Title: Depletion of cholinergic habenulo-interpeduncular neurons by selectively timed methylazoxymethanol acetate (MAM) treatment during pregnancy
Abstract: Methylazoxymethanol acetate (MAM) was injected to female rats at the beginning of the 17th day of gestation. Resulting offspring showed a remarkable decrease in the size of the medial habenula while the interpeduncular nucleus, whose neurons are generated before the time of MAM treatment, appeared anatomically unaffected. Choline acetyltransferase was significantly reduced in the habenulae and in the interpeduncular nucleus suggesting that MAM treatment had depleted a portion of the cholinergic neurons of the medial habenula which project on the interpeduncular nucleus. Aromatic amino acid decar☐ylase significantly increased in the interpeduncular nucleus, a likely effect of monoaminergic hyperinnervation in response to partial cholinergic deprivation. MAM strategy can be usefully adopted for the study of general aspects of brain development when connected nuclei showing no overlapping in neuronal generation times are involved.
Publication Year: 1988
Publication Date: 1988-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 5
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot