Publication Information

{'id': 'https://openalex.org/W1986295842', 'doi': 'https://doi.org/10.1159/000236899', 'title': 'A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells', 'display_name': 'A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells', 'publication_year': 2009, 'publication_date': '2009-01-01', 'ids': {'openalex': 'https://openalex.org/W1986295842', 'doi': 'https://doi.org/10.1159/000236899', 'mag': '1986295842', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19738365', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2818457'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1159/000236899', 'pdf_url': 'https://karger.com/dne/article-pdf/31/6/497/3840984/000236899.pdf', 'source': {'id': 'https://openalex.org/S88959177', 'display_name': 'Developmental Neuroscience', 'issn_l': '0378-5866', 'issn': ['0378-5866', '1421-9859'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317820', 'host_organization_name': 'Karger Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317820'], 'host_organization_lineage_names': ['Karger Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://karger.com/dne/article-pdf/31/6/497/3840984/000236899.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014311864', 'display_name': 'Anita Bhattacharyya', 'orcid': 'https://orcid.org/0000-0002-0360-7145'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anita Bhattacharyya', 'raw_affiliation_strings': ['aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA'], 'affiliations': [{'raw_affiliation_string': 'aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045826335', 'display_name': 'Erin McMillan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Erin McMillan', 'raw_affiliation_strings': ['aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA'], 'affiliations': [{'raw_affiliation_string': 'aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022015528', 'display_name': 'Serene I. Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Serene I. Chen', 'raw_affiliation_strings': ['aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA'], 'affiliations': [{'raw_affiliation_string': 'aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025813209', 'display_name': 'Kyle Wallace', 'orcid': 'https://orcid.org/0000-0002-4901-8709'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kyle Wallace', 'raw_affiliation_strings': ['aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA'], 'affiliations': [{'raw_affiliation_string': 'aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076105306', 'display_name': 'Clive N. Svendsen', 'orcid': 'https://orcid.org/0000-0001-8696-3446'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Clive N. Svendsen', 'raw_affiliation_strings': ['aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA'], 'affiliations': [{'raw_affiliation_string': 'aStem Cell Research Group, The Waisman Center, and bDepartment of Anatomy, University of Wisconsin, Madison, Wisc., USA', 'institution_ids': ['https://openalex.org/I135310074']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.644, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 75, 'citation_normalized_percentile': {'value': 0.960089, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '31', 'issue': '6', 'first_page': '497', 'last_page': '510'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11015', 'display_name': 'Down syndrome and intellectual disability research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11015', 'display_name': 'Down syndrome and intellectual disability research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 0.9788, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10549', 'display_name': 'Neonatal Respiratory Health Research', 'score': 0.9308, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/interneuron', 'display_name': 'Interneuron', 'score': 0.8506587}, {'id': 'https://openalex.org/keywords/progenitor', 'display_name': 'Progenitor', 'score': 0.672447}, {'id': 'https://openalex.org/keywords/neurosphere', 'display_name': 'Neurosphere', 'score': 0.4443425}], 'concepts': [{'id': 'https://openalex.org/C4746552', 'wikidata': 'https://www.wikidata.org/wiki/Q1456827', 'display_name': 'Neurogenesis', 'level': 2, 'score': 0.9359926}, {'id': 'https://openalex.org/C2779296341', 'wikidata': 'https://www.wikidata.org/wiki/Q1500732', 'display_name': 'Interneuron', 'level': 3, 'score': 0.8506587}, {'id': 'https://openalex.org/C201750760', 'wikidata': 'https://www.wikidata.org/wiki/Q1896218', 'display_name': 'Progenitor cell', 'level': 3, 'score': 0.8228635}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.7015575}, {'id': 'https://openalex.org/C15729860', 'wikidata': 'https://www.wikidata.org/wiki/Q2329919', 'display_name': 'Progenitor', 'level': 4, 'score': 0.672447}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.63571244}, {'id': 'https://openalex.org/C136834591', 'wikidata': 'https://www.wikidata.org/wiki/Q2944097', 'display_name': 'Neural stem cell', 'level': 3, 'score': 0.62372476}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.49352968}, {'id': 