Publication Information

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3025, 3034, 3118, 3145, 3153, 3205, 3240, 3282, 3338, 3378, 3388, 3401, 3464, 3470, 3475, 3505, 3517, 3532, 3594, 3598, 3606, 3637, 3665, 3686, 3770, 3776, 3808, 3832, 3844, 3864, 3879, 3890, 3914, 3979, 3984, 4057, 4072, 4089, 4205, 4222, 4264, 4286], 'Cu+': [5, 28, 49, 61, 206, 231, 254, 275, 287, 432, 562, 822, 949, 1950, 1998, 2052, 2057, 2076, 2135, 2145, 2156, 2373, 2393, 2448, 2754, 2832, 2848, 2873, 2930, 2959, 3043, 3119, 3206, 3262, 3274, 3280, 3313, 3316, 3500, 3508, 3536, 3657, 3760, 3772, 3815, 3852, 3891, 3962, 3977, 4027, 4058, 4210, 4278, 4302], 'from': [6, 232, 1458, 2491, 2540, 2756, 3122, 3659, 3853, 3892], 'cell': [8, 234, 520], 'cytoplasm.': [9, 235, 1075], 'During': [10, 236], 'their': [11, 144, 237, 370], 'catalytic/transport': [12, 238], 'cycle,': [13, 239], 'cytoplasmic': [14, 74, 165, 218, 240, 300, 391, 444, 821, 948, 1313, 1767, 2250, 3143], 'Cu+-chaperones': [15, 241, 551, 667, 2005, 3467], 'deliver': [16, 199, 242, 425, 3499], 'metal': [18, 244, 693, 712, 798, 1060, 2039, 2152, 2216, 2274, 2336, 2435, 3612, 3997, 4218], 'to': [19, 51, 62, 66, 101, 196, 245, 277, 288, 292, 327, 422, 507, 510, 536, 555, 691, 900, 951, 1033, 1050, 1053, 1067, 1464, 1484, 1964, 2003, 2042, 2059, 2097, 2158, 2165, 2218, 2429, 2450, 2759, 2892, 3003, 3060, 3098, 3314, 3324, 3357, 3370, 3454, 3502, 3519, 3529, 3643, 3647, 3669, 3758, 3816, 3827, 3894, 3909, 3998, 4059, 4113], 'two': [21, 247, 952, 1290, 1755, 1891, 2917, 3541, 3851, 3866], 'transmembrane': [22, 248, 684, 953, 1198, 1241, 1288, 1896, 2034, 2276], 'metal-binding': [23, 75, 219, 249, 301, 445, 954, 962, 999, 1199, 1233, 1242, 1276, 1314, 1481, 1892], 'sites': [24, 134, 250, 360, 955, 1893, 1948, 2129, 2899, 4207, 4215], '(TM-MBSs)': [25, 251, 956], 'responsible': [26, 252, 819, 1894], 'for': [27, 253, 820, 1762, 1895, 2066, 2223, 2273, 2371, 2408, 2434, 2484, 2516, 2824, 2905, 2924, 2988, 3015, 3194, 3252, 3343, 3354, 3603, 4054, 4068], 'translocation.': [29, 255], 'Here,': [30, 256], 'using': [31, 257, 2319, 2497, 3215, 3286, 3422, 3515, 3682, 4096], 'Archaeoglobus': [32, 258, 1718], 'fulgidus': [33, 259, 1719, 2385, 2466, 3667, 3672, 3703], 'Cu+-ATPase': [34, 260, 1683, 2325, 2386, 3520], 'CopA': [35, 64, 68, 126, 261, 290, 294, 352, 1203, 1207, 1213, 1224, 1246, 1250, 1256, 1267, 1720, 2424, 2451, 2467, 2488, 2493, 2762, 2885, 2903, 3093, 3146, 3673, 3739, 3743, 3753, 3956, 4060, 4114, 4269], 'and': [36, 65, 138, 160, 198, 262, 291, 364, 386, 424, 558, 666, 695, 706, 843, 977, 1014, 1036, 1218, 1261, 1298, 1308, 1312, 1462, 1477, 1491, 1666, 1731, 1882, 1903, 1908, 1914, 1968, 2032, 2049, 2086, 2143, 2246, 2252, 2269, 2278, 2381, 2468, 2500, 2520, 2543, 2549, 2616, 2620, 2796, 2814, 2846, 3042, 3048, 3073, 3166, 3188, 3207, 3349, 3385, 3415, 3426, 3530, 3750, 3752, 3821, 3859, 4037], 'C-terminal': [38, 264, 2512], 'Cu+-chaperone': [39, 178, 265, 404, 3518, 3692], 'domain': [40, 220, 266, 446, 1226, 1228, 1230, 1232, 1234, 1269, 1271, 1273, 1275, 1277, 1301, 2330, 3450, 3664, 3699], 'CopZ': [42, 268, 1492, 2469, 3123, 3668, 3704], '(Ct-CopZ),': [43, 269], 'we': [44, 270, 2388, 3655], 'describe': [45, 271], 'mechanism': [47, 273], 'transfer': [50, 111, 276, 337, 2053, 2157, 2394, 2449, 2874, 2960, 2973, 3509, 3528, 3613, 3658, 3887, 4112, 4279], 'both': [52, 105, 108, 133, 278, 331, 334, 359, 966, 1003, 1205, 1248, 2128, 2219, 3645, 3747, 4214], 'TM-MBSs.': [53, 106, 122, 279, 332, 348, 2425, 3868], 'In': [54, 107, 280, 333, 1633], 'absence': [55, 187, 281, 413, 670, 2150, 3807, 4221], 'other': [57, 283, 3809, 3861], 'ligands,': [58, 189, 284, 415], 'Ct-CopZ': [59, 285, 2415, 2758, 2787, 2795, 2839, 3076, 3091, 3688, 3893], 'transfers': [60, 286, 2755, 3995], 'wild-type': [63, 289], 'various': [67, 293, 3670], 'constructs': [69, 295, 2470, 2763, 2886, 3094], 'lacking': [70, 128, 296, 354, 965, 1002, 1204, 1247, 3103, 3459, 3521, 3744], 'or': [71, 297, 2920, 3092, 3164, 3218, 3473, 3600, 3746], 'having': [72, 298, 688], 'mutated': [73, 299, 1212, 1222, 1255, 1265, 3755], 'domains,': [76, 302, 1311], 'in': [77, 90, 185, 303, 316, 411, 458, 674, 811, 975, 1012, 1216, 1259, 1317, 1460, 1466, 1638, 1645, 1679, 1688, 1901, 1906, 1911, 1916, 1951, 2148, 2258, 2334, 2472, 2477, 2553, 2609, 2738, 2798, 2901, 2910, 2963, 2971, 2998, 3038, 3045, 3068, 3079, 3173, 3223, 3242, 3362, 3382, 3392, 3405, 3412, 3701, 3799, 3805, 3819, 3856, 3862, 3981, 4023, 4034, 4134, 4179, 4200, 4219, 4283], 'a': [78, 84, 154, 304, 310, 380, 532, 910, 1044, 1094, 1473, 1560, 1671, 1689, 1759, 1904, 1952, 2024, 2168, 2511, 2799, 2841, 2928, 3174, 3236, 3268, 3638, 3954, 3971, 4031, 4035, 4073, 4099, 4201, 4226, 4257, 4271], 'fashion': [79, 305], 'consistent': [80, 306], 'with': [81, 125, 221, 307, 351, 447, 704, 1057, 1071, 1090, 1685, 2077, 2139, 2462, 2740, 2827, 2850, 2887, 3022, 3031, 3200, 3235, 3258, 3335, 3375, 3398, 3801, 3825, 3904, 3953, 3974, 4268], 'occupancy': [82, 103, 308, 329, 2166, 2436, 3531, 3605, 3843, 4088], 'single': [85, 311, 1727, 2169, 2929, 3535, 3842, 4074, 4100], 'TM-MBS.': [86, 312, 4075, 4091], 'Similar': [87, 313], 'experiments': [88, 314, 