Publication Information

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'https://openalex.org/W2081500438', 'https://openalex.org/W2082507157', 'https://openalex.org/W2092163284', 'https://openalex.org/W2100409705', 'https://openalex.org/W2106782182', 'https://openalex.org/W2107813515', 'https://openalex.org/W2108277395', 'https://openalex.org/W2108582952', 'https://openalex.org/W2108699145', 'https://openalex.org/W2108787781', 'https://openalex.org/W2115847000', 'https://openalex.org/W2123832957', 'https://openalex.org/W2129237528', 'https://openalex.org/W2144942220', 'https://openalex.org/W2148135961', 'https://openalex.org/W2150726150', 'https://openalex.org/W2157640167', 'https://openalex.org/W2159058105', 'https://openalex.org/W2163917183', 'https://openalex.org/W2170832451', 'https://openalex.org/W2171346238', 'https://openalex.org/W2174160083', 'https://openalex.org/W2413512642', 'https://openalex.org/W2468467363', 'https://openalex.org/W2599086095', 'https://openalex.org/W4231136244', 'https://openalex.org/W59254821'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W2788277189', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2083571924', 'https://openalex.org/W2082860237', 'https://openalex.org/W2046158694', 'https://openalex.org/W2023254290', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418'], 'abstract_inverted_index': {'Pigmentation': [0, 300, 600], 'of': [1, 7, 13, 22, 32, 78, 131, 156, 164, 206, 216, 239, 274, 285, 293, 301, 307, 313, 322, 332, 378, 431, 456, 464, 506, 516, 539, 574, 585, 593, 609, 619, 892, 1005, 1019, 1022, 1027, 1049, 1089, 1182, 1187, 1201, 1310, 1493, 1690, 1799, 1807, 1823, 1901, 1917, 1924, 2024, 2088, 2172, 2183, 2203, 2223, 2366, 2514, 2653, 2727, 2761, 2764, 2820, 2865, 2870, 2885, 2893, 2916, 2926, 2950, 2962, 2971, 3086, 3374, 3402, 3446, 3486, 3533, 3574, 3590, 3631, 3728, 3775, 3847, 3911, 3979, 4032, 4074, 4089], 'the': [2, 20, 27, 34, 76, 89, 127, 134, 150, 154, 162, 184, 201, 204, 214, 226, 233, 246, 251, 291, 302, 320, 327, 334, 376, 389, 427, 434, 450, 454, 462, 484, 501, 504, 514, 526, 533, 546, 551, 591, 629, 1020, 1030, 1087, 1173, 1198, 1427, 1491, 1499, 1513, 1570, 1578, 1672, 1681, 1743, 1753, 1757, 1794, 1802, 1805, 1808, 1813, 1914, 1918, 1922, 2002, 2022, 2025, 2029, 2046, 2071, 2084, 2089, 2095, 2176, 2186, 2213, 2364, 2443, 2585, 2651, 2725, 2759, 2814, 2860, 2863, 2891, 2908, 2914, 2924, 2936, 2939, 2960, 2969, 2987, 3083, 3291, 3377, 3384, 3406, 3531, 3571, 3575, 3588, 3619, 3643, 3810, 3831, 3841, 3977, 4026, 4030, 4033, 4044, 4053, 4066, 4431, 4450], 'hair,': [3, 303], 'skin,': [4, 304], 'and': [5, 29, 42, 59, 81, 103, 129, 143, 160, 186, 228, 267, 283, 305, 329, 342, 359, 381, 403, 429, 443, 460, 486, 528, 567, 583, 885, 899, 989, 993, 1014, 1197, 1327, 1437, 1495, 1508, 1510, 1658, 1669, 1825, 2031, 2097, 2181, 2197, 2230, 2378, 2389, 2418, 2434, 2537, 2595, 2733, 2756, 2817, 2828, 2832, 2840, 2855, 2867, 2872, 2901, 2943, 2959, 2991, 3019, 3067, 3071, 3091, 3226, 3228, 3265, 3284, 3346, 3363, 3381, 3383, 3458, 3491, 3507, 3528, 3545, 3570, 3599, 3618, 3621, 3673, 3681, 3702, 3732, 3748, 3788, 3807, 3817, 3838, 3849, 3883, 3915, 3931, 3947, 3974, 3989, 4016, 4023, 4035, 4041, 4095, 4121, 4164, 4169, 4173, 4240, 4297, 4300, 4350, 4483], 'eyes': [6, 306], 'mammals': [8, 308, 602], 'results': [9, 276, 309, 576, 1312, 2952], 'from': [10, 200, 310, 500, 1569, 1680, 1752, 1756, 1793, 2210, 2218, 2502, 2519, 2656, 2935, 2986, 3273, 3353, 3368, 3390, 4052, 4071], 'a': [11, 99, 122, 258, 311, 399, 422, 558, 606, 616, 625, 902, 1039, 1046, 1323, 1342, 1581, 1790, 2041, 2221, 2244, 2762, 3207, 3217, 3229, 3255, 3267, 3487, 3534, 3558, 3591, 3648, 3703, 3729, 3755, 3776, 3854, 3912, 3956, 3980, 4002, 4102, 4304], 'number': [12, 312, 618, 2222], 'melanocyte-specific': [14, 314, 1024], 'proteins': [15, 25, 315, 325, 621, 718, 895, 1093, 1661, 1692, 2823, 3200], 'that': [16, 195, 278, 316, 495, 578, 614, 622, 1178, 1314, 1328, 2178, 2239, 2298, 2499, 2528, 2541, 2648, 2874, 2881, 2890, 2904, 2954], 'are': [17, 317, 2233, 3287], 'required': [18, 48, 318, 348], 'for': [19, 49, 113, 319, 349, 413, 906, 1337, 1688, 1817, 1820, 2043, 2190, 3247, 3471, 3497, 3514, 3564, 3612, 3713, 3738, 3759, 3794, 3825, 3896, 3921, 3937, 3960, 4008, 4092, 4111, 4118, 4126, 4161, 4326, 4438, 4458, 4474], 'biosynthesis': [21, 321], 'melanin.': [23, 323, 1002], 'Those': [24, 324, 716, 2857], 'comprise': [26, 326], 'structural': [28, 328, 721], 'enzymatic': [30, 330, 727, 2192], 'components': [31, 331], 'melanosomes,': [33, 333, 2196, 2849, 3403], 'membrane-bound': [35, 335, 638], 'organelles': [36, 148, 174, 336, 448, 474, 639, 2238, 2858, 3251], 'in': [37, 65, 98, 177, 203, 245, 250, 295, 337, 365, 398, 477, 503, 545, 550, 595, 601, 624, 636, 644, 1000, 1007, 1012, 1015, 1172, 1176, 1192, 1315, 1322, 1430, 1789, 1801, 1904, 2018, 2021, 2028, 2045, 2073, 2076, 2094, 2103, 2185, 2227, 2384, 2390, 2423, 2583, 2830, 2833, 2847, 2878, 2897, 2907, 2913, 2973, 2993, 3028, 3076, 3202, 3249, 3396, 3410, 3461, 3524, 3557, 3587, 3642, 3684, 3754, 3780, 3805, 3836, 3886, 3955, 3970, 3976, 4001, 4176, 4183, 4250, 4259, 4264, 4277, 4286, 4315, 4332, 4429, 4435, 4448], 'which': [38, 212, 220, 241, 338, 512, 520, 541, 632, 1811, 1910, 2394, 2584, 2922, 2930, 3286, 3993], 'melanin': [39, 115, 270, 339, 415, 570, 1338, 1431, 2199, 2204, 2421, 2511], 'is': [40, 46, 85, 170, 181, 187, 222, 248, 255, 340, 346, 385, 470, 481, 487, 522, 548, 555, 603, 633, 1009, 1341, 1518, 1566, 1685, 1740, 1746, 1911, 2005, 2014, 2188, 2589, 2895, 2932], 'synthesized': [41, 341], 'deposited.': [43, 343], 'Tyrosinase': [44, 344], '(TYR)': [45, 345], 'absolutely': [47, 347], 'melanogenesis,': [50, 350], 'but': [51, 176, 351, 476, 1745, 2016, 2216, 2397], 'other': [52, 352, 2224, 3243], 'melanosomal': [53, 353, 894, 1092, 2301, 2444, 2822, 2845, 3199], 'proteins,': [54, 354, 722, 728], 'such': [55, 355, 723, 729, 2580], 'as': [56, 262, 356, 562, 