Publication Information

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4896], 'nuclear': [1, 122, 1393, 1556, 1566, 1646, 1695, 1751, 1789, 1965, 2117, 2149, 2388, 2511, 2919, 3019, 3620, 3631, 3739, 3801, 4004, 4178, 4187, 4309], 'extract': [2, 123, 1752, 1790, 1900, 2118, 2169, 2389, 2512, 3632, 3740, 3828, 3958, 4008, 4179, 4188, 4366, 4409, 4520, 4574, 4629, 4887], 'was': [3, 19, 56, 124, 140, 177, 1793, 1876, 1903, 1953, 2119, 2153, 2250, 2298, 2313, 2357, 2371, 2384, 2423, 2478, 2524, 2536, 2572, 2624, 2657, 2672, 2697, 2753, 2786, 2798, 2823, 2930, 2972, 2984, 2992, 3030, 3068, 3087, 3095, 3137, 3168, 3306, 3315, 3362, 3404, 3470, 3541, 3557, 3633, 3676, 3706, 3741, 3775, 3795, 3806, 3829, 3850, 3909, 3941, 3973, 4024, 4036, 4072, 4141, 4367, 4388, 4410, 4468, 4509, 4521, 4564, 4654, 4900, 4908], 'resolved': [4, 125, 1754, 1904, 3634, 3742, 4091], 'into': [5, 126, 2163, 3435, 3499, 3635, 3682], 'a': [6, 25, 43, 127, 146, 164, 714, 1188, 1198, 1208, 1348, 1473, 1549, 1649, 1812, 1846, 1906, 1910, 2059, 2066, 2122, 2156, 2372, 2434, 2459, 2489, 2505, 2553, 2583, 2601, 2678, 2708, 2804, 2833, 2951, 3004, 3048, 3083, 3107, 3171, 3335, 3356, 3405, 3471, 3538, 3542, 3568, 3683, 3695, 3725, 3729, 3767, 3835, 3871, 3947, 3963, 4427, 4524, 4634, 4696, 4829, 4996, 5158, 5184, 5216, 5270, 5410, 5424], 'depleted': [7, 77, 104, 128, 198, 225, 1656, 2116, 2168, 2509, 2596, 2740, 2858, 3718, 3761, 3957, 4006, 4079, 4102, 4185, 4364, 4519, 4551, 4628, 4860, 4886], 'fraction': [8, 27, 50, 129, 148, 171, 3719, 3792, 4028, 4106, 4194, 4209, 4231], 'incapable': [9, 130], 'of': [10, 24, 58, 96, 108, 112, 131, 145, 179, 217, 229, 233, 445, 716, 909, 1207, 1241, 1259, 1351, 1368, 1376, 1384, 1395, 1620, 1648, 1671, 1748, 1852, 1872, 1915, 1949, 1974, 2079, 2115, 2132, 2138, 2148, 2159, 2179, 2182, 2266, 2288, 2330, 2347, 2378, 2415, 2483, 2492, 2504, 2577, 2587, 2702, 2712, 2734, 2828, 2837, 2900, 2905, 2912, 2927, 2941, 2959, 2969, 2976, 2997, 3027, 3041, 3056, 3065, 3072, 3100, 3132, 3187, 3191, 3231, 3382, 3393, 3407, 3417, 3425, 3432, 3474, 3478, 3484, 3494, 3497, 3510, 3537, 3544, 3570, 3573, 3654, 3771, 3834, 3845, 3848, 3855, 3861, 3899, 3917, 3922, 3985, 4016, 4045, 4050, 4130, 4220, 4238, 4241, 4262, 4272, 4286, 4299, 4317, 4372, 4454, 4462, 4491, 4496, 4504, 4536, 4572, 4624, 4638, 4641, 4661, 4686, 4698, 4770, 4788, 4840, 4853, 4856, 4866, 4881, 4890, 4910, 4913, 4986, 4990, 5002, 5028, 5057, 5160, 5315, 5331, 5337, 5339, 5346, 5416], 'supporting': [11, 132], 'mismatch': [12, 73, 86, 133, 194, 207, 1145, 1189, 1255, 1362, 1390, 1581, 1685, 1784, 1961, 2081, 3602, 3626, 3665, 3757, 3849, 3864, 3880, 3923, 3931, 4291, 4431, 4515, 4776, 4847, 4920, 5062, 5075, 5167, 5318, 5385], 'repair': [13, 17, 74, 87, 134, 138, 195, 208, 243, 1146, 1232, 1363, 1582, 1630, 1651, 1686, 1785, 1962, 2097, 2187, 2503, 2901, 2922, 3022, 3627, 3714, 3735, 3758, 3833, 3844, 3865, 3904, 3944, 3968, 4292, 4300, 4306, 4362, 4404, 4432, 4460, 4497, 4516, 4554, 4589, 4787, 4848, 4867, 4921, 5063, 5076, 5168, 5217, 5319], 'in': [14, 33, 88, 102, 115, 135, 154, 209, 223, 236, 261, 302, 308, 448, 713, 980, 1151, 1238, 1359, 1469, 1551, 1578, 1616, 1663, 1682, 1817, 1856, 1886, 1905, 1920, 2121, 2146, 2252, 2316, 2429, 2497, 2563, 2591, 2614, 2688, 2716, 2814, 2841, 2874, 2887, 2956, 3053, 3082, 3125, 3170, 3334, 3343, 3379, 3390, 3440, 3501, 3507, 3600, 3625, 3628, 3659, 3724, 3785, 3832, 3841, 3936, 3950, 3962, 4002, 4026, 4042, 4077, 4101, 4228, 4290, 4307, 4324, 4406, 4430, 4494, 4513, 4517, 4588, 4619, 4626, 4644, 4758, 4774, 4832, 4846, 4859, 4884, 4893, 4940, 4995, 4999, 5009, 5032, 5041, 5061, 5134, 5169, 5350, 5382, 5413, 5438], 'vitro,': [15, 136, 3667], 'and': [16, 46, 63, 100, 137, 167, 184, 221, 252, 709, 962, 1190, 1237, 1251, 1331, 1370, 1372, 1378, 1546, 1623, 1653, 1694, 1773, 1819, 1843, 1892, 1936, 1969, 2135, 2151, 2170, 2186, 2278, 2285, 2344, 2382, 2453, 2486, 2547, 2580, 2617, 2630, 2705, 2727, 2844, 2851, 2865, 2880, 2950, 3047, 3255, 3290, 3310, 3329, 3369, 3562, 3575, 3638, 3645, 3747, 3783, 3970, 3997, 4013, 4048, 4083, 4104, 4116, 4136, 4205, 4301, 4376, 4744, 4791, 4795, 4927, 5153, 5191, 5333, 5335, 5341], 'activity': [18, 40, 139, 161, 1627, 1652, 2249, 2312, 2908, 2926, 3026, 3421, 3488, 3759, 3805, 3916, 3972, 3979, 4063, 4075, 4094, 4122, 4402, 4405, 4467, 4503, 4539, 4555, 4643, 4660, 4664, 4689, 4750, 4756, 4801, 4907], 'restored': [20, 72, 141, 193, 1335, 2502, 3852, 4522, 4556], 'upon': [21, 142, 4570], 'the': [22, 47, 76, 94, 103, 116, 143, 168, 197, 215, 224, 237, 442, 1204, 1221, 1227, 1234, 1239, 1249, 1254, 1257, 1270, 1276, 1281, 1337, 1352, 1360, 1477, 1579, 1613, 1617, 1621, 1624, 1659, 1672, 1683, 1774, 1827, 1868, 1873, 1945, 1950, 2075, 2080, 2104, 2177, 2534, 2655, 2670, 2732, 2784, 2891, 2898, 2924, 2933, 2966, 2977, 2995, 3024, 3033, 3062, 3073, 3098, 3128, 3177, 3188, 3260, 3344, 3350, 3380, 3391, 3423, 3492, 3508, 3535, 3571, 3655, 3734, 3862, 3879, 3897, 3915, 3951, 3956, 4031, 4037, 4073, 4078, 4084, 4109, 4197, 4217, 4221, 4229, 4325, 4354, 4373, 4448, 4459, 4489, 4501, 4518, 4537, 4550, 4622, 4627, 4639, 4645, 4752, 4759, 4797, 4805, 4811, 4820, 4833, 4851, 4863, 4878, 4918, 4937, 4941, 4947, 4987, 5019, 5025, 5029, 5058, 5177, 5223, 5313, 5316, 5326, 5347, 5375, 5394, 5414, 5421], 'addition': [23, 144, 851, 1464, 2178, 2733, 3818, 3854], 'purified': [26, 147, 3563, 3777, 3791, 3807, 4374], 'isolated': [28, 149, 1381, 4540, 4662, 4761, 4905], 'from': [29, 150, 2374, 2385, 2412, 2909, 2932, 3032, 3243, 3268, 3298, 3308, 3316, 4092, 4196, 4276], 'cells': [31, 152, 1691], 'by': [32, 153, 247, 253, 1326, 1340, 1382, 2093, 2167, 2176, 2668, 2731, 2974, 2994, 3070, 3097, 3140, 3227, 3388, 3567, 3743, 3808, 3853, 3870, 3988, 4054, 4296, 4313, 4385, 4392, 4412, 4483, 4527, 4557, 4567, 4676, 4690, 5141, 5180, 5183, 5389], 'vitrocomplementation': [34, 