Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1987814777', 'doi': 'https://doi.org/10.1073/pnas.77.5.2559', 'title': 'Three-dimensional structure of a pyridoxal-phosphate-dependent enzyme, mitochondrial aspartate aminotransferase.', 'display_name': 'Three-dimensional structure of a pyridoxal-phosphate-dependent enzyme, mitochondrial aspartate aminotransferase.', 'publication_year': 1980, 'publication_date': '1980-05-01', 'ids': {'openalex': 'https://openalex.org/W1987814777', 'doi': 'https://doi.org/10.1073/pnas.77.5.2559', 'mag': '1987814777', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6930651', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/349441'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.77.5.2559', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc349441?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045521182', 'display_name': 'Geoffrey C. Ford', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'G C Ford', 'raw_affiliation_strings': ['Abteilung Strukturbiologie, Biozentrum der Universitit Basel, CH-4056 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Abteilung Strukturbiologie, Biozentrum der Universitit Basel, CH-4056 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076574682', 'display_name': 'Gregor Eichele', 'orcid': 'https://orcid.org/0000-0002-2863-9127'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'G Eichele', 'raw_affiliation_strings': ['Abteilung Strukturbiologie, Biozentrum der Universitit Basel, CH-4056 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Abteilung Strukturbiologie, Biozentrum der Universitit Basel, CH-4056 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060003736', 'display_name': 'J.N. Jansonius', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'J N Jansonius', 'raw_affiliation_strings': ['Abteilung Strukturbiologie, Biozentrum der Universitit Basel, CH-4056 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Abteilung Strukturbiologie, Biozentrum der Universitit Basel, CH-4056 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 16.343, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 240, 'citation_normalized_percentile': {'value': 0.990015, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '77', 'issue': '5', 'first_page': '2559', 'last_page': '2563'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11162', 'display_name': 'Macromolecular Crystallography Techniques', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11162', 'display_name': 'Macromolecular Crystallography Techniques', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Transport and Metabolism in Health and Disease', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure Prediction and Analysis', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pyridoxal-phosphate', 'display_name': 'Pyridoxal phosphate', 'score': 0.6836656}, {'id': 'https://openalex.org/keywords/pyridoxal-5-phosphate', 'display_name': 'Pyridoxal 5-Phosphate', 'score': 0.6786972}, {'id': 'https://openalex.org/keywords/enzyme-structure', 'display_name': 'Enzyme Structure', 'score': 0.561474}, {'id': 'https://openalex.org/keywords/aspartate-aminotransferases', 'display_name': 'Aspartate Aminotransferases', 'score': 0.55277574}, {'id': 'https://openalex.org/keywords/structures', 'display_name': 'Structures', 'score': 0.522038}], 'concepts': [{'id': 'https://openalex.org/C2780859938', 'wikidata': 'https://www.wikidata.org/wiki/Q3065731', 'display_name': 'Pyridoxal', 'level': 3, 'score': 0.76763844}, {'id': 'https://openalex.org/C2779546866', 'wikidata': 'https://www.wikidata.org/wiki/Q531306', 'display_name': 'Dimer', 'level': 2, 'score': 0.6913309}, {'id': 'https://openalex.org/C2776834122', 'wikidata': 'https://www.wikidata.org/wiki/Q418957', 'display_name': 'Pyridoxal phosphate', 'level': 4, 'score': 0.6836656}, {'id': 'https://openalex.org/C2910491791', 'wikidata': 'https://www.wikidata.org/wiki/Q418957', 'display_name': 'Pyridoxal 5-Phosphate', 'level': 4, 'score': 0.6786972}, {'id': 'https://openalex.org/C197957613', 'wikidata': 'https://www.wikidata.org/wiki/Q407280', 'display_name': 'Cofactor', 'level': 3, 'score': 0.67768526}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5884929}, {'id': 'https://openalex.org/C2910413745', 'wikidata': 'https://www.wikidata.org/wiki/Q412474', 'display_name': 'Aspartate Aminotransferases', 'level': 3, 'score': 0.55277574}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.5257412}, {'id': 'https://openalex.org/C41183919', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Active site', 'level': 3, 'score': 