641, 724, 730, 986, 1045, 1921, 2040, 2246, 2248, 2581, 3034, 3094, 3252, 3640, 3809, 3840, 4025, 4043, 4063, 4133, 4204, 4357], 'TYRP1,': [57, 240, 357, 540, 778, 852, 898, 2825, 3088, 4094, 4163], 'DCT,': [58, 358, 752, 826, 1659, 2826, 3090], 'gp100,': [60, 360, 725, 2827, 3092], 'also': [61, 86, 361, 386, 1170, 2217], 'play': [62, 362], 'important': [63, 110, 363, 410, 1191, 1334], 'roles': [64, 364], 'regulating': [66, 114, 366, 414], 'mammalian': [67, 367], 'pigmentation.': [68, 368], 'However,': [69, 369, 1166], 'pigmentation': [70, 294, 370, 594, 1006, 1199, 2972], 'does': [71, 94, 371, 394, 1318], 'not': [72, 95, 372, 395, 1319, 2208, 2399], 'always': [73, 373], 'correlate': [74, 374], 'with': [75, 375, 1347, 1913, 2767, 3290, 3441, 3451, 4101, 4185, 4294, 4303, 4337, 4454, 4471, 4486], 'expression': [77, 238, 287, 377, 538, 587, 1052, 1088, 2964], 'TYR': [79, 93, 132, 157, 169, 180, 196, 221, 243, 379, 393, 432, 457, 469, 480, 496, 521, 543, 1317, 1340, 1425, 1494, 1565, 1800, 1818, 1902, 2004, 2013, 2027, 2044, 2074, 2184, 2214, 2228, 2396, 2432, 2894, 2931, 3234, 4135, 4139], 'mRNA/protein,': [80, 380], 'thus': [82, 161, 382, 461, 990], 'its': [83, 104, 383, 404, 1329, 1496, 1575, 1821, 1826, 2032, 2191, 2905], 'function': [84, 384, 999, 2075, 2722], 'regulated': [87, 387, 604], 'at': [88, 388, 1029, 2212, 2220, 2442, 2542, 3467, 3474, 3493, 3500, 3510, 3517, 3530, 3553, 3567, 3608, 3615, 3709, 3716, 3734, 3741, 3750, 3762, 3790, 3797, 3821, 3828, 3892, 3899, 3917, 3924, 3933, 3940, 3951, 3963, 3997, 4011, 4108, 4115, 4123, 4244, 4256, 4279, 4329, 4441, 4461, 4477], 'post-translational': [90, 105, 390, 405], 'level.': [91, 391], 'Thus,': [92, 392, 2201], 'necessarily': [96, 396, 1320], 'exist': [97, 397, 1321], 'catalytically': [100, 400, 1324], 'active': [101, 401, 1325], 'state,': [102, 402], 'activation': [106, 406, 1330, 2365, 2513], 'could': [107, 407, 1331, 2080], 'be': [108, 198, 408, 498, 720, 1190, 1332, 2081, 2236, 2876, 2911], 'an': [109, 409, 1333, 3372, 4056], 'control': [111, 411, 1335, 2086], 'point': [112, 412, 1336], 'synthesis.': [116, 416, 2200], 'In': [117, 166, 417, 466, 2010, 2809], 'this': [118, 254, 418, 554, 1185, 2299, 2810, 3203], 'study,': [119, 419, 2811], 'we': [120, 420, 2812, 2902, 3404, 3852], 'used': [121, 421, 735, 809, 1676, 2575, 3201, 3242, 3405, 3647, 3808, 3839, 3853, 4024, 4042, 4131], 'multidisciplinary': [123, 423], 'approach': [124, 424], 'to': [125, 152, 158, 225, 230, 257, 290, 425, 452, 458, 525, 530, 557, 590, 627, 1085, 1435, 1441, 1574, 1664, 1677, 1683, 1748, 2038, 2195, 2235, 2506, 2524, 2576, 2591, 2658, 2721, 2757, 2843, 2862, 2938, 2946, 2968, 3082, 3198, 3245, 3670], 'examine': [126, 426], 'processing': [128, 244, 428, 544, 1668, 1798, 2182, 2229, 2433, 2892], 'sorting': [130, 235, 430, 535, 1673, 2597], 'through': [133, 172, 433, 472, 1742], 'endoplasmic': [135, 435, 750, 824, 1500], 'reticulum': [136, 436, 1501], '(ER),': [137, 437, 1502], 'Golgi': [138, 438, 1514, 1759, 2853, 3293, 3850], 'apparatus,': [139, 439, 2854, 3851], 'coated': [140, 440, 2851, 3674, 3842], 'vesicles,': [141, 441, 2852], 'endosomes': [142, 442, 2657, 2735, 3315, 3672], 'early': [144, 444, 1749, 1758, 2431, 2732, 2768, 2848, 3312], 'melanosomes': [145, 159, 231, 445, 459, 531, 642, 1684, 1750, 2871], 'because': [146, 446, 1018, 2091], 'those': [147, 173, 447, 473, 893, 1023, 1311, 1691, 2507, 2525], 'hold': [149, 449, 2859], 'key': [151, 451, 2861], 'understanding': [153, 453, 2864], 'trafficking': [155, 455, 2435, 2818], 'regulation': [163, 463, 1188], 'melanogenesis.': [165, 465], 'pigmented': [167, 467, 3022], 'cells,': [168, 179, 468, 479, 2393, 2900], 'trafficked': [171, 471], 'rapidly,': [175, 475], 'amelanotic': [178, 252, 297, 478, 552, 597, 1174, 2077, 2385, 2831, 2898, 2975, 2980], 'retained': [182, 482], 'within': [183, 483], 'ER': [185, 202, 485, 502, 1754, 1803, 1814, 1915, 2030, 2047, 2096, 2187, 2909, 2937, 3848], 'eventually': [188, 488, 1567], 'degraded': [189, 489, 2007], 'by': [190, 490, 605, 1580, 2008, 2034, 2083, 2100, 2368, 2429, 2438, 2509, 2723, 3465, 3635, 3707, 3890, 4065, 4106, 4242, 4352], 'proteasomes.': [191, 491, 2009], 'We': [192, 492, 2888, 3241, 3646], 'now': [193, 493], 'show': [194, 494, 2903], 'can': [197, 497, 719, 1169, 2242, 2910], 'released': [199, 499], 'presence': [205, 505, 1806, 2915], 'protonophore': [207, 507, 2917, 3385], 'or': [208, 508, 726, 1755, 2918, 4338, 4346, 4470], 'proton': [209, 509, 792, 866, 2372, 2548, 2919], 'pump': [210, 510, 2373, 2920], 'inhibitors': [211, 511, 3360, 3379, 3393], 'increase': [213, 513, 2923], 'pH': [215, 515, 2245, 2302, 2530, 2588, 2925, 3691], 'intracellular': [217, 517, 2529, 2927], 'organelles,': [218, 518, 2928], 'after': [219, 519, 2512, 2929], 'transported': [223, 523, 1568, 2933], 'correctly': [224, 524, 2934], 'Golgi,': [227, 527, 2940], 'then': [229, 529, 634, 1511, 2006, 2944, 3479, 3585, 3721, 3904, 3995, 4275, 4301, 4484], 'via': [232, 532], 'endosomal': [234, 534, 2769], 'system.': [236, 536], 'The': [237, 272, 537, 572, 1003, 1308, 1797, 1897, 2170, 2948, 3520, 3549, 3580, 3628, 3744, 3800, 3813, 3927, 3966, 4014, 4128, 4272], 'facilitates': [242, 542, 2303], 'ER,': [247, 547, 749, 823, 1744, 2090, 3292], 'down-regulated': [249, 549], 'cells;': [253, 553], 'analogous': [256, 556], 'hypopigmentary': [259, 559], 'disease': [260, 560], 'known': [261, 561, 640, 985, 1044, 1091, 2234, 2590], 'oculocutaneous': [263, 563, 769, 843, 1905], 'albinism': [264, 564, 1906], 'type': [265, 565, 1343, 1907, 2371], '3': [266, 566, 4327, 4459], 'further': [268, 568, 1520, 2941, 3508, 3949, 4446], 'impairs': [269, 569], 'production.': [271, 571], 'sum': [273, 573, 1309, 2171, 2949], 'these': [275, 575, 2173, 2951], 'shows': [277, 577, 2953], 'organellar': [279, 579, 2955], 'pH,': [280, 580, 2956], 'proteasome': [281, 581, 2957], 'activity,': [282, 582, 2193, 2958], 'down-regulation': [284, 584, 2961], 'TYRP1': [286, 586, 1657, 2019, 