Publication Information

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2534, 2559, 2561, 2616, 2628, 2643, 2749, 3007, 3018, 3022, 3025, 3034, 3053, 3056, 3086, 3103, 3121, 3210, 3219, 3227, 3230, 3233, 3242, 3258, 3262, 3268, 3297, 3306, 3322, 3497, 3528, 3573, 3586, 3606, 3623, 3627, 3640, 3687, 3690, 3698, 3707, 3764, 3774, 3790, 3793, 3802, 3805, 3911, 3951, 3958, 3973, 3991, 3997, 4004, 4008, 4026, 4036, 4041, 4055, 4079, 4082, 4116], 'accumulation': [15, 178, 377, 3054], 'of': [16, 20, 76, 85, 93, 104, 117, 141, 157, 179, 183, 239, 248, 256, 267, 280, 304, 320, 351, 357, 378, 381, 400, 494, 604, 610, 645, 703, 797, 809, 829, 997, 1022, 1028, 1149, 1159, 1173, 1183, 1194, 1198, 1204, 1239, 1287, 1297, 1303, 1306, 1328, 1335, 1348, 1376, 1388, 1397, 1420, 1514, 1528, 1532, 1573, 1577, 1586, 1591, 1593, 1643, 1690, 1722, 1725, 1736, 1794, 1802, 1847, 1869, 1881, 1891, 1897, 1906, 1924, 1935, 1952, 1959, 1969, 2005, 2021, 2047, 2063, 2076, 2124, 2174, 2206, 2230, 2244, 2262, 2270, 2291, 2299, 2305, 2335, 2365, 2382, 2400, 2408, 2466, 2482, 2492, 2522, 2604, 2645, 2648, 2736, 2745, 2997, 3021, 3036, 3055, 3102, 3117, 3129, 3229, 3244, 3257, 3261, 3267, 3300, 3305, 3336, 3482, 3493, 3496, 3563, 3580, 3626, 3629, 3653, 3686, 3701, 3763, 3773, 3777, 3792, 3804, 3814, 3828, 3900, 3907, 3961, 3975, 3996, 3999, 4007, 4050, 4081, 4098], 'abnormal': [18, 181, 393], 'isoform': [19, 182, 395, 497, 3123, 3886], 'prion': [22, 26, 185, 189, 383, 1206, 1216, 4009], 'protein.': [23, 186], 'The': [24, 144, 187, 307, 392, 492, 778, 815, 1026, 1201, 1215, 1301, 1338, 1404, 1424, 1589, 1613, 1792, 1850, 1900, 1932, 2019, 2288, 2393, 2416, 2463, 3264, 3317, 3329, 3415, 3683, 4021], 'amyloid': [25, 188, 405, 931, 3337, 3529, 3794], 'protein': [27, 190, 1207, 4010], 'fragment': [28, 191, 849, 1127, 1208, 1217, 3813, 4011], '106–126': [29, 192], '(P106–126)': [30, 193, 850], 'has': [31, 194, 396, 529, 800, 1030, 2999, 3153, 3339, 3823, 3915], 'been': [32, 195, 801, 852, 1031, 3001, 3154, 3340, 3583, 3657, 3824, 3903, 3916], 'shown': [33, 196, 853, 993, 2634, 3525, 3882], 'to': [34, 137, 152, 197, 300, 315, 411, 698, 783, 823, 827, 834, 854, 920, 1003, 1343, 1416, 1541, 1826, 1878, 1894, 1945, 1997, 2129, 2241, 2252, 2406, 2410, 2527, 2549, 2555, 2591, 2738, 3048, 3089, 3217, 3223, 3248, 3487, 3569, 3609, 3695, 3821, 3918, 4033, 4040, 4064, 4107], 'be': [35, 198, 820, 855, 2622, 3012, 3090, 3281, 3310, 4046], 'toxic': [36, 91, 199, 254, 2311, 2945, 3775, 3977], 'in': [37, 72, 149, 200, 235, 312, 386, 508, 514, 525, 652, 779, 812, 933, 1015, 1033, 1058, 1134, 1233, 1369, 1385, 1429, 1433, 1441, 1448, 1538, 1621, 1646, 1687, 1694, 1705, 1845, 2085, 2095, 2162, 2322, 2326, 2443, 2452, 2514, 2733, 2800, 2855, 2993, 3033, 3093, 3126, 3156, 3226, 3321, 3343, 3535, 3585, 3642, 3768, 3788, 3817, 3893, 3905, 3954, 3983, 3993, 4003, 4019, 4025], 'cultured': [38, 201], 'hippocampal': [39, 202], 'neurons': [40, 203, 358], '(1Forloni': [41, 204, 865, 2651, 2888, 3427], 'G.': [42, 205, 565, 585, 713, 866, 949, 2652, 2778, 2821, 2833, 2889, 2926, 2928, 3370, 3428], 'Angeretti': [43, 206, 867, 2653, 2890, 3429], 'N.': [44, 207, 868, 1074, 2654, 2891, 3160, 3430, 3736], 'Chiesa': [45, 208, 869, 2655, 2892, 3431], 'R.': [46, 209, 561, 567, 581, 589, 870, 1098, 1100, 2656, 2823, 2893, 3065, 3135, 3404, 3432], 'Monzani': [47, 210, 871, 2657, 2894, 3433], 'E.': [48, 211, 872, 943, 2658, 2772, 2831, 2895, 3434, 3668, 3738], 'Salmona': [49, 212, 873, 954, 2659, 2783, 2896, 2919, 3435], 'M.': [50, 213, 437, 441, 587, 623, 666, 715, 744, 754, 874, 900, 955, 1102, 1106, 1758, 1766, 2660, 2784, 2870, 2897, 2918, 2920, 3162, 3346, 3355, 3436, 3664, 3732], 'Bugiani': [51, 214, 875, 950, 2661, 2779, 2898, 2921, 3367, 3437], 'O.': [52, 215, 876, 951, 2662, 2780, 2899, 2922, 3368, 3438], 'Tagliavini': [53, 216, 877, 952, 2663, 2781, 2900, 2923, 3371, 3439], 'F.': [54, 217, 878, 947, 953, 1062, 1064, 2664, 2776, 2782, 2815, 2817, 2829, 2901, 2924, 3196, 3360, 3372, 3394, 3440], 'Nature.': [55, 218, 592, 634, 879, 2665, 2716, 2902, 3441, 3516], '1993;': [56, 219, 364, 463, 483, 670, 880, 904, 960, 