155], 'assay.': [35, 156], 'The': [36, 157, 1142, 1223, 1319, 1863, 1939, 2077, 2367, 2476, 2570, 2695, 2796, 2821, 3528, 3788, 4284, 5367], 'highly': [37, 158, 3790], 'enriched': [38, 159, 3796], 'complementing': [39, 160, 2595, 2739, 2857, 2902, 2907, 3772, 3804, 3978, 4046, 4062, 4093, 4121, 4466, 4502, 4538, 4663, 4906], 'copurified': [41, 162], 'with': [42, 163, 969, 1476, 1795, 1889, 1964, 2096, 2470, 2480, 2488, 2574, 2582, 2699, 2707, 2722, 2825, 2832, 2877, 3364, 3686, 3691, 3905, 3943, 3977, 4060, 4216, 4353, 4369, 4472, 4575, 4583, 4680, 5074, 5148, 5215, 5284, 5429], 'DNA': [44, 52, 60, 67, 80, 97, 165, 173, 181, 188, 201, 218, 249, 258, 910, 1242, 1327, 1341, 1625, 1679, 1977, 2247, 2310, 3134, 3165, 3194, 3221, 3261, 3401, 3418, 3439, 3467, 3485, 3680, 3697, 3715, 3730, 3964, 3993, 4010, 4039, 4069, 4124, 4150, 4156, 4162, 4287, 4302, 4318, 4377, 4383, 4400, 4421, 4658, 4671, 4687, 4754, 4771, 4841, 4954, 5039, 5194, 5376, 5380, 5390, 5404, 5418, 5436], 'polymerase,': [45, 166], 'most': [48, 169, 3789], 'pure': [49, 170], 'contained': [51, 172, 2129, 4009, 4108], 'polymerase': [53, 68, 81, 174, 189, 202, 1328, 1680, 2248, 2311, 2368, 3135, 3166, 3195, 3222, 3262, 3402, 3419, 3468, 3486, 3731, 3965, 3971, 4011, 4040, 4052, 4070, 4110, 4125, 4132, 4134, 4151, 4157, 4163, 4288, 4303, 4401, 4422, 4659, 4688, 4772, 4938, 4955, 5377, 5391, 5405], 'δ': [54, 69, 82, 175, 190, 203, 1681, 3167, 3196, 3469, 3487, 4023, 4035, 4071, 4158, 4223, 4249, 4289, 4456, 4493, 4508, 4532, 4560, 4700, 4773, 4783, 4827, 4926, 4932, 4993, 5221, 5408], 'but': [55, 176, 3668, 4021, 4127, 4675, 5006, 5054], 'free': [57, 178, 4129, 4261], 'detectable': [59, 180, 4131, 4263, 4911], 'polymerases': [61, 98, 182, 219, 3994, 4319, 4842, 5031], 'α': [62, 99, 183, 220, 3403, 3420, 4012, 4152, 4423, 4546, 4843, 4872], 'ε.': [64, 185], 'Calf': [65, 186], 'thymus': [66, 187, 3193, 3466, 4530], 'also': [70, 191, 905, 1347, 1575, 2314, 2778, 3830, 3910, 4107, 4294, 4958, 5164, 5282, 5398], 'fully': [71, 192, 3851, 4894], 'to': [75, 93, 196, 214, 852, 855, 971, 1193, 1220, 1233, 1269, 1280, 1336, 1387, 1392, 1465, 1543, 1633, 1644, 1667, 1782, 1811, 1825, 1830, 1839, 1845, 2070, 2074, 2090, 2100, 2142, 2432, 2437, 2449, 2458, 2508, 2538, 2552, 2659, 2724, 2729, 2789, 2847, 2963, 3059, 3164, 3184, 3219, 3280, 3288, 3295, 3304, 3355, 3428, 3564, 3595, 3616, 3721, 3755, 3760, 3800, 3812, 3819, 3822, 3878, 3902, 3975, 4258, 4498, 4523, 4656, 4819, 4850, 4868, 4902, 4935, 4945, 5017, 5176, 5189, 5228, 5325, 5374], 'extract,': [78, 105, 199, 226, 2150, 3938, 4005, 4103, 4464, 4500, 4862], 'indicating': [79, 200, 4315], 'is': [83, 204, 1267, 1278, 1323, 1334, 1346, 2110, 3489, 3920, 4128, 4175, 4184, 4193, 4208, 4293, 4311, 4581, 4648, 4695, 4751, 4784, 4802, 4813, 4933, 5015, 5157, 5173, 5387, 5397], 'required': [84, 205, 1349, 1650, 3427, 3712, 3727, 3732, 3966, 4074, 4785], 'for': [85, 206, 1629, 1661, 2085, 2113, 2305, 2364, 2935, 3035, 3606, 3694, 3713, 3733, 3752, 3967, 4458, 4768, 4786, 4799, 5066, 5219, 5400], 'human': [89, 210, 303, 1361, 1580, 1684, 3133, 3220, 3250, 3398, 3532, 3601, 3863, 4085, 4544, 4775, 4919, 5170, 5317], 'cells.': [90, 211], 'However,': [91, 212, 1612, 4236], 'due': [92, 213, 4849], 'presence': [95, 216, 1240, 2078, 3509, 4271, 4623, 4852], 'ε': [101, 222, 3223, 3998, 4018, 4164, 4323, 4845, 4883, 5011, 5286, 5431], 'potential': [106, 227], 'involvement': [107, 228, 4316, 4769, 5211, 5336], 'one': [109, 230, 2101, 3708], 'or': [110, 231, 305, 964, 1218, 1262, 1272, 2103, 2350, 2872, 3387, 3709, 3876, 4533, 4561, 4672, 4817, 4844, 4930, 5182], 'both': [111, 232, 3642, 3671, 3846, 3906, 4098, 4857, 4924], 'these': [113, 234, 4252, 5372], 'activities': [114, 235, 1355, 1614, 3598, 4858], 'reaction': [117, 238, 1147, 1583, 1622, 3866, 4326, 4812, 4922, 5320, 5348], 'cannot': [118, 239, 4268, 4837, 5273], 'be': [119, 240, 1214, 1634, 3722, 3868, 3960, 4259, 5213, 5274], 'excluded.': [120, 241], 'Mismatch': [242, 4305], 'ensures': [244], 'genetic': [245, 309, 443], 'stability': [246], 'correcting': [248], 'biosynthetic': [250, 1626, 4755], 'errors': [251], 'blocking': [254], 'recombination': [255], 'between': [256, 4251], 'diverged': [257], 'sequences': [259], '(reviewed': [260, 5349], 'Refs.': [262], '1Radman': [263], 'M.': [264, 381, 406, 467, 501, 630, 646, 886, 1015, 1031, 1035, 1064, 1106, 1302, 1426, 1488, 4726, 4967, 5038, 5079, 5235, 5435], 'Genome.': [265], '1989;': [266], '31:': [267], '68-73Crossref': [268], 'PubMed': [269, 284, 296, 333, 367, 392, 412, 477, 561, 612, 657, 704, 748, 780, 795, 812, 845, 872, 899, 936, 957, 1005, 1022, 1046, 1137, 1162, 1182, 1298, 1316, 1412, 1439, 1458, 1503, 1534, 1607, 1713, 1734, 1768, 2012, 2029, 2050, 2221, 2242, 2406, 3013, 3116, 3160, 3213, 3459, 3523, 3587, 3894, 4343, 4442, 4613, 4718, 4739, 4978, 5090, 5121, 5204, 5248, 5265, 5307, 5362], 'Scopus': [270, 285, 297, 334, 368, 393, 413, 478, 562, 613, 658, 705, 749, 781, 796, 813, 846, 873, 900, 937, 958, 1006, 1023, 1047, 1138, 1163, 1413, 1440, 1459, 1504, 1535, 1608, 1714, 1735, 1769, 2013, 2030, 2051, 2222, 2243, 2407, 3014, 3117, 3214, 3460, 3524, 3588, 4344, 4443, 4614, 4740, 4979, 5091, 5122, 5205, 5249, 5266, 5363], '(50)': [271], 'Google': [272, 287, 299, 336, 370, 395, 415, 439, 480, 564, 615, 660, 707, 751, 783, 798, 815, 848, 875, 902, 939, 960, 1008, 1025, 1049, 1070, 1087, 1116, 1140, 1165, 1183, 1299, 1317, 1415, 1442, 1461, 1506, 1537, 1610, 1716, 1737, 1771, 2015, 2032, 2053, 2224, 2245, 2409, 3016, 3119, 3161, 3216, 3462, 3526, 3590, 3895, 4346, 4445, 4616, 4719, 4742, 4981, 5093, 5124, 5207, 5251, 5268, 5308, 5365], 'Scholar,': [273, 288, 337, 371, 396, 416, 481, 565, 616, 661, 752, 784, 799, 816, 876, 940, 1009, 1026, 1050, 1071, 1088, 1117, 1166, 1300, 1416, 1443, 1507, 1717, 2016, 2033, 2225, 4720, 5252], '2Modrich': [274, 5352], 'P.': [275, 