'https://openalex.org/C162746124', 'wikidata': 'https://www.wikidata.org/wiki/Q7002675', 'display_name': 'Neurosphere', 'level': 5, 'score': 0.4443425}, {'id': 'https://openalex.org/C2781041448', 'wikidata': 'https://www.wikidata.org/wiki/Q75839', 'display_name': 'Cerebral cortex', 'level': 2, 'score': 0.4439427}, {'id': 'https://openalex.org/C2781291010', 'wikidata': 'https://www.wikidata.org/wiki/Q178580', 'display_name': 'Period (music)', 'level': 2, 'score': 0.42055055}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.36274764}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.24374491}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.24223015}, {'id': 'https://openalex.org/C20875687', 'wikidata': 'https://www.wikidata.org/wiki/Q2642600', 'display_name': 'Adult stem cell', 'level': 4, 'score': 0.17973939}, {'id': 'https://openalex.org/C17077164', 'wikidata': 'https://www.wikidata.org/wiki/Q1185869', 'display_name': 'Inhibitory postsynaptic potential', 'level': 2, 'score': 0.12980649}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.10567802}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09269312}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.086643785}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C24890656', 'wikidata': 'https://www.wikidata.org/wiki/Q82811', 'display_name': 'Acoustics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D004314', 'descriptor_name': 'Down Syndrome', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D007395', 'descriptor_name': 'Interneurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D055495', 'descriptor_name': 'Neurogenesis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002452', 'descriptor_name': 'Cell Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004314', 'descriptor_name': 'Down Syndrome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004314', 'descriptor_name': 'Down Syndrome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004314', 'descriptor_name': 'Down Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005333', 'descriptor_name': 'Fetus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005455', 'descriptor_name': 'Fluorescent Antibody Technique', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018698', 'descriptor_name': 'Glutamic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018698', 'descriptor_name': 'Glutamic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007395', 'descriptor_name': 'Interneurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007395', 'descriptor_name': 'Interneurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039902', 'descriptor_name': 'Multipotent Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055495', 'descriptor_name': 'Neurogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055495', 'descriptor_name': 'Neurogenesis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050598', 'descriptor_name': 'Vesicular Glutamate Transport Protein 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050598', 'descriptor_name': 'Vesicular Glutamate Transport Protein 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050495', 'descriptor_name': 'Vesicular Inhibitory Amino Acid Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050495', 'descriptor_name': 'Vesicular Inhibitory Amino Acid Transport Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005680', 'descriptor_name': 'gamma-Aminobutyric Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005680', 'descriptor_name': 'gamma-Aminobutyric Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1159/000236899', 'pdf_url': 'https://karger.com/dne/article-pdf/31/6/497/3840984/000236899.pdf', 'source': {'id': 'https://openalex.org/S88959177', 'display_name': 'Developmental Neuroscience', 'issn_l': '0378-5866', 'issn': ['0378-5866', '1421-9859'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317820', 'host_organization_name': 'Karger Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317820'], 'host_organization_lineage_names': ['Karger Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2818457', 'pdf_url': 'https://europepmc.org/articles/pmc2818457?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818457', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19738365', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1159/000236899', 'pdf_url': 'https://karger.com/dne/article-pdf/31/6/497/3840984/000236899.pdf', 'source': {'id': 'https://openalex.org/S88959177', 'display_name': 'Developmental Neuroscience', 'issn_l': '0378-5866', 'issn': ['0378-5866', '1421-9859'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317820', 'host_organization_name': 'Karger Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317820'], 'host_organization_lineage_names': ['Karger Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.79, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': ['https://openalex.org/W4394126468'], 'versions': [], 'referenced_works_count': 80, 'referenced_works': ['https://openalex.org/W120484358', 'https://openalex.org/W158374110', 