2666, 2789, 2841, 2874, 2903, 3442], '362:': [57, 220, 881, 2667, 2904, 3443], '543-546Crossref': [58, 221, 882, 2668, 2905, 3444], 'PubMed': [59, 222, 367, 429, 466, 489, 555, 575, 596, 638, 676, 734, 773, 883, 907, 963, 987, 1050, 1086, 1113, 2669, 2690, 2705, 2720, 2792, 2844, 2877, 2906, 2935, 2965, 2985, 3078, 3145, 3175, 3204, 3378, 3410, 3445, 3466, 3678, 3750, 3856, 3877, 3945], 'Scopus': [60, 223, 368, 430, 467, 556, 576, 597, 639, 677, 735, 774, 884, 908, 964, 988, 1051, 1087, 1114, 2670, 2691, 2706, 2721, 2793, 2845, 2878, 2907, 2936, 2966, 2986, 3079, 3146, 3176, 3205, 3379, 3411, 3446, 3467, 3520, 3679, 3727, 3751, 3857, 3946], '(896)': [61, 224, 885, 2671, 2908, 3447], 'Google': [62, 225, 370, 432, 469, 490, 558, 578, 599, 641, 679, 737, 776, 886, 910, 966, 990, 1053, 1089, 1116, 1774, 2672, 2693, 2708, 2723, 2795, 2847, 2880, 2909, 2938, 2968, 2988, 3081, 3148, 3178, 3191, 3207, 3381, 3413, 3448, 3469, 3522, 3681, 3729, 3753, 3859, 3878, 3948], 'Scholar).': [63, 226, 371, 491, 600, 680, 777, 911, 967, 1117, 1775, 2724, 2796, 2848, 2939, 2989, 3082, 3149, 3208, 3414, 3470, 3682, 3754, 3860, 3949], 'Here,': [64, 227], 'we': [65, 228, 1122, 1140, 1359, 3236], 'show': [66, 229, 3237], 'that': [67, 79, 132, 230, 242, 295, 690, 994, 1152, 2120, 2227, 2343, 2635, 3238, 3527, 3622, 3759, 3883, 3979, 4014, 4044], 'P106–126': [68, 105, 231, 268, 915, 1002, 1128, 1143, 1168, 1535, 2026, 2078, 2106, 2307, 2336, 2385, 2459, 2638, 2726, 2754, 2803, 2882, 2942, 2998, 3240, 3292, 3323, 3420, 3485, 3600, 3654, 4012], 'is': [69, 81, 135, 232, 244, 298, 408, 499, 520, 804, 917, 999, 1155, 2266, 2755, 3031, 3098, 3109, 3124, 3212, 3637, 3771, 3799, 3891, 4029], 'also': [70, 233, 3538, 3881, 4017], 'cytotoxic': [71, 234, 835, 1006, 2122, 2185, 4005], 'vivo.': [73, 236, 1135], 'Taking': [74, 237], 'advantage': [75, 238, 1148], 'fact': [78, 241, 1151], 'retina': [80, 145, 243, 308, 1154, 1560, 2034, 2049, 2065, 2176, 2210, 2314, 3087, 3097, 3131, 3211, 4022, 4056], 'an': [82, 245, 649, 1156, 1284, 1395, 1583, 2259, 3091, 3099, 3249, 4000], 'integral': [83, 246, 1157, 3100], 'part': [84, 247, 1158, 3101, 3762], 'central': [87, 250, 510, 1161, 3104], 'nervous': [88, 251, 511, 1162, 3105], 'system,': [89, 252], 'effect': [92, 255, 2020, 2123, 2186, 2481], 'peptide': [95, 258, 848, 916, 1222, 1350, 1534, 2000, 2126, 2150, 2384, 2458, 2606, 2637, 3023, 3269, 3315, 3688], 'was': [96, 259, 688, 1169, 1190, 1211, 1225, 1411, 1483, 1605, 1616, 1667, 1676, 1712, 1810, 1824, 1833, 1872, 1886, 1995, 2037, 2107, 2127, 2187, 2238, 2308, 2369, 2419, 2429, 2440, 2471, 3550], 'investigated': [97, 260], 'direct': [99, 262, 2520, 2948, 3004], 'intravitreous': [100, 263, 3480, 3544], 'injection.': [101, 264, 2041, 3290], 'Aged': [102, 265], 'solutions': [103, 266, 3560, 3579], 'induced': [106, 269, 837, 1166, 2318, 3539, 3576], 'apoptotic-mediated': [107, 270, 1131], 'retinal': [108, 271, 1578, 1632, 2263, 2367, 2528, 3245], 'cell': [109, 272, 862, 1132, 1480, 2035, 2361, 2853, 2886, 3489, 3548, 3644, 3691, 3708, 4066], 'death': [110, 273, 789, 863, 1133, 1189, 1481, 2036, 2854, 2887, 3225, 3243, 3490, 3549, 3709], 'irreversibly': [112, 275], 'altered': [113, 276], 'electrical': [115, 278, 1196, 2464, 3259, 3494], 'activity': [116, 279, 1197, 2465, 3260, 3299, 3495], 'retina.': [119, 282, 1200, 3263, 3498], 'Neither': [120, 283], 'apoptosis': [121, 284, 1029, 3542], 'nor': [122, 285], 'electroretinogram': [123, 286, 1857, 2598, 3276], 'damages': [124, 287, 818, 2526, 3295], 'were': [125, 288, 1231, 1252, 1281, 1312, 1340, 1383, 1392, 1406, 1426, 1455, 1463, 1516, 1547, 1557, 1562, 1580, 1628, 1637, 1703, 1727, 1741, 1752, 1779, 1797, 1852, 1915, 1943, 1963, 1982, 2008, 2015, 2083, 2114, 2165, 2179, 2191, 2212, 2337, 2352, 2373, 2600, 3561], 'observed': [126, 289, 2084, 2115, 2166, 2441, 2623, 3155, 3265, 3311, 3551, 3641, 3767], 'with': [127, 160, 290, 323, 684, 806, 1255, 1283, 1315, 1373, 1394, 1522, 1640, 1678, 1782, 1799, 1819, 1940, 1972, 2067, 2141, 2196, 2220, 2296, 2375, 2379, 2403, 2455, 2504, 2748, 2952, 2992, 3113, 3475, 3553, 3785, 4078], 'freshly': [128, 291, 2022, 