2036, 2963, 4143, 4147], 'all': [288, 588, 1090, 2966], 'contribute': [289, 589, 2967], 'lack': [292, 592, 2970], 'TYR-positive': [296, 596, 2974], 'melanoma': [298, 598, 1203, 2078, 2387, 2392, 2835, 2899, 2976, 2982, 3024], 'cells.': [299, 599, 2977], 'small': [607], 'population': [608], 'specialized': [610], 'cells': [611, 2079, 2388, 2836, 2983, 3025, 3448, 3678, 3880, 4054, 4237, 4252, 4432, 4451], '(termed': [612], 'melanocytes)': [613], 'express': [615, 1179, 2395, 2882], 'limited': [617], 'specific': [620, 903], 'act': [623, 2039], 'cascade': [626], 'synthesize': [628], 'biopolymer': [630], 'melanin,': [631], 'deposited': [635], 'discrete': [637], '(reviewed': [643], 'Refs.': [645], '1Spritz': [646], 'R.A.': [647, 1477, 1524, 1719, 1834], 'Pigment': [648, 677, 1055, 1070, 1603, 2159, 2336, 2467, 2602, 3185], 'Cell': [649, 678, 1056, 1071, 1298, 1604, 1625, 1646, 2160, 2337, 2468, 2488, 2603, 2692, 2711, 2780, 2978, 3186], 'Res.': [650, 679, 941, 962, 979, 1057, 1072, 1299, 1605, 1843, 2161, 2321, 2338, 2469, 2489, 2604, 3187, 4417], '2000;': [651, 1058, 1073, 1530, 1606, 1962, 1994, 2145, 2281, 2408], '13:': [652, 1059, 1074, 1607, 2456, 3305], '15-20Crossref': [653], 'PubMed': [654, 683, 698, 711, 927, 1061, 1076, 1115, 1161, 1225, 1246, 1263, 1280, 1303, 1365, 1388, 1420, 1451, 1463, 1487, 1538, 1560, 1609, 1630, 1651, 1711, 1733, 1784, 1848, 1870, 1892, 1944, 1970, 1997, 2065, 2133, 2148, 2165, 2267, 2289, 2325, 2342, 2358, 2411, 2458, 2473, 2493, 2567, 2608, 2625, 2639, 2677, 2697, 2753, 2785, 2804, 3061, 3112, 3142, 3160, 3191, 3307, 3337, 3436, 3665, 3873, 4231, 4384, 4421], 'Scopus': [655, 684, 699, 712, 928, 1062, 1077, 1116, 1162, 1226, 1247, 1264, 1281, 1304, 1366, 1389, 1421, 1452, 1464, 1539, 1561, 1610, 1631, 1652, 1712, 1734, 1785, 1849, 1871, 1893, 1945, 1971, 1998, 2066, 2134, 2149, 2166, 2268, 2290, 2326, 2343, 2359, 2412, 2459, 2474, 2494, 2568, 2609, 2640, 2698, 2786, 2805, 3062, 3113, 3192, 3308, 3338, 3437, 3666, 3874, 4232, 4385, 4422], '(36)': [656], 'Google': [657, 686, 701, 714, 930, 945, 966, 983, 1064, 1079, 1118, 1136, 1164, 1228, 1249, 1266, 1283, 1306, 1368, 1391, 1423, 1454, 1466, 1488, 1541, 1563, 1612, 1633, 1654, 1714, 1736, 1787, 1851, 1873, 1895, 1947, 1973, 2000, 2068, 2136, 2151, 2168, 2270, 2292, 2328, 2345, 2361, 2414, 2461, 2476, 2496, 2570, 2611, 2626, 2642, 2678, 2700, 2716, 2754, 2788, 2807, 3064, 3115, 3143, 3161, 3194, 3310, 3340, 3439, 3668, 3876, 4234, 4387, 4424], 'Scholar,': [658, 687, 702, 917, 931, 946, 967, 1065, 1119, 1137, 1229, 1250, 1267, 1284, 1369, 1392, 1455, 1467, 1542, 1613, 1634, 1715, 1852, 1874, 1948, 1974, 2137, 2152, 2271, 2329, 2346, 2462, 2612, 2627, 2679, 2701, 2789, 3116, 3144, 3162, 4388], '2Kushimoto': [659], 'T.': [660, 1398, 1550, 1596, 1602, 1761, 1934, 2055, 3038, 3118, 3319, 3413, 4208, 4361, 4394], 'Valencia': [661, 1547, 1637, 1931, 2052, 3169, 4399], 'J.C.': [662, 1548, 1638, 1880, 1932, 2053], 'Costin': [663], 'G.E.': [664, 1233, 1636], 'Toyofuku': [665], 'K.': [666, 670, 1231, 1294, 1473, 1544, 1586, 1592, 1594, 1854, 1858, 1864, 1928, 2049, 2447, 2556, 2708, 2795, 3098, 3102, 3120, 3124, 3148, 3174, 3296, 3317, 3325, 4398], 'Watabe': [667, 4405], 'H.': [668, 969, 1402, 1598, 2791, 3861, 4406], 'Yasumoto': [669, 4397], 'Rouzaud': [671], 'F.': [672, 960, 1878, 2665, 2741, 2772, 2774, 4392], 'Vieira': [673, 1639, 1766, 3043, 3179, 3418, 4213, 4366, 4403], 'W.D.': [674, 1640, 1767, 3044, 3180, 3419, 4214, 4367, 4404], 'Hearing': [675, 1470, 1553, 1643, 1772, 1937, 2058, 3049, 3105, 3131, 3149, 3183, 3424, 4219, 4372, 4409], 'V.J.': [676, 1457, 1471, 1552, 1554, 1644, 1773, 1936, 1938, 2057, 2059, 3050, 3106, 3132, 3150, 3178, 3184, 3425, 4220, 4373, 4410], '2003;': [680, 980, 1153, 1648, 1725, 1884, 3865, 4418], '16:': [681], '237-244Crossref': [682], '(72)': [685], '3Shen': [688], 'B.': [689, 691, 939, 2704], 'Rosenberg': [690], 'Orlow': [692, 2450, 2465, 2600, 3121, 3299], 'S.J.': [693, 933, 2451, 2466, 2601, 3122, 3300], 'Traffic.': [694, 707, 2144], '2001;': [695, 963, 1217, 1300, 1412, 1557, 1627, 1708, 1781, 1941, 2062, 2470, 2490, 2605, 3058, 3188, 3433, 4228, 4381], '2:': [696, 2340, 4419], '202-211Crossref': [697], '(39)': [700, 1894], '4Raposo': [703], 'G.': [704, 950, 1101, 1129, 1353, 1359, 1522, 1615, 1717, 2114, 3126], 'Marks': [705, 1622, 1957], 'M.S.': [706, 1623, 1958], '2002;': [708, 2162, 2455, 3304, 3329], '3:': [709], '237-248Crossref': [710], '(123)': [713], 'Scholar).': [715, 1080, 1165, 1307, 1424, 1489, 1564, 1655, 1737, 1896, 2069, 2169, 2293, 2362, 2415, 2477, 2643, 2717, 2808, 3065, 3195, 3877, 4235, 4425], 'melanogenic': [717, 1050, 2886], 'tyrosinase': [731], '(TYR),': [732], '1The': [733, 807], 'abbreviations': [734, 808], 'are:': [736, 810], 'TYR,': [737, 811, 897, 1665, 2515, 3089, 4093, 4162], 'tyrosinase;': [738, 812], 'ALLN,': [739, 813], 'N-acetyl-Leu-Leu-norleucinal;': [740, 814], 'Baf,': [741, 815, 4345], 'bafilomycin': [742, 816, 2375], 'A1;': [743, 817], 'CCM,': [744, 818, 2538, 4349], 'concanamycin': [745, 819, 2379], 'A;': [746, 820], 'CHX,': [747, 821], 'cycloheximide;': [748, 822], 'reticulum;': [751, 825], 'tyrosinase-related': [753, 779, 827, 853, 881, 886], 'protein': [754, 780, 828, 854, 882, 887, 2596, 3262, 3343, 3348, 3375], '2;': [755, 829], 'Endo': [756, 830], 'H,': [757, 831], 'endoglycosidase': [758, 832], 'H;': [759, 833], 'MG132,': [760, 834], 'benzyloxycarbonyl-Leu-Leu-leucinal;': [761, 835], 'MITF,': [762, 836], 'microphthalmia-associated': [763, 837, 1035], 'transcription': [764, 838, 1036, 1042], 'factor;': [765, 839], 'Mon,': [766, 840, 4342], 'monensin;': [767, 841], 'OCA,': [768, 842], 'albinism;': [770, 844], 'PNGase': [771, 845], 'F,': [772, 846], 'Peptide:N-glycosidase': [773, 847], 'F;': [774, 848], 'TGN,': [775, 849], 'trans-Golgi': [776, 850, 1571], 'network;': [777, 851], '1;': [781, 855], 'DAPI,': [782, 856], '4,6-diamidino-2-phenylindole;': [783, 857], 'MES,': [784, 858, 3690], '4-morpho-lineethanesulfonic': [785, 