3510, 3902, 3951, 4093, 4280], 'performed': [89, 124, 315, 350, 2138, 2737, 2765, 2962, 3059, 3088, 3446, 3511, 3677, 3824, 3903, 3952, 4282], 'presence': [92, 318, 663, 3472, 3983, 4285], '2.5': [94, 320, 2966, 3035, 4287], 'mm': [95, 321, 2803, 2808, 2811, 2967, 3036, 3178, 3183, 3186, 3190, 3221, 3244, 3249, 3380, 3390, 3403, 4128, 4288], 'ADP-Mg2+,': [96, 322], 'stabilizing': [97, 323, 4225], 'an': [98, 181, 324, 407, 454, 524, 1478, 3533, 4066, 4295], 'E1·ADP,': [99, 325], 'lead': [100, 326], 'full': [102, 328, 3604], 'cases,': [109, 335], 'is': [112, 150, 172, 338, 376, 398, 453, 1031, 1077, 1083, 2040, 2130, 2221, 2227, 2432, 3120, 3468, 3882, 4033, 4040, 4102, 4107], 'largely': [113, 339], 'stoichiometric,': [114, 340], 'i.e.': [115, 341, 1093, 2147, 3102, 3458], 'equimolar': [116, 342, 2792], 'amounts': [117, 343, 2793], 'Ct-CopZ·Cu+': [119, 345, 2890, 2909, 2923, 3812, 3833, 3987, 4055, 4267], 'saturated': [120, 346], 'Experiments': [123, 349, 2318, 3823], 'mutants': [127, 353, 4097], 'either': [129, 355, 2409, 3595], 'TM-MBS': [130, 205, 356, 431, 2043, 2160, 2220, 2231, 2410, 3845, 4101], 'showed': [131, 357, 3110, 3527, 3766, 3870, 3970], 'that': [132, 358, 546, 552, 560, 702, 1079, 1670, 1889, 2327, 2405, 3062, 3074, 3111, 3899, 4022, 4047, 4078, 4105, 4213, 4261], 'are': [135, 361, 818, 825, 1636, 2054, 2063, 2271, 2418, 2475, 3540, 4050, 4119, 4168], 'loaded': [136, 362], 'independently,': [137, 363], 'nucleotide': [139, 208, 223, 365, 434, 449, 1231, 1274, 1309, 2266, 2427, 2980], 'binding': [140, 209, 224, 366, 435, 450, 950, 1963, 2058, 2136, 2217, 2428], 'does': [141, 367], 'not': [142, 368, 2064, 2443, 4052, 4064, 4108], 'affect': [143, 369], 'availability.': [145, 371], 'The': [146, 372, 468, 1453, 2464, 3203, 3304, 3367], 'nucleotide-induced': [147, 373], 'E2→E1': [148, 374, 1081], 'transition': [149, 375, 1082], 'structurally': [151, 377], 'characterized': [152, 378, 840, 2383], 'by': [153, 379, 1085, 2036, 2069, 2265, 2397, 2495, 2790, 2879, 3010, 3029, 3149, 3156, 3214, 3231, 3265, 3278, 3396, 3420, 3428, 3466, 3591, 3884, 4086, 4115, 4208, 4301], 'large': [155, 381, 1291, 2244, 2329], 'displacement': [156, 382], 'A': [159, 385], 'N': [161, 387, 1319], 'domains': [162, 388, 1315, 3144, 3155], 'opening': [163, 389, 1052], 'region': [166, 392], 'P-type': [168, 394, 829, 893, 2259], 'ATPases.': [169, 395, 1469, 2260], 'Then,': [170, 396], 'it': [171, 397, 500, 554, 677, 4018], 'apparent': [173, 399, 4070], 'that,': [174, 400, 3798], 'whereas': [175, 401], 'first': [177, 403], 'can': [179, 405, 501, 2044, 3649], 'bind': [180, 406, 2075, 3004, 3759], 'ATPase': [182, 408, 830, 2035, 2067], 'form': [183, 409, 1070, 1890], 'available': [184, 410, 2900, 3867], 'second': [191, 417, 2230, 2439, 4032, 4266], 'requires': [192, 418, 4270], 'E1·nucleotide': [194, 420], 'intermediary': [195, 421], 'interact': [197, 423], 'metal.': [201, 427, 539], 'Interestingly,': [202, 428], 'independent': [203, 429, 2055, 2456, 3469], 'loading,': [207, 433], 'also': [210, 436, 502, 678, 836, 2332, 2453, 4083], 'prevents': [211, 437], 'regulatory': [213, 439, 1561, 1764, 2460], 'interaction': [214, 440, 2027, 2048, 2248, 2457, 3211, 3617, 4263], 'N-terminal': [217, 443, 3698], 'domain.': [225, 451], 'Copper': [452], 'essential': [455, 907], 'micronutrient': [456], 'involved': [457, 1637], 'many': [459], 'critical': [460, 2272], 'processes': [461], '(1Fraústro': [462], 'da': [463], 'Silva': [464], 'J.J.R.': [465], 'Williams': [466], 'R.J.P.': [467], 'Biological': [469], 'Chemistry': [470], 'Elements.': [473], '2nd': [474], 'Ed.': [475], 'Oxford': [476], 'University': [477], 'Press,': [478], 'New': [479], 'York2001:': [480], '418-435Google': [481], 'Scholar,': [482, 583, 598, 615, 632, 645, 731, 748, 774, 861, 874, 928, 1111, 1133, 1153, 1168, 1179, 1335, 1350, 1363, 1380, 1404, 1429, 1516, 1536, 1587, 1600, 1792, 1805, 1837, 1859, 2292, 2581, 2653, 2675, 2699, 3568], '2Tapiero': [483], 'H.': [484, 1608, 1813], 'Townsend': [485], 'D.M.': [486], 'Tew': [487], 'K.D.': [488], 'Biomed.': [489], 'Pharmacother.': [490], '2003;': [491, 1356, 1593, 1798], '57:': [492], '386-398Crossref': [493], 'PubMed': [494, 579, 594, 611, 628, 641, 656, 727, 744, 770, 792, 857, 870, 886, 924, 942, 1107, 1129, 1149, 1164, 1195, 1331, 1346, 1359, 1376, 1400, 1425, 1445, 1512, 1532, 1553, 1583, 1596, 1628, 1660, 1709, 1749, 1788, 1801, 1833, 1855, 1873, 1942, 1992, 2018, 2120, 2183, 2211, 2288, 2313, 2359, 2577, 2599, 2649, 2671, 2695, 2729, 2749, 2781, 2865, 2954, 3136, 3299, 3439, 3492, 3564, 3581, 3630, 3734, 3790, 3945, 4012, 4193, 4250], 'Scopus': [495, 580, 595, 612, 629, 642, 657, 728, 745, 771, 793, 858, 871, 887, 925, 943, 1108, 1130, 1150, 1165, 1332, 1347, 1360, 1377, 1401, 1426, 1446, 1513, 1533, 1554, 1584, 1597, 1629, 1661, 1710, 1750, 1789, 1802, 1834, 1856, 1874, 1943, 1993, 2019, 2121, 2184, 2212, 2289, 2314, 2360, 2578, 2600, 2650, 2672, 2696, 2730, 2750, 2782, 2866, 2955, 3137, 3300, 3440, 3493, 3565, 3582, 3631, 3735, 3791, 3946, 4013, 4194, 4251], '(694)': [496], 'Google': [497, 582, 597, 614, 631, 644, 659, 730, 747, 773, 795, 860, 873, 889, 927, 945, 1110, 1132, 1152, 1167, 1178, 1196, 1334, 1349, 1362, 1379, 1403, 1428, 1448, 1515, 1535, 1556, 1586, 1599, 1631, 1663, 1712, 1752, 1791, 1804, 1836, 1858, 1876, 1945, 1995, 2021, 2123, 2186, 2214, 2291, 2316, 2362, 2580, 2602, 2652, 2674, 2698, 2732, 2752, 2784, 2868, 2957, 3139, 3302, 3442, 3495, 3567, 3584, 3633, 3737, 3793, 3948, 4015, 4196, 4253], 'Scholar).': [498, 660, 796, 890, 946, 1197, 1557, 1632, 1664, 1713, 1753, 1877, 1946, 1996, 2022, 2124, 2187, 2317, 2363, 2603, 2733, 2753, 2785, 2869, 2958, 3140, 3303, 3443, 3496, 3585, 3738, 3794, 3949, 4016, 4197, 4254], 'However,': [499, 2154, 2426, 3507, 3877, 4092], 'cause': [503], 'cellular': [504], 'damage': [505], 'due': [506], 'its': [508, 1726, 2094], 'ability': [509], 'catalyze': [511], 'production': [513], 'free': [515, 672, 2831, 3771], 'radicals.': [516], 'To': [517], 'maintain': [518], 'integrity': [521], 'while': [522], 'ensuring': [523], 'adequate': [525], 'supply': [526], 'copper,': [528], 'organisms': [529], 'have': [530, 970, 979, 1007, 1016, 1210, 1220, 1253, 1263, 1472, 1559, 1668, 2241, 2389, 2403, 3897], 'developed': [531], 'complex': [533], 'molecular': [534], 'machinery': [535], 'mobilize': [537], 'This': [540, 2047, 2442, 2502, 2604, 3586, 4290], 'involves': [541], 'copper-dependent': [542], 'transcription': [543], 'factors,': [544], 'chelators': [545, 665], 'sequester': [547], 'excess': [549, 3239, 3516, 3597, 3831, 3907, 3986], 'metal,': [550], 'shuttle': [553], 'target': [556], 'proteins,': [557], 'transporters': [559], 'facilitate': [561], 'translocation': [563, 2279], 'across': [564, 715], 'membranes': [566, 716], '(3Lutsenko': [567], 'S.': [568, 754, 863, 930, 1185, 1367, 1416, 1500, 1612, 1648, 1697, 1817, 1843, 1926, 2104, 2561, 2633, 2938, 3548, 4234], 'LeShane': [569], 'E.S.': [570], 'Shinde': [571], 'U.': [572], 'Arch.': [573, 2282], 'Biochem.': [574, 1160, 2283, 2745, 2861, 3295], 'Biophys.': [575, 651, 2284], '2007;': [576, 591, 625, 724, 741, 921, 939, 1104, 1328, 1657, 2310, 2351, 2721, 3726, 3937], '463:': [577], '134-148Crossref': [578], '(111)': [581], '4Argüello': [584], 'J.M.': [585, 718, 758, 915, 1098, 1117, 1322, 1352, 1369, 1386, 1591, 1796, 1861, 1930, 1980, 2009, 2108, 2174, 2199, 2565, 2587, 2637, 2659, 2681, 2715, 2772, 2942, 3127, 3483, 3552, 3572, 3621, 3720, 3781, 3931, 4003, 4184, 4238], 'Eren': [586, 719, 751, 916, 1099, 1323, 1923, 2101, 2558, 2630, 2935, 3545, 4231], 'E.': [587, 720, 752, 917, 1100, 1324, 1502, 1924, 2102, 2343, 2559, 2611, 2631, 2936, 3546, 4232], 'González-Guerrero': [588, 721, 918, 1101, 1325, 1862], 'M.': [589, 722, 750, 919, 1102, 1326, 1606, 1610, 1811, 1815, 1863, 1922, 2007, 2100, 2172, 2296, 2557, 2629, 2705, 2770, 2934, 3125, 3481, 3544, 3570, 3619, 3710, 3779, 3921, 4001, 4182, 4230], 'Biometals.': [590, 723, 920, 1103, 1327], '20:': [592, 626, 725, 742, 922, 1105, 1329], '233-248Crossref': [593, 726, 923, 1106, 1330], '(264)': [596, 729, 926, 1109, 1333], '5Kim': [599], 'B.E.': [600], 'Nevitt': [601], 'T.': [602, 2345, 2965, 3040], 'Thiele': [603], 'D.J.': [604], 'Nat.': [605, 1547], 'Chem.': [606, 761, 787, 1120, 1188, 1391, 1574, 1619, 1700, 1779, 1824, 1846, 1933, 1983, 2111, 2202, 2350, 2568, 2590, 2640, 2662, 2686, 2720, 2945, 3555, 3725, 3936, 4241], 'Biol.': [607, 760, 1119, 1187, 1355, 1390, 1549, 1573, 1618, 1699, 1778, 1823, 1845, 1932, 1982, 2110, 2201, 2349, 2567, 2589, 2639, 2661, 2685, 2719, 2944, 3554, 3724, 3935, 4240], '2008;': [608, 638, 762, 1437, 1741, 1865, 1934, 2015, 2112, 2180, 2285, 2569, 2641, 2778, 2946, 3133, 3489, 3556, 3578, 3627, 3787, 4009, 4190, 4242], '4:': [609], '176-185Crossref': [610], '(910)': [613], '6Maryon': [616, 732], 'E.B.': [617, 733], 'Molloy': [618, 734], 'S.A.': [619, 735], 'Zimnicka': [620, 736], 'A.M.': [621, 737, 1135, 2298], 'Kaplan': [622, 738, 864], 'J.H.': [623, 739, 865], 'BioMetals.': [624, 740], '355-364Crossref': [627, 743], '(62)': [630, 746], '7Bird': [633], 'A.J.': [634, 2857, 3291], 'Adv.': [635], 'Microb.': [636], 'Physiol.': [637, 937, 1173, 1655], '53:': [639], '231-267Crossref': [640], '(16)': [643], '8Balamurugan': [646], 'K.': [647], 'Schaffner': [648], 'W.': [649], 'Biochim.': [650], 'Acta.': [652], '2006;': [653, 1146, 1373, 1392, 1422, 2687], '1763:': [654], '737-746Crossref': [655], '(183)': [658], 'Although': [661, 4043], 'ensures': [668], 'copper': [673], 'cell,': [676], 'creates': [679], 'need': [681, 3636], 'singular': [683], 'transporters.': [685], 'These,': [686], 'although': [687], 'structures': [689, 1716, 2235], 'similar': [690, 1483, 2328, 3847, 3972], 'alkali': [692], 'carriers': [694], 'pumps,': [696], 'should': [697, 808], 'possess': [698], 'distinct': [699], 'transport': [700, 799, 899, 2339, 2376, 2440, 3607], 'mechanisms': [701], 'deal': [703], 'protein-metal': [705], 'protein-protein': [707, 3616], 'affinity': [708, 2079, 2518, 3158], 'constants': [709], 'rather': [710], 'than': [711], 'concentration': [713, 3044], 'gradients': [714], '(4Argüello': [717, 914, 1097, 1321], '9González-Guerrero': [749], 'Rawat': [753, 1925, 2103, 2560, 2632, 2937, 3547, 4233], 'Stemmler': [755, 1927, 2105, 2562, 2634, 2710, 2939, 3549, 3715, 3926, 4235], 'T.L.': [756, 1137, 1928, 2106, 2563, 2635, 2711, 2940, 3550, 3716, 