Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1986197523', 'doi': 'https://doi.org/10.1073/pnas.0912739107', 'title': 'A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells', 'display_name': 'A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells', 'publication_year': 2010, 'publication_date': '2010-04-12', 'ids': {'openalex': 'https://openalex.org/W1986197523', 'doi': 'https://doi.org/10.1073/pnas.0912739107', 'mag': '1986197523', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20385838', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2867880'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.0912739107', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2867880?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090820903', 'display_name': 'Sam Walcott', 'orcid': 'https://orcid.org/0000-0002-8871-6964'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sam Walcott', 'raw_affiliation_strings': ['Mechanical Engineering and Johns Hopkins Physical Science Oncology Center, Johns Hopkins University, Baltimore, MD 21218, USA.'], 'affiliations': [{'raw_affiliation_string': 'Mechanical Engineering and Johns Hopkins Physical Science Oncology Center, Johns Hopkins University, Baltimore, MD 21218, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033299619', 'display_name': 'Sean X. Sun', 'orcid': 'https://orcid.org/0000-0002-9077-7088'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Sean X. Sun', 'raw_affiliation_strings': ['Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218', 'Mechanical Engineering and Johns Hopkins Physical Science Oncology Center and'], 'affiliations': [{'raw_affiliation_string': 'Mechanical Engineering and Johns Hopkins Physical Science Oncology Center and', 'institution_ids': []}, {'raw_affiliation_string': 'Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218', 'institution_ids': ['https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5033299619'], 'corresponding_institution_ids': ['https://openalex.org/I145311948'], 'apc_list': None, 'apc_paid': None, 'fwci': 9.335, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 228, 'citation_normalized_percentile': {'value': 0.999874, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '107', 'issue': '17', 'first_page': '7757', 'last_page': '7762'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10923', 'display_name': 'Force Microscopy Techniques and Applications', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/3107', 'display_name': 'Atomic and Molecular Physics, and Optics'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11190', 'display_name': '3D Printing in Biomedical Research', 'score': 0.9882, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stress-fiber', 'display_name': 'Stress fiber', 'score': 0.6637707}, {'id': 'https://openalex.org/keywords/elasticity', 'display_name': 'Elasticity', 'score': 0.52399623}], 'concepts': [{'id': 'https://openalex.org/C2781099445', 'wikidata': 'https://www.wikidata.org/wiki/Q4121060', 'display_name': 'Stress fiber', 'level': 4, 'score': 0.6637707}, {'id': 'https://openalex.org/C6997183', 'wikidata': 'https://www.wikidata.org/wiki/Q271727', 'display_name': 'Myosin', 'level': 2, 'score': 0.6430235}, {'id': 'https://openalex.org/C2779372316', 'wikidata': 'https://www.wikidata.org/wiki/Q569057', 'display_name': 'Stiffness', 'level': 2, 'score': 0.63032097}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.60091674}, {'id': 'https://openalex.org/C125705527', 'wikidata': 'https://www.wikidata.org/wiki/Q185269', 'display_name': 'Actin', 'level': 2, 'score': 0.57435656}, {'id': 'https://openalex.org/C121854251', 'wikidata': 'https://www.wikidata.org/wiki/Q62932', 'display_name': 'Elasticity (physics)', 'level': 2, 'score': 0.52399623}, {'id': 'https://openalex.org/C2993400109', 'wikidata': 'https://www.wikidata.org/wiki/Q329638', 'display_name': 'Actin cytoskeleton', 'level': 4, 'score': 0.5221458}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.48410857}, {'id': 'https://openalex.org/C84416704', 'wikidata': 'https://www.wikidata.org/wiki/Q188666', 'display_name': 'Adhesion', 'level': 2, 'score': 0.46251005}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.40371102}, {'id': 'https://openalex.org/C57879066', 'wikidata': 'https://www.wikidata.org/wiki/Q41217', 'display_name': 'Mechanics', 'level': 1, 'score': 0.35542744}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.35074556}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.21897244}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.18362722}, {'id': 'https://openalex.org/C159985019', 'wikidata': 'https://www.wikidata.org/wiki/Q181790', 'display_name': 'Composite material', 'level': 1, 'score': 0.17090398}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.10041565}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D040542', 'descriptor_name': 'Mechanotransduction, Cellular', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009218', 'descriptor_name': 'Myosins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001696', 'descriptor_name': 'Biomechanical Phenomena', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004548', 'descriptor_name': 'Elasticity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004548', 'descriptor_name': 'Elasticity', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017276', 'descriptor_name': 'Friction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017276', 'descriptor_name': 'Friction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D040542', 'descriptor_name': 'Mechanotransduction, Cellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009218', 'descriptor_name': 'Myosins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.0912739107', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2867880', 'pdf_url': 'https://europepmc.org/articles/pmc2867880?