322, 359, 495, 497, 541, 593, 597, 638, 740, 807, 867, 880, 925, 994, 1011, 1017, 1125, 1156, 1172, 1288, 1306, 1407, 1420, 1447, 1708, 1723, 2004, 2024, 2039, 2213, 2231, 2395, 3884, 4332, 5353], 'Lahue': [276, 1169, 1285, 5354], 'R.': [277, 290, 339, 424, 455, 469, 493, 648, 650, 720, 824, 946, 1081, 1094, 1108, 1123, 1521, 1523, 1984, 2193, 5254, 5256, 5355], 'Annu.': [278, 5356], 'Rev.': [279, 5357], 'Biochem.': [280, 3009, 3112, 5358], '1996;': [281, 293, 933, 951, 1084, 1113, 1129, 1495, 1531, 1599, 4605, 5113, 5359], '65:': [282, 1766, 5360], '101-133Crossref': [283, 5361], '(1337)': [286, 5364], '3Kolodner': [289], 'Genes': [291], 'Dev.': [292], '10:': [294, 437], '1433-1442Crossref': [295], '(544)': [298], 'Scholar).': [300, 849, 1141, 1184, 1318, 1462, 1538, 1611, 1738, 2054, 2246, 3120, 3162, 3217, 3463, 3527, 3591, 4347, 4446, 5094, 5208, 5309, 5366, 5450], 'Defects': [301], 'MutSα': [304, 904, 963, 1365], 'MutLα': [306, 965, 1373], 'result': [307], 'destabilization': [310], '(4Kat': [311, 983], 'A.': [312, 329, 353, 375, 377, 388, 549, 603, 636, 695, 734, 768, 830, 888, 921, 932, 984, 1001, 1033, 1054, 1073, 1075, 1079, 1121, 1428, 1454, 1530, 1585, 1730, 1998, 2046, 2207, 2238, 2402, 2499, 2593, 4339, 4591, 5099], 'Thilly': [313, 985], 'W.G.': [314, 986], 'Fang': [315, 344, 725, 987, 1989, 2198], 'W.': [316, 988, 1077, 3153, 3882], 'Longley': [317, 342, 723, 804, 864, 989, 1404, 1705, 1987, 2021, 2196], 'M.J.': [318, 343, 724, 805, 865, 990, 1405, 1706, 1988, 2022, 2197], 'Li': [319, 340, 721, 802, 862, 991, 1402, 1703, 1985, 2019, 2194], 'G.-M.': [320, 803, 863, 992, 1403, 1445, 1704, 2020], 'Modrich': [321, 358, 739, 806, 866, 924, 993, 1124, 1155, 1171, 1287, 1305, 1406, 1446, 1707, 1722, 2003, 2023, 2038, 2212, 2230, 2394, 3883, 4331], 'Proc.': [323, 382, 926, 995, 1448, 1524, 1724, 2040, 2232, 2396, 4333], 'Natl.': [324, 383, 927, 996, 1449, 1525, 1725, 2041, 2233, 2397, 4334], 'Acad.': [325, 384, 928, 997, 1450, 1526, 1726, 2042, 2234, 2398, 4335], 'Sci.': [326, 385, 929, 998, 1451, 1527, 1727, 2043, 2235, 2399, 4336], 'U.': [327, 386, 930, 999, 1452, 1528, 1728, 2044, 2236, 2400, 4337], 'S.': [328, 387, 404, 519, 620, 758, 832, 931, 944, 1000, 1090, 1453, 1509, 1513, 1517, 1529, 1721, 1729, 2037, 2045, 2229, 2237, 2393, 2401, 3152, 4330, 4338, 5197], '1993;': [330, 361, 471, 555, 742, 1002, 1019, 1176, 1292, 1310, 2006, 2215, 3157, 3888, 4975, 5087], '90:': [331, 1003], '6424-6428Crossref': [332, 1004], '(427)': [335, 1007], '5Parsons': [338], 'G.M.': [341, 533, 591, 691, 722, 1986, 2195], 'W.H.': [345, 726, 1990, 2199], 'Papadopoulos': [346, 486, 664, 727, 1991, 2200], 'N.': [347, 487, 567, 665, 728, 818, 1029, 1992, 2201], 'Jen': [348, 490, 729, 763, 1993, 2202], 'J.': [349, 379, 465, 491, 505, 527, 537, 539, 634, 730, 764, 838, 894, 1126, 1173, 1289, 1304, 1307, 1434, 1492, 1719, 1994, 2035, 2203, 2227, 2391, 3198, 3885, 4328, 4709, 5297, 5298], 'de': [350, 546, 600, 692, 731, 765, 1995, 2204], 'la': [351, 547, 601, 693, 732, 766, 1996, 2205], 'Chapelle': [352, 548, 602, 694, 733, 767, 1997, 2206], 'Kinzler': [354, 550, 604, 698, 735, 771, 835, 1999, 2208], 'K.W.': [355, 551, 605, 699, 736, 2000, 2209], 'Vogelstein': [356, 425, 552, 606, 696, 737, 773, 839, 2001, 2210], 'B.': [357, 426, 489, 553, 607, 667, 697, 738, 754, 774, 822, 840, 1092, 1096, 2002, 2211, 2718, 3580, 4734, 5199, 5243], 'Cell.': [360, 470, 554, 741, 1039, 1598, 2005, 2214, 3155, 3582, 4604, 5112], '75:': [362, 472, 556, 743, 2007, 2216], '1227-1236Abstract': [363, 744, 2008, 2217], 'Full': [364, 474, 558, 745, 954, 1043, 1132, 1134, 1179, 1295, 1313, 1498, 1500, 1602, 1604, 2009, 2218, 3891, 4608, 4610, 4715, 5116, 5118, 5304], 'Text': [365, 475, 559, 746, 955, 1044, 1133, 1135, 1180, 1296, 1314, 1499, 1501, 1603, 1605, 2010, 2219, 3892, 4609, 4611, 4716, 5117, 5119, 5305], 'PDF': [366, 476, 560, 747, 956, 1045, 1136, 1181, 1297, 1315, 1502, 1606, 2011, 2220, 3893, 4612, 4717, 5120, 5306], '(966)': [369, 750, 2014, 2223], '6Bhattacharyya': [372], 'N.P.': [373], 'Skandalis': [374], 'Ganesh': [376], 'Groden': [378], 'Meuth': [380], '1994;': [389, 409, 609, 654, 701, 5201], '91:': [390], '6319-6323Crossref': [391], '(404)': [394], '7Shibata': [397], 'D.': [398, 1100], 'Peinado': [399], 'M.A.': [400], 'Ionov': [401], 'Y.': [402], 'Malkhosyan': [403], 'Perucho': [405], 'Nat.': [407, 775], 'Genet.': [408, 776], '6:': [410, 1496], '273-281Crossref': [411], '(455)': [414], '8Eshleman': [417], 'J.R.': [418, 786], 'Lang': [419], 'E.Z.': [420], 'Bowerfind': [421], 'G.K.': [422], 'Parsons': [423, 492, 761, 823], 'Willson': [427, 759, 833], 'J.K.': [428], 'Veigl': [429], 'M.L.': [430], 'Sedwick': [431], 'W.D.': [432], 'Markowitz': [433, 757, 787, 831], 'S.D.': [434, 788], 'Oncogene.': [435], '1995;': [436, 777, 792, 809, 842, 869, 896, 1040, 1067, 1409, 1436, 1455, 1710, 2026, 3456, 3520, 4439], '33-37PubMed': [438], 'Scholar),': [440, 708, 903, 961, 3896, 4617, 5053, 5269], 'are': [441, 967, 978, 2921, 3021, 4226, 5132, 5226], 'basis': [444, 1660], 'tumor': [446, 1397], 'predisposition': [447], 'hereditary': [449], 'nonpolyposis': [450], 'colorectal': [451], 'cancer': [452], 'kindreds': [453], '(9Fishel': [454], 'Lescoe': [456, 627], 'M.K.': [457, 628], 'Rao': [458], 'M.R.': [459], 'Copeland': [460, 3149, 3409, 3448], 'N.G.': [461], 'Jenkins': [462], 'N.A.': [463], 'Garber': [464], 'Kane': [466, 629, 1514], 'Kolodner': [468, 649, 1520], '1027-1038Abstract': [473], '(2610)': [479], '10Leach': [482], 'F.S.': [483], 'Nicolaides': [484, 568, 755, 819], 'N.C.': [485, 569, 663, 756, 820, 4434], 'Liu': [488, 666, 821], 'Peltomäki': [494, 596], 'Sistonen': [496], 'Aaltonen': [498], 'L.A.': [499], 'Nyström-Lahti': [500], 'Guan': [502], 'X.-Y.': [503], 'Zhang': [504], 'Meltzer': [506], 'P.S.': [507], 'Yu': [508], 'J.-W.': [509], 'Kao': [510], 'F.