859], 'acid;': [786, 860], 'G3PDH,': [787, 861], 'glyceraldehyde-3-phosphate': [788, 862], 'dehydrogenase;': [789, 863], 'vATPase,': [790, 864], 'vacuolar-type': [791, 865, 2547], 'ATPase;': [793, 867], 'mAb,': [794, 868], 'monoclonal': [795, 869], 'antibody;': [796, 870], 'AP,': [797, 871], 'adaptor': [798, 872, 3342, 3347], 'protein;': [799, 803, 873, 877], 'LAMP,': [800, 874], 'lysosome-associated': [801, 875, 3260], 'membrane': [802, 876, 1345, 3261], 'PBS,': [804, 878, 4251, 4430, 4449], 'phosphate-buffered': [805, 879], 'saline.': [806, 880], '1': [883, 1908, 3008, 3263, 3565, 3613, 3693], '(TYRP1),': [884], '2': [888, 3016], '(DCT).': [889], 'Interestingly,': [890, 1656], 'each': [891, 1689], '(gp100,': [896], 'DCT)': [900], 'represents': [901], 'immune': [904], 'target': [905, 1576], 'transformed': [907], 'melanocytes': [908, 1177, 2428, 2500, 2517, 2880], '(5Chapman': [909], 'P.B.': [910], 'Immunol.': [911], 'Hum.': [912], 'Melanoma.': [913], '1996;': [914, 924, 1109, 2713, 2782], '12:': [915, 1709], '195-200Google': [916], '6Rosenberg': [918], 'S.A.': [919, 1269], 'White': [920], 'D.E.': [921, 1149], 'J.': [922, 1106, 1127, 1139, 1151, 1214, 1240, 1257, 1286, 1361, 1409, 1478, 1527, 1556, 1624, 1645, 1722, 1765, 1769, 1865, 1881, 1940, 1959, 2061, 2278, 2306, 2354, 2403, 2667, 2668, 2691, 2710, 2743, 2744, 2778, 2779, 2797, 3042, 3046, 3108, 3133, 3151, 3168, 3170, 3326, 3417, 3421, 3654, 3859, 3862, 4212, 4216, 4365, 4369, 4400, 4402, 4408, 4415], 'Immunother.': [923], '19:': [925], '81-84Crossref': [926], '(298)': [929], '7Orlow': [932], 'Silvers': [934], 'W.K.': [935], 'Zhou': [936], 'B.K.': [937], 'Mintz': [938], 'Cancer': [940, 961, 978], '1998;': [942, 2801], '58:': [943], '1521-1523PubMed': [944], '8Mendiratta': [947], 'S.K.': [948], 'Thai': [949], 'Eslahi': [951], 'N.K.': [952], 'Thull': [953], 'N.M.': [954], 'Matar': [955], 'M.': [956, 1054, 1097, 1694, 2118, 2139, 2154, 2793, 3146, 3656], 'Bronte': [957], 'V.': [958, 1763, 2251, 3040, 3164, 3415, 4210, 4363, 4390], 'Pericle': [959], '61:': [964], '859-863PubMed': [965], '9Takeuchi': [968], 'Kuo': [970], 'C.': [971, 1588, 1876, 3652], 'Morton': [972], 'D.L.': [973], 'Wang': [974], 'H.-J.': [975], 'Hoon': [976], 'D.S.B.': [977], '63:': [981], '441-448PubMed': [982], 'Scholar),': [984, 2571, 3311, 3341], 'malignant': [987, 1202], 'melanoma,': [988], 'their': [991, 998], 'biological': [992], 'clinical': [994], 'importance': [995], 'far': [996], 'exceeds': [997], 'producing': [1001, 2510], 'loss': [1004], 'melanomas': [1008], 'very': [1010], 'common': [1011, 1899], 'advanced': [1013], 'metastatic': [1016], 'lesions': [1017], 'dysfunction': [1021], 'proteins.': [1025, 1796, 2887], 'Regulation': [1026], 'melanogenesis': [1028, 2304, 2367], 'transcriptional': [1031], 'level': [1032, 1186, 2445], 'usually': [1033], 'involves': [1034], 'factor': [1037, 1043], '(MITF),': [1038], 'basic': [1040], 'helix-loop-helix': [1041], 'master': [1047], 'regulator': [1048], 'gene': [1051, 2426], '(10Tachibana': [1053], '230-240Crossref': [1060], '(237)': [1063], '11Busca': [1066], 'R.': [1067, 1069, 1095, 1205, 1211, 1235, 1377, 1396, 1406, 1696, 1976, 1984, 2108, 2616], 'Ballotti': [1068], '60-69Crossref': [1075], '(646)': [1078], 'MITF': [1081], 'has': [1082, 2295], 'been': [1083, 2296, 2573], 'shown': [1084, 2383, 2647, 2720], 'regulate': [1086, 2532], '(12Halaban': [1094], 'Bohm': [1096], 'Dotto': [1098], 'P.': [1099, 1125, 1475, 2449, 2464, 2599, 3298], 'Moellmann': [1100, 2113], 'Cheng': [1102, 1206, 1399, 1979, 2109], 'E.': [1103, 1123, 1207, 1357, 1400, 1698, 1771, 1980, 2110, 3048, 3423, 4218, 4371, 4414], 'Zhang': [1104, 2111], 'Y.': [1105, 1404, 1700, 1862, 1982, 2112, 2141, 4396], 'Investig.': [1107, 1241, 2279, 3327], 'Dermatol.': [1108, 1242, 2280, 2320, 3328], '106:': [1110], '1266-1272Abstract': [1111], 'Full': [1112, 1156, 1158, 1220, 1222, 1415, 1417, 1484, 1533, 1535, 1728, 1730, 1887, 1889, 1965, 1967, 2284, 2286, 2674, 2750, 3139, 3157, 3332, 3334, 3868, 3870], 'Text': [1113, 1157, 1159, 1221, 1223, 1416, 1418, 1485, 1534, 1536, 1729, 1731, 1888, 1890, 1966, 1968, 2285, 2287, 2675, 2751, 3140, 3158, 3333, 3335, 3869, 3871], 'PDF': [1114, 1160, 1224, 1419, 1486, 1537, 1732, 1891, 1969, 2288, 2676, 2752, 3141, 3159, 3336, 3872], '(40)': [1117, 3339], '13Yavuzer': [1120], 'U.': [1121, 1382, 1778, 1991, 2127, 2561, 3055, 3430, 4225, 4378], 'Keenan': [1122], 'Lowings': [1124], 'Vachtenheim': [1126], 'Currie': [1128], 'Goding': [1130], 'C.R.': [1131], 'Oncogene.': [1132], '1995;': [1133, 2694], '10:': [1134], '123-134PubMed': [1135], '14Du': [1138], 'Miller': [1140], 'A.J.': [1141, 1275, 1296, 1832, 2314, 2405], 'Widlund': [1142], 'H.R.': [1143], 'Horstmann': [1144], 'M.A.': [1145, 1237], 'Ramaswamy': [1146], 'S.': [1147, 1209, 1355, 1383, 1779, 1978, 1992, 2120, 2128, 2253, 2318, 2562, 2629, 2663, 2739, 3056, 3431, 4226, 4379], 'Fisher': [1148], 'Am.': [1150], 'Path.': [1152], '163:': [1154], '333-343Abstract': [1155], '(233)': [1163], 'post-transcriptional': [1167], 'processes': [1168], 'result': [1171, 1903, 1923, 2020, 2207], 'phenotype': [1175, 1200], 'normal': [1180, 2012, 2883], 'amounts': [1181], 'wild-type': [1183, 2026], 'TYR;': [1184], 'might': [1189, 2531, 2875], 'determining': [1193], 'constitutive': [1194, 2533], 'skin': [1195, 2534], 'color': [1196], '(15Halaban': [1204], 'Svedine': [1208, 1977], 'Aron': [1210, 1395, 1983], 'Hebert': [1212, 1407, 1985, 2121], 'D.N.': [1213, 1408, 1986, 2122], 'Biol.': [1215, 1410, 1479, 1528, 1626, 1706, 1723, 1882, 1960, 2453, 2669, 2693, 2712, 2745, 2781, 2799, 3134, 3152, 3302, 3863], 'Chem.': [1216, 1411, 1480, 1529, 1724, 1883, 1961, 2670, 2746, 3135, 3153, 3864], '276:': [1218, 1413], '11933-11938Abstract': [1219], '(80)': [1227], '16Iozumi': [1230], 'Hoganson': [1232], 'Pennella': [1234], 'Everett': [1236], 'Fuller': [1238, 2478], 'B.B.': [1239, 1252, 2482], '1993;': [1243, 2264], '100:': [1244], '806-811Crossref': [1245], '(195)': [1248], '17Fuller': [1251], 