2104, 2456, 2609, 3483, 3558], 'diluted': [129, 292, 1253, 1536, 3484], 'P106–126,': [130, 293, 2611, 3630], 'suggesting': [131, 294, 2119, 4013], 'toxicity': [134, 297, 3324, 3332, 3655], 'linked': [136, 299, 2128], 'aggregation': [139, 302, 3423, 3628], 'state': [140, 303, 3424], 'peptide.': [143, 306], 'provides': [146, 309, 3253, 3990], 'a': [147, 310, 397, 500, 521, 699, 846, 924, 1220, 1237, 1294, 1316, 1345, 1409, 1458, 1495, 1688, 1744, 1800, 1820, 1836, 2254, 2267, 2397, 2743, 3040, 3110, 3114, 3213, 3254, 3566, 3884, 4030, 4047], 'convenient': [148, 311], 'vivo': [150, 313, 780, 3094, 3643, 3994], 'system': [151, 314, 512, 1859, 3112], 'look': [153, 316], 'for': [154, 317, 1001, 1014, 1270, 1435, 1468, 1504, 1565, 1659, 2193, 2276, 2312, 3014, 3639, 3706, 4060, 4076, 4087, 4095, 4111], 'potential': [155, 318], 'inhibitors': [156, 319], 'cytotoxicity': [158, 321], 'associated': [159, 322], 'encephalopathies.': [162, 325], 'transmissible': [326], 'terminal': [329, 1175], 'deoxynucleotidyl': [330, 1176], 'transferase': [331, 1177], 'dUTP-end': [332, 1178], 'labeling': [333, 1179, 2055, 2163], 'phosphate-buffered': [334], 'saline': [335], '3,3′-diaminobenzidine': [336, 1496], 'electroretinograms': [337, 2487], '(TSE)1': [341], 'disorders': [344], 'having': [345], 'common': [346], 'pathological': [347, 496, 3969], 'signs': [348], 'like': [349], 'vacuolization': [350], 'neurophils,': [353], 'astrocytosis,': [354], 'loss': [356, 786, 3766, 4043], '(2Fraser': [359], 'H.': [360, 656, 758, 890, 1066, 2860, 3672], 'Br.': [361], 'Med.': [362], 'Bull.': [363], '49:': [365], '792-809Crossref': [366], '(57)': [369], 'TSE': [372, 1023, 2649, 3769], 'large': [379, 2255], 'aggregates': [380], 'protein,': [384, 523], 'PrP-res,': [385, 518, 913, 2850], 'both': [387, 611, 1360, 2515, 3603], 'human': [388, 1202], 'animal': [390, 1942, 4088], 'brains.': [391, 814], 'PrP-res': [394, 498, 613, 824, 842, 844, 2739, 2750, 3030, 3058, 3778, 3885], 'high': [398, 925, 2761], 'content': [399, 3116], 'β-sheet': [401, 926, 2762, 3416, 3611], 'secondary': [402], 'structure,': [403, 928], 'forms': [404, 930], 'fibrils,': [406], 'partially': [409, 918, 2756], 'resistant': [410, 919, 3820], 'proteolysis': [412], '(3Caughey': [413], 'B.W.': [414], 'Dong': [415], 'A.': [416, 443, 462, 551, 625, 633, 658, 660, 730, 769, 978, 1038, 1068, 1104, 2681, 2840, 3171, 3357, 3392, 3457, 3507], 'Bhat': [417], 'K.S.': [418], 'Ernst': [419, 3868], 'D.': [420, 445, 717, 719, 1096, 3071, 3139, 3869], 'Hayes': [421], 'S.F.': [422], 'Caughey': [423, 3861], 'W.S.': [424], 'Biochemistry.': [425], '1991;': [426, 3874], '30:': [427], '7672-7680Crossref': [428], '(742)': [431], 'Scholar,': [433, 470, 559, 579, 738, 2673, 2694, 2709, 2910, 2969, 3179, 3192, 3382, 3449, 3730], '4Pan': [434], 'K.-M.': [435], 'Baldwin': [436], 'Nguyen': [438], 'J.': [439, 472, 480, 752, 902, 972, 1079, 1107, 2675, 2698, 2872, 2929, 2958, 2979, 3072, 3374, 3405, 3451, 3716, 3739, 3845, 3872, 3934], 'Gasset': [440], 'Serban': [442], 'Groth': [444, 716], 'Mehlhorn': [446], 'I.': [447], 'Huang': [448], 'Z.': [449, 742], 'Fletterick': [450], 'R.J.': [451], 'Cohen': [452], 'F.E.': [453], 'Prusiner': [454, 543, 722, 761, 3184], 'S.B.': [455, 544, 723, 762, 3185], 'Proc.': [456, 545, 724, 763, 2834, 3165], 'Natl.': [457, 546, 725, 764, 2835, 3166], 'Acad.': [458, 547, 726, 765, 2836, 3167], 'Sci.': [459, 548, 727, 766, 1770, 2837, 3168], 'U.': [460, 549, 728, 767, 2838, 3169], 'S.': [461, 550, 563, 583, 617, 619, 629, 729, 768, 2839, 2914, 3170, 3353], '90:': [464, 2842], '10962-10966Crossref': [465], '(2076)': [468], '5Safar': [471], 'Roller': [473], 'P.P.': [474], 'Gajdusek': [475], 'D.C.': [476], 'Gibbs': [477], 'Jr.,': [478], 'C.J.': [479, 3400], 'Biol.': [481, 2981, 3717, 3740, 3846, 3935], 'Chem.': [482, 3718, 3741, 3847, 3936], '268:': [484], '20276-20284Abstract': [485], 'Full': [486, 673, 3722, 3724, 3745, 3747, 3851, 3853, 3940, 3942], 'Text': [487, 674, 3723, 3725, 3746, 3748, 3852, 3854, 3941, 3943], 'PDF': [488, 675, 3726, 3749, 3855, 3944], 'precursor': [493], 'normal': [501, 3908], 'host': [502], 