-T.': [511], 'Chen': [512], 'D.J.': [513], 'Cerosaletti': [514], 'K.M.': [515, 3204, 3515, 4708, 4732, 5241], 'Fournier': [516], 'R.E.K.': [517], 'Todd': [518], 'Lewis': [520], 'T.': [521, 884, 1424, 1490, 1511, 3151], 'Leach': [522], 'R.J.': [523, 640], 'Naylor': [524], 'S.L.': [525], 'Weissenbach': [526], 'Mecklin': [528, 598], 'J.-P.': [529, 599], 'Järvinen': [530], 'H.': [531, 1038, 1098, 5260], 'Petersen': [532, 690], 'Hamilton': [534, 588, 688, 769], 'S.R.': [535, 589, 689, 770], 'Green': [536], 'Jass': [538], 'Watson': [540, 592], 'Lynch': [542, 594], 'H.T.': [543, 595], 'Trent': [544], 'J.M.': [545, 948, 1056], '1215-1225Abstract': [557], '(2105)': [563], '11Papadopoulos': [566], 'Wei': [570, 668], 'Y.-F.': [571, 669], 'Ruben': [572, 672], 'S.M.': [573, 673], 'Carter': [574, 670], 'K.C.': [575, 671], 'Rosen': [576, 674], 'C.A.': [577, 675], 'Haseltine': [578, 676], 'W.A.': [579, 677], 'Fleischmann': [580, 678], 'R.D.': [581, 679, 1102], 'Fraser': [582, 680], 'C.M.': [583, 681], 'Adams': [584, 682], 'M.D.': [585, 683], 'Venter': [586, 684], 'J.C.': [587, 685], 'Peterson': [590], 'Science.': [608, 808, 841, 868, 895, 1408, 1435, 1709, 2025], '263:': [610], '1625-1629Crossref': [611], '(1774)': [614], '12Bronner': [617], 'C.E.': [618], 'Baker': [619], 'Morrison': [621], 'P.T.': [622], 'Warren': [623], 'G.': [624, 1013, 1058, 4722, 5231], 'Smith': [625], 'L.G.': [626], 'Earabino': [631], 'C.': [632, 826, 4704], 'Lipford': [633], 'Lindblom': [635], 'Tannergard': [637], 'Bollag': [639], 'Godwin': [641], 'A.R.': [642], 'Ward': [643], 'D.C.': [644, 1591, 4597, 5105], 'Nordenskjold': [645], 'Fishel': [647, 945, 1107, 1522], 'Liskay': [651, 1594, 4600, 4970, 5082, 5108], 'R.M.': [652, 1595, 4601, 4971, 5083, 5109], 'Nature.': [653, 700, 1018, 4735, 4974, 5086, 5200, 5244, 5261], '368:': [655], '258-261Crossref': [656], '(1935)': [659], '13Nicolaides': [662], 'Dunlop': [686], 'M.G.': [687], '371:': [702], '75-80Crossref': [703], '(1448)': [706], 'have': [710, 1356, 1640, 1654, 4349, 4426, 4779, 5126], 'been': [711, 1149, 1357, 1576], 'implicated': [712, 1358, 1577], 'subset': [715], 'sporadic': [717], 'cancers': [718], '(5Parsons': [719, 1983, 2192], '14Liu': [753], 'J.K.V.': [760, 834], 'R.E.': [762], 'K.': [772, 836, 3578], '9:': [778], '48-55Crossref': [779], '(754)': [782], '15Eshleman': [785], 'Curr.': [789, 1493], 'Opin.': [790], 'Oncol.': [791], '7:': [793], '83-89Crossref': [794], '(248)': [797], '16Drummond': [800, 2017], 'J.T.': [801, 861, 915, 919, 1119, 1401, 1702, 2018], '268:': [810, 843, 870, 897, 1177, 1293, 1311, 1410, 1437, 1711, 2027, 3889], '1909-1912Crossref': [811, 871, 1411, 1712, 2028], '(538)': [814, 874, 1414, 1715, 2031], '17Papadopoulos': [817], 'Lengauer': [825], 'Palombo': [827], 'F.': [828, 878, 1418, 1482], "D'Arrigo": [829, 887, 1427], 'Jiricny': [837, 893, 1433, 1491], '1915-1917Crossref': [844], '(474)': [847], 'In': [850, 1463, 1959, 3592, 3817, 4170], 'its': [853, 1466, 3810, 3820], 'ability': [854, 1386, 3754, 3811, 3898], 'recognize': [856], 'mismatched': [857], 'base': [858], 'pairs': [859], '(16Drummond': [860, 1400, 1701], '18Palombo': [877, 1417], 'Gallinari': [879, 1419], 'Iaccarino': [881, 1421, 1483], 'I.': [882, 1422, 1484, 3148, 3787], 'Lettieri': [883, 1423], 'Hughes': [885, 1425], 'Truong': [889, 1429], 'O.': [890, 1430], 'Hsuan': [891, 1431], 'J.J.': [892, 1432], '1912-1914Crossref': [898, 1438], '(481)': [901, 1441], 'recognizes': [906, 1187], 'certain': [907, 972], 'classes': [908], 'damage': [911], '(19Duckett': [912], 'D.R.': [913], 'Drummond': [914], 'Murchie': [916], 'A.I.H.': [917], 'Reardon': [918], 'Sancar': [920], 'Lilley': [922], 'D.M.J.': [923], '93:': [934, 1532], '6443-6447Crossref': [935], '(377)': [938], '20Mello': [941], 'J.A.': [942, 1589, 4595, 5103], 'Acharya': [943], 'Essigman': [947], 'Chem.': [949, 1128, 1175, 1291, 1309, 3887, 4711, 5300], 'Biol.': [950, 1127, 1174, 1290, 1308, 1494, 3156, 3583, 3886, 4710, 5299], '3:': [952], '579-589Abstract': [953], '(186)': [959], 'defects': [966, 5077], 'associated': [968], 'resistance': [970], 'DNA-damaging': [973], 'agents,': [974], 'including': [975, 3604, 5329], 'several': [976, 4239], 'that': [977, 1202, 1230, 1865, 1941, 2064, 2501, 3622, 3692, 3704, 3914, 3955, 4068, 4246, 4356, 4420, 4452, 4650, 4748, 4781, 4796, 4809, 4825, 4891, 4984, 5129, 5145, 5166, 5396], 'used': [979, 1561, 1641, 1655, 2870], 'anticancer': [981], 'chemotherapy': [982], '21Branch': [1010], 'Aquilina': [1012], 'Bignami': [1014], 'Karran': [1016], '362:': [1020], '652-654Crossref': [1021], '(351)': [1024], '22de': [1027], 'Wind': [1028], 'Dekker': [1030], 'Berns': [1032], 'Radman': [1034], 'te': [1036], 'Riele': [1037], '82:': [1041], '321-330Abstract': [1042], '(732)': [1048], '23Hawn': [1051], 'M.T.': [1052], 'Umar': [1053, 5095], 'Carethers': [1055], 'Marra': [1057], 'Kunkel': [1059, 1596, 4602, 5110], 'T.A.': [1060, 1597, 1762, 4603, 4969, 5081, 5111], 'Boland': [1061, 1103], 'C.R.': [1062, 1104], 'Koi': [1063, 1105], 'Cancer': [1065, 1082, 1111, 3272], 'Res.': [1066, 1083, 1112, 1158], '55:': [1068], '3721-3725PubMed': [1069], '24Anthoney': [1072], 'McIlwrath': [1074], 'Gallagher': [1076], 'Edlin': [1078], 'Brown': [1080, 1122, 1779, 1917, 3647], '56:': [1085, 1114], '1374-1381PubMed': [1086], '25Aebi': [1089], 'Kurdi-Haidar': [1091], 'Gordon': [1093], 'Cenni': [1095], 'Zheng': [1097], 'Fink': [1099], 'Christen': [1101], 'Howell': [1109], 'S.B.': [1110], '3087-3090PubMed': [1115], '26Drummond': [1118], 'Anthoney': [1120], '271:': [1130], '19645-19648Abstract': [1131], '(283)': [1139], 'Escherichia': [1143], 'coli': [1144, 3560], 'has': [1148, 1574, 4244, 5321], 'reconstituted': [1150], 'vitro': [1152, 1664, 1960], '(27Lahue': [1153], 'R.S.': [1154, 1170, 1286], 'Mutat.': [1157], '1988;': [1159], '198:': [1160], '37-43Crossref': [1161], '(22)': [1164], '28Cooper': [1167], 'D.L.': [1168, 1284], '11823-11829Abstract': [1178, 