'Iman': [1253], 'D.S.': [1254], 'Lunsford': [1255], 'J.B.': [1256], 'Cell.': [1258, 1707, 2454, 2800, 3303], 'Physiol.': [1259, 2634], '1988;': [1260, 1362, 2355, 2564], '134:': [1261], '149-154Crossref': [1262], '(21)': [1265], '18Burchill': [1268], 'Bennett': [1270], 'D.C.': [1271], 'Holmes': [1272], 'A.': [1273, 1384, 1394, 1780, 1993, 2129, 2260, 2335, 2352, 2554, 2563, 2618, 3057, 3432, 4227, 4380], 'Thody': [1274, 1295, 2404], 'Pathobiology.': [1276], '1991;': [1277, 3154], '59:': [1278], '335-339Crossref': [1279], '(17)': [1282], '19Ancans': [1285], 'Tobin': [1287], 'D.J.': [1288], 'Hoogduijn': [1289], 'M.J.': [1290, 2661, 2737], 'Smit': [1291, 2309], 'N.P.': [1292], 'Wakamatsu': [1293], 'Exp.': [1297, 2487], '268:': [1301], '26-35Crossref': [1302], '(164)': [1305], 'suggests': [1313], 'melanocytes,': [1316], 'state': [1326], 'biosynthesis.': [1339], 'I': [1344], 'glycoprotein': [1346], 'seven': [1348], 'potential': [1349], 'N-glycosylation': [1350], 'sites': [1351], '(20Müller': [1352], 'Ruppert': [1354], 'Schmid': [1356], 'Schütz': [1358], 'EMBO': [1360, 3107], '7:': [1363], '2723-2730Crossref': [1364], '(228)': [1367], '21Kwon': [1370], 'B.S.': [1371, 3128], 'Haq': [1372], 'A.K.': [1373], 'Pomerantz': [1374], 'S.H.': [1375], 'Halaban': [1376, 1405], 'Proc.': [1378, 1774, 1987, 2123, 2557, 3051, 3426, 4221, 4374], 'Natl.': [1379, 1775, 1988, 2124, 2558, 3052, 3427, 4222, 4375], 'Acad.': [1380, 1776, 1989, 2125, 2559, 3053, 3428, 4223, 4376], 'Sci.': [1381, 1647, 1777, 1990, 2126, 2560, 3054, 3429, 4224, 4377], '1987;': [1385, 1460], '84:': [1386], '7473-7477Crossref': [1387], '(393)': [1390], '22Ujvari': [1393], 'Eisenhaure': [1397], 'Parag': [1401], 'Smicun': [1403, 1981], '5924-5931Abstract': [1414], '(68)': [1422], 'catalyzes': [1426], 'rate-limiting': [1428], 'reactions': [1429, 4087, 4098], 'synthesis,': [1432], 'converting': [1433], 'tyrosine': [1434], 'DOPA-quinone': [1436], 'subsequently': [1438], 'oxidizing': [1439], '5,6-dihydroxyindole': [1440], 'indole-5,6-quinone': [1442], '(23Körner': [1443], 'A.M.': [1444, 2308], 'Pawelek': [1445], 'J.M.': [1446, 2275], 'Science.': [1447], '1982;': [1448], '217:': [1449], '1163-1165Crossref': [1450], '(470)': [1453], '24Hearing': [1456], 'Methods': [1458], 'Enzymol.': [1459], '142:': [1461], '154-165Crossref': [1462], '(221)': [1465], '25Tripathi': [1468], 'R.K.': [1469, 2333, 2348], 'Urabe': [1472, 3101, 3119], 'Aroca': [1474], 'Spritz': [1476], '1992;': [1481, 3109], '267:': [1482], '23707-23712Abstract': [1483], 'After': [1490, 4247, 4426, 4444], 'translation': [1492], 'insertion': [1497], 'into': [1498], 'it': [1503, 1517], 'undergoes': [1504], 'some': [1505], 'initial': [1506], 'glycosylation': [1507], 'maturation': [1509], 'enters': [1512], 'network,': [1515], 'where': [1516], 'processed': [1519, 1741], '(26Negroiu': [1521], 'Dwek': [1523, 1718, 1833], 'Petrescu': [1525, 1720, 1831, 1839], 'S.M.': [1526, 1721, 1840], '275:': [1531, 1963], '32200-32207Abstract': [1532], '(47)': [1540, 2413], '27Toyofuku': [1543], 'Wada': [1545, 1855, 1929, 2050, 3320], 'I.': [1546, 1856, 1930, 2051, 2614, 3321], 'Kushimoto': [1549, 1933, 2054, 4393], 'Ferrans': [1551, 1935, 2056, 3177], 'FASEB': [1555, 1939, 2060], '15:': [1558, 1942, 2063, 2163], '2149-2161Crossref': [1559, 1943, 2064], '(128)': [1562, 1946, 2067], 'network': [1572], '(TGN)': [1573], 'organelle,': [1577], 'melanosome,': [1579], 'vesicular': [1582], 'transport': [1583], 'system': [1584, 1675, 2087], '(28Jimbow': [1585], 'Hua': [1587], 'Gomez': [1589], 'P.F.': [1590, 3658], 'Hirosaki': [1591, 1857], 'Shinoda': [1593], 'Salopek': [1595], 'Matsusaka': [1597], 'Jin': [1599, 3322], 'H.Y.': [1600, 3323], 'Yamashita': [1601, 3318], '110-117Crossref': [1608], '(41)': [1611], '29Raposo': [1614], 'Tenza': [1616], 'D.': [1617, 2312], 'Murphy': [1618], 'D.M.': [1619], 'Berson': [1620], 'J.F.': [1621, 1950], '152:': [1628], '809-823Crossref': [1629], '(350)': [1632], '30Costin': [1635], 'Lamoreux': [1641], 'M.L.': [1642], '116:': [1649], '3203-3212Crossref': [1650], '(144)': [1653], 'two': [1660], 'closely': [1662], 'related': [1663], 'undergo': [1666], 'similar': [1667], 'sorting,': [1670], 'although': [1671], 'vesicle': [1674, 3843], 'deliver': [1678], 'them': [1679], 'TGN': [1682], 'presumably': [1686, 1920], 'unique': [1687], '(31Huizing': [1693], 'Sarangarajan': [1695], 'Strovel': [1697], 'Zhao': [1699], 'Gahl': [1701, 2142, 2157], 'W.A.': [1702, 2143, 2158], 'Boissy': [1703, 2155], 'R.E.': [1704, 2156, 3660], 'Mol.': [1705, 2452, 2798, 3301], '2075-2085Crossref': [1710], '(129)': [1713], '32Negroiu': [1716], '278:': [1726, 1885, 3866], '27035-27042Abstract': [1727], '(31)': [1735], 'Even': [1738], 'gp100': [1739, 3222], 'transferred': [1747], 'directly': [1751], '(33Kushimoto': [1760, 3037, 4207, 4360], 'Basrur': [1762, 3039, 3414, 4209, 4362], 'Matsunaga': [1764, 3041, 3165, 3167, 3416, 4211, 4364], 'Muller': [1768, 3045, 3420, 4215, 4368, 4401], 'Appella': [1770, 3047, 3422, 4217, 4370, 4413], '98:': [1782, 3059, 3434, 4229, 4382], '10698-10703Crossref': [1783, 3060, 3435, 4230, 4383], '(188)': [1786, 3063, 3438, 4233, 4386], 'Scholar)': [1788, 2497, 2755, 3669], 'manner': [1791], 'distinct': [1792], 'TYR-related': [1795], 'requires': [1804], 'chaperone': [1809, 2042], 'calnexin,': [1810], 'increases': [1812], 'retention': [1815, 1916, 2023, 2093, 2906], 'time': [1816], 'necessary': [1819], 'binding': [1822], 'copper': [1824], 'conformational': [1827], 'folding': [1828, 2180], '(34Branza-Nichita': [1829], 'N.': [1830, 2255, 2273, 3166], 'Wormald': [1835], 'M.R.': [1836], 'Platt': [1837], 'F.M.': [1838], 'Biochem.': [1841, 1866, 2262, 2353, 2621], 'Biophys.': [1842, 2263], 'Commun.': [1844], '1999;': [1845, 1867], '261:': [1846], '720-725Crossref': [1847], '(74)': [1850], '35Toyofuku': [1853], 'Park': [1859], 'J.S.': [1860], 'Hori': [1861], 'Jimbow': [1863, 3324], '125:': [1868], '82-89Crossref': [1869], '(63)': [1872], '36Olivares': [1875], 