'glycoprotein': [503], '(termed': [504], 'PrP-sen)': [505], 'widely': [506], 'expressed': [507, 1617, 1956, 1964, 3125], 'peripheral': [515], 'tissues.': [516], 'Unlike': [517, 2558], 'PrP-sen': [519, 615, 646, 830, 998, 2737, 3122, 3901, 3962], 'protease-sensitive': [522], 'soluble': [524, 2028, 2148], 'mild': [526], 'detergents,': [527], 'mainly': [530], 'α-helix': [531], 'structures': [532, 3612], '(6Meyer': [533], 'R.K.': [534], 'McKinley': [535], 'M.P.': [536], 'Bowman': [537], 'K.A.': [538], 'Braunfeld': [539], 'M.B.': [540, 1072], 'Barry': [541], 'R.A.': [542, 662], '1986;': [552], '83:': [553], '2310-2314Crossref': [554], '(517)': [557], '7Riek': [560], 'Hornemann': [562, 582], 'Wider': [564, 584], 'Glockshuber': [566, 588], 'Wuthrich': [568, 590], 'K.': [569, 591, 1760, 3396], 'FEBS': [570, 3673], 'Lett.': [571, 3141, 3674], '1997;': [572, 3142], '413:': [573], '282-288Crossref': [574], '(664)': [577], '8Riek': [580], 'Billeter': [586], '1996;': [593, 635, 984, 2687, 2717, 3075, 3463, 3719], '382:': [594], '180-182Crossref': [595], '(1128)': [598], 'Interestingly,': [601, 3950], 'development': [603, 1021], 'pathologies': [606], 'requires': [607], 'presence': [609], 'isoforms': [612], '(9Brandner': [616], 'Isenmann': [618], 'Raeber': [620], 'A.J.': [621, 3505, 3515], 'Fischer': [622], 'Sailer': [624, 659], 'Kobayashi': [626], 'Y.': [627, 3734], 'Marino': [628], 'Weissmann': [630, 667], 'C.': [631, 668, 709, 746, 748, 936, 1078, 1762, 1764, 2765, 2916, 3390], 'Aguzzi': [632, 657], '379:': [636], '339-343Crossref': [637], '(718)': [640], 'Scholar),': [642, 1054, 2881], 'level': [644], 'expression': [647, 996], 'being': [648, 3704], 'essential': [650], 'factor': [651], 'pathology': [654, 2650], '(10Büeler': [655], 'Greiner': [661], 'Autenried': [663], 'P.': [664, 740, 2825, 3348, 3670, 3838, 3842, 3927, 3931], 'Aguet': [665], 'Cell.': [669], '73:': [671, 3408], '1339-1347Abstract': [672], '(1810)': [678], 'In': [681, 1118, 2530, 2940, 2990, 3783, 3986], 'experimental': [682, 1389], 'transmissions': [683], 'transgenic': [685], 'mice,': [686], 'it': [687, 2741, 3046, 3108], 'found': [689], 'increasing': [691], 'number': [693, 1572, 2243, 2261, 2744], 'ofPrP': [694], 'gene': [695], 'copies': [696], 'led': [697], 'decreased': [700, 2537, 2565, 2584], 'incubation': [701, 1266], 'time': [702, 1950], 'disease': [705, 1060, 3537, 3787, 3830], '(11Carlson': [706], 'G.A.': [707, 3137], 'Ebeling': [708], 'Yang': [710], 'S.L.': [711], 'Telling': [712], 'Torchia': [714, 753], 'Westaway': [718, 3138], 'DeArmond': [720, 759], 'S.J.': [721, 760, 3402], '1994;': [731, 2702, 2962], '91:': [732], '5690-5694Crossref': [733], '(135)': [736], '12Tremblay': [739], 'Meiner': [741], 'Galou': [743], 'Heinrich': [745], 'Petromilli': [747], 'Lisse': [749], 'T.': [750, 1070, 2912, 3366, 3713], 'Cayetano': [751], 'Mobley': [755], 'W.': [756], 'Bujard': [757], '1998;': [770, 2932, 2982, 3517], '95:': [771], '12580-12585Crossref': [772], '(138)': [775], 'mechanisms': [781, 3319, 3652, 4006, 4016, 4038], 'leading': [782, 3222, 4039], 'synaptic': [785], 'not': [791, 1983, 2136, 2309, 2461, 2625, 2728, 3326, 3590], 'elucidated,': [792], 'but': [793, 2421, 3659], 'possible': [795, 3684], 'involvement': [796, 3998], 'apoptotic': [798, 1010, 2360, 2885, 3250, 3574, 4001], 'processes': [799], 'postulated': [802], 'consistent': [805, 3474], 'lack': [808], 'inflammation': [810], 'stigmata': [811], 'TSE-affected': [813], 'neural': [816], 'tissue': [817], 'could': [819, 1012, 2621, 2639, 3693, 3971, 4045], 'due': [821], 'exclusively': [822], 'deposits,': [825], 'and/or': [826, 833, 3779], 'disruption': [828, 3700], 'physiological': [831, 3298, 3955, 3984], 'functions,': [832], 'effects': [836, 2946, 3266, 3308, 3776], 'PrP': [839, 1126, 2030, 2149, 2636, 3806, 3815, 3976], 'fragments': [840, 3899, 3978], 'or': [841, 1263, 1308, 1531, 2024, 2147, 2199, 2203, 2378, 2451, 2468, 2608, 2731, 3920], 'aggregates.': [843, 3615], 'synthetic': [847], 'have': [851, 992, 2633, 3524, 3582, 3656, 3880, 3902], 'cytotoxicin': [856], 'vitro': [857, 934, 2734, 2801, 2856, 2994, 3344], 'likely': [858], 'via': [859], 