1294], 'Briefly,': [1185, 2055], 'MutS': [1186, 1478, 5340], 'MutL': [1191, 5150, 5342], 'binds': [1192, 1542, 5188], 'this': [1194, 1637, 2056, 3660, 3986, 4027, 4051, 4105, 4242, 4277, 4351, 4642, 4693, 4749, 4800, 4914, 4961, 5067, 5277], 'complex.': [1195], 'This': [1196, 1539, 3702, 3717, 3764, 3953, 4579, 4763], 'activates': [1197], 'latent,': [1199], 'MutH-associated': [1200], 'endonuclease': [1201, 2102], 'incises': [1203], 'unmethylated': [1205, 1235], 'strand': [1206, 1339, 2072, 2109, 3859, 4807], 'hemimethylated': [1209], 'd(GATC)': [1210], 'sequence,': [1211], 'which': [1212, 2108, 3361, 3607, 3774, 5187], 'may': [1213, 4957], 'located': [1215, 3873, 4814], 'either': [1216, 1260, 2094, 2348, 2869, 3874, 4528, 4558, 4815, 4917], '5′': [1217, 1268, 3877, 4816], '3′': [1219, 1279, 3875, 4818], 'mispair.': [1222, 4821], 'nick': [1224, 1250, 1277, 3872, 3925], 'serves': [1225, 2089], 'as': [1226, 1658, 1698, 1955, 1980, 2144, 2189, 2545, 2600, 2854, 2986, 3003, 3089, 3106, 3367, 3491, 3778, 4143, 4481, 5139], 'primary': [1228, 3365], 'signal': [1229], 'directs': [1231, 4810], 'strand,': [1236], 'helicase': [1243], 'II,': [1244, 2519, 2937, 3037], 'exonucleolytic': [1245], 'excision': [1246, 1618, 5178], 'initiates': [1247], 'at': [1248, 1744, 1894, 2155, 2302, 2361, 2445, 2455, 2514, 2549, 2605, 2619, 2674, 2744, 2800, 2862, 2882, 3331, 3443, 3504, 3946, 5343, 5420], 'proceeds': [1252], 'toward': [1253], 'through': [1256, 1867], 'action': [1258], 'RecJ': [1261], 'exonuclease': [1263, 1273], 'VII': [1264], 'when': [1265, 1275, 4363, 4804], 'incision': [1266, 2069], 'mismatch,': [1271], 'I': [1274, 2889, 2929, 3029], 'mispair': [1282], '(28Cooper': [1283], '29Grilley': [1301], 'Griffith': [1303], '11830-11837Abstract': [1312], 'resulting': [1320], 'single-strand': [1321], 'gap': [1322], 'then': [1324], 'filled': [1325], 'III': [1329, 2623, 5392], 'holoenzyme,': [1330, 5393], 'covalent': [1332], 'continuity': [1333], 'repaired': [1338], 'ligase.': [1342], 'Single-stranded': [1343], 'DNA-binding': [1344, 3252, 4087], 'protein': [1345, 2948, 2967, 3045, 3063, 3253, 4088, 4479], 'component': [1350], 'reaction.': [1353, 1364, 1687, 2076, 3737, 3952, 4646, 4834, 4942], 'Four': [1354], '(a': [1366, 1374], 'heterodimer': [1367, 1375], 'MSH2': [1369, 1471], 'MSH6)': [1371], 'MLH1': [1377, 5154], 'PMS2)': [1379], 'were': [1380, 1692, 1742, 1753, 1978, 2174, 2720, 2868, 3224, 3241, 3266, 3297, 3323, 3353, 3623, 3662, 3750, 3999, 4090, 4099], 'virtue': [1383, 3809], 'their': [1385, 1552, 3753], 'restore': [1388, 3756, 3813, 3903], 'strand-specific': [1389, 2068], 'correction': [1391, 5386], 'extracts': [1394, 1647, 1657, 1696, 1966, 2598, 2742, 2860, 2920, 3020, 4310, 5172], 'repair-deficient': [1396], 'cell': [1398, 1555, 1565, 3400, 3611, 5171], 'lines': [1399, 3612], '30Li': [1444], '92:': [1456], '1950-1954Crossref': [1457], '(356)': [1460], 'subunit': [1467, 3131, 3190, 4225], 'function': [1468, 4989, 5425], 'MutSα,': [1470], 'forms': [1472], 'molecular': [1474], 'complex': [1475, 1541], 'homolog': [1479, 5159], 'MSH3': [1480], '(31Palombo': [1481], 'Nakajima': [1485], 'E.': [1486, 5383], 'Ikejima': [1487], 'Shimada': [1489], '1181-1184Abstract': [1497], '(303)': [1505], '32Acharya': [1508], 'Wilson': [1510], 'Gradia': [1512], 'M.F.': [1515], 'Guerrette': [1516], 'Marsischky': [1518], 'G.T.': [1519], '13629-13634Crossref': [1533], '(471)': [1536], 'MutSβ': [1540], 'insertion/deletion': [1544, 3837, 4793], 'mismatches': [1545, 4790], 'presumably': [1547], 'plays': [1548, 4828, 5409], 'role': [1550, 4429, 4640, 4831, 5218, 5412], 'processing.': [1553], 'Proliferating': [1554], 'antigen': [1557], '(PCNA)': [1558], '1The': [1559], 'abbreviations': [1560], 'are:': [1562], 'PCNA,': [1563], 'proliferating': [1564], 'antigen;': [1567], 'PMSF,': [1568, 1932], 'phenylmethylsulfonyl': [1569, 1806], 'fluoride;': [1570], 'HRP,': [1571, 3289], 'horseradish': [1572, 3281], 'peroxidase.': [1573], '(33Umar': [1584, 4590, 5098], 'Buermeyer': [1586, 4592, 5100], 'A.B.': [1587, 1593, 4593, 4599, 5101, 5107], 'Simon': [1588, 4594, 5102], 'Thomas': [1590, 4596, 5104], 'Clark': [1592, 1720, 2036, 2228, 2392, 4329, 4598, 5106], '87:': [1600, 1732, 2048, 2240, 2404, 4341, 4606, 5114], '65-73Abstract': [1601, 4607, 5115], '(502)': [1609, 4615, 5123], 'involved': [1615, 3599], 'stage': [1619, 3949], 'responsible': [1628, 5399], 'synthesis': [1631, 3736, 4378, 5381, 5415], 'remain': [1632], 'identified.': [1635], 'To': [1636, 4487], 'end': [1638], 'we': [1639, 3614, 4267, 4836], 'biochemical': [1642], 'methods': [1643], 'deplete': [1645], 'an': [1662, 3374, 3593, 3687, 4873], 'complementation': [1665, 2114], 'assay': [1666], 'isolate': [1668, 3596], 'additional': [1669, 4576], 'components': [1670, 3711], 'system.': [1673], 'We': [1674, 4348, 4778, 4943], 'describe': [1675], 'here': [1676, 5370], 'experiments': [1677, 4450, 4585], 'implicating': [1678, 4586], 'Human': [1688, 3555], 'S3': [1690], 'cultured': [1693], 'prepared': [1697], 'described': [1699, 1981, 2190, 2987, 3090, 3779, 4144, 5369], 'previously': [1700, 1982, 2191], '34Holmes': [1718, 2034, 2226], '1990;': [1731, 2047, 2239, 2403, 4340], '5837-5841Crossref': [1733, 2049, 2241, 2405, 4342], '(336)': [1736, 2052, 2244, 2408, 4345], 'All': [1739], 'fractionation': [1740], 'steps': [1741, 5345], 'performed': [1743, 1979, 2120, 2985, 3088, 4142], '0–4': [1745], '°C.': [1746, 2884], 'Samples': [1747], 'repair-proficient': [1749], 'independently': [1755], 'on': [1756, 1909, 2107, 2425, 2627, 3641, 3745, 4379, 4667, 4692, 4960, 5024, 5276, 5312], 'heparin-Sepharose': [1757, 1853, 2554, 3643], '4B': [1758, 1854, 2555, 3644], '(35Pirrotta': [1759], 'V.': [1760, 3857], 'Bickle': [1761], 'Methods': [1763, 3454, 3518, 4437], 'Enzymol.': [1764, 3455, 3519, 4438], '1980;': [1765], '89-95Crossref': [1767], '(51)': [1770], 'Scholar)': [1772, 