Title: Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives
Abstract: A series of quinoline-3-carbonitrile derivatives were designed and synthesized. Their cytotoxicity in vitro against four cancer cell lines (A549, HT-29, MDA-MB-231 and SMMC-7721) were evaluated by standard MTT assay. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC-7721 cell line. Among them, compounds 7c, 7e, 11b, 11f and 11g were more active than Gefitinb against SMMC-7721 cell line.
Publication Year: 2010
Publication Date: 2010-08-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 13
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