'programmed': [861], 'pathway': [864], 'Scholar,13Müller': [887], 'W.E.G.': [888, 2858], 'Ushijima': [889, 2859], 'Schröder': [891, 2861], 'H.C.': [892, 976, 2679, 2862, 3455], 'Forrest': [893, 2863], 'J.M.S.': [894, 2864], 'Schatton': [895, 2865], 'W.F.H.': [896, 2866], 'Rytik': [897, 2867], 'P.G.': [898, 2868], 'Heffner-Lauc': [899, 2869], 'Eur.': [901, 2871, 2978], 'Pharmacol.': [903, 2873], '246:': [905, 2875], '261-267Crossref': [906, 2876], '(157)': [909, 2879], 'Like': [912, 2849], 'proteinase': [921, 1644, 2757], 'K,': [922], 'presents': [923], 'enriched': [927], 'fibrils': [932, 2798], '(14Selvaginni': [935, 2764], 'De': [937, 2766, 3349], 'Gioia': [938, 2767, 3350], 'L.': [939, 941, 945, 2768, 2770, 2774, 2819, 3351, 3844, 3933], 'Cantù': [940, 2769], 'Ghibaudi': [942, 2771, 2830], 'Diomede': [944, 2773], 'Passerini': [946, 2775, 2828], 'Forloni': [948, 2777, 2832, 2925, 3369], 'Biochem.': [956, 2785, 3373], 'Biophys.': [957, 2786], 'Res.': [958, 2787, 2931], 'Commun.': [959, 2788], '194:': [961, 2790], '1380-1386Crossref': [962, 2791], '(195)': [965, 2794], 'Hope': [968], 'et': [969, 3862], 'al.': [970, 3501, 3863], '(15Hope': [971], 'Shearman': [973, 2676, 3452], 'M.S.': [974, 2677, 3453], 'Baxter': [975, 2678, 3454], 'Chong': [977, 2680, 3456], 'Kelly': [979, 2682, 3458], 'S.M.': [980, 2683, 3459, 3511], 'Price': [981, 2684, 3460], 'N.C.': [982, 2685, 3194, 3461], 'Neurodegeneration.': [983, 2686, 3462], '5:': [985, 1048, 2688, 2703, 2963, 3464], '1-11Crossref': [986, 2689, 3465], '(65)': [989, 2692, 3468], 'Scholar)': [991, 1090, 3523, 3879], 'necessary': [1000], 'exert': [1004], 'its': [1005, 2130, 2944, 3422, 3633, 3780], 'effects.': [1007], 'Whether': [1008], 'process': [1011, 1165, 3251, 4002], 'account': [1013], 'vivoneurodegeneration': [1016], 'taking': [1017, 1147], 'place': [1018], 'during': [1019], 'remains': [1024, 3808], 'unclear.': [1025, 3809], 'induction': [1027], 'suggested': [1032], 'scrapie-infected': [1034, 3894], 'mouse': [1035, 3895], 'brain': [1036, 3035], '(16Giese': [1037], 'Groschup': [1039, 2974], 'M.H.': [1040, 2975], 'Hess': [1041], 'B.': [1042, 2713, 2827, 2973, 3362, 3666, 3865], 'Kretzschmar': [1043, 2699, 2714, 2959, 2976], 'H.A.': [1044, 2700, 2715, 2960, 2977], 'Brain': [1045], 'Pathol.': [1046, 1109], '1995;': [1047, 3848, 3937], '213-221Crossref': [1049], '(146)': [1052], 'as': [1055, 1057, 1219, 1549, 1754, 1957, 1965, 2092, 2094, 3283, 3285], 'well': [1056, 2093, 3214, 3800], 'Creutzfeldt-Jakob': [1059, 3829], '(17Gray': [1061], 'Chretien': [1063], 'Adle-Biassette': [1065], 'Dorandeu': [1067], 'Ereau': [1069], 'Delisle': [1071], 'Kopp': [1073], 'Ironside': [1075], 'J.W.': [1076], 'Vital': [1077], 'Neuropathol.': [1080], 'Exp.': [1081, 3199], 'Neurol.': [1082, 3200], '1999;': [1083, 1110, 1771, 3375, 3407], '58:': [1084], '321-328Crossref': [1085], '(147)': [1088], 'bovine': [1092], 'encephalopathy': [1094], '(18Theil': [1095], 'Fatzer': [1097], 'Meyer': [1099], 'Schobesberger': [1101], 'Zurbriggen': [1103], 'Vandevelde': [1105], 'Comp.': [1108], '121:': [1111], '357-367Crossref': [1112], '(20)': [1115, 3147], 'present': [1120, 3587, 4027], 'report,': [1121], 'examined': [1123, 2038], 'whether': [1124, 2183], 'can': [1129, 2883, 3011, 3280, 3309], 'induce': [1130, 2732, 2884], 'To': [1136, 1569, 2181, 2354], 'address': [1137], 'this': [1138, 3015, 3028, 4099], 'question,': [1139], 'directly': [1141, 2239], 'administrated': [1142], 'into': [1144, 1243, 1320, 2642, 3006, 3689], 'rat': [1145, 2189], 'eyes': [1146, 1365, 1367, 1405, 1425, 2190, 2372], 'system.': [1163, 1612], 'Apoptotic': [1164], 'demonstrated': [1170], 'means': [1172], '(TUNEL)': [1180], 'staining': [1181, 1519], 'DNA': [1185, 1666, 1701, 1710, 1726, 1739, 2368, 2401, 2417, 2438, 3273], 'fragmentation': [1186, 2364, 3274], 'technique.': [1187], 'Neuronal': [1188], 'confirmed': [1191], 'measurement': [1193], 'sequence': [1203, 3595], '(P106–126;': [1209], 'KTNMKHMAGAAAAGAVVGGLG)': [1210], 'purchased': [1212], 'from': [1213, 1630, 1874, 1888, 1978, 2348, 2552, 2585, 3647, 3826], 'Bachem.': [1214], 'used': [1218, 1262, 1384, 1996, 4024], 'control': [1221, 