3927, 4236], 'Argüello': [757, 1116, 1368, 1385, 1590, 1795, 1929, 1979, 2008, 2107, 2173, 2198, 2564, 2586, 2636, 2658, 2680, 2714, 2771, 2941, 3126, 3482, 3551, 3571, 3620, 3719, 3780, 3930, 4002, 4183, 4237], 'J.': [759, 785, 851, 880, 1118, 1145, 1186, 1340, 1353, 1389, 1525, 1572, 1616, 1617, 1698, 1777, 1821, 1822, 1844, 1931, 1981, 2109, 2200, 2348, 2566, 2588, 2638, 2660, 2684, 2718, 2943, 3553, 3723, 3934, 4239], '283:': [763, 1935, 2113, 2570, 2642, 2947, 3557, 4243], '29753-29759Abstract': [764, 1936, 2114, 2571, 2643, 2948, 3558, 4244], 'Full': [765, 767, 1124, 1126, 1192, 1395, 1397, 1440, 1442, 1578, 1580, 1623, 1625, 1704, 1706, 1744, 1746, 1783, 1785, 1828, 1830, 1850, 1852, 1868, 1870, 1937, 1939, 1987, 1989, 2115, 2117, 2206, 2208, 2354, 2356, 2572, 2574, 2594, 2596, 2644, 2646, 2666, 2668, 2690, 2692, 2724, 2726, 2949, 2951, 3559, 3561, 3729, 3731, 3940, 3942, 4245, 4247], 'Text': [766, 768, 1125, 1127, 1193, 1396, 1398, 1441, 1443, 1579, 1581, 1624, 1626, 1705, 1707, 1745, 1747, 1784, 1786, 1829, 1831, 1851, 1853, 1869, 1871, 1938, 1940, 1988, 1990, 2116, 2118, 2207, 2209, 2355, 2357, 2573, 2575, 2595, 2597, 2645, 2647, 2667, 2669, 2691, 2693, 2725, 2727, 2950, 2952, 3560, 3562, 3730, 3732, 3941, 3943, 4246, 4248], 'PDF': [769, 1128, 1194, 1399, 1444, 1582, 1627, 1708, 1748, 1787, 1832, 1854, 1872, 1941, 1991, 2119, 2210, 2358, 2576, 2598, 2648, 2670, 2694, 2728, 2953, 3563, 3733, 3944, 4249], '(86)': [772, 1944, 2122, 2579, 2651, 2956, 3566, 4252], '10Xiao': [775], 'Z.': [776], 'Loughlin': [777], 'F.': [778, 1410, 1494], 'George': [779], 'G.N.': [780], 'Howlett': [781], 'G.J.': [782], 'Wedd': [783], 'A.G.': [784], 'Am.': [786], 'Soc.': [788, 1171], '2004;': [789, 1161, 1984, 2203], '126:': [790], '3081-3090Crossref': [791], '(220)': [794], 'Consequently,': [797, 2023], 'characteristics': [800], 'such': [801], 'as': [802, 2189, 2626, 2766], 'rate,': [803], 'specificity,': [804], 'energy': [805], 'requirement,': [806], 'etc.,': [807], 'be': [809, 2045, 2369, 3589, 3650, 4020, 4084], 'evaluated': [810], 'light': [812], 'these': [814, 1960, 2062, 3113, 3653, 4044], 'alternative': [815], 'paradigms.': [816], 'efflux.': [823], 'They': [824], 'members': [826], 'family': [831], 'ion': [833, 897], 'transporters,': [834], 'which': [835, 1303, 2037, 2509], 'includes': [837, 1304], 'well': [839, 1486, 2382], 'Ca2+-ATPases,': [841], 'Na+/K+-ATPases': [842], 'H+-ATPases,': [844], 'among': [845, 3142], 'others': [846], '(11Axelsen': [847], 'K.B.': [848, 1337], 'Palmgren': [849, 1338], 'M.G.': [850, 1339], 'Mol.': [852, 881, 1341], 'Evol.': [853, 882, 1342], '1998;': [854, 1343], '46:': [855, 1344], '84-101Crossref': [856, 1345], '(747)': [859, 1348], '12Lutsenko': [862], 'Biochemistry.': [866, 1372, 1528, 1592, 1797], '1995;': [867, 2862, 3296], '34:': [868], '15607-15613Crossref': [869], '(416)': [872], '13Fagan': [875], 'M.J.': [876], 'Saier': [877], 'Jr.,': [878], 'M.H.': [879, 1365, 1382, 2677, 2701, 3706, 3917], '1994;': [883], '38:': [884, 1176], '57-99Crossref': [885], '(146)': [888], 'As': [891], 'all': [892], 'ATPases,': [894], 'couple': [896], '(Cu+)': [898], 'hydrolysis': [902, 1035], 'ATP': [904, 1034, 1086], 'following': [905], 'elements': [908], 'classic': [911, 3691], 'Albers-Post': [912], 'cycle': [913, 2257], '14Lutsenko': [929], 'Barnes': [931, 1649], 'N.L.': [932, 1650], 'Bartee': [933, 1651], 'M.Y.': [934, 1652], 'Dmitriev': [935, 1653], 'O.Y.': [936, 1654], 'Rev.': [938, 1159, 1656], '87:': [940, 1658], '1011-1046Crossref': [941, 1659], '(560)': [944, 1662], 'Briefly,': [947], '2The': [957, 994], 'abbreviations': [958, 995], 'used': [959, 996, 2471, 3308], 'are:': [960, 997], 'TM-MBStransmembrane': [961, 998], 'siteBCAbicinchoninic': [963, 1000], 'acidΔN,C-CopACopA': [964, 1001], 'MBDsC2-CopACopA': [967, 1004], 'where': [968, 973, 1005, 1010, 1208, 1214, 1251, 1257, 3089, 3447, 3958, 4098], 'MBDs': [969, 1006, 1206, 1209, 1249, 1252, 1471, 1768, 3522, 3748, 3756, 4049], 'been': [971, 980, 1008, 1017, 1211, 1221, 1254, 1264], 'mutatedC2N-MBD-CopACopA': [972, 1009], 'Cys': [974, 1011, 1215, 1258, 1900], 'TM-MBSs': [976, 1013, 1051, 1072, 1217, 1260, 2001, 2074, 2396, 3542, 3646, 3817], 'C-MBD': [978, 1015, 1219, 1262, 3858, 3999], 'mutatedC0-CopACys-less': [981, 1018], 'CopAA-domainactuator': [982, 1019], 'domainATP-BDATP-binding': [983, 1020], 'domainP-domainphosphorylation': [984, 1021], 'domainN-domainnucleotide': [985, 1022], 'domainMBDmetal-binding': [986, 1023], 'domainBP': [987, 1024], 'fractionbound': [988, 1025], 'protein': [989, 992, 1026, 1029, 1236, 1239, 1279, 1282, 1672, 3007, 3050, 3071, 3234, 3285, 3449], 'fractionUP': [990, 1027], 'fractionunbound': [991, 1028], 'fraction.': [993, 1030, 1240, 1283], 'coupled': [1032], 'enzyme': [1037, 1042, 2224, 3640, 3810, 4273, 4293], 'phosphorylation': [1038, 1229, 1272, 1306, 2268, 4299], '(E1P(Cu+)2).': [1039], 'Subsequently,': [1040], 'undergoes': [1043], 'conformational': [1045, 2367], 'change': [1046], '(to': [1047], 'E2P)': [1048], 'leading': [1049], 'vesicular/extracellular': [1055], 'compartment': [1056], 'consequent': [1059], 'release.': [1061], 'Enzyme': [1062], 'dephosphorylation': [1063], 