Title: AMP-activated protein kinase (AMPK) regulates the activation process of hepatic stellate cells
Abstract: Background and aims. AMPK is a fuel-sensing enzyme which regulates cellular metabolism in response to different stimuli, including stress conditions, antidiabetic drugs and adiponectin. We recently demonstrated that activation of AMPK inhibits PDGF-stimulated proliferation and migration, as well as collagen and chemokine secretion by human activated HSC. However, the potential role of this enzyme in the process leading to activation of HSC has not been fully established. Aim of this study was to investigate whether AMPK modulates the trans-differentiation (activation) process of HSC.
Publication Year: 2008
Publication Date: 2008-05-01
Language: en
Type: article
Indexed In: ['crossref']
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