2449, 2605, 3568], '(P89–103;': [1223], 'GQGGGTHNQWNKPSK)': [1224], 'synthesized': [1226], 'Eurogentec.': [1228], 'Lyophilized': [1229], 'peptides': [1230, 1307, 2031, 3338, 3530, 3604, 3795], 'dissolved': [1232], 'deionized': [1234], 'water': [1235], 'at': [1236, 1248, 1267, 1413, 1465, 1473, 1582, 1662, 1697, 1718, 1921, 1948, 2388, 2539, 2566, 2576, 3760, 3888], 'concentration': [1238, 1711], '5': [1240, 1545, 1654, 2204, 2333, 2380], 'mm,': [1241], 'distributed': [1242, 1984], '20-μl': [1244], 'aliquots,': [1245], 'stored': [1247, 1472, 1865], '−20': [1249, 1474, 1698], '°C.': [1250, 1664, 1699], 'Peptides': [1251], 'twice': [1254], '2×': [1256], 'PBS': [1257, 1434, 1442, 1529, 1539, 2142, 2197], 'minus': [1258], 'Ca2+': [1259], 'immediately': [1261, 1427], 'aged': [1264, 2077, 2207, 2383, 2508, 3239, 3554, 3578], 'room': [1268], 'temperature': [1269], '3': [1271, 1400, 2587], 'days.': [1272], 'Adult': [1273], 'male': [1274], 'albino': [1275], 'Wistar': [1276], 'rats': [1277, 1556, 1784, 1796, 1974], '(35–55': [1278], 'days': [1279, 1401, 2499, 3042, 3313], 'old)': [1280], 'anesthetized': [1282, 1795], 'intraperitoneal': [1285], 'injection': [1286, 2427, 2603], '60': [1288, 1469], 'mg/kg': [1289], 'sodium': [1290, 1398], 'pentobarbital': [1291, 1399], 'followed': [1292], 'topical': [1295], 'application': [1296], '0.4%': [1298], 'oxybuprocaine': [1299], 'hydrochloride.': [1300], 'injections': [1302, 1339, 2075, 2178, 2484, 3481], '2': [1304, 1374, 1526, 1660, 2554, 2578], 'μl': [1305, 1375, 1527], 'vehicle': [1309, 1377, 2376], '(phosphate-buffered': [1310], 'solution)': [1311], 'done': [1313, 1517, 2601], 'unilaterally': [1314], '30-gauge': [1317], 'needle': [1318], 'introduced': [1319], 'posterior': [1322], 'chamber': [1323], 'on': [1324, 1457, 1812, 2032, 2485, 2615, 3296, 4115], 'upper': [1326, 2172], 'pole': [1327], 'eye': [1330], 'directed': [1331], 'toward': [1332], 'center': [1334], 'vitreous.': [1337], 'performed': [1341, 1484, 1753], 'slowly': [1342, 2551], 'allow': [1344], 'better': [1346, 2355], 'diffusion': [1347], 'avoid': [1352], 'any': [1353], 'ocular': [1354], 'hypertension.': [1355], 'For': [1356, 1552, 2627, 2752, 3083, 3232], 'negative': [1357], 'controls,': [1358], 'considered': [1361, 2009], 'uninjected': [1363], 'contralateral': [1364], 'injected': [1368, 1548, 2300, 2306, 2374], 'same': [1371, 3607], 'conditions': [1372, 3956, 3970], '(PBS).': [1378], 'At': [1379], 'least': [1380, 3761], 'four': [1381, 1555, 1911], 'animals': [1382], 'each': [1386, 1553, 1594, 1941, 1949], 'group': [1387, 2004, 2510], 'conditions.': [1390], 'Rats': [1391], 'euthanatized': [1393], 'overdose': [1396], 'post-intravitreal': [1402], 'injections.': [1403, 3545], 'enucleated,': [1407], 'puncture': [1410], 'made': [1412], 'limbus': [1415], 'permit': [1417], 'infusion': [1419], 'fixative': [1422], 'solution.': [1423], 'fixed': [1428], 'ice-cold': [1430], '4%': [1431], 'paraformaldehyde': [1432], '4': [1436, 1973, 2478], 'h': [1437, 1661, 2195, 2425, 3287], 'then': [1438, 1471, 1492, 1638, 1685, 1864, 1920, 2573, 3045], 'cryoprotected': [1439], 'overnight': [1440, 1696, 1781], 'containing': [1443, 1733, 2200], '20%': [1444], 'sucrose': [1445], 'embedded': [1447], 'Tissue-Tek®': [1449], '(Sakura).': [1450], 'Frozen': [1451], 'sections': [1452, 1521, 1561, 1579, 2050, 2211], '(10': [1453, 1649, 1831], 'μm)': [1454], 'cut': [1456], 'cryostat': [1459], '(Leica),': [1460], 'slides': [1462], 'heated': [1464], '50': [1466], '°C': [1467, 1475], 'min': [1470, 1912], 'until': [1476], 'use.': [1477], 'Thein': [1478], 'situ': [1479], 'detection': [1482], 'following': [1485], "manufacturer's": [1487], 'recommendations': [1488], '(Roche': [1489], 'Molecular': [1490], 'Biochemicals)': [1491], 'revealed': [1493, 2219], 'using': [1494, 1607, 1854], '(DAB)': [1497], 'substrate': [1498, 2237], 'kit': [1499], '(Vector': [1500], 'Laboratories)': [1501], 'processed': [1503, 1563, 2051, 2213], 'detailed': [1505], 'examination': [1506], 'light': [1508, 1746, 1789, 2808], 'microscopy.': [1509], 'Morphological': [1510], 'histological': [1512], 'observations': [1513], 