'https://openalex.org/W160573174', 'https://openalex.org/W1715204582', 'https://openalex.org/W1784678798', 'https://openalex.org/W1884108341', 'https://openalex.org/W1970629663', 'https://openalex.org/W1971305731', 'https://openalex.org/W1977879168', 'https://openalex.org/W1979952856', 'https://openalex.org/W1981164058', 'https://openalex.org/W1982449679', 'https://openalex.org/W1985657116', 'https://openalex.org/W1989266013', 'https://openalex.org/W1992689843', 'https://openalex.org/W1992933562', 'https://openalex.org/W1998444616', 'https://openalex.org/W2001070008', 'https://openalex.org/W2005804025', 'https://openalex.org/W2006792093', 'https://openalex.org/W2008462286', 'https://openalex.org/W2009311165', 'https://openalex.org/W2010597204', 'https://openalex.org/W2017535499', 'https://openalex.org/W2022197542', 'https://openalex.org/W2031224620', 'https://openalex.org/W2040670434', 'https://openalex.org/W2043429907', 'https://openalex.org/W2046450144', 'https://openalex.org/W2050951687', 'https://openalex.org/W2054562862', 'https://openalex.org/W2055842243', 'https://openalex.org/W2057700337', 'https://openalex.org/W2061005933', 'https://openalex.org/W2061127877', 'https://openalex.org/W2061228854', 'https://openalex.org/W2063478423', 'https://openalex.org/W2066351593', 'https://openalex.org/W2066490736', 'https://openalex.org/W2067198472', 'https://openalex.org/W2067991344', 'https://openalex.org/W2071296318', 'https://openalex.org/W2073727997', 'https://openalex.org/W2075761659', 'https://openalex.org/W2077630079', 'https://openalex.org/W2080353653', 'https://openalex.org/W2082178034', 'https://openalex.org/W2082980172', 'https://openalex.org/W2083678523', 'https://openalex.org/W2084314442', 'https://openalex.org/W2084425904', 'https://openalex.org/W2085702771', 'https://openalex.org/W2086948882', 'https://openalex.org/W2089916678', 'https://openalex.org/W2090407590', 'https://openalex.org/W2095387881', 'https://openalex.org/W2098125372', 'https://openalex.org/W2104401594', 'https://openalex.org/W2108690261', 'https://openalex.org/W2117058176', 'https://openalex.org/W2120580225', 'https://openalex.org/W2124908967', 'https://openalex.org/W2125578099', 'https://openalex.org/W2125920059', 'https://openalex.org/W2128464557', 'https://openalex.org/W2129605816', 'https://openalex.org/W2131163919', 'https://openalex.org/W2149290739', 'https://openalex.org/W2149414924', 'https://openalex.org/W2152092203', 'https://openalex.org/W2153684163', 'https://openalex.org/W2159929448', 'https://openalex.org/W2160205444', 'https://openalex.org/W2165132176', 'https://openalex.org/W2165432413', 'https://openalex.org/W2317698447', 'https://openalex.org/W2398471454', 'https://openalex.org/W2614575602', 'https://openalex.org/W568469018', 'https://openalex.org/W615286208'], 'related_works': ['https://openalex.org/W2940660660', 'https://openalex.org/W2619900882', 'https://openalex.org/W2389439744', 'https://openalex.org/W2382491987', 'https://openalex.org/W2379202182', 'https://openalex.org/W2375850355', 'https://openalex.org/W2146882327', 'https://openalex.org/W2125082889', 'https://openalex.org/W2040221552', 'https://openalex.org/W104091822'], 'abstract_inverted_index': {'Down': [0], 'syndrome': [1], '(DS)': [2], 'is': [3, 10], 'a': [4, 99, 108, 122], 'developmental': [5], 'disorder': [6], 'whose': [7], 'mental': [8], 'impairment': [9], 'due': [11], 'to': [12, 41, 85, 131], 'defective': [13], 'cortical': [14], 'development.': [15, 70], 'Human': [16], 'neural': [17, 80], 'progenitor': [18, 69, 81, 89, 126], 'cells': [19, 127], '(hNPCs)': [20], 'derived': [21], 'from': [22], 'fetal': [23], 'DS': [24, 49, 55, 106, 119], 'cortex': [25], 'initially': [26], 'produce': [27], 'normal': [28], 'numbers': [29], 'of': [30, 44, 54, 65, 75, 98, 112, 115], 'neurons,': [31], 'but': [32], 'generate': [33], 'fewer': [34], 'neurons': [35], 'with': [36], 'time': [37, 60, 123], 'in': [38, 48, 50, 67, 79, 87, 94, 102, 105, 118], 'culture,': [39], 'similar': [40], 'the': [42, 88, 113], 'pattern': [43], 'neurogenesis': [45, 117], 'that': [46], 'occurs': [47], 'vivo.': [51], 'Microarray': [52], 'analysis': [53], 'hNPCs': [56], 'at': [57], 'this': [58], 'critical': [59, 100], 'reveals': [61], 'gene': [62], 'changes': [63, 86], 'indicative': [64], 'defects': [66], 'interneuron': [68, 95, 103], 'In': [71], 'addition,': [72], 'dysregulated': [73], 'expression': [74], 'many': [76], 'genes': [77], 'involved': [78], 'cell': [82], 'biology': [83], 'points': [84], 'population': [90], 'and': [91, 120], 'subsequent': [92], 'reduction': [93], 'neurogenesis.': [96], 'Delineation': [97], 'period': [101], 'development': [104], 'provides': [107], 'foundation': [109], 'for': [110], 'investigation': [111], 'basis': [114], 'reduced': [116], 'defines': [121], 'when': [124], 'these': [125], 'may': [128], 'be': [129], 'amenable': [130], 'therapeutic': [132], 'treatment.': [133]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1986295842', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2025-01-10T20:42:34.027398', 'created_date': '2016-06-24'}