Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1988100478', 'doi': 'https://doi.org/10.1371/journal.pone.0092845', 'title': 'Cellular Processing of Myocilin', 'display_name': 'Cellular Processing of Myocilin', 'publication_year': 2014, 'publication_date': '2014-04-14', 'ids': {'openalex': 'https://openalex.org/W1988100478', 'doi': 'https://doi.org/10.1371/journal.pone.0092845', 'mag': '1988100478', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24732711', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3986080'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0092845', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092845&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092845&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101886709', 'display_name': 'Ye Qiu', 'orcid': 'https://orcid.org/0000-0001-9182-1952'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ye Qiu', 'raw_affiliation_strings': ['Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I39422238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064435573', 'display_name': 'Xiang Shen', 'orcid': 'https://orcid.org/0000-0003-0702-6847'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiang Shen', 'raw_affiliation_strings': ['Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I39422238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020929451', 'display_name': 'Rajalekshmy Shyam', 'orcid': 'https://orcid.org/0000-0003-2154-4173'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rajalekshmy Shyam', 'raw_affiliation_strings': ['Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I39422238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045591905', 'display_name': 'Beatrice Y.J.T. Yue', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Beatrice Y. J. T. Yue', 'raw_affiliation_strings': ['Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I39422238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064689576', 'display_name': 'Hongyu Ying', 'orcid': 'https://orcid.org/0000-0001-5154-4233'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hongyu Ying', 'raw_affiliation_strings': ['Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I39422238']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 2.455, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.999865, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '9', 'issue': '4', 'first_page': 'e92845', 'last_page': 'e92845'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10250', 'display_name': 'Global Prevalence and Treatment of Glaucoma', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10250', 'display_name': 'Global Prevalence and Treatment of Glaucoma', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation in Health and Disease', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Mechanisms of Intracellular Membrane Trafficking', 'score': 0.9878, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/myocilin', 'display_name': 'Myocilin', 'score': 0.99852043}, {'id': 'https://openalex.org/keywords/protein-glycosylation', 'display_name': 'Protein Glycosylation', 'score': 0.489651}], 'concepts': [{'id': 'https://openalex.org/C2781147369', 'wikidata': 'https://www.wikidata.org/wiki/Q18029808', 'display_name': 'Myocilin', 'level': 4, 'score': 0.99852043}, {'id': 'https://openalex.org/C2781121420', 'wikidata': 'https://www.wikidata.org/wiki/Q750873', 'display_name': 'Trabecular meshwork', 'level': 3, 'score': 0.7510377}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.7113485}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.642008}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.6377238}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.5612437}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.52476287}, {'id': 'https://openalex.org/C16613235', 'wikidata': 'https://www.wikidata.org/wiki/Q285982', 'display_name': 'Endogeny', 'level': 2, 'score': 0.4741789}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.45371825}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45043612}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39228046}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.32144254}, {'id': 'https://openalex.org/C2778527774', 'wikidata': 'https://www.wikidata.org/wiki/Q159701', 'display_name': 'Glaucoma', 'level': 2, 'score': 0.2060208}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16911691}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14768332}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13236618}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.10187781}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003598', 'descriptor_name': 'Cytoskeletal Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005136', 'descriptor_name': 'Eye Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014129', 'descriptor_name': 'Trabecular Meshwork', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D014129', 'descriptor_name': 'Trabecular Meshwork', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003598', 'descriptor_name': 'Cytoskeletal Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D003598', 'descriptor_name': 'Cytoskeletal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005136', 'descriptor_name': 'Eye Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D005136', 'descriptor_name': 'Eye Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008027', 'descriptor_name': 'Light', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014129', 'descriptor_name': 'Trabecular Meshwork', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014129', 'descriptor_name': 'Trabecular Meshwork', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0092845', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092845&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/b3cef52033db498fa78bae00798ed59f', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3986080', 'pdf_url': 'https://europepmc.org/articles/pmc3986080?