0.5185676}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4791995}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.44167936}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36572498}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.3414399}, {'id': 'https://openalex.org/C2778606649', 'wikidata': 'https://www.wikidata.org/wiki/Q305481', 'display_name': 'Alanine transaminase', 'level': 2, 'score': 0.1010879}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001219', 'descriptor_name': 'Aspartate Aminotransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001219', 'descriptor_name': 'Aspartate Aminotransferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006860', 'descriptor_name': 'Hydrogen Bonding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011732', 'descriptor_name': 'Pyridoxal Phosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011732', 'descriptor_name': 'Pyridoxal Phosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014961', 'descriptor_name': 'X-Ray Diffraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.77.5.2559', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc349441', 'pdf_url': 'https://europepmc.org/articles/pmc349441?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC349441', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6930651', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc349441', 'pdf_url': 'https://europepmc.org/articles/pmc349441?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W14355065', 'https://openalex.org/W1490121921', 'https://openalex.org/W1502266075', 'https://openalex.org/W150624595', 'https://openalex.org/W1518350746', 'https://openalex.org/W1524648410', 'https://openalex.org/W1554316381', 'https://openalex.org/W1565511216', 'https://openalex.org/W1585431411', 'https://openalex.org/W1602626372', 'https://openalex.org/W1969260203', 'https://openalex.org/W1973314777', 'https://openalex.org/W1976192207', 'https://openalex.org/W1978435746', 'https://openalex.org/W1982431451', 'https://openalex.org/W1983255192', 'https://openalex.org/W1986535831', 'https://openalex.org/W1986970656', 'https://openalex.org/W1992887350', 'https://openalex.org/W1999980461', 'https://openalex.org/W2000388754', 'https://openalex.org/W2003276139', 'https://openalex.org/W2005902014', 'https://openalex.org/W2007586786', 'https://openalex.org/W2010838626', 'https://openalex.org/W2014443189', 'https://openalex.org/W2018575514', 'https://openalex.org/W2019907300', 'https://openalex.org/W2024255258', 'https://openalex.org/W2027792474', 'https://openalex.org/W2035402464', 'https://openalex.org/W2041695045', 'https://openalex.org/W2050158044', 'https://openalex.org/W2054151922', 'https://openalex.org/W2056191458', 'https://openalex.org/W2059755939', 'https://openalex.org/W2059890422', 'https://openalex.org/W2079414398', 'https://openalex.org/W2079476223', 'https://openalex.org/W2082488805', 'https://openalex.org/W2089352451', 'https://openalex.org/W2108362929', 'https://openalex.org/W2119503430', 'https://openalex.org/W4240571721', 'https://openalex.org/W4243005211', 'https://openalex.org/W4542026', 'https://openalex.org/W561325876', 'https://openalex.org/W71638550', 'https://openalex.org/W74837706'], 'related_works': ['https://openalex.org/W4238826175', 'https://openalex.org/W2946487632', 'https://openalex.org/W2843789058', 'https://openalex.org/W2811032335', 'https://openalex.org/W2406106057', 'https://openalex.org/W2110249947', 'https://openalex.org/W2081350093', 'https://openalex.org/W2048372851', 'https://openalex.org/W1992012570', 'https://openalex.org/W1858542342'], 'abstract_inverted_index': {'X-ray': [0], 'diffraction': [1], 'studies': [2], 'to': [3], '2.8-A': [4], 'resolution': [5], 'have': [6], 'yielded': [7], 'the': [8, 44, 53], 'three-dimensional': [9], 'structure': [10, 35], 'of': [11, 41, 58, 62], 'mitochondrial': [12], 'aspartate': [13], 'aminotransferase': [14], '(L-aspartate:2-oxoglutarate': [15], 'aminotransferase,': [16], 'EC': [17], '2.6.1.1),': [18], 'an': [19], 'isologous': [20], 'alpha': [21], '2': [22, 26], 'dimer': [23], '(Mr': [24], '=': [25], 'x': [27], '45,000).': [28], 'The': [29], 'subunits': [30, 54], 'are': [31], 'rich': [32], 'in': [33], 'secondary': [34], 'and': [36, 55], 'contain': [37], 'two': [38], 'domains,': [39], 'one': [40], 'which': [42], 'anchors': [43], 'coenzyme,': [45], 'pyridoxal': [46], "5'-phosphate.": [47], 'Each': [48], 'active': [49], 'site': [50], 'lies': [51], 'between': [52], 'is': [56], 'composed': [57], 'residues': [59], 'from': [60], 'both': [61], 'them.': [63]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1987814777', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-18T22:36:23.127458', 'created_date': '2016-06-24'}