'allows': [1064], 'return': [1066], 'E1': [1069, 4296], 'facing': [1073], 'It': [1076], 'relevant': [1078], 'accelerated': [1084], '(or': [1087, 3478], 'ADP)': [1088], 'acting': [1089], 'low': [1091], 'affinity;': [1092], 'modulatory': [1095], 'mode': [1096], '15Mandal': [1112, 2582, 2654], 'A.K.': [1113, 1384, 1538, 1589, 1794, 1974, 2193, 2583, 2655, 2679], 'Cheung': [1114, 2584, 2656], 'W.D.': [1115, 2585, 2657], '2002;': [1121, 1509, 1575, 1780, 2591, 2663], '277:': [1122, 1576, 1781, 2592, 2664], '7201-7208Abstract': [1123, 2593, 2665], '(119)': [1131, 2601, 2673], '16Jensen': [1134], 'Sørensen': [1136], 'Olesen': [1138], 'C.': [1139, 1155, 1183, 2281, 2294, 2300, 2304, 2347], 'Møller': [1140, 2305], 'J.V.': [1141, 2306], 'Nissen': [1142, 2307], 'P.': [1143, 2308], 'EMBO': [1144], '25:': [1147], '2305-2314Crossref': [1148], '(164)': [1151], '17Toyoshima': [1154], 'Inesi': [1156], 'G.': [1157], 'Annu.': [1158], '73:': [1162], '269-292Crossref': [1163], '(294)': [1166], '18Glynn': [1169], 'I.M.': [1170], 'Gen.': [1172], 'Ser.': [1174], '1984;': [1175], '33-48PubMed': [1177], '19Post': [1180], 'R.L.': [1181], 'Hegyvary': [1182], 'Kume': [1184], '1972;': [1189], '247:': [1190], '6530-6540Abstract': [1191], 'site': [1200, 1243, 1967, 2170, 2931, 3963], 'bicinchoninic': [1201, 1244, 2852], 'acid': [1202, 1245, 2853, 3251, 3321, 3340], 'Cys-less': [1223, 1266], 'actuator': [1225, 1268, 1296], 'ATP-binding': [1227, 1270, 1300], 'bound': [1235, 1278, 2002, 2071, 3049, 3369], 'fraction': [1237, 1280, 3072, 3082], 'unbound': [1238, 1281, 3047, 3070, 3312, 3360], 'consist': [1285], 'eight': [1287], 'helices,': [1289], 'cytosolic': [1292], 'loops': [1293], 'comprising': [1294], '(A)': [1297], '(ATP-BD),': [1302], '(P)': [1307], '(N)': [1310], '(MBDs)': [1316], 'terminus': [1320, 3663], '11Axelsen': [1336], '20Argüello': [1351], 'Membr.': [1354], '195:': [1357], '93-108Crossref': [1358], '(219)': [1361], '21Sazinsky': [1364], 'Agarwal': [1366], 'Rosenzweig': [1370, 1387, 1545, 2682, 2716, 3721, 3932], 'A.C.': [1371, 1388, 1546, 2683, 2717, 3722, 3933], '45:': [1374], '9949-9955Crossref': [1375], '(56)': [1378], '22Sazinsky': [1381, 2676], 'Mandal': [1383, 2678], '281:': [1393, 2688], '11161-11166Abstract': [1394, 2689], '(81)': [1402, 2697], '23Dmitriev': [1405], 'O.': [1406], 'Tsivkovskii': [1407], 'R.': [1408, 1523, 1693, 1839, 2707, 3712, 3923], 'Abildgaard': [1409], 'Morgan': [1411], 'C.T.': [1412], 'Markley': [1413], 'J.L.': [1414], 'Lutsenko': [1415, 1665, 1696, 1842], 'Proc.': [1417, 2010, 2175, 2773, 3128, 3484, 3573, 3622, 3782, 4004, 4185], 'Natl.': [1418, 2011, 2176, 2774, 3129, 3485, 3574, 3623, 3783, 4005, 4186], 'Acad.': [1419, 2012, 2177, 2775, 3130, 3486, 3575, 3624, 3784, 4006, 4187], 'Sci.': [1420, 2013, 2178, 2776, 3131, 3487, 3576, 3625, 3785, 4007, 4188], 'U.S.A.': [1421, 2014, 2179, 2777, 3132, 3488, 3577, 3626, 3786, 4008, 4189], '103:': [1423], '5302-5307Crossref': [1424], '(100)': [1427, 1534], '24Wu': [1430], 'C.C.': [1431, 1735], 'Rice': [1432, 1736], 'W.J.': [1433, 1737], 'Stokes': [1434, 1738], 'D.L.': [1435, 1504, 1540, 1739], 'Structure.': [1436, 1740, 1864], '16:': [1438, 1742, 1866], '976-985Abstract': [1439, 1743], '(67)': [1447, 1751, 1994, 2213], 'Scholar)': [1449], '(see': [1450, 1918], 'Fig.': [1451, 1919, 3084], '1).': [1452, 3876, 3989], 'number': [1454, 2896], 'N-MBDs': [1456, 1558, 1677, 3306, 3602], 'varies': [1457], 'one': [1459, 3745, 3814, 3855, 3863, 4026], 'bacteria': [1461], 'archaea': [1463], 'six': [1465, 1676, 1885, 3905], 'higher': [1467, 3873], 'eukaryote': [1468], 'Cytoplasmic': [1470, 1997], 'conserved': [1474, 1886], 'βαββαβ': [1475], 'fold': [1476], 'invariant': [1479], 'CXXC': [1480], 'sequence': [1482], 'described': [1487, 2627, 2768, 4080, 4094], 'Cu+-chaperones,': [1488], 'Atox1,': [1489], 'Atx1,': [1490], '(25Arnesano': [1493], 'Banci': [1495], 'L.': [1496, 1518], 'Bertini': [1497, 1519], 'I.': [1498, 1520, 1602, 1807], 'Ciofi-Baffoni': [1499], 'Molteni': [1501], 'Huffman': [1503, 1539], "O'Halloran": [1505, 1543], 'T.V.': [1506, 1544], 'Genome': [1507], 'Res.': [1508], '12:': [1510], '255-271Crossref': [1511], '(232)': [1514], '26Banci': [1517], 'Del': [1521], 'Conte': [1522], 'Markey': [1524], 'Ruiz-Dueñas': [1526], 'F.J.': [1527], '2001;': [1529, 1701, 1847], '40:': [1530], '15660-15668Crossref': [1531], '27Wernimont': [1537], 'Lamb': [1541], 'A.L.': [1542], 'Struct.': [1548], '2000;': [1550], '7:': [1551], '766-771Crossref': [1552], '(350)': [1555], 'role': [1562, 1765], 'controlling': [1563], 'transporter': [1565], 'turnover': [1566], 'rate': [1567], '(28Fan': [1568, 1773], 'B.': [1569, 1774, 2703, 3708, 3919], 'Rosen': [1570, 1775], 'B.P.': [1571, 1776], '46987-46992Abstract': [1577, 1782], '(110)': [1585, 1790], '29Mandal': [1588, 1793], '42:': [1594, 1799], '11040-11047Crossref': [1595, 1800], '(89)': [1598, 1803], '30Voskoboinik': [1601, 1806], 'Strausak': [1603, 1808], 'D.': [1604, 1809], 'Greenough': [1605, 1810], 'Brooks': [1607, 1812], 'Petris': [1609, 1814], 'Smith': [1611, 1816], 'Mercer': [1613, 1818], 'J.F.': [1614, 1819], 'Camakaris': [1615, 1820], '1999;': [1620, 1825], '274:': [1621, 1826], '22008-22012Abstract': [1622, 