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Cellular_Processing_of_Myocilin/10761263', 'pdf_url': 'https://figshare.com/ndownloader/files/19273238', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois at Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois at Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986080', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24732711', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0092845', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092845&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.48, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 72, 'referenced_works': ['https://openalex.org/W1494673328', 'https://openalex.org/W1529963958', 'https://openalex.org/W1595351482', 'https://openalex.org/W1670364606', 'https://openalex.org/W1878275597', 'https://openalex.org/W1966415110', 'https://openalex.org/W1969342645', 'https://openalex.org/W1970149009', 'https://openalex.org/W1970905846', 'https://openalex.org/W1973646189', 'https://openalex.org/W1974778184', 'https://openalex.org/W1975915706', 'https://openalex.org/W1976481038', 'https://openalex.org/W1987769185', 'https://openalex.org/W1988156393', 'https://openalex.org/W1988326309', 'https://openalex.org/W1988924514', 'https://openalex.org/W2002868732', 'https://openalex.org/W2006520238', 'https://openalex.org/W2008128102', 'https://openalex.org/W2011647356', 'https://openalex.org/W2012915144', 'https://openalex.org/W2013769968', 'https://openalex.org/W2016299657', 'https://openalex.org/W2021242983', 'https://openalex.org/W2025665129', 'https://openalex.org/W2027673202', 'https://openalex.org/W2031214260', 'https://openalex.org/W2031264242', 'https://openalex.org/W2035107735', 'https://openalex.org/W2035641748', 'https://openalex.org/W2036220628', 'https://openalex.org/W2036494014', 'https://openalex.org/W2037652817', 'https://openalex.org/W2043187960', 'https://openalex.org/W2045733021', 'https://openalex.org/W2050634569', 'https://openalex.org/W2054296302', 'https://openalex.org/W2054424245', 'https://openalex.org/W2060909830', 'https://openalex.org/W2064417092', 'https://openalex.org/W2065515567', 'https://openalex.org/W2069778339', 'https://openalex.org/W2071749662', 'https://openalex.org/W2072778722', 'https://openalex.org/W2074911710', 'https://openalex.org/W2075286956', 'https://openalex.org/W2079080309', 'https://openalex.org/W2083161608', 'https://openalex.org/W2084719535', 'https://openalex.org/W2087910285', 'https://openalex.org/W2091001685', 'https://openalex.org/W2100159037', 'https://openalex.org/W2110310702', 'https://openalex.org/W2129856680', 'https://openalex.org/W2133149402', 'https://openalex.org/W2133749776', 'https://openalex.org/W2133989466', 'https://openalex.org/W2144370836', 'https://openalex.org/W2145192598', 'https://openalex.org/W2150123812', 'https://openalex.org/W2153168892', 'https://openalex.org/W2154602568', 'https://openalex.org/W2154886355', 'https://openalex.org/W2158230021', 'https://openalex.org/W2161526079', 'https://openalex.org/W2170642535', 'https://openalex.org/W2172238326', 'https://openalex.org/W2327494097', 'https://openalex.org/W2415876914', 'https://openalex.org/W29733925', 'https://openalex.org/W4240661191'], 'related_works': ['https://openalex.org/W996076411', 'https://openalex.org/W2992070878', 'https://openalex.org/W2400923798', 'https://openalex.org/W2399685746', 'https://openalex.org/W2126692750', 'https://openalex.org/W2081232316', 'https://openalex.org/W2054083019', 'https://openalex.org/W2031214260', 'https://openalex.org/W1992282721', 'https://openalex.org/W1487304615'], 'abstract_inverted_index': {'Background': [0], 'Myocilin': [1], '(MYOC)': [2], 'is': [3, 190, 194], 'a': [4, 71], 'gene': [5], 'linked': [6], 'directly': [7], 'to': [8, 102], 'juvenile-': [9], 'and': [10, 19, 56, 91, 126, 129, 142, 150, 178, 192], 'adult-onset': [11], 'open': [12], 'angle': [13], 'glaucoma.': [14, 214], 'Mutations': [15], 'including': [16], 'Pro370Leu': [17], '(P370L)': [18], 'Gln368stop': [20], '(Q368X)': [21], 'have': [22], 'been': [23], 'identified': [24], 'in': [25, 37, 46, 64, 82, 106, 167, 206], 'patients.': [26], 'In': [27, 116], 'the': [28, 33, 61, 78, 107, 120, 171, 187, 198], 'present': [29], 'study,': [30], 'we': [31], 'investigated': [32], 'processing': [34], 'of': [35, 89, 123, 154, 173, 197, 208], 'myocilin': [36, 63, 80, 108, 113, 175, 182, 203], 'human': [38, 65], 'trabecular': [39, 66], 'meshwork': [40, 67], '(TM)': [41, 68], 'cells': [42, 69, 84], 'as': [43, 45], 'well': [44], 'inducible,': [47], 'stable': [48], 'RGC5': [49], 'cell': [50, 118], 'lines.': [51], 'Methodology/Principal': [52], 'Findings': [53], 'The': [54, 137, 161], 'turnover': [55, 121, 172], 'photoactivation': [57], 'experiments': [58], 'revealed': [59], 'that': [60, 77, 112, 166], 'endogenous': [62, 79, 174], 'was': [70, 75, 85, 114, 134, 140, 144, 183], 'short-lived': [72], 'protein.': [73], 'It': [74], 'found': [76], 'level': [81, 149, 153], 'TM': [83], 'increased': [86, 152], 'by': [87, 96], 'treatment': [88], 'lysosomal': [90, 179], 'proteasomal': [92], 'inhibitors,': [93], 'but': [94], 'not': [95], 'autophagic': [97, 155], 'inhibitor.': [98], 'Multiple': [99], 'bands': [100], 'immunoreactive': [101], 'anti-ubiquitin': [103], 'were': [104, 158], 'seen': [105], 'pull': [109], 'down,': [110], 'indicating': [111], 'ubiquitinated.': [115], 'inducible': [117], 'lines,': [119], 'rate': [122], 'overexpressed': [124], 'wild-type': [125], 'mutant': [127], 'P370L': [128], 'Q368X': [130], 'myocilin-GFP': [131], 'fusion': [132], 'proteins': [133], 'much': [135], 'prolonged.': [136], 'proteasome': [138], 'function': [139, 189], 'compromised': [141, 191], 'autophagy': [143, 193], 'induced.': [145, 195], 'A': [146], 'decreased': [147], 'PSMB5': [148], 'an': [151], 'marker,': [156], 'LC3,': [157], 'demonstrated.': [159], 'Conclusions/Significance': [160], 'current': [162], 'study': [163], 'provided': [164], 'evidence': [165], 'normal': [168], 'homeostatic': [169], 'situation,': [170], 'involves': [176], 'ubiquitin-proteasome': [177, 188], 'pathways.': [180], 'When': [181], 'upregulated': [184], 'or': [185], 'mutated,': [186], 'Knowledge': [196], 'degradation': [199], 'pathways': [200], 'acting': [201], 'on': [202], 'can': [204], 'help': [205], 'design': [207], 'novel': [209], 'therapeutic': [210], 'strategies': [211], 'for': [212], 'myocilin-related': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1988100478', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-08-15T04:43:23.957728', 'created_date': '2016-06-24'}