Title: The Predictive Value Of Inspiratory Fraction To Exercise Capacity In Patients With Stable Moderate To Severe Chronic Obstructive Pulmonary Disease
Abstract:Objective To study the relationship between inspiratory-to-total lung capacity ratio or inspiratory fraction to exercise capacity in patients with stable moderate to severe chronic obstructive pulmona...Objective To study the relationship between inspiratory-to-total lung capacity ratio or inspiratory fraction to exercise capacity in patients with stable moderate to severe chronic obstructive pulmonary disease.
Methods Pulmonary lung function test(PFT) and Cardiopulmonary exercise testing(CPET) were tested in 50 patients with stable moderate to severe chronic obstructive pulmonary disease and 34 controls, and measured the parameters of ventilation and gas exchange. The stopped reasons at the end of exercise testing were be noted.
Results (1)IF was significant associated with peak peak VO2%pred(r=0.52,p<0.001)in COPD and remained as independent predictor in the final model: peak VO2%pred = 65.9IF + 0.45FEV1%pred + 35.8(RC2=0.39,p<0.001),the sensitivity and specificity of IF for predicting exercise capacity were both better than FEV1%pred, (2)The patients with IF<0.23 had more severe hyperinflation and lower exercise capacity. In the peak exercise, the patients with IF<0.23 had lower peak VE and lower peak VT than the patients with IF≥0.23, and their peak breath frequencies had no significant difference. Conclusion Inspiratory fraction provides the efficient information to reflect lung hyperinflation and to estimate the exercise capacity in patients with stable moderate to severe chronic obstructive pulmonary disease, and its predictive value is better than FEV1%pred.Read More
Publication Year: 2012
Publication Date: 2012-05-01
Language: en
Type: article
Indexed In: ['crossref']
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