'Solano': [1877], 'Garcia-Borron': [1879], '15735-15743Abstract': [1886], 'most': [1898], 'mutations': [1900, 2017, 2211, 2219], '(OCA1),': [1909], 'associated': [1912], 'protein,': [1919], 'enzyme': [1925], 'misfolding': [1926], '(27Toyofuku': [1927, 2048], '37Berson': [1949], 'Frank': [1951], 'D.W.': [1952], 'Calvo': [1953], 'P.A.': [1954], 'Bieler': [1955], 'B.M.': [1956], '12281-12289Abstract': [1964], '(107)': [1972, 2460, 3309], '38Halaban': [1975], '97:': [1995], '5889-5894Crossref': [1996], '(155)': [1999], 'Scholar);': [2001], 'misfolded': [2003], 'OCA3,': [2011], 'produced,': [2015], 'proteolysis': [2033], 'proteasomes;': [2035], 'seems': [2037], 'Thus': [2070], 'reduction': [2072], 'mediated': [2082], 'quality': [2085], 'selective': [2092, 2369], 'subsequent': [2098, 2198], 'degradation': [2099], 'proteasomes': [2101], 'occurs': [2102], 'several': [2104, 4248], 'genetic': [2105], 'diseases': [2106], '(39Halaban': [2107], 'Hanlon': [2115], 'D.P.': [2116], 'Michalak': [2117], 'Vijayasaradhi': [2119], '1997;': [2130, 2322, 2636], '94:': [2131], '6210-6215Crossref': [2132], '(229)': [2135], '40Huizing': [2138], 'Anikster': [2140], '1:': [2146], '823-835Crossref': [2147], '(127)': [2150], '41Huizing': [2153], '405-419Crossref': [2164], '(89)': [2167], 'studies': [2174, 2645], 'underscore': [2175], 'fact': [2177], 'proper': [2179], 'crucial': [2189], 'delivery': [2194, 2652], 'disruption': [2202], 'synthesis': [2205, 2422, 2869], 'may': [2206, 2965], 'only': [2209], 'locus': [2215], 'loci': [2225], 'involved': [2226], 'transport.': [2231], 'Melanosomes': [2232], 'acidic': [2237, 2578], 'when': [2240], 'mature': [2241], 'have': [2243, 2572, 2646], 'low': [2247, 2300, 2543, 2586], '4.0': [2249], '(42Bhatnagar': [2250], 'Anjaiah': [2252], 'Puri': [2254], 'Arudhra': [2256], 'Darshanam': [2257], 'B.N.': [2258], 'Ramaiah': [2259, 2334, 2351], 'Arch.': [2261, 2319], '307:': [2265], '183-192Crossref': [2266], '(96)': [2269], '43Puri': [2272], 'Gardner': [2274], 'Brilliant': [2276], 'M.H.': [2277], '115:': [2282], '607-613Abstract': [2283], '(147)': [2291], 'It': [2294], 'assumed': [2297], '(44Borovansky': [2305], 'Mommaas': [2307], 'N.P.M.': [2310], 'Eygendaal': [2311], 'Winder': [2313], 'Vermeer': [2315], 'B.J.': [2316], 'Pavel': [2317], '289:': [2323], '145-150Crossref': [2324], '(10)': [2327], '45Devi': [2330], 'C.C.': [2331, 2350], 'Tripathi': [2332], '1989;': [2339], '117-122Crossref': [2341], '(5)': [2344], '46Tripathi': [2347], 'Devi': [2349], '252:': [2356], '481-487Crossref': [2357], '(32)': [2360], 'Recently,': [2363], 'vacuolar': [2370], 'inhibitors,': [2374, 2921], 'A1': [2376], '(Baf)': [2377], 'A': [2380], '(CCM),': [2381], 'was': [2382, 2719, 3505, 3522, 3551, 3584, 3605, 3746, 3767, 3802, 3815, 3818, 3834, 3929, 3945, 3948, 3968, 3994, 4050, 4069, 4202], 'human': [2386, 2981, 3023, 3087, 3211, 3221, 3233, 3259], 'mouse': [2391, 3208, 3218, 3230, 3256, 3268], 'do': [2398], 'produce': [2400], 'pigment': [2401, 2868], '(47Ancans': [2402], 'FEBS': [2406], 'Lett.': [2407], '478:': [2409], '57-60Crossref': [2410], 'Further,': [2416], 'Baf': [2417, 2536, 2649, 2718], 'CCM': [2419], 'induce': [2420], 'pink-eyed': [2424], 'dilution': [2425], '(p)-null': [2427], 'affecting': [2430, 2440], 'rather': [2436], 'than': [2437], 'simply': [2439], 'activity': [2441], '(48Chen': [2446, 3295], 'Manga': [2448, 3297], '1953-1964Crossref': [2457, 3306], '49Manga': [2463], '14:': [2471, 2606, 3189], '362-367Crossref': [2472, 2607], '(34)': [2475, 2610], 'et': [2479], 'al.': [2480], '(50Fuller': [2481], 'Spaulding': [2483], 'D.T.': [2484], 'Smith': [2485], 'D.R.': [2486], '262:': [2491], '197-208Crossref': [2492], '(121)': [2495], 'showed': [2498], 'derived': [2501, 2518], 'caucasian': [2503], 'donors': [2504, 2521], 'respond': [2505], 'agents': [2508], 'whereas': [2516, 4029], 'black': [2520], 'were': [2522, 2984, 3026, 3074, 3366, 3388, 3394, 3449, 3478, 3577, 3625, 3633, 3679, 3720, 3881, 3903, 4020, 4039, 4099, 4132, 4166, 4174, 4191, 4238, 4253, 4274, 4284, 4291, 4313, 4433, 4452], 'refractory': [2523], 'agents,': [2526], 'suggesting': [2527], 'color.': [2535], 'macrolide': [2539], 'antibiotics': [2540], 'concentrations': [2544], 'specifically': [2545], 'inhibit': [2546], 'ATPases': [2549], '(vATPase)': [2550], '(51Bowman': [2551], 'E.J.': [2552], 'Siebers': [2553], 'Altendorf': [2555], '85:': [2565], '7972-7976Crossref': [2566], '(1582)': [2569], 'commonly': [2574], 'neutralize': [2577], 'compartments': [2579], 'endosomes,': [2582, 2850, 3313], 'luminal': [2587], 'affect': [2592], 'receptor-ligand': [2593], 'interactions': [2594], '(49Manga': [2598], '52Mellman': [2613], 'Fuchs': [2615], 'Helenius': [2617], 'Ann.': [2619], 'Rev.': [2620, 2635], '1986;': [2622], '55:': [2623], '663-700Crossref': [2624], '53Mukherjee': [2628], 'Ghosh': [2630], 'R.N.': [2631], 'Maxfield': [2632, 2687], 'F.R.': [2633, 2688], '77:': [2637], '759-803Crossref': [2638], '(1284)': [2641], 'Recent': [2644], 'inhibits': [2650], 'endocytosed': [2654], 'material': [2655], 'lysosomes': [2659], '(54Clague': [2660, 2736], 'Urbe': [2662, 2738], 'Aniento': [2664, 2740], 'Gruenberg': [2666, 2742, 2777], '1994;': [2671, 2747, 3136], '269:': [2672, 2748, 3137], '21-24Abstract': [2673, 2749], '55van': [2680], 'Weert': [2681], 'A.W.': [2682], 'Dunn': [2683], 'K.W.': [2684], 'Gueze': [2685], 'H.J.': [2686], 'Stoorvogel': [2689], 'W.': [2690], '130:': [2695], '821-834Crossref': [2696], '(295)': [2699], '56van': [2702], 'Deurs': [2703], 'Holm': [2705], 'P.K.': [2706], 'Sandvig': [2707], 'Eur.': [2709], '69:': [2714], '343-350PubMed': [2715], 'inhibiting': [2724], 'formation': [2726], 'carrier': [2728], 'vesicles': [2729], 'operating': [2730], 'between': [2731], 'late': [2734, 3314], 'block': [2758], 'association': [2760], 'subset': [2763], 'coatamer': [2765], 'subunits': [2766], 'membranes': [2770], '(57Aniento': [2771], 'Gu': [2773], 'Parton': [2775], 