'retinas': [1515, 1627, 2134, 2139, 2395, 2446, 2453, 2470], '1%': [1523, 1657], 'cresyl': [1524, 2068], 'violet.': [1525], 'alone': [1530, 2143, 2198, 2377], '3-day-aged': [1533, 2025], 'extemporarily': [1537], '(corresponding': [1540], '0.05,': [1542, 2201], '0.5,': [1543, 2202], 'nmol)': [1546], 'described': [1550, 1755], 'above.': [1551], 'condition,': [1554], 'treated,': [1558], 'simultaneously': [1564], 'TUNEL-labeling': [1567, 2216, 2340], 'assay.': [1568], 'evaluate': [1570], 'TUNEL-positive': [1574, 2081, 2112, 2158, 2245], 'cells,': [1575, 2315], 'photographs': [1576], 'collected': [1581], 'original': [1584], 'magnification': [1585], '×': [1587], '10.': [1588], 'intensity': [1590, 1615, 2229, 2274, 2290], 'gray': [1592, 1614, 2231, 2273, 2289], 'layer': [1595, 2099, 2257], '(ganglion': [1596], 'cell,': [1597], 'G;': [1598], 'inner': [1599, 2087, 2278, 2327], 'nuclear,': [1600, 1603], 'INL;': [1601], 'outer': [1602, 2089, 2280, 2329], 'ONL)': [1604], 'quantified': [1606], 'NIH': [1609], 'image': [1610], 'software': [1611], 'per': [1618, 1975], 'surface': [1619, 2256], 'unit': [1620], 'arbitrary': [1622], 'units.': [1623], 'After': [1624, 2073], 'enucleation,': [1625], 'dissected': [1629], 'epithelium': [1633], 'choroid.': [1635], 'Proteins': [1636], 'digested': [1639], '200': [1641, 2411], 'μg/ml': [1642, 1735], 'K': [1645], 'lysis': [1647], 'buffer': [1648], 'mm': [1650, 1655], 'Tris,': [1651], 'pH': [1652], '7.4,': [1653], 'EDTA,': [1656], 'SDS)': [1658], '55': [1663], 'Retinal': [1665], 'extracted': [1668], 'phenol-chloroform': [1670], 'solutions,': [1671], 'aqueous': [1674], 'phase': [1675], 'incubated': [1677], 'Dnase-free': [1679], 'RNase': [1680], 'A': [1681, 1805, 4101], '(100': [1682], 'μg/ml)': [1683], 'precipitated': [1686], 'solution': [1689], '0.3': [1691], 'msodium': [1692], 'acetate': [1693], 'ethanol': [1695], 'Precipitated': [1700], 'samples': [1702], 'resuspended': [1704], 'distilled': [1706], 'water,': [1707], 'determined': [1713], 'measuring': [1715], 'absorbance': [1717], '260': [1719], 'nm.': [1720], 'Samples': [1721], '10': [1723], 'μg': [1724], 'electrophoresed': [1728], 'through': [1729, 2052, 2214, 2947], '1.2%': [1730], 'agarose': [1731], 'gel': [1732], '1': [1734, 2043, 2071, 2101, 2117, 2145, 2153, 2541, 2568], 'ethidium': [1737], 'bromide.': [1738], 'bands': [1740, 2404], 'visualized': [1742], 'UV': [1745], 'transilluminator': [1747], 'photographed.': [1749], 'Dark-adapted': [1750], 'ERGs': [1751, 1851], 'previously': [1756, 2225], '(19Ettaiche': [1757], 'Fillacier': [1759], 'Widmann': [1761], 'Heurteaux': [1763], 'Lazdunski': [1765], 'Invest.': [1767, 3187], 'Ophthalmol.': [1768], 'Visual': [1769], '40:': [1772], '729-736PubMed': [1773], 'Full-field': [1776], 'ERG': [1777, 1980], 'responses': [1778, 1902], 'obtained': [1780, 1939, 1971, 2275], 'dark-adapted': [1783], 'prepared': [1785, 2023, 2105, 2457, 2610, 3559], 'under': [1786, 2806], 'dim': [1787], 'red': [1788, 2813], 'before': [1790, 1917], 'recording.': [1791], 'pupils': [1793], 'dilated': [1798], 'drop': [1801], '0.5%': [1803], 'tropicamide.': [1804], 'silver': [1806], 'chloride': [1807, 1822], 'ring-recording': [1808], 'electrode': [1809], 'placed': [1811, 1842], 'cornea,': [1814], 'reference': [1817], 'electrode,': [1818], 'silver-silver': [1821], 'tip,': [1823], 'connected': [1825], 'ear.': [1828], 'Light': [1829], 'stimulus': [1830], 'μs)': [1832], 'provided': [1834], 'stroboscopic': [1837], 'flash': [1838], '(Grass': [1839], 'Instruments': [1840], 'Inc.)': [1841, 1862], '0.25': [1843], 'm': [1844], 'front': [1846], 'rat.': [1849], 'recorded': [1853, 1916], 'visual': [1856], 'test': [1858, 1994], '(LKC': [1860], 'Technologies,': [1861], 'analyzed.': [1867], 'Amplitude': [1868], 'a-wave': [1871, 1893, 2535], 'measured': [1873, 1887], 'base': [1876, 2412], 'line': [1877], 'trough': [1880, 1890], 'a-wave;': [1883], 'b-wave': [1884, 2496, 2518, 2562, 2619], 'amplitude': [1885, 1933, 2536, 2563], 'peak': [1896], 'b-wave.': [1899], 'averaged': [1901], 'represent': [1903], 'mean': [1905, 1966], 'five': [1907], 'white': [1908], 'flashes': [1909], 