 'migrated': [3412], 'werestained,': [3416], 'random': [3419], 'fields': [3420], 'counted': [3422], '250×magnification.RESULTSDab2': [3426], 'Is': [3428], 'Required': [3429], 'FNInduction—We': [3432], 'FNinduction': [3438], 'greatly': [3440], 'abrogated': [3441], 'line,derived': [3446], 'HT1080': [3450, 3794], 'fibrosarcoma': [3451, 3795], 'expresses': [3455], 'mutantform': [3457], '(11Hocevar': [3460, 3893], 'totest': [3494], 'whether': [3495, 3835], 'inductionin': [3503], 'different': [3505, 3928], 'types': [3507, 3765], 'respond': [3509], 'namelyfibroblast': [3513], 'ablate': [3519], 'choseto': [3525], 'use': [3526], 'siRNA': [3531], 'specifically': [3532], 'targeted': [3533], 'decreaseexpression': [3535], 'p96': [3538, 3588], 'splice-form': [3539], 'torestore': [3547], 'mutant': [3552], 'line(11Hocevar': [3554], 'previouslycharacterized': [3574], 'siRNA-Dab2': [3576], 'lines': [3581], 'regard': [3583], 'itsspecificity': [3585], 'Dab2(71Prunier': [3591], 'J.Biol.': [3595], '2005;': [3597], '280:': [3598], '17540-17548Abstract': [3599], '(106)': [3607], 'introduction': [3611], 'fibroblast': [3617, 3778], 'smoothmuscle': [3623], 'performed.': [3626], 'As': [3627, 3935], 'inFig.': [3632], '1A,': [3633], 'siDab2construct': [3635], 'able': [3637], 'decrease': [3639], 'p96,': [3641], 'but': [3642], 'not': [3643], 'p67,': [3644], 'expressionin': [3648], '(left': [3654], 'panel)': [3655, 3662], 'ofA10': [3660], '(right': [3661], 'varying': [3665], 'extents.': [3666], 'Analysis': [3667], 'clonesfor': [3670], 'reveals': [3678], 'dosedependence': [3680], 'basal': [3686, 3708], 'lowest': [3696, 3707], 'Dab2(i.e.': [3699], '8': [3701], '9)': [3703], 'andTGFβ-stimulated': [3709], 'induction(Fig.': [3712], '1B).': [3713], 'proteinexpression': [3715], 'assessed': [3718, 3951], 'wild-type': [3720], 'siDab2-expressing': [3723], 'cellsafter': [3725], 'Similarly': [3734], 'cells,TGFβ-mediated': [3737], 'markedly': [3741], 'withdecreased': [3746], '(Fig.1C).': [3749], 'These': [3750, 4023], 'results,': [3751], 'Dab2expression': [3755], 'differentcell': [3764], 'physiologically': [3769], 'cells.Dab2': [3782], 'Directly': [3783], 'Stimulates': [3784], 'Activity—We': [3786], 'previouslyshown': [3788], 'toactivation': [3798], 'FNcould': [3808], 'dominant-negative': [3814], 'MKK4(21Hocevar': [3817], 'toassess': [3834], 'pathway,': [3842], 'observedthat': [3845], 'dependent': [3850], 'Dab2.': [3854, 4056], 'Inaddition,': [3855], 'assess': [3859, 3912], 'contribution': [3861], 'domains': [3865, 3891, 3929], 'ofDab2': [3866, 3892], 'because': [3870], 'thatrestoration': [3875], 'cellline': [3882], 'proline-rich': [3890], 'this,COS7': [3913], 'transiently': [3916], 'along': [3920], 'full-length': [3922, 3941, 3987, 4020], 'Dab2or': [3923], 'Dab2(Fig.': [3931], '2,': [3932], 'andC).': [3934], 'Fig.2B,': [3938], 'capable': [3944], 'ofefficiently': [3945], 'stimulating': [3946], 'JNKto': [3956], 'vitro': [3962], 'assay.': [3964], 'Furthermore,the': [3965], 'bearing': [3967, 3993], 'only': [3968], 'portion': [3971], 'designated': [3974], '#323consisting': [3975], 'amino': [3977, 4001], 'acids': [3978, 4002], '323–770,': [3979], 'sameextent': [3985], '(Fig.2B).': [3988], 'proline-richdomain': [3995], '#534,': [3998], 'consisting': [3999], '534–770,': [4003], 'notsufficient': [4006], 'even': [4011], 'though': [4012], 'it': [4013], 'samelevel': [4018], '(Fig.2C).': [4022], 'results': [4024], 'directlymediate': [4029], 'localized': [4038], 'theC-terminal': [4040], 'Dab2.Fig.': [4043], '2Dab2': [4044], 'activity.': [4048], 'A,': [4049], 'diagrammaticrepresentation': [4050], 'Depicted': [4057], 'full-lengthand': [4060], 'deletion': [4061], 'N-ter': [4067]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1988616931', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-09T10:37:23.308342', 'created_date': '2016-06-24'}