Influence of low-level resistance to vancomycin on efficacy of teicoplanin and vancomycin for treatment of experimental endocarditis due to Enterococcus faecium

Name: Work Video:
Duration: 3 min 30 s
B. Fantin; Roland Leclercq; Michel Arthur; J Duval; C Carbon
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'CFU/g': [67, 183, 191, 226, 234, 272], 'vegetation.': [69], 'We': [70, 292], 'evaluated': [71], 'this': [73], 'model': [74], 'the': [75, 255, 298], 'efficacy': [76], '(30': [79], 'mg/kg': [80], 'body': [82], 'weight;': [83], 'mean': [84, 100, 115, 128], 'peak': [85, 101, 116, 129], 'trough': [87, 103, 118, 131], 'serum': [88], 'levels,': [89, 104, 119, 132], '27': [90], '5': [92, 150], 'respectively),': [94, 124, 139], '(standard': [96], 'dose,': [97, 112], '10': [98], 'mg/kg;': [99, 114, 127], '23': [105], '9': [107], 'respectively;': [109, 204, 243, 285], 'high': [111, 209, 239], '20': [113], '63': [120], '25': [122], 'gentamicin': [125, 278, 305], '(6': [126], '8.6': [133], 'less': [135, 245], 'than': [136, 216, 246], '0.1': [137], 'alone': [140], 'or': [141, 297], 'combination,': [143], 'given': [144], 'every': [145], '12': [146], 'h': [147], 'intramuscularly': [148], 'for': [149, 194, 237, 275], 'days.': [151], 'Teicoplanin': [152], 'standard': [153, 281], 'dose': [154, 210, 240, 282], 'was': [155, 164, 172, 213, 306], 'as': [156, 158], 'active': [157], 'both': [161], 'strains.': [162], 'Vancomycin': [163], 'not': [165], 'effective': [166, 174, 215, 257, 307], 'BM4172': [170, 199, 221, 251], 'but': [171], 'highly': [173], '(7.5': [179], '+/-': [180, 188, 223, 231, 265, 269], '1.1': [181, 232], 'vegetation': [185, 193, 228, 236, 274], 'versus': [186, 229, 289], '4.9': [187], '1.0': [189], 'BM4172S,': [203], 'P': [205, 244, 286], '=': [206], '0.0012).': [207], 'A': [208], 'more': [214], '(4.4': [222], '1.8': [224], '7.5': [230], 'vancomycin,': [242], '0.05).': [247], 'Against': [248], 'glycopeptide-gentamicin': [252], 'combinations': [253], 'most': [256], 'regimens': [258], 'vivo': [263], '(2.8': [264], '0.7': [266], '3.5': [268], '1.3': [270], 'plus': [277, 283, 304], 'gentamicin,': [284], '&lt;': [287], '0.05': [288], 'single-drug': [290], 'regimens).': [291], 'concluded': [293], 'that': [294], 'high-dose': [295], 'combination': [299], 'glycopeptide': [302], 'antibiotic': [303], 'experimental': [309], 'infection': [310], 'due': [311], 'low-level': [316], 'resistance': [317], 'vancomycin.': [319]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1986215468', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-12T13:35:41.078374', 'created_date': '2016-06-24'}
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