Title: Expression of the thrombin receptor in human liver: Up-regulation during acute and chronic injury
Abstract: HepatologyVolume 27, Issue 2 p. 462-471 Original ArticleFree Access Expression of the thrombin receptor in human liver: Up-regulation during acute and chronic injury Fabio Marra M.D., Ph.D., Corresponding Author Fabio Marra M.D., Ph.D. Istituto di Medicina Interna, Università di Firenze, Florence, ItalyIstituto di Medicina Interna, Università di Firenze, Viale Morgagni 85, I-50134 Florence, Italy. Fax: 39-55-417123===Search for more papers by this authorRaffaella DeFranco, Raffaella DeFranco Istituto di Medicina Interna, Università di Firenze, Florence, ItalySearch for more papers by this authorCecilia Grappone, Cecilia Grappone Dipartimento di Fisiopatologia Clinica, Unità di Gastroenterologia, Università di Firenze, Florence, ItalySearch for more papers by this authorStefano Milani, Stefano Milani Dipartimento di Fisiopatologia Clinica, Unità di Gastroenterologia, Università di Firenze, Florence, ItalySearch for more papers by this authorMassimo Pinzani, Massimo Pinzani Istituto di Medicina Interna, Università di Firenze, Florence, ItalySearch for more papers by this authorGiulia Pellegrini, Giulia Pellegrini Dipartimento di Fisiopatologia Clinica, Unità di Gastroenterologia, Università di Firenze, Florence, ItalySearch for more papers by this authorGiacomo Laffi, Giacomo Laffi Istituto di Medicina Interna, Università di Firenze, Florence, ItalySearch for more papers by this authorPaolo Gentilini, Paolo Gentilini Istituto di Medicina Interna, Università di Firenze, Florence, ItalySearch for more papers by this author Fabio Marra M.D., Ph.D., Corresponding Author Fabio Marra M.D., Ph.D. Istituto di Medicina Interna, Università di Firenze, Florence, ItalyIstituto di Medicina Interna, Università di Firenze, Viale Morgagni 85, I-50134 Florence, Italy. Fax: 39-55-417123===Search for more papers by this authorRaffaella DeFranco, Raffaella DeFranco Istituto di Medicina Interna, Università di Firenze, Florence, ItalySearch for more papers by this authorCecilia Grappone, Cecilia Grappone Dipartimento di Fisiopatologia Clinica, Unità di Gastroenterologia, Università di Firenze, Florence, ItalySearch for more papers by this authorStefano Milani, Stefano Milani Dipartimento di Fisiopatologia Clinica, Unità di Gastroenterologia, Università di Firenze, Florence, ItalySearch for more papers by this authorMassimo Pinzani, Massimo Pinzani Istituto di Medicina Interna, Università di Firenze, Florence, ItalySearch for more papers by this authorGiulia Pellegrini, Giulia Pellegrini Dipartimento di Fisiopatologia Clinica, Unità di Gastroenterologia, Università di Firenze, Florence, ItalySearch for more papers by this authorGiacomo Laffi, Giacomo Laffi Istituto di Medicina Interna, Università di Firenze, Florence, ItalySearch for more papers by this authorPaolo Gentilini, Paolo Gentilini Istituto di Medicina Interna, Università di Firenze, Florence, ItalySearch for more papers by this author First published: 30 December 2003 https://doi.org/10.1002/hep.510270221Citations: 73AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Thrombin is generated during tissue damage in several organs, including the liver, and participates in the process of tissue repair through proteolytic activation of a specific thrombin receptor(TR).The aim of this study was to investigate TR expression in human liver by immunohistochemistry and in situ hybridization. In normal liver, immunostaining for TR was present in the endothelial lining of the hepatic sinusoids. During chronic hepatitis, several cells expressing the TR were detected in the inflammatory infiltrate of portal tracts. In cirrhosis with chronic active hepatitis, expression of the TR was also present in mesenchymal cells of fibrous septa. TR expression was markedly up-regulated during fulminant hepatitis, with the highest expression in mesenchymal cells in areas of regeneration. Up-regulation of TR expression was associated with increased levels of TR messenger RNA (mRNA), as assessed byin situ hybridization and RNAse protection assay of liver RNA. Immunostaining of serial sections using specific cellular markers showed that different nonparenchymal cells contribute to TR expression during liver injury. TR expression was also shown in cultured human hepatic stellate cells, with increasing signal comparing activated versus quiescent cells. Because thrombin is rapidly generated after tissue damage, regulated TR expression may be involved in tissue remodeling and/or scarring during liver damage. Citing Literature Volume27, Issue2February 1998Pages 462-471 ReferencesRelatedInformation
Publication Year: 1998
Publication Date: 1998-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 100
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