'delivered': [1910], 'apart.': [1913], 'Electroretinograms': [1914], 'treatment': [1918], 'different': [1922, 2389], 'times': [1923, 2390], 'recovery': [1925, 3304], '(1,': [1926], '2,': [1927], '3,': [1928, 2448], '7': [1930, 2593, 3312], 'days).': [1931], 'values': [1934, 1970, 2014], 'a-': [1936, 2494, 2516, 2617], 'b-waves': [1938], 'normalized': [1944], 'base-line': [1946, 1960], 'amplitudes': [1947, 2497, 2620], 'point': [1951], 'study': [1954, 3218, 3989], 'percentage': [1958], 'value.': [1961], 'Data': [1962], '±': [1967, 2543, 2570, 2580, 2589, 2595], 'S.E.': [1968], 'group.': [1976], 'Results': [1977], 'recordings': [1981, 2599], 'normally': [1985], 'had': [1987], 'unequal': [1988], 'variance.': [1989], 'Therefore,': [1990, 3209], 'Mann': [1992], 'WitneyU': [1993], 'compare': [1998], 'vehicle-treated': [2003, 2505], 'rats.': [2006], 'Differences': [2007], 'statistically': [2010], 'significant': [2011, 2512, 2613, 3255], 'when': [2012, 2809], 'P': [2013], 'less': [2016], 'than': [2017, 3632], '0.02.': [2018], 'P89–103': [2029, 2151, 2607], 'after': [2039, 2391, 2426, 2432, 2500, 2602, 3003, 3043, 3288, 3314, 3543], 'intravitreal': [2040, 2074, 2483, 3289], 'Fig.': [2042, 2477], 'shows': [2044, 2479], 'representative': [2045], 'photomicrographs': [2046], 'treated': [2048, 2140, 2192, 2454], 'TUNEL': [2054], 'assay': [2056, 2217], '(Fig.': [2057, 2070, 2100, 2116, 2144, 2152, 2414, 2447], '1,': [2058], 'B–E)': [2059], 'histology': [2062], 'PBS-treated': [2064, 2445], 'stained': [2066, 2810], 'violet': [2069], 'A).': [2072], '(5': [2079], 'nmol),': [2080], 'cells': [2082, 2098, 2113, 2286, 2321, 2324, 2954, 3128, 3246, 3541], 'nuclear': [2090, 2281, 2330], 'layers,': [2091], 'ganglion': [2097, 2285, 2323], 'D).': [2102], 'When': [2103, 2332, 2502, 2597], 'intravitreally': [2108], 'injected,': [2109, 2338], 'only': [2110, 2156, 3552], 'occasional': [2111], 'C)': [2118], 'physicochemical': [2131, 2746, 3334], 'state.': [2132], 'Intact': [2133], '(data': [2135, 2460, 2624, 3589], 'shown)': [2137], 'B)': [2146], 'E)': [2154], 'showed': [2155, 2342, 2396], 'few': [2157, 3041], 'cells.': [2159, 2246, 3897], 'No': [2160, 2437], 'differences': [2161], 'patterns': [2164], 'between': [2167, 2357, 3331, 3597], 'lower': [2169], 'poles': [2173], 'where': [2177], 'done.': [2180], 'assess': [2182], 'dose-dependent,': [2188], '72': [2194, 2435], 'nmol': [2205, 2304, 2334, 2381], 'P106–126.': [2208, 2301], 'Corresponding': [2209], 'DAB': [2222, 2236], 'substrate.': [2223], 'We': [2224, 4072, 4090], 'checked': [2226], 'coloration': [2232], 'developed': [2233], 'proportional': [2240], 'This': [2247], 'estimation': [2248], 'method': [2249, 2341], 'allowed': [2250], 'us': [2251], 'screen': [2253], 'important': [2260], 'sections.': [2264], 'Fig.2': [2265], 'histogram': [2268], 'representation': [2269], 'relative': [2272], 'layers': [2282, 2294, 2351], 'layer.': [2287], 'three': [2293, 2350], 'increases': [2295], 'quantity': [2298], 'Although': [2302, 2725], '0.05': [2303], 'significantly': [2310, 2538], 'higher': [2316], 'quantities': [2317], 'TUNEL-labeled': [2319], 'positive': [2320, 3567], 'layers.': [2331], 'almost': [2344], 'all': [2345], 'nuclei': [2347], 'positive.': [2353], 'discriminate': [2356], 'necrosis': [2358], 'death,': [2362, 3649], 'studied.': [2370], 'Four': [2371], 'analyzed': [2387], 'inoculation.': [2392, 2501, 3316], 'peptide-treated': [2394, 2467], 'ladder': [2398], 'pattern': [2399], 'degradation': [2402, 2439, 3781], 'corresponding': [2405], 'multiples': [2407], '180': [2409], 'pairs': [2413], '3).': [2415], 'laddering': [2418], 'clearly': [2420], 'slightly': [2422], 'observable': [2423], '24': [2424, 3286], 'more': [2430], 'intense': [2431], '48': [2433], 'h.': [2436], 'either': [2442], 'lane)': [2450], 'shown).': [2462, 2626, 3591], 'untreated': [2469], 'monitored': [2472, 3271], 'recording': [2474, 3277], 'ERGs.': [2476], 'describes': [2489], 'variation': [2491], 'several': [2498, 3084, 4051], 'compared': [2503], 'group,': [2506, 2533], 'P106–126-treated': [2509], 'exhibited': [2511], 'deficits': 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