1827], '(102)': [1630, 1835], 'addition,': [1634], 'they': [1635, 4062], 'important': [1640], 'sorting': [1641], 'observed': [1644, 2404], 'eukaryotes': [1646], '(14Lutsenko': [1647], 'collaborators': [1667], 'shown': [1669, 2191, 2242, 4212], 'construct': [1673, 2605, 3957], 'containing': [1674, 2801, 3176, 3754], 'present': [1678, 3067, 3078, 3700, 3818], 'human': [1681], 'ATP7B': [1682], 'interacts': [1684], 'ATP-BD': [1687, 1733, 2253, 2431, 3163], 'Cu+-dependent': [1690, 1770, 1970], 'manner': [1691], '(31Tsivkovskii': [1692], 'MacArthur': [1694, 1840], 'B.C.': [1695, 1841], '276:': [1702, 1848], '2234-2242Abstract': [1703, 1849], '(136)': [1711, 1857], 'Recently': [1714], 'obtained': [1715, 2539, 2789, 3230], 'show': [1721, 4104], 'physical': [1723], 'proximity': [1724], 'between': [1725, 2028], 'N-MBD,': [1728], 'A-domain,': [1730], '(24Wu': [1734], 'These': [1754, 2261], 'observations': [1756], 'could': [1757, 3588, 4019, 4082], 'provide': [1758, 4065], 'structural': [1760], 'basis': [1761], 'via': [1769], 'domain-domain': [1771, 3210], 'interactions': [1772], '31Tsivkovskii': [1838], '32Argüello': [1860], '833-834Abstract': [1867], '(12)': [1875], 'Transmembrane': [1878], 'helices': [1879], 'H6,': [1880], 'H7,': [1881, 1912], 'H8': [1883], 'contain': [1884], 'amino': [1887], 'acids': [1888], 'transport:': [1897], 'TM-MBS-I': [1898], '(two': [1899], 'H6': [1902], 'Tyr': [1905], 'H7)': [1907], 'TM-MBS-II': [1909], '(Asn': [1910], 'Ser': [1913], 'Met': [1915], 'H8)': [1917], '1)': [1920], '(9González-Guerrero': [1921, 2099, 2556, 2628, 2933, 3543, 4229], 'Both': [1947, 2073], 'coordinate': [1949], 'trigonal': [1953], 'planar': [1954], 'geometry.': [1955], 'Mutation': [1956], 'any': [1958, 4223], 'residues': [1961], 'removes': [1962], 'corresponding': [1966, 2399, 2891], 'precludes': [1969], 'partial': [1971, 3886], 'reactions': [1972], '(33Mandal': [1973, 2192], 'Yang': [1975, 2194], 'Y.': [1976, 2195, 2341], 'Kertesz': [1977, 2196], 'T.M.': [1978, 2197], '279:': [1985, 2204], '54802-54807Abstract': [1986, 2205], 'accesses': [1999], 'specific': [2004, 2025, 3639], '(34González-Guerrero': [2006, 2171, 2769, 3124, 3480, 3618, 3778, 4000, 4181], '105:': [2016, 2181, 2779, 3134, 3490, 3579, 3628, 3788, 4010, 4191], '5992-5997Crossref': [2017, 2182, 2780, 3135, 3491, 3580, 3629, 3789, 4011, 4192], '(187)': [2020, 2185, 2783, 3138, 3494, 3583, 3632, 3792, 4014, 4195], 'transient': [2026], 'metal-loaded': [2030], 'chaperone': [2031, 2070], 'delivered': [2041], 'predicted.': [2046], 'associated': [2051], 'N-MBDs,': [2060], 'because': [2061, 3610], 'required': [2065, 2222, 2370, 2433], 'activation': [2068], 'Cu+.': [2072], 'high': [2078], '(KaI': [2080], '=': [2081, 2088, 4125, 4174], '1.12': [2082], '±': [2083, 2090, 4122, 4130, 4137, 4139, 4141, 4143, 4145, 4147, 4149, 4152, 4154, 4157, 4159, 4163, 4165, 4171], '0.25': [2084], 'fM−1,': [2085], 'KaII': [2087], '1.3': [2089], '0.22': [2091], 'fM−1)': [2092], 'preventing': [2093], 'backward': [2095], 'release': [2096, 3769, 4303], 'cytoplasm': [2098], 'Thus,': [2125, 3497, 4017], 'saturation': [2126, 2422], 'easily': [2131], 'achieved': [2132], 'during': [2133, 2254, 2338, 3112, 3773], 'equilibrium': [2134, 2162, 3513, 3679, 3900, 3973], 'assays': [2137, 2875, 3114, 3765], 'purified': [2140], 'micellar': [2141], 'proteins': [2142, 2622, 3019, 3065, 3361, 3368, 3740], '"free"': [2144, 4209], 'ion;': [2146], 'chaperones.': [2153], 'chaperone-mediated': [2155, 2372], 'under': [2161, 3512, 3678, 3846], 'conditions': [2163, 3329, 3514, 3681], 'leads': [2164], 'If,': [2188], 'previously': [2190, 2551, 2767], 'Scholar),': [2215, 3634], 'turnover,': [2225], 'how': [2226], 'then': [2228], 'loaded?': [2232], 'High': [2233], 'resolution': [2234], 'sarcoplasmic': [2238], 'reticulum': [2239], 'Ca2+-ATPase': [2240], 'movements': [2245], 'coordinated': [2247], 'A-domain': [2251, 2486, 3165], 'catalytic': [2256, 2262], 'events': [2263], 'driven': [2264], 'binding,': [2267, 2275], 'dephosphorylation,': [2270], 'occlusion,': [2277], '(35Toyoshima': [2280], '476:': [2286], '3-11Crossref': [2287], '(179)': [2290], '36Olesen': [2293], 'Picard': [2295], 'Winther': [2297], 'Gyrup': [2299], 'Morth': [2301], 'J.P.': [2302], 'Oxvig': [2303], 'Nature.': [2309, 3435], '450:': [2311], '1036-1042Crossref': [2312], '(373)': [2315], 'limited': [2320], 'proteolysis': [2321], 'Thermotoga': [2323], 'maritima': [2324], 'suggest': [2326], 'rearrangements': [2331], 'occur': [2333], 'heavy': [2335], 'ATPases': [2337], '(37Hatori': [2340], 'Majima': [2342], 'Tsuda': [2344], 'Toyoshima': [2346], '282:': [2352, 2722, 3727, 3938], '25213-25221Abstract': [2353], '(39)': [2361], 'Could': [2364], 'ligand-driven': [2366], 'transitions': [2368], 'loading': [2374, 3275, 3978, 4071], 'sites?': [2377], 'Employing': [2378], 'simple': [2380], 'A.': [2384, 2465, 3666, 3671, 3702], 'CopA,': [2387], 'further': [2390], 'explored': [2391], 'into': [2395, 2506, 2522, 4294], 'chaperone,': [2400], 'CopZ.': [2401], 'We': [2402, 3896, 4076], 'equilibria': [2407], '(Ct-CopZ·Cu+': [2411], '+': [2412, 2416], 'TM-MBDs': [2413, 3504, 4206], '→': [2414], 'TM-MBDs·Cu+)': [2417], 'fully': [2419, 3994], 'displaced': [2420], 'toward': [2421], 'site.': [2441], 'only': [2444, 3063, 3075, 3871, 3912, 3960, 3975], 'affects': [2445], 'CopZ-mediated': [2447], 'but': [2452, 3694, 4298], 'disrupts': [2454], 'N-MBD': [2461, 3170, 3217, 3228, 3477, 3910, 3967, 3980, 4039], 'ATP-BD.': [2463], 'this': [2473, 3774, 3880, 4106, 4276, 4307], 'work': [2474], 'listed': [2476], 'supplemental': [2479], 'Table': [2480, 3795], 'S1.': [2481], 'cDNA': [2482, 2494], 'coding': [2483], 'was': [2489, 2504, 2529, 2606, 2788, 2833, 2961, 2969, 2981, 3001, 3008, 3058, 3077, 3229, 3263, 3276, 3307, 3322, 3418, 3451, 3964, 4132, 4177, 4260], 'amplified': [2490], 'PCR': [2496], 'primers': [2498], '5′-ATGGGGGAGGCCATAAAGAAGCTCGTA-3′': [2499], '5′-GCCCATCGCGTCCTCGACCAGCTT-3′.': [2501], 'DNA': [2503, 2537], 'cloned': [2505, 2552], 'pBAD/TOPO': [2507], 'vector,': [2508], 'introduces': [2510], 'hexahistidine': [2513], 'tag': [2514], 'suitable': [2515], 'Ni2+': [2517], 'purification,': [2519], 'transformed': [2521, 2608], 'Escherichia': [2523], 'coli': [2524, 2612], 'Top10': [2525], 'cells.': [2526], 'S715A': [2527, 2547], 'C2N-MBD-CopA': [2528], 'result': [2531, 3881], 'ligation': [2534], 'fragments': [2538], 'HindIII': [2542], 'BsmI': [2544], 'digestion': [2545], 'C2-CopA': [2548, 2914], 'Wt-CopA': [2550, 3869, 4025], 'pCRT7/NT-TOPO': [2554], 'vector': [2555], 'subsequently': [2607], 'B127(DE3)pLysS': [2610], 'cells': [2613], '(Invitrogen).': [2614], 'Expression': [2615], 'purification': [2617], 'membrane': [2619], 'soluble': [2621, 3683], 'were': [2623, 2736, 2764, 2876, 3020, 3052, 3066, 3087, 3095, 3147, 3171, 3212, 3330, 3333, 3373, 3445, 3676, 4281], 'carried': [2624, 2877], 'out': [2625, 2878], '38Sazinsky': [2700], 'LeMoine': [2702, 3707, 3918], 'Orofino': [2704, 3709, 3920], 'Davydov': [2706, 3711, 3922], 'Bencze': [2708, 3713, 3924], 'K.Z.': [2709, 3714, 3925], 'Hoffman': [2712, 3717, 3928], 'B.M.': [2713, 3718, 3929], '25950-25959Abstract': [2723, 3728, 3939], '(27)': [2731, 3736, 3947], 'Protein': [2734, 3041, 3410], 'determinations': [2735], 'accordance': [2739], 'Bradford': [2741], '(39Bradford': [2742], 'M.M.': [2743], 'Anal.': [2744, 2860, 3294], '1976;': [2746], '72:': [2747], '248-254Crossref': [2748], '(214455)': [2751], 'Strep-tagged': [2757, 3169], 'different': [2760, 4272], 'His-tagged': [2761, 3162], 'Cu+-loaded': [2786, 2838, 3090, 3216, 3227, 3305, 3661], 'incubating': [2791, 2880, 3232], 'CuSO4': [2797, 3241], 'buffer': [2800, 2964, 2999, 3026, 3039, 3175], '25': [2802, 3177, 3243], 'HEPES,': [2804], 'pH': [2805, 3180, 3246], '8.0,': [2806, 3181], '500': [2807], 'NaCl,': [2809, 3184], '10': [2810, 3195, 3248, 3253, 3344], 'ascorbic': [2812, 3250], 'acid,': [2813], '0.01%': [2815, 2817], 'n-dodecyl-β-d-maltopyranoside,': [2816], 'asolectin': [2818], '(Buffer': [2819, 3192], 'T)': [2820], 'at': [2821, 2985, 3012, 3197, 3255, 3346, 3351, 3965], 'room': [2822, 2986, 3198, 3256, 3347], 'temperature': [2823, 2987, 3199, 3257, 3348], '5': [2825, 2881, 2989, 3189, 3220, 3355, 3379], 'min': [2826, 3196, 3254, 3345, 3356], 'gentle': [2828, 3201, 3259], 'agitation.': [2829, 3202, 3260], 'No': [2830], 'detected': [2834], 'after': [2835, 3310], 'passing': [2836, 3266], 'through': [2840, 3267, 3615], 'Sephadex': [2842, 3269], 'G-25': [2843, 3270], 'column': [2844, 3271], '(Sigma)': [2845], 'measuring': [2847, 3279], 'levels': [2849], '(BCA)': [2854], 'assay': [2855, 2974, 3225, 3289], '(40Brenner': [2856, 3290], 'Harris': [2858, 3292], 'E.D.': [2859, 3293], '226:': [2863, 3297], '80-84Crossref': [2864, 3298], '(169)': [2867, 3301], 'Except': [2870], 'when': [2871, 2976, 3327], 'indicated,': [2872], 'μm': [2882, 2908, 2922, 3161, 3168, 3319], 'indicated': [2884, 4046], 'concentrations': [2888], '1.5': [2893, 3985], 'times': [2894, 3829, 3906], 'Cu+-binding': [2898, 2918], 'construct;': [2904], 'example,': [2906], '15': [2907], 'case': [2912], '(which': [2915, 2926], 'has': [2916, 2927, 4211], 'sites)': [2919], '7.5': [2921], 'C0-CopA': [2925], 'remaining)': [2932], 'ADP-MgCl2': [2968, 3222], 'included': [2970, 3741], 'media': [2975], 'effect': [2978], 'tested.': [2982], 'Following': [2983], 'incubation': [2984], 'min,': [2990], '150': [2991, 3402], 'μl': [2992, 3337, 3377, 3387, 3400], 'Strep-Tactin': [2994], 'resin': [2995, 3341, 3372], '(IBA)': [2996], 'pre-equilibrated': [2997], 'T': [3000], 'added': [3002, 3323], 'Ct-CopZ.': [3005], 'Unbound': [3006, 3261], 'separated': [3009], 'centrifugation': [3011], '14,000': [3013, 3352], 'rpm': [3014, 3353], '2': [3016], 'min.': [3017], 'Resin-bound': [3018], 'washed': [3021, 3374], '1': [3023, 3796], 'ml': [3024, 3033], 'T,': [3027], 'followed': [3028, 3395, 4300], 'elution': [3030, 3081, 3397], '0.5': [3032], 'desthiobiotin': [3037], 'fractions': [3051, 3417], 'determined.': [3053], 'SDS-PAGE': [3054, 3421], '(15%': [3055], 'acrylamide': [3056, 3424], 'gel)': [3057], 'verify': [3061], 'CopA-derived': [3064], '(supplemental': [3083], 'S1).': [3085], 'Controls': [3086, 3444], 'individually': [3096, 3452], 'subjected': [3097, 3453], 'same': [3100, 3456], 'procedures;': [3101, 3457], 'partner': [3105], 'protein.': [3106], 'Previously': [3107, 3762], 'reported': [3108, 3763, 3898], 'results': [3109, 3836, 4081], 'no': [3115, 3767], 'significant': [3116], 'amount': [3117], 'released': [3121], 'Interactions': [3141], 'studied': [3148], 'assessing': [3150], 'co-purification': [3152], 'isolated': [3154], 'batch': [3157], 'chromatography.': [3159], '20': [3160, 3336, 3389], '40': [3167], 'incubated': [3172, 3334], 'Tris-HCl,': [3179, 3245], '250': [3182], '50': [3185, 3399], 'sucrose,': [3187], 'dithiothreitol': [3191], 'I)': [3193], 'effects': [3204], 'nucleotides': [3208], 'on': [3209], 'investigated': [3213], 'including': [3219], 'media.': [3226], 'five': [3237, 3828], 'molar': [3238, 3525, 3830], '7.5,': [3247], 'removed': [3264], '(Sigma).': [3272], 'Efficient': [3273], 'verified': [3277], 'content': [3281, 3411], 'eluted': [3284], 'BCA': [3288], 'immediately': [3309], 'removing': [3311], 'minimize': [3315], 'dissociation.': [3317], '200': [3318, 3376, 3386], 'bathocuproindesidulfonic': [3320], 'reaction': [3326], 'Cu+-free': [3328], 'required.': [3331], 'Samples': [3332], 'Ni2+-nitrilotriacetic': [3339], '(Qiagen)': [3342], 'centrifuged': [3350], 'collect': [3358], 'supernatant': [3364], '(UP': [3365], 'fraction).': [3366, 3409], 'imidazole': [3381, 3391, 3404], 'Buffer': [3383, 3393, 3406], 'I': [3384, 3407], 'I,': [3394], '(BP': [3408], 'UP': [3414], 'BP': [3416], 'analyzed': [3419], '15%': [3423], 'gels': [3425], 'visualized': [3427], 'Coomassie': [3429], 'Brilliant': [3430], 'Blue': [3431], 'staining': [3432], '(41Laemmli': [3433], 'U.K.': [3434], '1970;': [3436], '227:': [3437], '680-685Crossref': [3438], '(206631)': [3441], 'each': [3448, 4090], 'interacting': [3461], 'partner.': [3462], 'Activation': [3463], 'functionality': [3474], 'C-MBD)': [3479], 'chaperones': [3498], 'directly': [3501], 'Cu+-ATPases.': [3506], '(CopZ·Cu+:ΔN,C-CopA,': [3523], '3:1': [3524], 'ratio)': [3526], 'apparently': [3534], 'site,': [3537], 'albeit': [3538], 'there': [3539], '34González-Guerrero': [3569], 'observation': [3587], 'explained': [3590, 4085], 'requirement': [3593], 'larger': [3596], 'chaperone·Cu+': [3599, 3648], 'functional': [3601], 'sites.': [3608], 'Alternatively,': [3609], 'occurs': [3614], 'conformation': [3641, 4228], 'able': [3642], 'open': [3644], 'postulated.': [3651], 'Testing': [3652, 4275], 'hypotheses,': [3654], 'measured': [3656], 'C': [3662], 'constructs.': [3674], 'Assays': [3675], '(non-turnover)': [3680], '(micellar)': [3684], 'forms': [3685], 'CopA.': [3687], 'contains': [3689], 'structure': [3693], 'lacks': [3695], 'ferredoxin-like': [3697], '(38Sazinsky': [3705, 3916], 'Wt-CopA,': [3742], '(ΔN,C-CopA': [3749], 'ΔN-CopA),': [3751], 'unable': [3757], '(C2-CopA).': [3761], 'control': [3764], 'appreciable': [3768], 'type': [3775], 'experiment': [3777], 'shows': [3797], 'agreement': [3800], 'our': [3802], 'previous': [3803], 'observations,': [3804], 'ligand': [3811, 4224], 'transferred': [3813], 'ΔN,C-CopA': [3820], 'C2-CopA.': [3822], 'up': [3826], 'yielded': [3834, 3911], 'identical': [3835], '(not': [3837, 3888], 'shown).': [3838], 'Further': [3839], 'supporting': [3840], 'conditions,': [3848], 'ΔN-CopA': [3849], 'accepted': [3850], 'Ct-CopZ·Cu+,': [3854], 'slightly': [3872], 'values': [3874], '(Table': [3875, 3988], 'analysis': [3878], 'complicated': [3883], 'stoichiometric)': [3889], 'N-MBD.': [3895], 'exchange': [3901], 'CopZ·Cu+': [3908, 3993], '35%': [3913], 'N-MBD·Cu+': [3915], 'Control': [3950], 'full-length': [3955], 'remaining': [3961], '(S715A': [3968], 'C2N-MBD-CopA)': [3969], '24–34%': [3976], 'On': [3990], 'contrary,': [3992], 'assumed': [4021], 'occupies': [4028], 'C-MBD,': [4030], 'TM-MBS,': [4036], 'partially': [4041], 'occupied.': [4042], 'data': [4045], 'indeed': [4051], 'necessary': [4053], 'delivery': [4056], 'TM-MBDs,': [4061], 'do': [4063], 'explanation': [4067], 'realize': [4077], '50%': [4087], 'below,': [4095], 'available,': [4103], 'case.TABLE': [4110], '1Cu+': [4111], 'Ct-CopZConstructCu+': [4116], 'ions/CopA': [4117], 'moleculeaValues': [4118], 'mean': [4121, 4170], 'S.E.': [4123, 4172], '(n': [4124, 4173], '3).No': [4126], 'nucleotide2.5': [4127], 'ADP-MgCl2ΔN,C-CopA0.8': [4129], '0.1bDatum': [4131], 'published': [4133, 4178], 'Ref.': [4135, 4180], '(34).1.8': [4136], '0.2C2-CopA1.1': [4138], '0.21.9': [4140], '0.1ΔN-CopA1.9': [4142], '0.22.9': [4144], '0.3Wt-CopA2.2': [4146], '0.13.1': [4148], '0.1S715A': [4150], 'C2N-MBD-CopA0.2': [4151], '0.20.3': [4153], '0.1N683A': [4155], 'C0-CopA0.1': [4156], '0.00.0': [4158], '0.0ΔN-CopA/Ct-CopZ1:2': [4160], 'ratio1:3': [4161], 'ratio2.0': [4162], '0.12.8': [4164], '0.1a': [4166], 'Values': [4167], '3).b': [4175], 'Datum': [4176], 'Open': [4198], 'table': [4199], 'new': [4202], 'tab': [4203], 'Loading': [4204], 'accept': [4216], 'particular': [4227], 'Despite': [4255], 'this,': [4256], 'certain': [4258], 'possibility': [4259], 'conformation.': [4274], 'hypothesis,': [4277], 'ADP-Mg2+.': [4289], 'drives': [4291], 'conformation,': [4297], 'cannot': [4304], 'occur.': [4305], 'Under': [4306], 'condit': [4308]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1988123037', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-31T07:53:48.306404', 'created_date': '2016-06-24'}