'R.G.': [2776], '133:': [2783], '29-41Crossref': [2784], '(313)': [2787], '58Palokangas': [2790], 'Ying': [2792], 'Vaananen': [2794], 'Saraste': [2796], '9:': [2802], '3561-3578Crossref': [2803], '(86)': [2806], 'examined': [2813, 4302], 'expression,': [2815], 'processing,': [2816], 'mechanisms': [2819], 'various': [2821, 3572, 3629], '(TYR,': [2824], 'MART1)': [2829], 'melanotic': [2834], 'using': [2837, 3483, 3638, 3725, 3772, 3908, 4055, 4077, 4193], 'immunological,': [2838], 'biochemical,': [2839], 'molecular': [2841, 4187], 'approaches': [2842], 'characterize': [2844], 'localization': [2846, 3248], 'ER.': [2856], 'biogenesis': [2866], 'how': [2873], 'disrupted': [2877], 'unpigmented': [2879], 'levels': [2884], 'confirm': [2889], 'altered': [2896], 'corrected': [2912], 'glycosylated,': [2942], 'sorted': [2945], 'melanosomes.': [2947], 'Cultures—SK-MEL-28': [2979], 'obtained': [2985], 'ATCC': [2988], '(Manassas,': [2989], 'VA)': [2990], 'cultured': [2992, 3027], 'minimum': [2994, 4333], 'essential': [2995, 4334], 'medium': [2996, 3032, 4335], '(Invitrogen)': [2997, 3033, 3457], 'containing': [2998, 4180], '10%': [2999], 'fetal': [3000], 'bovine': [3001], 'serum,': [3002], '0.1': [3003, 4265], 'mm': [3004, 3009, 3017, 3455, 3694, 3697], 'nonessential': [3005], 'amino': [3006], 'acids,': [3007], 'sodium': [3010, 3014, 3689, 3700, 4267], 'pyruvate,': [3011], '2.8': [3012], 'μg/ml': [3013], 'bicarbonate,': [3015], 'l-glutamine,': [3018], 'penicillin/streptomycin.': [3020], 'MNT-1': [3021], "Dulbecco's": [3029], 'modified': [3030], "Eagle's": [3031], 'described': [3035, 3095, 3409, 4064, 4358], 'previously': [3036, 3096, 3855, 4206, 4359], 'Antibodies': [3066], 'Reagents—αPEP1h,': [3068], 'αPEP7h,': [3069], 'αPEP8h,': [3070], 'αPEP13h': [3072], 'antibodies': [3073, 3197, 3244, 3639], 'generated': [3075], 'rabbits': [3077], 'against': [3078, 3210, 3220, 3232, 3258, 3270], 'synthetic': [3079], 'peptides': [3080], 'corresponding': [3081], 'carboxyl': [3084], 'termini': [3085], 'respectively,': [3093, 4172], '(59Tsukamoto': [3097], 'Jackson': [3099], 'I.J.': [3100], 'Montague': [3103], 'P.M.': [3104], '11:': [3110], '519-526Crossref': [3111], '(466)': [3114], '60Kobayashi': [3117], 'Higashi': [3123], 'Imokawa': [3125], 'Kwon': [3127], 'Potterf': [3129], 'S.B.': [3130], '29198-29205Abstract': [3138], '61Jiménez': [3145], 'Tsukamoto': [3147], '266:': [3155], '1147-1156Abstract': [3156], '62Virador': [3163], 'Oldham': [3171], 'R.J.': [3172], 'Kameyama': [3173], 'Peck': [3175], 'G.L.': [3176], 'Abdel-Malek': [3181], 'Z.A.': [3182], '289-297Crossref': [3190], '(58)': [3193], 'Other': [3196], 'study': [3204], 'included': [3205], 'M2–9E3,': [3206], 'mAb': [3209, 3219, 3231, 3257, 3269, 3288], 'MART-1': [3212], '(Neomarkers,': [3213], 'Fremont,': [3214], 'CA),': [3215, 3225], 'HMB45,': [3216, 4468], '(Dako,': [3223], 'Carpinteria,': [3224], 'T311,': [3227], '(Novocastra': [3235], 'Laboratories,': [3236, 3356], 'Newcastle': [3237], 'upon': [3238], 'Tyne,': [3239], 'UK).': [3240], 'check': [3246], 'subcellular': [3250], 'follows:': [3253, 4134], 'CD107a,': [3254], '(LAMP1),': [3264], 'MTC02,': [3266], 'mitochondria': [3271], '(both': [3272], 'Research': [3274], 'Diagnostics,': [3275], 'Flanders,': [3276], 'NJ);': [3277], 'Bip/GRP78,': [3278, 4481], 'Vti1b,': [3279, 4465], 'EEA1,': [3280], 'syntaxin': [3281, 4466], '8,': [3282, 4467], 'p47A,': [3283], 'adaptin-γ,': [3285], 'reactive': [3289], 'apparatus': [3294], '(63Hirosaki': [3316], '119:': [3330], '475-480Abstract': [3331], 'complex-3': [3344], '(AP-3),': [3345], 'complex-1': [3349], '(AP-1),': [3350], 'respectively': [3351], '(all': [3352], 'BD': [3354], 'Transduction': [3355], 'Lexington,': [3357], 'KY).': [3358], 'Proteasome': [3359], 'N-Acetyl-Leu-Leu-norleucinal': [3361], '(ALLN)': [3362], 'benzyloxycarbonyl-Leu-Leu-leucinal': [3364], '(MG132)': [3365], 'purchased': [3367, 3389], 'Calbiochem.': [3369], 'Cycloheximide': [3370], '(CHX,': [3371], 'inhibitor': [3373, 3705], 'synthesis),': [3376], 'vATPase': [3378], '(Baf': [3380], 'CCM),': [3382], 'monensin': [3386], '(Mon)': [3387], 'Sigma.': [3391], 'All': [3392], 'dissolved': [3395], 'dimethyl': [3397], 'sulfoxide.': [3398], 'Subcellular': [3399], 'Fractionation—For': [3400], 'purification': [3401, 3846], 'protocol': [3407], 'originally': [3408], 'Ref.': [3411], '33Kushimoto': [3412], 'Scholar': [3440], 'modifications.': [3442], 'Briefly,': [3443, 3676, 3878, 4236], 'confluent': [3444], 'monolayers': [3445], 'SK-MEL-28': [3447, 3677, 3879], 'harvested': [3450, 3680, 3882, 4239], '0.05%': [3452], 'trypsin,': [3453], '0.53': [3454], 'EDTA': [3456], 'washed': [3459, 3682, 3884], 'once': [3460, 3683, 3885], '0.25': [3462, 3887], 'm': [3463, 3526, 3536, 3582, 3593, 3623, 3688, 3888, 3972, 3982, 4018, 4037, 4266], 'sucrose': [3464, 3527, 3537, 3594, 3889, 3973, 3983], 'centrifugation': [3466, 3708, 3891, 4243], '1,000': [3468, 3494, 3893, 3918], '×': [3469, 3495, 3512, 3555, 3610, 3711, 3736, 3752, 3792, 3823, 3894, 3919, 3935, 3953, 3999], 'g': [3470, 3496, 3513, 3556, 3611, 3712, 3737, 3753, 3793, 3824, 3895, 3920, 3936, 3954, 4000], '5': [3472, 3714, 3897], 'min': [3473, 3499, 3516, 3715, 3740, 3761, 3796, 3827, 3898, 3923, 3939, 3962, 4440, 4460, 4476], '4': [3475, 3501, 3518, 3568, 3616, 3717, 3742, 3763, 3798, 3829, 3900, 3925, 3941, 3964, 4012, 4245, 4257, 4280, 4442, 4478], '°C.': [3476, 3502, 3519, 3718, 3743, 3764, 3799, 3901, 3926, 3942, 3965, 4013, 4246, 4443], 'Specimens': [3477, 3719, 3902], 'homogenized': [3480, 3722, 3769, 3905], 'on': [3481, 3723, 3770, 3906], 'ice': [3482, 3724, 3771, 3907], '20': [3484, 3726, 3909], 'strokes': [3485, 3727, 3774, 3910], 'Dounce': [3488], 'glass:glass': [3489, 3730, 3913], 'homogenizer': [3490, 3731, 3779, 3914], 'centrifuged': [3492, 3509, 3552, 3607, 3733, 3749, 3789, 3820, 3916, 3932, 3950, 3996], '10': [3498, 3773, 3922, 4072, 4340], 'That': [3503, 3603, 3765, 3943], 'supernatant': [3504, 3745, 3814, 3928, 3944], 'recovered': [3506, 3747, 3816, 3930, 3946, 4022, 4040], '19,000': [3511, 3735], '30': [3515, 3938, 4090], 'pellet': [3521, 3766, 3801, 3833, 3967], 'resuspended': [3523, 3804, 3835, 3969], '2.0': [3525, 3546], 'layered': [3529, 3586, 3975], 'bottom': [3532], '1.0–2.0': [3535], 'step': [3538, 3595, 3984], '(1.0,': [3539], '1.2,': [3540, 3598, 3987], '1.4,': [3541], '1.5,': [3542], '1.6,': [3543], '1.8,': [3544], 'm)': [3547, 3601, 3991], 'gradient.': [3548, 3602], 'gradient': [3550, 3604], '100,000': [3554, 3609, 3998], 'Beckman': [3559, 4003], 'SW': [3560, 4004], '28': [3561, 4005], 'swinging-bucket': [3562, 4006], 'rotor': [3563, 3758, 3959, 4007], 'h': [3566, 3614, 4010, 4328], '°C,': [3569], 'layers': [3573, 3630, 4019, 4031], 'fraction': [3576], 'carefully': [3578, 3626, 4021], 'recovered.': [3579, 3627], '1.0': [3581, 3622, 4017], 'sample': [3583], 'middle': [3589, 3978], '0.8–1.4': [3592], '(0.8,': [3596, 3985], '1.0,': [3597, 3986], '1.4': [3600], 'again': [3606, 3768, 3819], '°C': [3617, 4110, 4117, 4125, 4258, 4281, 4331, 4479], '0.8': [3620, 4015], 'fractions': [3624, 3632, 4038], 'analyzed': [3634], 'Western': [3636], 'blotting': [3637], 'indicated': [3641], 'figure': [3644], 'legends.': [3645], 'standard': [3649], 'technique': [3650], '(64Campbell': [3651], 'Squicciarini': [3653], 'Shia': [3655], 'Pilch': [3657], 'Fine': [3659], 'Biochemistry.': [3661], '1984;': [3662], '23:': [3663], '4420-4426Crossref': [3664], '(94)': [3667], 'purify': [3671], 'vesicles.': [3675], 'MES': [3685], 'buffer': [3686, 3782, 3837, 4269], '(0.1': [3687], '6.5,': [3692], 'EGTA,': [3695], '0.5': [3696], 'MgCl2,': [3698], '0.02%': [3699], 'azide,': [3701], 'protease': [3704], 'mixture)': [3706], '1,250': [3710], '40': [3739, 3795], '120,000': [3751], 'Sorvall': [3756, 3957], 'T1270': [3757, 3958], '70': [3760, 3826], 'glass:': [3777], 'glass': [3778], 'Percoll-sucrose-MES': [3781], '(12.5%': [3783], 'Percoll,': [3784], '12.5%': [3785], 'sucrose,': [3786], 'MES)': [3787], '35,000': [3791], 'recovered,': [3803], 'buffer,': [3806], 'endosomerich': [3811], 'fraction.': [3812, 3844, 4046], '82,000': [3822], '°C;': [3830], 'resulting': [3832], 'For': [3845], 'published': [3856], 'method': [3857], '(65Zhang': [3858], 'Herscovitz': [3860], '7459-7468Abstract': [3867], '(78)': [3875], '2,000': [3934], '105,000': [3952], '60': [3961], '1.35': [3971, 4034], '0.8–2.1': [3981], '1.35,': [3988], '2.1': [3990, 4036], 'gradient,': [3992], '6': [4009], 'Golgi-rich': [4027], 'fraction,': [4028], 'ER-rich': [4045], 'Reverse': [4047], 'Transcription-PCR—Total': [4048], 'RNA': [4049, 4057, 4076], 'extracted': [4051], 'isolation': [4058], 'kit': [4059], '(Qiagen,': [4060], 'Hilden,': [4061], 'Germany)': [4062], 'manufacturer.': [4067], 'cDNA': [4068], 'prepared': [4070], 'μg': [4073], 'total': [4075], 'Moloney': [4078], 'murine': [4079], 'leukemia': [4080], 'virus': [4081], 'reverse': [4082], 'transcriptase': [4083], '(MMLV-RT,': [4084], 'Invitrogen).': [4085], 'PCR': [4086, 4097, 4159], 'consisted': [4088], 'cycles': [4091], 'G3PDH.': [4096], 'initiated': [4100], '"cold': [4103], 'start"': [4104], 'followed': [4105], 'denaturation': [4107], '94': [4109], '45': [4112, 4119], 's,': [4113, 4120], 'annealing': [4114], '58': [4116], 'polymerization': [4122], '72': [4124], '60s.': [4127], 'primer': [4129, 4137, 4141, 4145, 4149, 4153, 4157], 'sequences': [4130], 'sense': [4136, 4144, 4152], '5′-TTGGCAGATTGTCTGTAGCC-3′;': [4138], 'antisense': [4140, 4148, 4156], '5′-AGGCATTGTGCATGCTGCTT-3′;': [4142], '5′-GGAAAATGCCCCTATTGGAC-3′;': [4146], '5′-AAAGGGTCTTCCCAGCTTTG-3′;': [4150], 'G3PDH': [4151, 4155, 4165], '5′-ACCACAGTCCATGCCATCAC-3′;': [4154], '5′-TCCACCACCCTGTTGCTGTA-3′.': [4158], 'products': [4160], '284,': [4167], '500,': [4168], '452': [4170], 'bp,': [4171], 'resolved': [4175], '1.5%': [4177], 'agarose': [4178], 'gels': [4179], 'ethidium': [4181], 'bromide': [4182], 'parallel': [4184], 'DNA': [4186], 'weight': [4188], 'markers.': [4189], 'Blots': [4190], 'quantitated': [4192], 'ScionImage': [4194], 'software': [4195], '(Scion,': [4196], 'Frederick,': [4197], 'MD).': [4198], 'Electron': [4199], 'Microscopy—Electron': [4200], 'microscopy': [4201], 'performed': [4203], 'reported': [4205], 'collected': [4241], 'washes': [4249, 4428, 4447], 'fixed': [4254, 4434], 'overnight': [4255], '2%': [4260, 4262], 'glutaraldehyde,': [4261], 'paraformaldehyde': [4263, 4437], 'cacodylate': [4268], '(pH': [4270], '7.3).': [4271], 'samples': [4273], 'stored': [4276], 'PBS': [4278], 'until': [4282], 'they': [4283], 'embedded': [4285], 'epoxy': [4287], 'resin.': [4288], 'Thin': [4289], 'sections': [4290], 'cut,': [4292], 'stained': [4293, 4351], 'uranyl': [4295], 'acetate': [4296], 'lead': [4298], 'citrate,': [4299], 'Zeiss': [4305], 'EM': [4306], '912': [4307], 'EX': [4308], 'electron': [4309], 'microscope.': [4310], 'Immunofluorescence': [4311], 'Microscopy—Cells': [4312], 'plated': [4314], '2-well': [4316], 'Lab-Tek': [4317], 'chamber': [4318], 'slides': [4319], '(Nalge': [4320], 'Nunc': [4321], 'International,': [4322], 'Naperville,': [4323], 'IL),': [4324], 'incubated': [4325], '37': [4330], 'supplemented': [4336], 'without': [4339], 'μm': [4341], '25': [4343, 4347], 'nm': [4344, 4348], 'double': [4353], 'indirect': [4354], 'immunofluorescence': [4355], 'methods': [4356], '66Basrur': [4389], 'Yang': [4391], 'Higashimoto': [4395], 'Shabanowitz': [4407], 'Hunt': [4411], 'D.F.': [4412], 'Protein': [4416], '69-79Crossref': [4420], '(131)': [4423], 'three': [4427, 4445], '4%': [4436], '15': [4439, 4475], 'permeabilized': [4453], '0.01%': [4455], 'Triton': [4456], 'X-100': [4457], 'room': [4462], 'temperature': [4463], '(for': [4464, 4480], 'T311)': [4469], '100%': [4472], 'methanol': [4473], 'EEA1)': [4482], 'blocked': [4485], '5%': [4487], 'norm': [4488]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1987948820', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2025-01-10T17:08:01.066203', 'created_date': '2016-06-24'}