2410, 4743, 4982, 5125], 'immobilized': [1775], 'dye': [1776, 3346], 'resin': [1777], 'Reactive': [1778, 1916, 3646], '10': [1780, 1918, 2264, 2328, 3648, 4413], '(Sigma)': [1781], 'generate': [1783, 3617], 'deficient': [1786, 3619, 3723, 3961], 'fractions.': [1787, 2172], '(93': [1791], 'mg)': [1792, 1902], 'diluted': [1794, 2428], '0.025': [1796, 1921, 2633], 'mHEPES·KOH': [1797], '(pH': [1798, 1923, 2260, 2323, 2636, 2759], '7.6),': [1799, 1924, 2637], '0.1': [1800, 1834, 1860, 1925, 2638, 2663, 2692, 2761], 'mm': [1801, 1926, 2161, 2326, 2639, 2726, 2762, 2849], 'EDTA,': [1802, 1927, 2640, 2763], '2': [1803, 1928, 2262, 2325, 2700, 4183, 4233], 'mmdithiothreitol,': [1804, 1929], '0.1%': [1805, 1930, 2730, 2852], 'fluoride': [1807], '(PMSF,': [1808], 'concentration': [1809, 2158, 2949, 3046], 'relative': [1810, 3799], '23': [1813, 2421], '°C': [1814, 1896, 2304, 2363, 3445, 3506], 'saturated': [1815], 'solution': [1816], 'isopropanol),': [1818], '1': [1820, 1933, 2345, 2641, 2644, 2725, 2769, 2772, 2848, 3430, 3441, 3495, 3502, 4174], 'μg/ml': [1821, 1934, 2642, 2645, 2770, 2773, 3512], 'leupeptin': [1822], '(buffer': [1823, 2648, 2776], 'A)': [1824], 'make': [1826], 'conductivity': [1828, 2435, 2535, 2656, 2785], 'equivalent': [1829, 2436, 2537, 2658, 2788], 'buffer': [1831, 1857, 1880, 2430, 2438, 2471, 2485, 2498, 2527, 2539, 2564, 2579, 2592, 2660, 2689, 2704, 2717, 2790, 2815, 2842], 'A': [1832, 1858, 1881, 2431, 2439, 2472, 2528, 2540, 2565, 2647, 2775, 2978, 3043, 3074], 'containing': [1833, 1859, 1882, 2256, 2320, 2440, 2473, 2529, 2541, 2566, 2650, 2662, 2691, 2779, 2792, 2817, 2897, 3670, 4475], 'm': [1835, 1861, 2184, 2258, 2442, 2516, 2531, 2568, 2634, 2652, 2664, 2693, 2781, 2794, 2819], 'KCl,': [1836, 1884, 2443], 'centrifuged': [1837, 2444], 'briefly': [1838, 1877], 'remove': [1840, 2450], 'insoluble': [1841, 2451], 'material,': [1842, 1875, 1952, 2452], 'applied': [1844, 2454, 2548, 2673, 2799], '5.5': [1847], 'cm': [1848, 1912, 2465, 2558], '×': [1849, 1913, 2447, 2466, 2559], '1.5-cm2': [1850], 'column': [1851, 2171, 2461, 2477, 2556, 2571, 2686, 2696, 2812, 2822, 2892, 3748, 3765, 4200], 'equilibrated': [1855, 1919, 2469, 2562, 2687, 2813], 'KCl.': [1862, 1938, 2475, 2569, 2665, 2694, 2795, 2820], 'material': [1864, 1940], 'flowed': [1866], 'column,': [1869], 'representing': [1870, 1947], '80%': [1871], 'starting': [1874, 1951], 'dialyzed': [1878, 2525, 2631, 2754], 'against': [1879, 2526, 2632, 2755, 3127, 3176, 3237, 3249, 3259], '0.1m': [1883], 'frozen': [1885, 2873], 'small': [1887, 2875, 4792], 'aliquots': [1888, 2876], 'liquid': [1890, 2615, 2878], 'nitrogen,': [1891], 'stored': [1893, 2881], '−80': [1895, 2620, 2883], '(Fraction': [1897, 1957, 2417, 2518, 2608, 2747, 3793], 'H1).': [1898], 'Nuclear': [1899, 2917], '(70': [1901], 'similar': [1907, 2123, 4525], 'manner': [1908, 3661], '5.1': [1911], '0.8-cm2column': [1914], 'mTris·HCl': [1922], '(saturated)': [1931], 'leupeptin,': [1935, 2643, 2771], '0.05m': [1937], 'did': [1942, 3933, 4547], 'not': [1943, 3700, 3934, 4118, 4417, 4425, 4548, 4683], 'bind': [1944], 'resin,': [1946], '60%': [1948], 'treated': [1954], 'above': [1956], 'R1).': [1958], 'assays': [1963], '(50': [1967, 2254, 2318, 4180, 4189], 'μg)': [1968], '100': [1970, 2419, 2456, 4357, 4393], 'ng': [1971], '(24': [1972], 'fmol)': [1973], 'heteroduplex': [1975, 2063, 2507, 3815, 3825, 3907, 3939], 'f1MR': [1976], 'method': [2057, 2996, 3099, 3572], 'uses': [2058], '6.4-kilobase': [2060], 'pair': [2061], 'circular': [2062], 'contains': [2065, 4123], 'site-specific,': [2067], 'provide': [2071], 'direction': [2073], 'within': [2082], 'overlapping': [2083], 'sites': [2084], 'two': [2086, 4253, 5030, 5059, 5142, 5224], 'restriction': [2087], 'endonucleases': [2088], 'block': [2091], 'cleavage': [2092], 'activity,': [2095, 3728, 3773, 4047, 4375], 'conferring': [2098], 'sensitivity': [2099], 'other': [2105, 4032], 'depending': [2106], 'corrected.': [2111], 'Assay': [2112], 'manner,': [2124], 'except': [2125], 'reactions': [2126, 2253, 2317, 3669], '(20': [2127], 'μl)': [2128, 2255, 2319], '35': [2130], 'μg': [2131, 2137, 2265, 2287, 2329, 2346], 'Fraction': [2133, 2139, 2522, 2622, 2751, 2885, 2928, 2936, 2970, 3028, 3036, 3066, 3856, 3900, 3918, 4043, 4370, 4386, 4398, 4473, 4534, 4562], 'H1': [2134], '27': [2136], 'R1': [2140], '(referred': [2141], 'below': [2143], 'H1/R1)': [2145, 3678], 'place': [2147], 'KCl': [2152, 2493, 2517, 2532, 2588, 2607, 2653, 2713, 2782, 2838], 'maintained': [2154], 'final': [2157], '105–110': [2160], 'taking': [2162], 'account': [2164, 5065], 'salt': [2165], 'contributed': [2166], 'Reactions': [2173], 'terminated': [2175], '5': [2180], 'μl': [2181], '0.5': [2183], 'EDTA': [2185], 'scored': [2188], 'determined': [2251, 2299, 2315, 2358, 2993, 3096], '0.02': [2257, 2441], 'Tris·HCl': [2259, 2322, 2635], '8.0),': [2261], 'mm2-mercaptoethanol,': [2263], 'acetylated': [2267, 2331], 'bovine': [2268, 2332, 3000, 3103], 'serum': [2269, 2333, 3001, 3104], 'albumin,': [2270, 2334], '0.01m': [2271], 'MgCl2,': [2272], '50': [2273, 2280, 2337, 2340, 2575, 4477], 'μm': [2274, 2281, 2338, 4358, 4394, 4414], 'each': [2275, 4171], 'dATP,': [2276, 2339], 'dGTP,': [2277], 'dTTP,': [2279], '[32P]dCTP': [2282], '(600–1900': [2283], 'cpm/pmol),': [2284, 2343], '40': [2286], 'sonicated,': [2289], 'DNase': [2290], 'I-activated': [2291], 'salmon': [2292, 3437, 4381, 4669], 'sperm': [2293, 3438, 4382, 4670], 'DNA.': [2294], 'Trichloroacetic': [2295], 'acid-insoluble': [2296], 'radioactivity': [2297, 2356], 'after': [2300], 'incubation': [2301, 2360], '37': [2303, 2362, 3444, 3505], '60': [2306], 'min.': [2307, 2366], 'When': [2308], 'indicated,': [2309, 3368], '0.04m': [2321], '6.8),': [2324], '2-mercaptoethanol,': [2327], '1.5': [2335], 'mmMgCl2,': [2336], 'μm[32P]dTTP': [2341], '(600–800': [2342], 'poly(dA-dT)': [2349, 