Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1986405458', 'doi': 'https://doi.org/10.1179/joc.2011.23.1.32', 'title': 'Trastuzumab and Vinorelbine in Early Stages of HER2-Positive Breast Cancer', 'display_name': 'Trastuzumab and Vinorelbine in Early Stages of HER2-Positive Breast Cancer', 'publication_year': 2011, 'publication_date': '2011-02-01', 'ids': {'openalex': 'https://openalex.org/W1986405458', 'doi': 'https://doi.org/10.1179/joc.2011.23.1.32', 'mag': '1986405458', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21482492'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1179/joc.2011.23.1.32', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S127202688', 'display_name': 'Journal of Chemotherapy', 'issn_l': '1120-009X', 'issn': ['1120-009X', '1973-9478'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113360528', 'display_name': 'Cristiano Ferrario', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801824472', 'display_name': 'Jewish General Hospital', 'ror': 'https://ror.org/056jjra10', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801824472']}, {'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'C. Ferrario', 'raw_affiliation_strings': ['Segal Cancer Center-Jewish General Hospital, Department of Oncology, McGill University, Montreal, QC, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Segal Cancer Center-Jewish General Hospital, Department of Oncology, McGill University, Montreal, QC, Canada.', 'institution_ids': ['https://openalex.org/I2801824472', 'https://openalex.org/I5023651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022787483', 'display_name': 'Andrew Barnabas Wong', 'orcid': 'https://orcid.org/0000-0002-0731-1931'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A. Wong', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108128415', 'display_name': 'Tao Gao', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'T. Gao', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052074115', 'display_name': 'N. Bouganim', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'N. Bouganim', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005764534', 'display_name': 'Raquel Aloyz', 'orcid': 'https://orcid.org/0000-0002-6812-497X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R. Aloyz', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110056997', 'display_name': 'Lawrence Panasci', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'L.C. Panasci', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.306, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.591353, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 81}, 'biblio': {'volume': '23', 'issue': '1', 'first_page': '32', 'last_page': '35'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vinorelbine', 'display_name': 'Vinorelbine', 'score': 0.9456543}], 'concepts': [{'id': 'https://openalex.org/C2780350996', 'wikidata': 'https://www.wikidata.org/wiki/Q420532', 'display_name': 'Vinorelbine', 'level': 4, 'score': 0.9456543}, {'id': 'https://openalex.org/C2779786085', 'wikidata': 'https://www.wikidata.org/wiki/Q412616', 'display_name': 'Trastuzumab', 'level': 4, 'score': 0.93240786}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.66400814}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6340449}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.59347534}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5815442}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.39934763}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.35830134}, {'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.08123335}], 'mesh': [{'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D018719', 'descriptor_name': 'Receptor, ErbB-2', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D017024', 'descriptor_name': 'Chemotherapy, Adjuvant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004361', 'descriptor_name': 'Drug Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009503', 'descriptor_name': 'Neutropenia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009503', 'descriptor_name': 'Neutropenia', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D018719', 'descriptor_name': 'Receptor, ErbB-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068878', 'descriptor_name': 'Trastuzumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014747', 'descriptor_name': 'Vinblastine', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D014747', 'descriptor_name': 'Vinblastine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D014747', 'descriptor_name': 'Vinblastine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D014747', 'descriptor_name': 'Vinblastine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077235', 'descriptor_name': 'Vinorelbine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1179/joc.2011.23.1.32', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S127202688', 'display_name': 'Journal of Chemotherapy', 'issn_l': '1120-009X', 'issn': ['1120-009X', '1973-9478'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21482492', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1836239578', 'https://openalex.org/W1966520215', 'https://openalex.org/W2009402447', 'https://openalex.org/W2017780448', 'https://openalex.org/W2018924086', 'https://openalex.org/W2035484878', 'https://openalex.org/W2045324973', 'https://openalex.org/W2061563172', 'https://openalex.org/W2108182027', 'https://openalex.org/W2108318793', 'https://openalex.org/W2113450161', 'https://openalex.org/W2130521606', 'https://openalex.org/W2137347078', 'https://openalex.org/W2140354367', 'https://openalex.org/W2141393790', 'https://openalex.org/W2144025679', 'https://openalex.org/W2146384083', 'https://openalex.org/W2149908785', 'https://openalex.org/W2152121934', 'https://openalex.org/W2156604663', 'https://openalex.org/W2159305151', 'https://openalex.org/W365809586'], 'related_works': ['https://openalex.org/W4383618614', 'https://openalex.org/W3024330839', 'https://openalex.org/W2945034398', 'https://openalex.org/W2468646525', 'https://openalex.org/W2342209702', 'https://openalex.org/W2156787342', 'https://openalex.org/W2085215324', 'https://openalex.org/W2013882331', 'https://openalex.org/W2001196910', 'https://openalex.org/W1974611354'], 'abstract_inverted_index': {'AbstractThe': [0], 'combination': [1], 'of': [2, 26, 92, 99], 'vinorelbine': [3], 'and': [4, 10, 24, 110, 124], 'trastuzumab': [5], '(VH)': [6], 'is': [7, 122, 146], 'highly': [8], 'active': [9], 'well': [11, 80, 125, 147], 'tolerated': [12], 'in': [13], 'patients': [14, 34, 48, 64, 140], 'with': [15, 35, 49, 57, 89], 'metastatic': [16], 'HER2+': [17], 'breast': [18, 37, 52, 103, 138], 'cancer.': [19], 'We': [20], 'assessed': [21], 'the': [22, 82], 'efficacy': [23], 'tolerability': [25], 'VH': [27, 58, 66, 78, 121, 127], 'as': [28, 59, 67, 132], 'an': [29], 'alternative': [30], 'adjuvant': [31, 44, 68, 133], 'treatment': [32, 69, 134, 145], 'for': [33, 42, 70, 135, 141], 'localized': [36], 'cancer': [38, 53, 104, 139, 151], 'refusing': [39], 'or': [40, 61, 73], 'ineligible': [41], 'standard': [43, 144], 'trastuzumab-based': [45], 'chemotherapy.': [46], 'Twenty-eight': [47], 'stage': [50], 'I-III': [51], 'were': [54, 106], 'treated': [55], 'only': [56, 83], 'preoperative': [60], 'postoperative': [62], 'chemotherapy.Fourteen': [63], 'received': [65], 'pT1a-b': [71, 137], 'pN0': [72, 76, 136], 'ER+': [74], 'pT1c': [75], 'cancers.': [77], 'was': [79, 113], 'tolerated,': [81], 'grade': [84], '3-4': [85], 'toxicity': [86], 'being': [87], 'neutropenia': [88], '2': [90], 'cases': [91], 'febrile': [93], 'neutropenia.': [94], 'At': [95], 'a': [96], 'median': [97], 'follow-up': [98], '39': [100], 'months,': [101], 'no': [102, 143], 'relapses': [105], 'documented;': [107], 'moreover,': [108], 'overall': [109], 'disease-free': [111], 'survival': [112], '96.4%.': [114], 'In': [115], 'summary,': [116], 'our': [117], 'results': [118], 'indicate': [119], 'that': [120], 'effective': [123], 'tolerated.': [126], 'should': [128], 'be': [129], 'prospectively': [130], 'tested': [131], 'which': [142], 'defined.Keywords:': [148], 'Vinorelbinetrastuzumabadjuvant': [149], 'chemotherapybreast': [150]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1986405458', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2024-12-17T02:05:41.912394', 'created_date': '2016-06-24'}