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867880', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20385838', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2867880', 'pdf_url': 'https://europepmc.org/articles/pmc2867880?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1963578828', 'https://openalex.org/W1967807546', 'https://openalex.org/W1979038578', 'https://openalex.org/W1993006648', 'https://openalex.org/W2006939412', 'https://openalex.org/W2014194778', 'https://openalex.org/W2018094651', 'https://openalex.org/W2018730824', 'https://openalex.org/W2022548948', 'https://openalex.org/W2032272287', 'https://openalex.org/W2033897003', 'https://openalex.org/W2048774144', 'https://openalex.org/W2051430013', 'https://openalex.org/W2054635074', 'https://openalex.org/W2060571642', 'https://openalex.org/W2072268903', 'https://openalex.org/W2084475925', 'https://openalex.org/W2086061329', 'https://openalex.org/W2086200436', 'https://openalex.org/W2089920144', 'https://openalex.org/W2095994722', 'https://openalex.org/W2098173227', 'https://openalex.org/W2108504970', 'https://openalex.org/W2117425975', 'https://openalex.org/W2123029770', 'https://openalex.org/W2126777451', 'https://openalex.org/W2134208433', 'https://openalex.org/W2148328620', 'https://openalex.org/W2151275196', 'https://openalex.org/W2152002380', 'https://openalex.org/W2164244652', 'https://openalex.org/W2169026935', 'https://openalex.org/W2625159833'], 'related_works': ['https://openalex.org/W2904912999', 'https://openalex.org/W2901611760', 'https://openalex.org/W2773405305', 'https://openalex.org/W2613165074', 'https://openalex.org/W2219307906', 'https://openalex.org/W2163215382', 'https://openalex.org/W2113186347', 'https://openalex.org/W1988263027', 'https://openalex.org/W197432475', 'https://openalex.org/W1908941310'], 'abstract_inverted_index': {'Tissue': [0], 'cells': [1, 17, 212], 'sense': [2, 18], 'and': [3, 123, 160, 208], 'respond': [4], 'to': [5, 55, 115, 121, 126, 214], 'the': [6, 9, 78, 82, 97, 116, 127, 134, 137, 143, 154, 171], 'stiffness': [7, 20, 34, 209], 'of': [8, 43, 63, 81, 87, 129, 146, 157, 163, 188], 'surface': [10, 19], 'on': [11, 38, 177, 195], 'which': [12], 'they': [13], 'adhere.': [14], 'Precisely': [15], 'how': [16], 'remains': [21], 'an': [22, 111], 'open': [23], 'question,': [24], 'though': [25], 'various': [26], 'biochemical': [27], 'pathways': [28], 'are': [29, 168], 'critical': [30], 'for': [31, 50, 204], 'a': [32, 39, 48, 72, 104, 151, 202, 215], 'proper': [33], 'response.': [35], 'Here,': [36], 'based': [37, 59], 'simple': [40, 105], 'mechanochemical': [41], 'model': [42, 49, 62, 200], 'biological': [44], 'friction,': [45], 'we': [46, 108], 'propose': [47], 'cell': [51], 'mechanosensation': [52], 'as': [53], 'opposed': [54], 'previous': [56], 'more': [57, 166], 'biochemically': [58], 'models.': [60], 'Our': [61], 'adhesion': [64, 98], 'complexes': [65, 99], 'predicts': [66], 'that': [67, 75, 91, 110], 'these': [68, 148, 185], 'cell-surface': [69], 'interactions': [70], 'provide': [71], 'viscous': [73], 'drag': [74], 'increases': [76], 'with': [77, 182], 'elastic': [79], 'modulus': [80], 'surface.': [83, 217], 'The': [84, 132], 'force-velocity': [85], 'relation': [86], 'myosin': [88, 92], 'II': [89], 'implies': [90], 'generates': [93], 'greater': [94, 133], 'force': [95, 113, 130], 'when': [96, 170], 'slide': [100], 'slowly.': [101], 'Then,': [102], 'using': [103], 'cytoskeleton': [106, 117, 172], 'model,': [107], 'show': [109], 'external': [112, 135], 'applied': [114], 'causes': [118], 'actin': [119, 164], 'filaments': [120], 'aggregate': [122], 'orient': [124], 'parallel': [125], 'direction': [128], 'application.': [131], 'force,': [136], 'faster': [138], 'this': [139], 'aggregation': [140], 'occurs.': [141], 'As': [142, 184], 'steady-state': [144], 'probability': [145], 'forming': [147], 'bundles': [149, 167, 187], 'reflects': [150], 'balance': [152], 'between': [153], 'time': [155], 'scale': [156], 'bundle': [158], 'formation': [159, 207], 'destruction': [161], '(because': [162], 'turnover),': [165], 'formed': [169], 'time-scale': [173], 'is': [174], 'small': [175], '(i.e.,': [176], 'stiff': [178, 196], 'surfaces),': [179], 'in': [180, 211], 'agreement': [181], 'experiment.': [183], 'large': [186], 'actin,': [189], 'called': [190], 'stress': [191, 205], 'fibers,': [192], 'appear': [193], 'preferentially': [194], 'surfaces,': [197], 'our': [198], 'mechanical': [199], 'provides': [201], 'mechanism': [203], 'fiber': [206], 'sensing': [210], 'adhered': [213], 'compliant': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1986197523', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 23}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-12-15T14:59:42.300035', 'created_date': '2016-06-24'}