4673], 'poly(dA)·oligo(dT)12–18,': [2351], '(20:1': [2352], 'nucleotide': [2353], 'ratio).': [2354], 'Acid-insoluble': [2355], 'following': [2359], '30': [2365], 'inhibitor': [2369], 'butylphenyl-dGTP': [2370, 4415, 4869], 'gift': [2373, 3406, 3473, 3543], 'George': [2375], 'Wright': [2376, 4435], '(University': [2377, 3230, 3477], 'Massachusetts,': [2379], 'Worcester,': [2380], 'MA),': [2381], 'aphidicolin': [2383, 4359], 'Sigma.': [2386, 3299], '(34Holmes': [2390, 4327], 'derived': [2411, 4275], '200': [2413, 2910, 3332], 'liters': [2414, 2911], 'culture': [2416], 'I,': [2418], 'ml,': [2420, 2495], 'mg/ml)': [2422], 'thawed': [2424, 2626], 'wet': [2426, 2628], 'ice,': [2427], 'yield': [2433], '12,000': [2446], 'g': [2448], 'ml/h': [2457, 2551], 'phosphocellulose': [2460, 4096], '(Whatman': [2462], 'P-11,': [2463], '18': [2464], '12.6': [2467], 'cm2)': [2468, 2561], '0.02m': [2474], 'washed': [2479, 2573, 2698, 2824], '450': [2481], 'ml': [2482, 2576, 2701, 2827], 'equilibration': [2484, 2578, 2703, 2829], 'developed': [2487, 2581], 'linear': [2490, 2585, 2710, 2835], 'gradient': [2491, 2586, 2711, 2836], '(2900': [2494], '0.02–0.9m)': [2496], 'Fractions': [2500, 2594, 2719, 2738, 2856], '5′-G·T': [2506], 'H1/R1': [2510, 2597, 2741, 2859, 2906, 3705, 3762, 3803, 3827, 3937, 4007, 4061, 4186, 4230, 4256, 4365, 4408, 4463, 4465, 4499, 4573, 4861], 'eluted': [2513, 2599, 2706, 2743, 2831, 2861], '∼0.39': [2515], '250': [2520], 'ml).': [2521, 2611, 2750], 'II': [2523], '0.05': [2530], 'until': [2533, 2654, 2783, 3339], '0.085': [2542, 2567, 2651, 2780, 2793, 2818], 'mKCl,': [2543, 2864], 'clarified': [2544], 'above,': [2546, 3929], '25': [2550], '(14.6': [2557], '1.75': [2560], '260-ml': [2584], '(0.085–0.5': [2589, 2839], 'm)': [2590, 2715, 2840], 'broad': [2602], 'peak': [2603, 2899, 3770], 'centered': [2604], '∼0.2m': [2606], 'III,': [2609, 5406], '84': [2610], 'After': [2612, 2666], 'freezing': [2613], 'nitrogen': [2616, 2879], 'storage': [2618], '°C,': [2621], 'later': [2625], 'ice': [2629], 'pepstatin': [2646, 2774], 'B)': [2649], 'B': [2661, 2690], 'clarification': [2667], 'centrifugation,': [2669], 'dialysate': [2671, 2797], '0.7': [2675, 2801], 'ml/min': [2676, 2802], 'onto': [2677, 2803, 3325], '1.0-ml': [2679, 2805], 'HR': [2680, 2806], '5/5': [2681, 2807], 'Mono': [2682, 2808, 2945, 2961, 4198], 'Q': [2683], '(Pharmacia)': [2684, 2810], 'FPLC': [2685, 2811], '20-ml': [2709], '(0.1–0.5': [2714], 'supplemented': [2721], 'dithiothreitol': [2723, 2850], 'PMSF': [2728, 2853], 'concentrated': [2735], 'stock': [2736], 'solutions.': [2737], '∼0.31': [2745], 'mKCl': [2746], 'IV,': [2748], '3.5': [2749], 'IV': [2752, 4371, 4399], '0.025m': [2756], 'potassium': [2757], 'phosphate': [2758], '7.0),': [2760], '10%': [2764], 'glycerol,': [2765], '0.01%': [2766], 'Nonidet': [2767], 'P-40,': [2768], 'C)': [2777], 'approximately': [2787, 4390], 'C': [2791, 2816], 'S': [2809, 4199], '3': [2826, 4115, 4192, 4631], 'buffer,': [2830], '15-ml': [2834], 'C,': [2843, 4161], 'fractions': [2845, 2867, 2893, 3640, 3673, 3749, 4760], 'adjusted': [2846], 'before.': [2855], '∼0.3': [2863], 'individual': [2866, 3656], 'directly': [2871], 'V': [2886, 2971, 3067, 3333, 3901, 3919, 4044, 4387, 4474, 4535, 4563], 'Table': [2888, 3786], 'represents': [2890, 3422], '(17–19,': [2894], '2.4': [2895], 'ml)': [2896], 'activity.Table': [2903], 'IPurification': [2904], 'cellsFractionTotal': [2914], 'proteinSpecific': [2915], 'activityYieldmgpmol/mg%I.': [2916], 'extract22700.20aSince': [2918], 'proficient,': [2923, 3023], 'specific': [2925, 3025], 'extrapolated': [2931, 3031], 'value': [2934, 3034], 'assuming': [2938, 3038], '100%': [2939, 3039], 'recovery': [2940, 3040], 'activity.100II.': [2942], 'Phosphocellulose785.70100III.': [2943], 'Heparin-Sepharose3.49875IV.': [2944], 'Q0.221005.0bA': [2946], 'low': [2947, 2964, 3044, 3060], 'single': [2952, 3049, 3726, 4806], 'freeze-thaw': [2953, 3050], 'cycle': [2954, 3051], 'resulted': [2955, 3052], 'significant': [2957, 3054, 4854], 'loss': [2958, 3055], 'activity.V.': [2960], 'S0.036cDue': [2962], 'abundance,': [2965, 3061], 'content': [2968, 3064], 'estimated': [2973, 3069, 4053], 'integration': [2975, 3071], '280': [2979, 3075], 'tracing': [2980, 3076], 'generated': [2981, 3077], 'during': [2982, 3078, 4064, 4095], 'FPLC.5604.5Purification': [2983], 'under': [2988, 3091, 3534, 3780, 4145], '“Experimental': [2989, 3092, 3651, 3781, 4146], 'Procedures.”': [2990, 3093, 4147], 'Protein': [2991, 3094], 'Bradford,': [2998, 3101], 'utilizing': [2999, 3102], 'albumin': [3002, 3105], 'standard': [3005, 3108], '(50Bradford': [3006, 3109], 'M.M.': [3007, 3110], 'Anal.': [3008, 3111], '1976;': [3010, 3113], '72:': [3011, 3114], '248-254Crossref': [3012, 3115], '(217544)': [3015, 3118], 'Scholar).a': [3017], 'Since': [3018, 3858], 'activity.b': [3042], 'activity.c': [3057], 'Due': [3058], 'FPLC.': [3079], 'Open': [3080], 'table': [3081], 'new': [3084, 3684, 5417], 'tab': [3085], 'Purification': [3086], 'Polyclonal': [3121], 'antibody': [3122], 'IDα,': [3123], 'raised': [3124, 3169, 3236, 3258], 'chicken': [3126], 'recombinant': [3129, 3238], 'p180': [3130], 'α,': [3136, 3995, 4133, 4320], 'kindly': [3138], 'provided': [3139, 3226, 3869], 'Teresa': [3141], 'Wang': [3142], '(Stanford': [3143], 'University,': [3144], 'Stanford,': [3145], 'CA)': [3146], '(36Dornreiter': [3147], 'W.C.': [3150, 3449], 'Mol.': [3154, 3581], '13:': [3158], '809-820Crossref': [3159], 'Antiserum': [3163], 'New': [3172, 3274], 'Zealand': [3173], 'White': [3174], 'rabbit': [3175, 3256, 3284], 'synthetic': [3178], 'multiple': [3179], 'antigenic': [3180], 'peptide': [3181], 'LYQKEVSHLSALEERFSRLW,': [3182], 'corresponding': [3183], 'residues': [3185], '1036–1055': [3186], 'catalytic': [3189, 4224], 'calf': [3192, 3465, 4529], '(37Zhang': [3197], 'Chung': [3199], 'D.W.': [3200], 'Tan': [3201, 4723, 5232], 'C.K.': [3202, 4724, 5233], 'Downey': [3203, 4707, 4731, 5240], 'Davie': [3205], 'E.W.': [3206], 'So': [3207, 3476, 3516, 4705, 4729, 5238], 'A.G.': [3208, 3517, 4706, 4730, 5239], 'Biochemistry.': [3209], '1991;': [3210, 5301], '30:': [3211], '11742-11750Crossref': [3212], '(64)': [3215], 'Antibodies': [3218], 'generously': [3225], 'Stuart': [3228], 'Linn': [3229], 'California,': [3232], 'Berkeley).': [3233], 'Monoclonal': [3234], 'antibodies': [3235, 3248, 3257, 3366], 'rat': [3239], 'PCNA': [3240, 3513, 3533, 3556, 4082, 4168, 4587, 4625, 4651, 4691, 5136, 5146, 5190, 5210, 5280], 'obtained': [3242, 3658, 4951], 'Boehringer': [3244], 'Mannheim.': [3245], 'Mouse': [3246], 'monoclonal': [3247], 'single-stranded': [3251, 4086], '(RPA)': [3254], 'accessory': [3263, 4111], 'factor': [3264, 4112], 'RF-C': [3265, 4113], 'gifts': [3267], 'Jerard': [3269], 'Hurwitz': [3270, 5296], '(Sloan-Kettering': [3271], 'Center,': [3273], 'York).': [3275], 'Rabbit': [3276], 'anti-chicken': [3277], 'IgG': [3278, 3286, 3293, 3302, 3314], 'cross-linked': [3279, 3287, 3294, 3303], 'peroxidase': [3282, 3383], '(HRP),': [3283], 'anti-mouse': [3285, 3301], 'goat': [3291, 3312], 'anti-rabbit': [3292, 3313], 'HRP': [3296, 3305], 'Sheep': [3300], 'purchased': [3307], 'Amersham,': [3309], '125I-labeled': [3311, 3394], 'ICN.': [3317], 'For': [3318], 'immunological': [3319, 3989, 4055], 'blot': [3320, 3990, 4056, 4139], 'analysis,': [3321, 5144], 'proteins': [3322, 5225], 'loaded': [3324], '8%': [3326], 'SDS-polyacrylamide': [3327, 4485], 'gels': [3328, 4240], 'electrophoresed': [3330], 'mini-gel': [3336], 'apparatus': [3337], '(Bio-Rad)': [3338], 'bromphenol': [3340], 'blue': [3341], 'present': [3342, 4001, 4100, 4757, 4892], 'loading': [3345], 'had': [3347], 'run': [3348], 'off': [3349], 'gel.': [3351], 'Proteins': [3352], 'transferred': [3354], 'nylon': [3357], 'membrane': [3358], '(Biotrans,': [3359], 'ICN),': [3360], 'probed': [3363], 'immune': [3370], 'complexes': [3371], 'visualized': [3372], 'using': [3373], 'ECL': [3375], 'chemiluminescence': [3376], 'kit': [3377], '(Amersham)': [3378], 'case': [3381, 3392, 4172, 4621], 'linked': [3384], 'secondary': [3385, 3395], 'antibodies,': [3386], 'autoradiography': [3389], 'antibodies.': [3396], 'Immunopurified': [3397], 'KB': [3399], 'William': [3408], '(NIEHS,': [3410], 'Research': [3411], 'Triangle': [3412], 'Park,': [3413], 'NC).': [3414], 'One': [3415, 3482], 'unit': [3416, 3483], 'amount': [3424], 'enzyme': [3426, 5395], 'incorporate': [3429], 'nmol': [3431, 3496], 'labeled': [3433], 'dNMP': [3434, 3498], 'activated': [3436, 4380, 4668], 'h': [3442, 3503], '(38Wang': [3446], 'T.S.': [3447], 'Rogge': [3450], 'L.': [3451], 'Dong': [3452], 'Q.': [3453], '262:': [3457, 3521, 4440], '77-84Crossref': [3458], '(13)': [3461, 3525], 'Purified': [3464], 'generous': [3472], 'Antero': [3475], 'Miami,': [3479, 3480], 'FL).': [3481], 'defined': [3490], 'incorporation': [3493], 'poly(dA)·oligo(dT)': [3500, 4681], '2–4': [3511], '(39Downey': [3514], '84-92Crossref': [3522], 'plasmid': [3529], 'pT7hPCNA,': [3530], 'encoding': [3531], 'control': [3536], 'T7': [3539], 'promoter,': [3540], 'Bruce': [3545], 'Stillman': [3546, 3576, 3579, 4733, 5198, 5242], '(Cold': [3547], 'Spring': [3548, 3552, 5045, 5049, 5442, 5446], 'Harbor': [3549, 5046, 5443], 'Laboratory,': [3550, 5047, 5444], 'Cold': [3551, 5044, 5048, 5441, 5445], 'Harbor,': [3553, 5050, 5447], 'NY).': [3554], 'expressed': [3558], 'inE.': [3559], 'BL21(DE3)': [3561], 'apparent': [3565], 'homogeneity': [3566], 'modification': [3569], 'Fein': [3574], '(40Fien': [3577], '1992;': [3584], '12:': [3585], '155-163Crossref': [3586], '(190)': [3589], 'effort': [3594], 'unidentified': [3597], 'repair,': [3603, 3826, 4904], 'those': [3605], 'mutations': [3608, 5008], 'might': [3609, 3959, 5064], 'render': [3610], 'inviable,': [3613], 'sought': [3615], 'biochemically': [3618], 'subfractions': [3621, 3657], 'defective': [3624, 3831], 'vitro.': [3629], 'crude': [3636], 'bound': [3637], 'unbound': [3639, 3672], 'resins': [3649], '(see': [3650], 'Procedures”).': [3652], 'None': [3653], 'able': [3663], 'support': [3664, 3823, 4903], 'repairin': [3666], '(this': [3674], 'mixture': [3675], 'designated': [3677], 'converted': [3679], 'heteroduplexes': [3681], 'species': [3685, 4480], 'eletrophoretic': [3688], 'mobility': [3689, 4219], 'consistent': [3690, 4582, 5214], 'expected': [3693], 'gapped': [3696], 'molecule': [3698], '(data': [3699, 4416, 4682], 'shown).': [3701, 4684], 'suggested': [3703, 3954, 4451], 'lacking': [3707, 4076], 'more': [3710, 4635, 4677], 'synthesis.': [3716], 'proved': [3720], 'chromatography': [3744], 'phosphocellulose,': [3746], 'assayed': [3751], 'extract.': [3763, 3802, 4080, 4552], 'yielded': [3766], 'single,': [3768], 'symmetrical': [3769], 'further': [3776, 3983, 4565, 4746], 'Procedures”': [3782], 'summarized': [3784], 'V)': [3794], 'about': [3797, 4476, 4568, 4665], '2,800-fold': [3798], 'G·T': [3814, 3824], 'repair.': [3816, 4777], 'inability': [3821], 'two-nucleotide': [3836], 'mismatch.': [3838], 'As': [3839, 3927, 4511], 'shown': [3840, 4512, 4780], 'Fig.': [3842, 3912, 4898], '1,': [3843], 'types': [3847], 'directionality': [3860], 'can': [3867], '(41Fang': [3881], '11838-11844Abstract': [3890], 'orientations': [3908], 'tested.': [3911, 4510], '1demonstrates': [3913], 'independent': [3921], '→': [3924], 'orientation.': [3926], 'noted': [3928], 'although': [3930, 4266, 4618], 'rectification': [3932], 'occur': [3935], 'processing': [3940], 'observed,': [3942], 'blocked': [3945, 4312, 5174], 'late': [3948], 'synthesis,': [3969], 'found': [3974, 4655, 5128], 'co-purify': [3976], '(Fig.': [3980, 4114, 4201, 4630], '2),': [3981], 'prompting': [3982], 'test': [3984, 4488], 'possibility': [3987], 'analyses.': [3991], 'Whereas': 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